DE602004029394D1 - Antikörper variable region eines monoklonalen antikörpers gegen den humanen tumor nekrose faktor-alpha und dafür kodierendes gen - Google Patents

Antikörper variable region eines monoklonalen antikörpers gegen den humanen tumor nekrose faktor-alpha und dafür kodierendes gen

Info

Publication number
DE602004029394D1
DE602004029394D1 DE602004029394T DE602004029394T DE602004029394D1 DE 602004029394 D1 DE602004029394 D1 DE 602004029394D1 DE 602004029394 T DE602004029394 T DE 602004029394T DE 602004029394 T DE602004029394 T DE 602004029394T DE 602004029394 D1 DE602004029394 D1 DE 602004029394D1
Authority
DE
Germany
Prior art keywords
variable region
monoclonal antibody
necrosis factor
tumor necrosis
human tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004029394T
Other languages
English (en)
Inventor
Heui Il Kang
In Young Ko
Moo Young Song
Chang Seok Shindongah A Kim
Sang Koo Sinyoungtong Park
Jae Sun Woncheon Sam Lee
Tae Hyoung Saicheonnyun Yoo
Kang In Na
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yuhan Corp
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of DE602004029394D1 publication Critical patent/DE602004029394D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
DE602004029394T 2003-11-17 2004-11-16 Antikörper variable region eines monoklonalen antikörpers gegen den humanen tumor nekrose faktor-alpha und dafür kodierendes gen Active DE602004029394D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020030080950A KR100772800B1 (ko) 2003-11-17 2003-11-17 인간 종양괴사인자 α를 인식하는 단일클론항체의가변영역 및 이를 코딩하는 유전자
PCT/KR2004/002964 WO2005047329A1 (en) 2003-11-17 2004-11-16 An antibody variable region of a monoclonal antibody against human tumor necrosis factor alpha and a gene encoding the same

Publications (1)

Publication Number Publication Date
DE602004029394D1 true DE602004029394D1 (de) 2010-11-11

Family

ID=36640673

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004029394T Active DE602004029394D1 (de) 2003-11-17 2004-11-16 Antikörper variable region eines monoklonalen antikörpers gegen den humanen tumor nekrose faktor-alpha und dafür kodierendes gen

Country Status (8)

Country Link
US (2) US7109320B2 (de)
EP (1) EP1692179B1 (de)
JP (1) JP4563397B2 (de)
KR (1) KR100772800B1 (de)
CN (2) CN101440131B (de)
AT (1) ATE482980T1 (de)
DE (1) DE602004029394D1 (de)
WO (1) WO2005047329A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006071091A1 (en) * 2004-12-29 2006-07-06 Yuhan Corporation Humanized antibody specific for tumor necrosis factor-alpha
CL2007002926A1 (es) 2006-10-12 2008-05-16 Genentech Inc Anticuerpo antilinfotoxina alfa (lt-alfa); composicion con el anticuerpo; hibridoma pta-7538; acido nucleico codificante del anticuerpo; vector y celula huesped que comprenden el acido nucleico; metodo para inhibir la proliferacion celular activada p
CN101177453B (zh) * 2006-11-07 2010-09-29 旭华（上海）生物研发中心有限公司 抗人肿瘤坏死因子α的重组嵌合抗体
WO2008141511A1 (fr) * 2007-05-22 2008-11-27 Human Antibodomics (Shanghai) Inc. ANTICORPS MONOCLONAL HUMAIN ANTI-TNFα ET SON UTILISATION
EP2409992B1 (de) * 2009-03-20 2017-10-25 Danyang Zhengyuan Biotech Co. Ltd. Humaner, monoklonaler anti-tumornekrosefaktor-alpha-antikörper und anwendung davon
TWI538918B (zh) 2010-10-20 2016-06-21 財團法人工業技術研究院 人源化之單株抗體、其核苷酸序列與其用途
CN102464718B (zh) * 2010-11-05 2014-08-13 财团法人工业技术研究院 人源化之单克隆抗体、其氨基酸序列与核苷酸序列与其用途
CN102675460B (zh) 2011-02-28 2015-08-19 珠海市丽珠单抗生物技术有限公司 抗肿瘤坏死因子α的人源化抗体
US8658171B2 (en) 2011-02-28 2014-02-25 Livzon Mabpharm Inc. Humanized anti-TNFα antibodies
CN103173457B (zh) * 2013-03-04 2015-01-28 百奇生物科技（苏州）有限公司 抗cd20单克隆抗体可变区序列及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6280825B1 (en) 1988-12-07 2001-08-28 Laminating Technologies, Inc. Method of making a composite of paper and plastic film and composites
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB9028123D0 (en) * 1990-12-28 1991-02-13 Erba Carlo Spa Monoclonal antibodies against human tumor necrosis factor alpha
SI9720020B (en) * 1996-02-09 2001-12-31 Basf Ag Human antibodies that bind human TNF alpha
GB0013810D0 (en) * 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
CN1280190A (zh) * 2000-07-14 2001-01-17 中国人民解放军第四军医大学 重组的抗人TNFα基因工程抗体及其制备方法
WO2006071091A1 (en) * 2004-12-29 2006-07-06 Yuhan Corporation Humanized antibody specific for tumor necrosis factor-alpha

Also Published As

Publication number Publication date
US7109320B2 (en) 2006-09-19
WO2005047329A1 (en) 2005-05-26
EP1692179A1 (de) 2006-08-23
ATE482980T1 (de) 2010-10-15
CN1882611A (zh) 2006-12-20
US7196177B2 (en) 2007-03-27
KR20050047182A (ko) 2005-05-20
US20050124041A1 (en) 2005-06-09
CN101440131B (zh) 2013-02-06
CN101440131A (zh) 2009-05-27
KR100772800B1 (ko) 2007-11-01
US20060147452A1 (en) 2006-07-06
EP1692179B1 (de) 2010-09-29
EP1692179A4 (de) 2007-10-31
JP4563397B2 (ja) 2010-10-13
JP2007530012A (ja) 2007-11-01

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