ATE482980T1 - Antikörper variable region eines monoklonalen antikörpers gegen den humanen tumor nekrose faktor-alpha und dafür kodierendes gen - Google Patents

Antikörper variable region eines monoklonalen antikörpers gegen den humanen tumor nekrose faktor-alpha und dafür kodierendes gen

Info

Publication number
ATE482980T1
ATE482980T1 AT04800099T AT04800099T ATE482980T1 AT E482980 T1 ATE482980 T1 AT E482980T1 AT 04800099 T AT04800099 T AT 04800099T AT 04800099 T AT04800099 T AT 04800099T AT E482980 T1 ATE482980 T1 AT E482980T1
Authority
AT
Austria
Prior art keywords
variable region
necrosis factor
tumor necrosis
human tumor
alpha
Prior art date
Application number
AT04800099T
Other languages
English (en)
Inventor
Heui Il Kang
In Young Ko
Moo Young Song
Chang Seok Kim
Sang Koo Park
Jae Sun Lee
Tae Hyoung Yoo
Kang In Na
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Application granted granted Critical
Publication of ATE482980T1 publication Critical patent/ATE482980T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT04800099T 2003-11-17 2004-11-16 Antikörper variable region eines monoklonalen antikörpers gegen den humanen tumor nekrose faktor-alpha und dafür kodierendes gen ATE482980T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020030080950A KR100772800B1 (ko) 2003-11-17 2003-11-17 인간 종양괴사인자 α를 인식하는 단일클론항체의가변영역 및 이를 코딩하는 유전자
PCT/KR2004/002964 WO2005047329A1 (en) 2003-11-17 2004-11-16 An antibody variable region of a monoclonal antibody against human tumor necrosis factor alpha and a gene encoding the same

Publications (1)

Publication Number Publication Date
ATE482980T1 true ATE482980T1 (de) 2010-10-15

Family

ID=36640673

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04800099T ATE482980T1 (de) 2003-11-17 2004-11-16 Antikörper variable region eines monoklonalen antikörpers gegen den humanen tumor nekrose faktor-alpha und dafür kodierendes gen

Country Status (8)

Country Link
US (2) US7109320B2 (de)
EP (1) EP1692179B1 (de)
JP (1) JP4563397B2 (de)
KR (1) KR100772800B1 (de)
CN (2) CN1882611A (de)
AT (1) ATE482980T1 (de)
DE (1) DE602004029394D1 (de)
WO (1) WO2005047329A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2359567T3 (es) 2004-12-29 2011-05-24 Yuhan Corporation Anticuerpo humanizado específico para el factor de necrosis tumoral-alfa.
RU2486201C2 (ru) * 2006-10-12 2013-06-27 Дженентек, Инк. Антитела к лимфотоксину-альфа
CN101177453B (zh) * 2006-11-07 2010-09-29 旭华（上海）生物研发中心有限公司 抗人肿瘤坏死因子α的重组嵌合抗体
WO2008141511A1 (fr) * 2007-05-22 2008-11-27 Human Antibodomics (Shanghai) Inc. ANTICORPS MONOCLONAL HUMAIN ANTI-TNFα ET SON UTILISATION
WO2010105446A1 (zh) * 2009-03-20 2010-09-23 上海宏源生物技术有限公司 抗人肿瘤坏死因子受体α单抗及其应用
TWI538918B (zh) 2010-10-20 2016-06-21 財團法人工業技術研究院 人源化之單株抗體、其核苷酸序列與其用途
CN102464718B (zh) * 2010-11-05 2014-08-13 财团法人工业技术研究院 人源化之单克隆抗体、其氨基酸序列与核苷酸序列与其用途
CN102675460B (zh) 2011-02-28 2015-08-19 珠海市丽珠单抗生物技术有限公司 抗肿瘤坏死因子α的人源化抗体
US8658171B2 (en) 2011-02-28 2014-02-25 Livzon Mabpharm Inc. Humanized anti-TNFα antibodies
CN103173457B (zh) * 2013-03-04 2015-01-28 百奇生物科技（苏州）有限公司 抗cd20单克隆抗体可变区序列及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6280825B1 (en) 1988-12-07 2001-08-28 Laminating Technologies, Inc. Method of making a composite of paper and plastic film and composites
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB9028123D0 (en) * 1990-12-28 1991-02-13 Erba Carlo Spa Monoclonal antibodies against human tumor necrosis factor alpha
CN103275221B (zh) * 1996-02-09 2016-08-17 艾伯维生物技术有限公司 结合人TNFα的人抗体
GB0013810D0 (en) * 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
CN1280190A (zh) * 2000-07-14 2001-01-17 中国人民解放军第四军医大学 重组的抗人TNFα基因工程抗体及其制备方法
ES2359567T3 (es) * 2004-12-29 2011-05-24 Yuhan Corporation Anticuerpo humanizado específico para el factor de necrosis tumoral-alfa.

Also Published As

Publication number Publication date
US20060147452A1 (en) 2006-07-06
EP1692179A4 (de) 2007-10-31
JP4563397B2 (ja) 2010-10-13
DE602004029394D1 (de) 2010-11-11
KR20050047182A (ko) 2005-05-20
CN1882611A (zh) 2006-12-20
CN101440131B (zh) 2013-02-06
US7109320B2 (en) 2006-09-19
EP1692179A1 (de) 2006-08-23
KR100772800B1 (ko) 2007-11-01
EP1692179B1 (de) 2010-09-29
CN101440131A (zh) 2009-05-27
WO2005047329A1 (en) 2005-05-26
US20050124041A1 (en) 2005-06-09
JP2007530012A (ja) 2007-11-01
US7196177B2 (en) 2007-03-27

Similar Documents

Publication Publication Date Title
EA200801509A1 (ru) Человеческие моноклональные антитела к протеинтирозинкиназе 7 ( ptk7) и способы применения антител против ptk7
ATE472556T1 (de) Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen
DE602006003695D1 (de) Synthetische Immunoglobulindomänen mit in Regionen des Moleküls, die sich von den die Komplementarität bestimmenden Bereichen unterscheiden, modifizierten Bindeeigenschaften
EA200970477A1 (ru) Человеческие моноклональные антитела к btla и способы применения
ATE492563T1 (de) Vollständige humane monoklonale antikörper gegen il-13
WO2005097185A3 (en) Irta-5 antibodies and their uses
EA200800094A1 (ru) Антитела cd19 и их использование
ATE476994T1 (de) Antikörper gegen gpnmb und ihre verwendungen
DE60237778D1 (de) Antikörper gegen kdr, deren herstellung und verwendungen
CY1114851T1 (el) Il-1βητα δεσμευτικα αντισωματα και θραυσματα αυτων
WO2007067991A3 (en) Human monoclonal antibodies to o8e
WO2006076691A8 (en) Irta-2 antibodies and their uses
TW200634027A (en) Antibodies directed to angiopoietin-2 and uses thereof
ATE504602T1 (de) Für humane matriptase spezifische bindungsproteine
WO2006113643A3 (en) High affinity fully human monoclonal antibodies to interleukin-8 and epitopes for such antibodies
ATE420660T1 (de) Antikörper gegen parath-hormon (pth) und ihre verwendungen
ATE482980T1 (de) Antikörper variable region eines monoklonalen antikörpers gegen den humanen tumor nekrose faktor-alpha und dafür kodierendes gen
WO2006039135A3 (en) Irta-4 antibodies and their uses
CY1117395T1 (el) Il-1βητα δεσμευτικα αντισωματα και θραυσματα αυτων
CY1113958T1 (el) Ανθρωπινα μονοκλωνικα αντισωματα σε φουκοζυλ-gμ1 και μεθοδοι για τη χρηση αντι-φουκοζυλ-gμ1

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties