DE602004030020D1 - Implantierbare oder einführbare medizinprodukte mit einem pfropf-copolymer zur kontrollierten abgabe von therapeutischen mitteln - Google Patents

Implantierbare oder einführbare medizinprodukte mit einem pfropf-copolymer zur kontrollierten abgabe von therapeutischen mitteln

Info

Publication number
DE602004030020D1
DE602004030020D1 DE602004030020T DE602004030020T DE602004030020D1 DE 602004030020 D1 DE602004030020 D1 DE 602004030020D1 DE 602004030020 T DE602004030020 T DE 602004030020T DE 602004030020 T DE602004030020 T DE 602004030020T DE 602004030020 D1 DE602004030020 D1 DE 602004030020D1
Authority
DE
Germany
Prior art keywords
introducable
peach
implantable
copolymer
therapeutic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004030020T
Other languages
German (de)
English (en)
Inventor
Robert E Richard
Frederick H Strickler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Ltd Barbados
Boston Scientific Corp
Original Assignee
Boston Scientific Ltd Barbados
Boston Scientific Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Ltd Barbados, Boston Scientific Corp filed Critical Boston Scientific Ltd Barbados
Publication of DE602004030020D1 publication Critical patent/DE602004030020D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08Materials for coatings
    • A61L29/085Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602Type of release, e.g. controlled, sustained, slow

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602004030020T 2003-07-31 2004-07-29 Implantierbare oder einführbare medizinprodukte mit einem pfropf-copolymer zur kontrollierten abgabe von therapeutischen mitteln Expired - Lifetime DE602004030020D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/632,413 US7357940B2 (en) 2003-07-31 2003-07-31 Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents
PCT/US2004/024530 WO2005011766A1 (en) 2003-07-31 2004-07-29 Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents

Publications (1)

Publication Number Publication Date
DE602004030020D1 true DE602004030020D1 (de) 2010-12-23

Family

ID=34104369

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004030020T Expired - Lifetime DE602004030020D1 (de) 2003-07-31 2004-07-29 Implantierbare oder einführbare medizinprodukte mit einem pfropf-copolymer zur kontrollierten abgabe von therapeutischen mitteln

Country Status (7)

