DE60132311D1 - Funktionalisierte eingekapselte fluoreszierende nanokristalle - Google Patents
Funktionalisierte eingekapselte fluoreszierende nanokristalleInfo
- Publication number
- DE60132311D1 DE60132311D1 DE60132311T DE60132311T DE60132311D1 DE 60132311 D1 DE60132311 D1 DE 60132311D1 DE 60132311 T DE60132311 T DE 60132311T DE 60132311 T DE60132311 T DE 60132311T DE 60132311 D1 DE60132311 D1 DE 60132311D1
- Authority
- DE
- Germany
- Prior art keywords
- functionalized
- fluorescent nanocrystals
- encapsulated fluorescent
- encapsulated
- complexes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/586—Liposomes, microcapsules or cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Nanotechnology (AREA)
- Genetics & Genomics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Materials Engineering (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Luminescent Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18360800P | 2000-02-18 | 2000-02-18 | |
US18360700P | 2000-02-18 | 2000-02-18 | |
US183607P | 2000-02-18 | ||
US183608P | 2000-02-18 | ||
US783469 | 2001-02-14 | ||
US09/783,469 US6761877B2 (en) | 2000-02-18 | 2001-02-14 | Functionalized encapsulated fluorescent nanocrystals |
PCT/US2001/005108 WO2001061045A1 (en) | 2000-02-18 | 2001-02-16 | Functionalized encapsulated fluorescent nanocrystals |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60132311D1 true DE60132311D1 (de) | 2008-02-21 |
DE60132311T2 DE60132311T2 (de) | 2009-01-02 |
Family
ID=27391706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60132311T Expired - Lifetime DE60132311T2 (de) | 2000-02-18 | 2001-02-16 | Funktionalisierte eingekapselte fluoreszierende nanokristalle |
Country Status (6)
Country | Link |
---|---|
US (3) | US6761877B2 (de) |
EP (1) | EP1266032B1 (de) |
AT (1) | ATE383440T1 (de) |
AU (1) | AU2001237057A1 (de) |
DE (1) | DE60132311T2 (de) |
WO (1) | WO2001061045A1 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6761877B2 (en) * | 2000-02-18 | 2004-07-13 | Biocrystal, Ltd. | Functionalized encapsulated fluorescent nanocrystals |
ATE536550T1 (de) * | 2000-10-06 | 2011-12-15 | Life Technologies Corp | Halbleiter nanokristalle enthaltende transfektibare mizellen |
US20050059031A1 (en) * | 2000-10-06 | 2005-03-17 | Quantum Dot Corporation | Method for enhancing transport of semiconductor nanocrystals across biological membranes |
JP2003028797A (ja) * | 2001-07-11 | 2003-01-29 | Hitachi Software Eng Co Ltd | 蛍光読み取り装置 |
JP4072994B2 (ja) * | 2001-10-11 | 2008-04-09 | 学校法人日本大学 | 磁性粒子 |
JP3701622B2 (ja) | 2002-03-27 | 2005-10-05 | 日立ソフトウエアエンジニアリング株式会社 | 半導体ナノ粒子蛍光試薬及び蛍光測定方法 |
JP3955225B2 (ja) * | 2002-03-27 | 2007-08-08 | 日立ソフトウエアエンジニアリング株式会社 | 半導体ナノ粒子を用いる反応の反応測定方法及び該測定方法を用いる半導体ナノ粒子の品質評価方法 |
JP3847677B2 (ja) | 2002-07-23 | 2006-11-22 | 日立ソフトウエアエンジニアリング株式会社 | 半導体ナノ粒子、その製造方法、及び半導体ナノ粒子蛍光試薬 |
JP2004077389A (ja) * | 2002-08-21 | 2004-03-11 | Hitachi Software Eng Co Ltd | 半導体ナノ粒子を含む機能性蛍光試薬 |
US20050032246A1 (en) * | 2002-11-14 | 2005-02-10 | Mcmaster University | Method of immobilizing membrane-associated molecules |
US8367324B2 (en) * | 2003-11-17 | 2013-02-05 | Canon Kabushiki Kaisha | Method for judging change in probe-bearing substrate, probe-bearing substrate and detecting apparatus |
JP4528990B2 (ja) * | 2003-12-09 | 2010-08-25 | 学校法人慶應義塾 | 脂質二重膜とナノサイズ蛍光体複合体 |
GB0400235D0 (en) * | 2004-01-07 | 2004-02-11 | Univ Sunderland | Nanoparticles as agents for imaging finger prints |
US20060014175A1 (en) * | 2004-05-17 | 2006-01-19 | Imad Naasani | Functionalized fluorescent nanocrystal detection system |
US7794600B1 (en) * | 2004-08-27 | 2010-09-14 | Nanosys, Inc. | Purification of nanocrystal solutions by chromatography |
US8486371B2 (en) * | 2004-09-17 | 2013-07-16 | The Regents Of The University Of Michigan | Quantitative two-photon flow cytometry |
US20060240227A1 (en) * | 2004-09-23 | 2006-10-26 | Zhijun Zhang | Nanocrystal coated surfaces |
US7368086B2 (en) | 2004-10-29 | 2008-05-06 | Invitrogen Corporation | Functionalized fluorescent nanocrystals, and methods for their preparation and use |
