CN1362957A - 作为抗肿瘤剂的c7杂取代乙酸酯取代的紫杉烷 - Google Patents
作为抗肿瘤剂的c7杂取代乙酸酯取代的紫杉烷 Download PDFInfo
- Publication number
- CN1362957A CN1362957A CN01800318A CN01800318A CN1362957A CN 1362957 A CN1362957 A CN 1362957A CN 01800318 A CN01800318 A CN 01800318A CN 01800318 A CN01800318 A CN 01800318A CN 1362957 A CN1362957 A CN 1362957A
- Authority
- CN
- China
- Prior art keywords
- pyridyl
- taxane
- furyl
- thienyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17967200P | 2000-02-02 | 2000-02-02 | |
| US60/179,672 | 2000-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362957A true CN1362957A (zh) | 2002-08-07 |
Family
ID=22657505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN01800318A Pending CN1362957A (zh) | 2000-02-02 | 2001-02-02 | 作为抗肿瘤剂的c7杂取代乙酸酯取代的紫杉烷 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6673833B2 (enExample) |
| EP (1) | EP1200424B1 (enExample) |
| JP (1) | JP2003522169A (enExample) |
| KR (1) | KR20010112393A (enExample) |
| CN (1) | CN1362957A (enExample) |
| AT (1) | ATE413397T1 (enExample) |
| AU (1) | AU776765B2 (enExample) |
| BR (1) | BR0104353A (enExample) |
| CA (1) | CA2368534A1 (enExample) |
| CZ (1) | CZ20013519A3 (enExample) |
| DE (1) | DE60136430D1 (enExample) |
| HK (1) | HK1047935A1 (enExample) |
| HU (1) | HUP0200651A3 (enExample) |
| IL (1) | IL145642A0 (enExample) |
| MX (1) | MXPA01009922A (enExample) |
| NO (1) | NO20014758L (enExample) |
| NZ (1) | NZ514411A (enExample) |
| PL (1) | PL350328A1 (enExample) |
| WO (1) | WO2001057029A1 (enExample) |
| ZA (1) | ZA200108063B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1712399B (zh) * | 2004-06-24 | 2010-08-11 | 中国医学科学院药物研究所 | 紫杉醇和免疫增强剂胞壁酰二肽共轭物的制备及用途 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1200424B1 (en) * | 2000-02-02 | 2008-11-05 | Florida State University Research Foundation, Inc. | C7 heterosubstituted acetate taxanes as antitumor agents |
| US20040210289A1 (en) * | 2002-03-04 | 2004-10-21 | Xingwu Wang | Novel nanomagnetic particles |
| US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| CA2494074A1 (en) * | 2002-08-02 | 2004-02-12 | Immunogen, Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| US20070149496A1 (en) * | 2003-10-31 | 2007-06-28 | Jack Tuszynski | Water-soluble compound |
| CN1960721A (zh) * | 2004-03-05 | 2007-05-09 | 佛罗里达州立大学研究基金有限公司 | C7乳酰氧基取代的紫杉烷类 |
| US20050249667A1 (en) * | 2004-03-24 | 2005-11-10 | Tuszynski Jack A | Process for treating a biological organism |
| US20080081067A1 (en) * | 2006-10-03 | 2008-04-03 | Gupta Manishkumar | Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof |
| US9085605B2 (en) | 2010-05-27 | 2015-07-21 | Shenzhen Salubris Pharmaceuticals Co., Ltd. | Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879929A (en) * | 1988-06-06 | 1989-11-14 | Roth Alfred C | Tapper/threader assembly |
| US4950790A (en) * | 1988-11-14 | 1990-08-21 | Air Products And Chemicals, Inc. | Volatile fluorinated β-ketoimines and associated metal complexes |
| US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| US5243253A (en) * | 1991-07-30 | 1993-09-07 | Thomson Consumer Electronics, Inc. | Color picture tube having shadow mask with improved tie bar grading |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| SG46582A1 (en) | 1991-09-23 | 1998-02-20 | Univ Florida State | 10-Desacetoxytaxol derivatives |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5250683A (en) | 1991-09-23 | 1993-10-05 | Florida State University | Certain substituted taxanes and pharmaceutical compositions containing them |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| ATE195973T1 (de) | 1992-01-15 | 2000-09-15 | Squibb & Sons Inc | Enzymatische verfahren zur resolution von enantiomeren-mischungen nützlich wie zwischenprodukte zur herstellung von taxanen |
| DE4302686C2 (de) | 1992-02-05 | 1994-12-15 | Bierther Hans Dietmar | Hochleistungsventil |
| FR2687150B1 (fr) | 1992-02-07 | 1995-04-28 | Rhone Poulenc Rorer Sa | Procede de preparation de derives du taxane. |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US5939561A (en) | 1992-03-10 | 1999-08-17 | Rhone-Poulence Rorer S.A. | Process for the preparation of β-phenylisoserine and β-lactam and their analogues |
| US5200534A (en) | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
| IL108443A0 (en) * | 1993-01-29 | 1994-04-12 | Univ Florida State | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5703247A (en) | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
| ATE232871T1 (de) * | 1993-03-22 | 2003-03-15 | Univ Florida State | Taxane mit furyl-oder thienyl substituierten seitenketten |
| US5350253A (en) * | 1993-03-24 | 1994-09-27 | John Cunningham | Method for supporting distribution means |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| EP0788493A1 (en) * | 1994-10-28 | 1997-08-13 | The Research Foundation Of State University Of New York | Taxoid derivatives, their preparation and their use as antitumor agents |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| CA2231837A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| US5767297A (en) * | 1997-02-05 | 1998-06-16 | Ensuiko Sugar Refining Co., Ltd. | Taxoid derivative and method of producing thereof |
| JP3786462B2 (ja) * | 1996-03-07 | 2006-06-14 | 塩水港精糖株式会社 | タキソイドの配糖化誘導体およびその製造方法 |
| WO1997042181A1 (en) | 1996-05-06 | 1997-11-13 | Florida State University | 1-deoxy baccatin iii, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
| US5780683A (en) * | 1996-09-11 | 1998-07-14 | Abb Lummus Global Inc. | Cyclohexane oxidation |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| HU224589B1 (hu) * | 1997-06-03 | 2005-11-28 | Ensuiko Sugar Refining Co., Ltd. | Taxoidszármazékok és eljárás előállításukra |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| US6136988A (en) | 1998-04-10 | 2000-10-24 | Hauser, Inc. | 7-hexanoyltaxol and methods for preparing the same |
| EP1200424B1 (en) * | 2000-02-02 | 2008-11-05 | Florida State University Research Foundation, Inc. | C7 heterosubstituted acetate taxanes as antitumor agents |
| KR20010111580A (ko) | 2000-02-02 | 2001-12-19 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | 개선된 용해도를 갖는 탁산 제형물 |
-
2001
- 2001-02-02 EP EP01906965A patent/EP1200424B1/en not_active Expired - Lifetime
- 2001-02-02 MX MXPA01009922A patent/MXPA01009922A/es active IP Right Grant
- 2001-02-02 HU HU0200651A patent/HUP0200651A3/hu unknown
- 2001-02-02 JP JP2001557861A patent/JP2003522169A/ja not_active Withdrawn
- 2001-02-02 KR KR1020017012589A patent/KR20010112393A/ko not_active Abandoned
- 2001-02-02 DE DE60136430T patent/DE60136430D1/de not_active Expired - Fee Related
- 2001-02-02 CZ CZ20013519A patent/CZ20013519A3/cs unknown
- 2001-02-02 HK HK03100169.2A patent/HK1047935A1/zh unknown
- 2001-02-02 BR BR0104353-6A patent/BR0104353A/pt not_active IP Right Cessation
- 2001-02-02 AU AU34804/01A patent/AU776765B2/en not_active Ceased
- 2001-02-02 US US09/776,393 patent/US6673833B2/en not_active Expired - Fee Related
- 2001-02-02 CA CA002368534A patent/CA2368534A1/en not_active Withdrawn
- 2001-02-02 WO PCT/US2001/003600 patent/WO2001057029A1/en not_active Ceased
- 2001-02-02 AT AT01906965T patent/ATE413397T1/de not_active IP Right Cessation
- 2001-02-02 IL IL14564201A patent/IL145642A0/xx unknown
- 2001-02-02 NZ NZ514411A patent/NZ514411A/en unknown
- 2001-02-02 CN CN01800318A patent/CN1362957A/zh active Pending
- 2001-02-02 PL PL01350328A patent/PL350328A1/xx not_active Application Discontinuation
- 2001-10-01 NO NO20014758A patent/NO20014758L/no not_active Application Discontinuation
- 2001-10-01 ZA ZA200108063A patent/ZA200108063B/en unknown
-
2003
- 2003-11-24 US US10/720,826 patent/US6861446B2/en not_active Expired - Fee Related
-
2005
- 2005-02-23 US US11/063,626 patent/US7183312B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1712399B (zh) * | 2004-06-24 | 2010-08-11 | 中国医学科学院药物研究所 | 紫杉醇和免疫增强剂胞壁酰二肽共轭物的制备及用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0200651A2 (hu) | 2002-07-29 |
| HK1047935A1 (zh) | 2003-03-14 |
| ZA200108063B (en) | 2003-12-01 |
| NO20014758D0 (no) | 2001-10-01 |
| NZ514411A (en) | 2005-02-25 |
| JP2003522169A (ja) | 2003-07-22 |
| IL145642A0 (en) | 2002-06-30 |
| EP1200424A1 (en) | 2002-05-02 |
| US20020065305A1 (en) | 2002-05-30 |
| US20050143446A1 (en) | 2005-06-30 |
| US7183312B2 (en) | 2007-02-27 |
| MXPA01009922A (es) | 2003-07-14 |
| WO2001057029A1 (en) | 2001-08-09 |
| EP1200424B1 (en) | 2008-11-05 |
| US20040087547A1 (en) | 2004-05-06 |
| CZ20013519A3 (cs) | 2002-04-17 |
| HUP0200651A3 (en) | 2002-10-28 |
| AU3480401A (en) | 2001-08-14 |
| NO20014758L (no) | 2001-11-29 |
| ATE413397T1 (de) | 2008-11-15 |
| KR20010112393A (ko) | 2001-12-20 |
| BR0104353A (pt) | 2002-04-16 |
| CA2368534A1 (en) | 2001-08-09 |
| DE60136430D1 (de) | 2008-12-18 |
| AU776765B2 (en) | 2004-09-23 |
| PL350328A1 (en) | 2002-12-02 |
| US6673833B2 (en) | 2004-01-06 |
| US6861446B2 (en) | 2005-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication | ||
| REG | Reference to a national code |
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