Country Link
US (1) US7357940B2 (https=)
EP (1) EP1660144B1 (https=)
JP (1) JP5001005B2 (https=)
AU (1) AU2004261247A1 (https=)
CA (1) CA2534078A1 (https=)
DE (1) DE602004030020D1 (https=)
WO (1) WO2005011766A1 (https=)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7056338B2 (en) 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
EP1610823B1 (en) 2003-03-28 2011-09-28 Innovational Holdings, LLC Implantable medical device with continuous agent concentration gradient
US7494665B1 (en) * 2004-07-30 2009-02-24 Advanced Cardiovascular Systems, Inc. Polymers containing siloxane monomers
WO2006078320A2 (en) 2004-08-04 2006-07-27 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
US8075906B2 (en) 2005-02-01 2011-12-13 Boston Scientific Scimed, Inc. Medical devices having polymeric regions with copolymers containing hydrocarbon and heteroatom-containing monomeric species
US20060240060A1 (en) * 2005-04-22 2006-10-26 Cardiac Pacemakers, Inc. Lubricious compound and medical device made of the same
US20060240059A1 (en) * 2005-04-22 2006-10-26 Cardiac Pacemakers, Inc. Lubricious eluting polymer blend and coating made from the same
US20060240253A1 (en) * 2005-04-22 2006-10-26 Cardiac Pacemakers, Inc. Guidewire and tube with lubricious coating
US20060241000A1 (en) * 2005-04-22 2006-10-26 Cardiac Pacemakers, Inc. Lubricious compound and medical device made of the same
US8778375B2 (en) * 2005-04-29 2014-07-15 Advanced Cardiovascular Systems, Inc. Amorphous poly(D,L-lactide) coating
US8034874B2 (en) 2005-11-23 2011-10-11 Boston Scientific Scimed, Inc. Medical devices having polymeric regions that contain fluorocarbon-containing block copolymers
US8834912B2 (en) * 2005-12-30 2014-09-16 Boston Scientific Scimed, Inc. Medical devices having multiple charged layers
US7879086B2 (en) * 2006-04-20 2011-02-01 Boston Scientific Scimed, Inc. Medical device having a coating comprising an adhesion promoter
US7727541B2 (en) 2006-05-18 2010-06-01 Boston Scientific Scimed, Inc. Medical devices having polymeric regions based on vinyl ether block copolymers
US7914806B2 (en) * 2006-06-01 2011-03-29 Boston Scientific Scimed, Inc. Medical devices having improved performance
US20100063585A1 (en) * 2006-07-03 2010-03-11 Hemoteq Ag Manufacture, method and use of active substance-releasing medical products for permanently keeping blood vessels open
WO2008076383A2 (en) * 2006-12-18 2008-06-26 Med Institute Inc. Stent graft with releasable therapeutic agent
ES2393639T3 (es) 2007-01-21 2012-12-26 Hemoteq Ag Producto médico para tratar cierres de conductos corporales y prevención de nuevos cierres
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US20110129514A1 (en) * 2007-09-06 2011-06-02 Hossainy Syed F A Hygroscopic coating on a balloon device
US8124601B2 (en) * 2007-11-21 2012-02-28 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
WO2009085952A1 (en) 2007-12-20 2009-07-09 Brookwood Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
DE102008006654A1 (de) * 2008-01-30 2009-08-06 Biotronik Vi Patent Ag Implantat mit einem Grundkörper aus einer biokorrodierbaren Legierung
US20090208553A1 (en) * 2008-02-15 2009-08-20 University Of Southern Mississippi Monomers and Polymers with Covalently - Attached Active Ingredients
US20090264478A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Sulfasalazine formulations in a biodegradable polymer carrier
JP5523464B2 (ja) * 2008-09-22 2014-06-18 カーディアック ペースメイカーズ, インコーポレイテッド スチレン−イソブチレンコポリマー及びそれを含有する医療装置
EP2344207B1 (en) 2008-09-22 2013-12-25 Boston Scientific Neuromodulation Corporation Implantable or insertable medical devices
US8049061B2 (en) 2008-09-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery
US8226603B2 (en) 2008-09-25 2012-07-24 Abbott Cardiovascular Systems Inc. Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery
US8076529B2 (en) 2008-09-26 2011-12-13 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix for intraluminal drug delivery
ES2659363T3 (es) 2008-12-01 2018-03-15 University College Cork-National University Of Ireland, Cork Infusión intracoronaria de IGF-1 para la reparación del miocardio
EP2944332B1 (en) 2009-07-10 2016-08-17 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
EP2453938B1 (en) 2009-07-17 2015-08-19 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
KR20120107070A (ko) * 2009-09-22 2012-09-28 에보닉 데구사 코포레이션 다양한 생리활성 물질 로딩 구성을 갖는 임플란트 장치
WO2011119536A1 (en) 2010-03-22 2011-09-29 Abbott Cardiovascular Systems Inc. Stent delivery system having a fibrous matrix covering with improved stent retention
US9295663B2 (en) 2010-07-14 2016-03-29 Abbott Cardiovascular Systems Inc. Drug coated balloon with in-situ formed drug containing microspheres
EP2611476B1 (en) 2010-09-02 2016-08-10 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
CN116407646B (zh) * 2021-12-30 2024-05-31 中南民族大学 一种双载体双药温度响应型给药系统的制备方法及其应用
US12514756B1 (en) 2024-10-08 2026-01-06 Covidien Lp Dermal patch and systems, kits, and methods associated therewith

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196731A (en) 1978-03-17 1980-04-08 Baxter Travenol Laboratories, Inc. Silicone-containing thermoplastic polymers for medical uses
US4861830A (en) 1980-02-29 1989-08-29 Th. Goldschmidt Ag Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming
DE3245633A1 (de) 1982-12-09 1984-06-14 Serag-Wiessner Catgutfabriken GmbH, 8674 Naila Resorbierbares fasermaterial fuer die chirurgische wundversorgung, insbesondere fuer chirurgische naehzwecke
JPS59189153A (ja) * 1983-04-11 1984-10-26 Terumo Corp 樹脂組成物
US4584356A (en) * 1984-11-02 1986-04-22 General Electric Company Method for making silicone-organic block polymers
US4951656A (en) 1988-11-09 1990-08-28 Polysar Financial Services S.A. Orthopaedic structures from polymeric materials
US4946899A (en) 1988-12-16 1990-08-07 The University Of Akron Thermoplastic elastomers of isobutylene and process of preparation
US5674192A (en) 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5258020A (en) 1990-09-14 1993-11-02 Michael Froix Method of using expandable polymeric stent with memory
DE4041525A1 (de) * 1990-12-22 1992-06-25 Roehm Gmbh Acrylat-methacrylat-pfropfpolymerisate
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
JPH05345016A (ja) * 1991-10-14 1993-12-27 Terumo Corp 血液適合性医療用材料
JPH05310868A (ja) * 1992-05-11 1993-11-22 Japan Synthetic Rubber Co Ltd 医療材用組成物
GB9222382D0 (en) * 1992-10-24 1992-12-09 Cranfield Inst Of Tech Polymeric biochemical compositions
US5886026A (en) 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
EP1118325B2 (en) 1993-07-29 2010-01-06 The United States of America, represented by the Secretary, Department of Health and Human Services Use of Paclitaxel and its derivatives in the manufacture of a medicament for treating restenosis.
US5502092A (en) 1994-02-18 1996-03-26 Minnesota Mining And Manufacturing Company Biocompatible porous matrix of bioabsorbable material
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
AU732803B2 (en) * 1996-01-17 2001-05-03 National Starch And Chemical Investment Holding Corporation Adhesives resistant to skin-penetration enhancers
US5741331A (en) 1996-07-29 1998-04-21 Corvita Corporation Biostable elastomeric polymers having quaternary carbons
US5814329A (en) * 1996-11-12 1998-09-29 Polytherapeutics, Inc. Hydrophilic polystyrene graft copolymer vehicle for intravaginal administration of pharmacologically active agents
KR20000070375A (ko) 1997-02-21 2000-11-25 에드워드 엘. 데이지 압력 민감성 접착제 약물 경피 전달 시스템과 이에 사용되는압력 민감성 접착제
US5879697A (en) 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
EP0893165A3 (de) * 1997-06-28 2000-09-20 Degussa-Hüls Aktiengesellschaft Bioaktive Beschichtung von Oberflächen unter Verwendung von Makroinitiatoren
US6280411B1 (en) 1998-05-18 2001-08-28 Scimed Life Systems, Inc. Localized delivery of drug agents
US6335029B1 (en) 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
US20020045706A1 (en) 1998-09-22 2002-04-18 Houston Michael R. Biomedical molding materials from semi-solid precursors
US6446671B2 (en) * 2000-08-04 2002-09-10 John G. Armenia Double wall safety hose
US6545097B2 (en) * 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
NZ528994A (en) * 2001-04-26 2006-02-24 Control Delivery Sys Inc Sustained release drug delivery system containing codrugs
JP5073891B2 (ja) * 2001-07-16 2012-11-14 川澄化学工業株式会社 ステント及びステントグラフト
US8211455B2 (en) 2002-06-19 2012-07-03 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US20030236513A1 (en) 2002-06-19 2003-12-25 Scimed Life Systems, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent

Also Published As

Publication number Publication date
US20050025803A1 (en) 2005-02-03
WO2005011766A1 (en) 2005-02-10
JP5001005B2 (ja) 2012-08-15
EP1660144A1 (en) 2006-05-31
JP2007513643A (ja) 2007-05-31
US7357940B2 (en) 2008-04-15
CA2534078A1 (en) 2005-02-10
EP1660144B1 (en) 2010-11-10
AU2004261247A1 (en) 2005-02-10

Similar Documents

Publication Publication Date Title
DE602004030020D1 (de) Implantierbare oder einführbare medizinprodukte mit einem pfropf-copolymer zur kontrollierten abgabe von therapeutischen mitteln
DE602004032040D1 (de) Implantierbare oder einführbare medizinprodukte mit einem silicon-copolymer zur kontrollierten abgabe von therapeutischen mitteln
ATE358505T1 (de) Beschichtete endovaskuläre vorrichtung
AU2003220317A8 (en) Methods and drug delivery systems for the treatment of orofacial diseases
AU2003287734A1 (en) Implantable device for delivering cardiac drug therapy
DE60202677D1 (de) Implantierbare medizinische vorrichtung mit kontrollierter freigabe von gasförmigen mitteln
AU2003284018A1 (en) Medical device for neural stimulation and controlled drug delivery
DE602004018299D1 (de) Medizinprodukt mit therapeutischen mitteln
WO2005014533A3 (en) Aryl and heteroaryl compounds, compositions, and methods of use
AU2003220312A1 (en) Patient controlled activation with implantable drug delivery devices
IL162719A0 (en) Drug delivery systems for the prevention and treatment of vascular diseases comprising rapamycin andderivatives thereof
AU2003295614A8 (en) Delivery of pharmaceutical agents via the human insulin receptor
AU2003243305A8 (en) Implantable medication delivery device
DE602004012816D1 (de) Selbstexpandierbarer Stent und Stenteinbringungssystem zur Behandlung von Gefässerkrankungen
DE59009462D1 (de) Implantierbare Vorrichtung zur dosierten Abgabe von Medikamenten in den menschlichen Körper.
DE60330144D1 (de) Beschichtung von stents mit verzögerter wirkstofffreisetzung
WO2004032881A3 (en) Implantation of encapsulated biological materials for treating diseases
EP4324521A3 (en) Treatment of fabry disease in ert-naive and ert-experienced patients
DE602004017296D1 (de) Implantierbare oder einführbare medizinprodukte mit strahlungsvernetztem polymer für die kontrollierte abgabe eines therapeutischen mittels
EP1477119A4 (en) METHOD FOR THE ADMINISTRATION OF MEDICINAL PRODUCTS
PL372323A1 (en) Implantable drug delivery system
NZ504026A (en) Methods for treating hypercoagulable states or acquired protein C deficiency using human-activated protein C
WO2001078698A3 (en) Use of ngf-antagonists for the prevention or treatment of chronic visceral pain
ATE445424T1 (de) Biokompatible beschichtung von medizinischen vorrichtungen mit molekularsieben
AU2003245570A1 (en) Implantable or insertable medical devices for controlled delivery of a therapeutic agent