WO2006084248A2 (en) * | 2005-02-04 | 2006-08-10 | Antigenics, Inc. | Compositions comprising a platinum complex, lipid, and surfactant |
GB2441666B (en) * | 2005-04-25 | 2010-12-29 | Univ Arkansas | Doped semiconductor nanocrystals and methods of making same |
BRPI0614746A2 (pt) | 2005-08-09 | 2011-04-12 | Univ Sunderland | partìculas de sìlica hidrofóbicas, métodos de fabricação e uso das mesmas, assim como métodos de detecção e/ou identificação de uma impressão digital ou outra massa ou depósito hidrofóbico |
WO2007021757A2 (en) * | 2005-08-15 | 2007-02-22 | Massachusetts Institute Of Technology | Fluorescent sensor and methods |
US7514267B1 (en) * | 2005-08-19 | 2009-04-07 | Stcunm | Detection systems utilizing supported lipid bilayers |
US20070134685A1 (en) * | 2005-09-06 | 2007-06-14 | Invitrogen Corporation | Control of chemical modification |
JP4415972B2 (ja) * | 2005-09-22 | 2010-02-17 | ソニー株式会社 | 金属酸化物ナノ粒子の製造方法 |
US8337721B2 (en) | 2005-12-02 | 2012-12-25 | Vanderbilt University | Broad-emission nanocrystals and methods of making and using same |
PL1962805T3 (pl) | 2005-12-08 | 2017-01-31 | Insmed Incorporated | Kompozycje środków przeciwzapalnych oparte na lipidach do leczenia infekcji płucnych |
US20080191604A1 (en) * | 2006-09-27 | 2008-08-14 | Evident Technologies | Retro-emission systems comprising microlens arrays and luminescent emitters |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
FR2918755B1 (fr) * | 2007-07-09 | 2009-10-30 | Commissariat Energie Atomique | Procede de detection et de quantification d'analytes sur support solide avec des molecules fluorescentes encapsulees dans des immunoliposomes. |
US20090171330A1 (en) * | 2007-12-28 | 2009-07-02 | Spectranetics | Tunable nanoparticle tags to enhance tissue recognition |
US20090270269A1 (en) * | 2008-04-28 | 2009-10-29 | Ashok Kumar | Nano-scale fluoro-biosensors exhibiting a low false alarm rate for rapid detection of biological contaminants |
US20110291049A1 (en) * | 2008-06-10 | 2011-12-01 | Board Of Trustees Of The University Of Arkansas | Indium arsenide nanocrystals and methods of making the same |
US20110070154A1 (en) * | 2008-08-13 | 2011-03-24 | Hyde Roderick A | Artificial cells |
US8895158B2 (en) | 2011-08-10 | 2014-11-25 | The Johns Hopkins University | Nanoparticle taggants for explosive precursors |
WO2013078252A1 (en) | 2011-11-22 | 2013-05-30 | Qd Vision, Inc. | Quantum dot-containing compositions including an emission stabilizer, products including same, and method |
EP2841108A4 (de) * | 2012-04-25 | 2015-11-25 | Tufts College | Seidenmikrokügelchen sowie verfahren zur oberflächenschmierung |
CA2891487A1 (en) | 2012-11-29 | 2014-06-05 | Insmed Incorporated | Stabilized vancomycin formulations |
WO2014134338A1 (en) * | 2013-03-01 | 2014-09-04 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Oligonucleotide functionalized quantum dots |
US9229611B2 (en) * | 2013-03-05 | 2016-01-05 | Oracle International Corporation | Automatic management of client data consistency |
CA2943049A1 (en) | 2014-04-08 | 2015-10-15 | Aradigm Corporation | Liposomal ciprofloxacin formulations with activity against non-tuberculous mycobacteria |
US9968555B2 (en) | 2014-04-08 | 2018-05-15 | Aradigm Corporation | Liposomal formulations that form drug nanocrystals after freeze-thaw |
PL3142643T3 (pl) | 2014-05-15 | 2019-12-31 | Insmed Incorporated | Sposoby leczenia zakażeń płuc prątkami niegruźliczymi |
WO2017147407A1 (en) * | 2016-02-25 | 2017-08-31 | Board Of Regents, The University Of Texas System | Compositions comprising composite nanocarriers and methods of making and uses thereof |
WO2019191627A1 (en) | 2018-03-30 | 2019-10-03 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
Family Cites Families (22)
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US4614796A (en) | 1983-03-25 | 1986-09-30 | Nippon Shinyaku Co., Ltd. | Liposome and method of manufacture therefor |
WO1987007150A1 (en) * | 1986-05-30 | 1987-12-03 | The Johns Hopkins University | Receptor-targeted drug delivery systems |
CA1340806C (en) * | 1986-07-02 | 1999-11-02 | James Merrill Prober | Method, system and reagents for dna sequencing |
US5151507A (en) * | 1986-07-02 | 1992-09-29 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
US5227489A (en) * | 1988-08-01 | 1993-07-13 | Ciba Corning Diagnostics Corp. | Stable hydrophilic acridinium esters suitable for liposome encapsulation |
US5578718A (en) * | 1990-01-11 | 1996-11-26 | Isis Pharmaceuticals, Inc. | Thiol-derivatized nucleosides |
US5187085A (en) * | 1990-09-28 | 1993-02-16 | Applied Biosystems, Inc. | Nucleic acid sequence analysis with nucleoside-5'-o-(1-thiotriphosphates) |
YU187991A (sh) * | 1990-12-11 | 1994-09-09 | Hoechst Aktiengesellschaft | 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba |
US5364759B2 (en) * | 1991-01-31 | 1999-07-20 | Baylor College Medicine | Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats |
US5650277A (en) * | 1992-07-02 | 1997-07-22 | Diagenetics Ltd. | Method of determining the presence and quantifying the number of di- and trinucleotide repeats |
US6048616A (en) | 1993-04-21 | 2000-04-11 | Philips Electronics N.A. Corp. | Encapsulated quantum sized doped semiconductor particles and method of manufacturing same |
US5637258A (en) * | 1996-03-18 | 1997-06-10 | Nanocrystals Technology L.P. | Method for producing rare earth activited metal oxide nanocrystals |
JP4245664B2 (ja) * | 1996-07-29 | 2009-03-25 | ナノスフェアー インコーポレイテッド | オリゴヌクレオチドを備えた金ナノ粒子を使用して標的該酸を検出する方法 |
DE19724796A1 (de) * | 1997-06-06 | 1998-12-10 | Max Delbrueck Centrum | Mittel zur Antitumortherapie |
US5990479A (en) | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US6207392B1 (en) * | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US6221602B1 (en) | 1998-11-10 | 2001-04-24 | Bio-Pixels Ltd. | Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination |
US6114038A (en) | 1998-11-10 | 2000-09-05 | Biocrystal Ltd. | Functionalized nanocrystals and their use in detection systems |
WO2000028089A1 (en) | 1998-11-10 | 2000-05-18 | Biocrystal Limited | Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination |
US6194213B1 (en) * | 1999-12-10 | 2001-02-27 | Bio-Pixels Ltd. | Lipophilic, functionalized nanocrystals and their use for fluorescence labeling of membranes |
US6179912B1 (en) * | 1999-12-20 | 2001-01-30 | Biocrystal Ltd. | Continuous flow process for production of semiconductor nanocrystals |
US6761877B2 (en) * | 2000-02-18 | 2004-07-13 | Biocrystal, Ltd. | Functionalized encapsulated fluorescent nanocrystals |
-
2001
- 2001-02-14 US US09/783,469 patent/US6761877B2/en not_active Expired - Lifetime
- 2001-02-16 AT AT01909283T patent/ATE383440T1/de not_active IP Right Cessation
- 2001-02-16 WO PCT/US2001/005108 patent/WO2001061045A1/en active Search and Examination
- 2001-02-16 DE DE60132311T patent/DE60132311T2/de not_active Expired - Lifetime
- 2001-02-16 EP EP01909283A patent/EP1266032B1/de not_active Expired - Lifetime
- 2001-02-16 AU AU2001237057A patent/AU2001237057A1/en not_active Abandoned
-
2004
- 2004-06-14 US US10/866,929 patent/US7060252B2/en not_active Expired - Lifetime
-
2005
- 2005-12-12 US US11/301,050 patent/US7244413B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE60132311T2 (de) | 2009-01-02 |
US20020001716A1 (en) | 2002-01-03 |
US7244413B2 (en) | 2007-07-17 |
EP1266032B1 (de) | 2008-01-09 |
US20050019486A1 (en) | 2005-01-27 |
ATE383440T1 (de) | 2008-01-15 |
US7060252B2 (en) | 2006-06-13 |
EP1266032A1 (de) | 2002-12-18 |
EP1266032A4 (de) | 2005-01-19 |
US20060099147A1 (en) | 2006-05-11 |
WO2001061045A1 (en) | 2001-08-23 |
US6761877B2 (en) | 2004-07-13 |
AU2001237057A1 (en) | 2001-08-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: LIFE TECHNOLOGIES CORP. (N.D.GES.D. STAATES DE, US |
|
8380 | Miscellaneous part iii |
Free format text: PFANDRECHT |
|
8380 | Miscellaneous part iii |
Free format text: PFANDRECHT AUFGEHOBEN |