DE60136430D1 - Heterosubstituierte c7-taxanacetate als antitumormittel - Google Patents
Heterosubstituierte c7-taxanacetate als antitumormittelInfo
- Publication number
- DE60136430D1 DE60136430D1 DE60136430T DE60136430T DE60136430D1 DE 60136430 D1 DE60136430 D1 DE 60136430D1 DE 60136430 T DE60136430 T DE 60136430T DE 60136430 T DE60136430 T DE 60136430T DE 60136430 D1 DE60136430 D1 DE 60136430D1
- Authority
- DE
- Germany
- Prior art keywords
- heterosubstituted
- taxanacetate
- antitum
- texanes
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17967200P | 2000-02-02 | 2000-02-02 | |
| PCT/US2001/003600 WO2001057029A1 (en) | 2000-02-02 | 2001-02-02 | C7 heterosubstituted acetate taxanes as antitumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60136430D1 true DE60136430D1 (de) | 2008-12-18 |
Family
ID=22657505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60136430T Expired - Fee Related DE60136430D1 (de) | 2000-02-02 | 2001-02-02 | Heterosubstituierte c7-taxanacetate als antitumormittel |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6673833B2 (enExample) |
| EP (1) | EP1200424B1 (enExample) |
| JP (1) | JP2003522169A (enExample) |
| KR (1) | KR20010112393A (enExample) |
| CN (1) | CN1362957A (enExample) |
| AT (1) | ATE413397T1 (enExample) |
| AU (1) | AU776765B2 (enExample) |
| BR (1) | BR0104353A (enExample) |
| CA (1) | CA2368534A1 (enExample) |
| CZ (1) | CZ20013519A3 (enExample) |
| DE (1) | DE60136430D1 (enExample) |
| HK (1) | HK1047935A1 (enExample) |
| HU (1) | HUP0200651A3 (enExample) |
| IL (1) | IL145642A0 (enExample) |
| MX (1) | MXPA01009922A (enExample) |
| NO (1) | NO20014758L (enExample) |
| NZ (1) | NZ514411A (enExample) |
| PL (1) | PL350328A1 (enExample) |
| WO (1) | WO2001057029A1 (enExample) |
| ZA (1) | ZA200108063B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1047935A1 (zh) * | 2000-02-02 | 2003-03-14 | 佛罗里达州立大学研究基金有限公司 | 作为抗肿瘤剂的c7杂取代乙酸酯取代的紫杉烷 |
| US20040210289A1 (en) * | 2002-03-04 | 2004-10-21 | Xingwu Wang | Novel nanomagnetic particles |
| CA2494074A1 (en) * | 2002-08-02 | 2004-02-12 | Immunogen, Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| US20070149496A1 (en) * | 2003-10-31 | 2007-06-28 | Jack Tuszynski | Water-soluble compound |
| JP2007527432A (ja) * | 2004-03-05 | 2007-09-27 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | Ｃ７ラクチルオキシ置換タキサン |
| US20050249667A1 (en) * | 2004-03-24 | 2005-11-10 | Tuszynski Jack A | Process for treating a biological organism |
| CN1712399B (zh) * | 2004-06-24 | 2010-08-11 | 中国医学科学院药物研究所 | 紫杉醇和免疫增强剂胞壁酰二肽共轭物的制备及用途 |
| US20080081067A1 (en) * | 2006-10-03 | 2008-04-03 | Gupta Manishkumar | Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof |
| KR101477194B1 (ko) | 2010-05-27 | 2014-12-29 | 심천 사루브리스 퍼머수티칼스 컴퍼니 리미티드 | 이중기능 복합체의 화학합성 및 항 종양과 항 종양 전이 작용 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879929A (en) * | 1988-06-06 | 1989-11-14 | Roth Alfred C | Tapper/threader assembly |
| US4950790A (en) * | 1988-11-14 | 1990-08-21 | Air Products And Chemicals, Inc. | Volatile fluorinated β-ketoimines and associated metal complexes |
| US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| US5243253A (en) * | 1991-07-30 | 1993-09-07 | Thomson Consumer Electronics, Inc. | Color picture tube having shadow mask with improved tie bar grading |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| SG46582A1 (en) | 1991-09-23 | 1998-02-20 | Univ Florida State | 10-Desacetoxytaxol derivatives |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5250683A (en) * | 1991-09-23 | 1993-10-05 | Florida State University | Certain substituted taxanes and pharmaceutical compositions containing them |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| ATE280240T1 (de) | 1992-01-15 | 2004-11-15 | Squibb & Sons Inc | Enzymatische verfahren zur aüftrennüng von enantiomeren-mischungen nützlich als zwischenprodukte zur herstellung von taxanen |
| DE4302686C2 (de) * | 1992-02-05 | 1994-12-15 | Bierther Hans Dietmar | Hochleistungsventil |
| FR2687150B1 (fr) | 1992-02-07 | 1995-04-28 | Rhone Poulenc Rorer Sa | Procede de preparation de derives du taxane. |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US5939561A (en) | 1992-03-10 | 1999-08-17 | Rhone-Poulence Rorer S.A. | Process for the preparation of β-phenylisoserine and β-lactam and their analogues |
| US5200534A (en) | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
| IL108443A0 (en) * | 1993-01-29 | 1994-04-12 | Univ Florida State | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5703247A (en) | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
| PT1228759E (pt) * | 1993-03-22 | 2005-04-29 | Univ Florida State | Composicoes farmaceuticas contendo um taxano possuindo uma cadeia lateral substituida com furilo ou tienilo |
| US5350253A (en) * | 1993-03-24 | 1994-09-27 | John Cunningham | Method for supporting distribution means |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| WO1996013495A1 (en) | 1994-10-28 | 1996-05-09 | The Research Foundation Of State University Of New York | Taxoid derivatives, their preparation and their use as antitumor agents |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| CA2231837A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| US5767297A (en) | 1997-02-05 | 1998-06-16 | Ensuiko Sugar Refining Co., Ltd. | Taxoid derivative and method of producing thereof |
| JP3786462B2 (ja) * | 1996-03-07 | 2006-06-14 | 塩水港精糖株式会社 | タキソイドの配糖化誘導体およびその製造方法 |
| EP0927175A4 (en) | 1996-05-06 | 2002-05-22 | Univ Florida State | 1-DEOXYBACCATIN III, 1-DEOXYTAXOL AND 1-DEOXYTAXOL ANALOG AND METHOD FOR THE PRODUCTION THEREOF |
| US5780683A (en) * | 1996-09-11 | 1998-07-14 | Abb Lummus Global Inc. | Cyclohexane oxidation |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| CA2206739C (en) | 1997-06-03 | 2006-10-10 | Ensuiko Sugar Refining Co., Ltd. | Taxoid derivative and method of producing thereof |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| US6136988A (en) | 1998-04-10 | 2000-10-24 | Hauser, Inc. | 7-hexanoyltaxol and methods for preparing the same |
| HK1047935A1 (zh) * | 2000-02-02 | 2003-03-14 | 佛罗里达州立大学研究基金有限公司 | 作为抗肿瘤剂的c7杂取代乙酸酯取代的紫杉烷 |
| IL145635A0 (en) | 2000-02-02 | 2002-06-30 | Univ Florida State Res Found | Taxane formulations having improved solubility |
-
2001
- 2001-02-02 HK HK03100169.2A patent/HK1047935A1/zh unknown
- 2001-02-02 EP EP01906965A patent/EP1200424B1/en not_active Expired - Lifetime
- 2001-02-02 WO PCT/US2001/003600 patent/WO2001057029A1/en not_active Ceased
- 2001-02-02 CZ CZ20013519A patent/CZ20013519A3/cs unknown
- 2001-02-02 MX MXPA01009922A patent/MXPA01009922A/es active IP Right Grant
- 2001-02-02 IL IL14564201A patent/IL145642A0/xx unknown
- 2001-02-02 NZ NZ514411A patent/NZ514411A/en unknown
- 2001-02-02 KR KR1020017012589A patent/KR20010112393A/ko not_active Abandoned
- 2001-02-02 HU HU0200651A patent/HUP0200651A3/hu unknown
- 2001-02-02 AT AT01906965T patent/ATE413397T1/de not_active IP Right Cessation
- 2001-02-02 AU AU34804/01A patent/AU776765B2/en not_active Ceased
- 2001-02-02 CA CA002368534A patent/CA2368534A1/en not_active Withdrawn
- 2001-02-02 DE DE60136430T patent/DE60136430D1/de not_active Expired - Fee Related
- 2001-02-02 BR BR0104353-6A patent/BR0104353A/pt not_active IP Right Cessation
- 2001-02-02 JP JP2001557861A patent/JP2003522169A/ja not_active Withdrawn
- 2001-02-02 US US09/776,393 patent/US6673833B2/en not_active Expired - Fee Related
- 2001-02-02 PL PL01350328A patent/PL350328A1/xx not_active Application Discontinuation
- 2001-02-02 CN CN01800318A patent/CN1362957A/zh active Pending
- 2001-10-01 ZA ZA200108063A patent/ZA200108063B/en unknown
- 2001-10-01 NO NO20014758A patent/NO20014758L/no not_active Application Discontinuation
-
2003
- 2003-11-24 US US10/720,826 patent/US6861446B2/en not_active Expired - Fee Related
-
2005
- 2005-02-23 US US11/063,626 patent/US7183312B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200108063B (en) | 2003-12-01 |
| JP2003522169A (ja) | 2003-07-22 |
| US6861446B2 (en) | 2005-03-01 |
| US6673833B2 (en) | 2004-01-06 |
| HK1047935A1 (zh) | 2003-03-14 |
| CZ20013519A3 (cs) | 2002-04-17 |
| NZ514411A (en) | 2005-02-25 |
| AU776765B2 (en) | 2004-09-23 |
| AU3480401A (en) | 2001-08-14 |
| IL145642A0 (en) | 2002-06-30 |
| US20040087547A1 (en) | 2004-05-06 |
| ATE413397T1 (de) | 2008-11-15 |
| BR0104353A (pt) | 2002-04-16 |
| MXPA01009922A (es) | 2003-07-14 |
| US20020065305A1 (en) | 2002-05-30 |
| HUP0200651A3 (en) | 2002-10-28 |
| PL350328A1 (en) | 2002-12-02 |
| EP1200424A1 (en) | 2002-05-02 |
| CA2368534A1 (en) | 2001-08-09 |
| KR20010112393A (ko) | 2001-12-20 |
| NO20014758L (no) | 2001-11-29 |
| HUP0200651A2 (hu) | 2002-07-29 |
| EP1200424B1 (en) | 2008-11-05 |
| CN1362957A (zh) | 2002-08-07 |
| NO20014758D0 (no) | 2001-10-01 |
| US7183312B2 (en) | 2007-02-27 |
| US20050143446A1 (en) | 2005-06-30 |
| WO2001057029A1 (en) | 2001-08-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |