DE60136088D1 - Heteroarylacryloylaminoalkyl-substituierte benzolsulfonamidderivate, deren herstellung, deren verwendung und pharmazeutische zusammensetzungen, die diese verbindungen enthalten - Google Patents

Heteroarylacryloylaminoalkyl-substituierte benzolsulfonamidderivate, deren herstellung, deren verwendung und pharmazeutische zusammensetzungen, die diese verbindungen enthalten

Info

Publication number
DE60136088D1
DE60136088D1 DE60136088T DE60136088T DE60136088D1 DE 60136088 D1 DE60136088 D1 DE 60136088D1 DE 60136088 T DE60136088 T DE 60136088T DE 60136088 T DE60136088 T DE 60136088T DE 60136088 D1 DE60136088 D1 DE 60136088D1
Authority
DE
Germany
Prior art keywords
compounds
heteroarylacryloylaminoalkyl
preparation
cardiac
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60136088T
Other languages
English (en)
Inventor
Holger Heitsch
Heinrich Christian Englert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Application granted granted Critical
Publication of DE60136088D1 publication Critical patent/DE60136088D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
DE60136088T 2000-11-03 2001-10-20 Heteroarylacryloylaminoalkyl-substituierte benzolsulfonamidderivate, deren herstellung, deren verwendung und pharmazeutische zusammensetzungen, die diese verbindungen enthalten Expired - Lifetime DE60136088D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10054482A DE10054482A1 (de) 2000-11-03 2000-11-03 Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
PCT/EP2001/012142 WO2002036565A1 (en) 2000-11-03 2001-10-20 Heteroarylacryloylaminoalkyl-substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them

Publications (1)

Publication Number Publication Date
DE60136088D1 true DE60136088D1 (de) 2008-11-20

Family

ID=7662010

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10054482A Withdrawn DE10054482A1 (de) 2000-11-03 2000-11-03 Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE60136088T Expired - Lifetime DE60136088D1 (de) 2000-11-03 2001-10-20 Heteroarylacryloylaminoalkyl-substituierte benzolsulfonamidderivate, deren herstellung, deren verwendung und pharmazeutische zusammensetzungen, die diese verbindungen enthalten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE10054482A Withdrawn DE10054482A1 (de) 2000-11-03 2000-11-03 Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate

Country Status (13)

Country Link
US (1) US6472413B2 (de)
EP (1) EP1335902B1 (de)
JP (1) JP4281991B2 (de)
AT (1) ATE410414T1 (de)
AU (2) AU2363102A (de)
CA (1) CA2427548C (de)
DE (2) DE10054482A1 (de)
DK (1) DK1335902T3 (de)
ES (1) ES2315314T3 (de)
IL (2) IL155658A0 (de)
MX (1) MXPA03003778A (de)
PT (1) PT1335902E (de)
WO (1) WO2002036565A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956846B2 (en) * 2002-08-16 2005-10-18 Utstarcom Incorporated System and method for foreign agent control node redundancy in a mobile internet protocol network

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1185180B (de) 1963-10-19 1965-01-14 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE1493672C3 (de) * 1964-08-01 1974-05-02 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE1518874C3 (de) 1964-10-07 1975-03-13 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung
DE1518816C3 (de) 1965-03-24 1975-05-22 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US4066639A (en) 1965-05-06 1978-01-03 Hoechst Aktiengesellschaft Benzene-sulfonyl semicarbazides and process for preparing them
ES2098069T3 (es) 1993-02-23 1997-04-16 Hoechst Ag Bencenosulfonil-ureas y -tioureas sustituidas, procedimiento para su preparacion y su utilizacion como agentes farmaceuticos.
DE4341655A1 (de) 1993-12-07 1995-06-08 Hoechst Ag Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
DE19505397A1 (de) 1995-02-17 1996-08-22 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832009A1 (de) * 1998-07-16 2000-01-20 Hoechst Marion Roussel De Gmbh 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate
WO2000015204A2 (en) 1998-09-10 2000-03-23 Aventis Pharma Deutschland Gmbh Use of benzenesulfonyl(thio)ureas for the treatment and prophylaxis of dysfunctions of the autonomous nervous system and use of benzenesulfonyl(thio)ureas in combination with beta-receptor blockers
DE19923086A1 (de) * 1999-05-20 2000-11-23 Aventis Pharma Gmbh Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
EP1335902B1 (de) 2008-10-08
JP2004513114A (ja) 2004-04-30
PT1335902E (pt) 2009-01-19
US6472413B2 (en) 2002-10-29
CA2427548C (en) 2010-11-16
DE10054482A1 (de) 2002-05-08
MXPA03003778A (es) 2003-07-28
IL155658A0 (en) 2003-11-23
IL155658A (en) 2010-04-15
WO2002036565A1 (en) 2002-05-10
AU2363102A (en) 2002-05-15
DK1335902T3 (da) 2009-02-16
US20020123495A1 (en) 2002-09-05
EP1335902A1 (de) 2003-08-20
ATE410414T1 (de) 2008-10-15
AU2002223631B2 (en) 2006-07-06
ES2315314T3 (es) 2009-04-01
CA2427548A1 (en) 2002-05-10
JP4281991B2 (ja) 2009-06-17

Similar Documents

Publication Publication Date Title
ATE290525T1 (de) Acylaminoalkyl-substituierte benzolsulfonamidderivate
DD279407A1 (de) Verfahren zur herstellung eines mittels gegen aids
WO2003048164A3 (en) Adenosine a2a receptor antagonists
CA2468649A1 (en) Adenosine a2a receptor antagonists
EP0444196A4 (en) Agent for treatment and prophylaxis of ischemic disease of heart or brain
DE68906609T2 (de) Dopamin-vorlaeufer.
WO1998032442A1 (de) Chinoxaline in dreier-kombination mit proteaseinhibitoren und reverse transkriptaseinhibitoren als arzneimittel zur behandlung von aids
DE69837564T2 (de) Azaheterozyklische derivate zur behandlung von haarausfall und neurologischer krankheiten
DK1124841T3 (da) Substituerede phenylalkenoylguanidiner, fremgangsmåde til fremstilling deraf, anvendelse deraf som lægemidler eller diagnosemidler og lægemidler, som indeholder dem
DK0748314T3 (da) Tetrasubstituerede imidazolderivater, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og farmaceutiske præparater med indhold deraf
DE60136088D1 (de) Heteroarylacryloylaminoalkyl-substituierte benzolsulfonamidderivate, deren herstellung, deren verwendung und pharmazeutische zusammensetzungen, die diese verbindungen enthalten
DK1150963T3 (da) Substituerede 4-amino-2-aryltetrahydroquinazoliner, fremstilling og anvendelse deraf og farmaceutiske præparater indeholdende dem
NO980694L (no) Sulfonamidsubstituerte kromaner, fremgangsmåte for deres fremstilling, deres anvendelse som medikament eller diagnostika såvel som medikamenter inneholdende dem
MX2009012644A (es) Derivados de di(hetero)arilciclohexano, su preparacion, su uso y composiciones farmaceuticas que los comprenden.
WO2000003978A3 (de) 2,5-substituierte benzolsulfonylharnstoffe und -thioharnstoffe, v,rfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate
DE602005007381D1 (de) Piperidinsulfonylharnstoffe und -thioharnstoffe, deren herstellung, deren verwendung und pharmazeutische zusammensetzungen, die sie enthalten
HRP20010845A9 (en) Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives
IL159767A0 (en) Sulfonamide derivatives, their preparation and pharmacetuical compositions containing them
NZ527216A (en) Regulation of organic nitrate tolerance
ATE265459T1 (de) Triazolpurin-derivate, medikamentzusammensetzungen, die diese enthalten und mittel, die affinität zum adenosin a3 rezeptor zeigen
MX9606397A (es) Cromanilsulfonil(tio)ureas sustituidas, procedimientos para prepararlas, y su utilizacion en preparados farmaceuticos, asi como preparados farmaceuticos que las contienen.
CA2270026A1 (en) Substituted bicyclic derivatives for treating central nervous system disorders
CA2534558A1 (en) Ammonium salts of ornithine derivatives for treating inflammatory diseases
DE19961302A1 (de) Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen
MX9708783A (es) 3-amido-cromanilsulfonil (tio) ureas, procedimiento para su preparacion, su empleo y preparados farmaceuticos que las contienen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition