DE60132311D1 - Funktionalisierte eingekapselte fluoreszierende nanokristalle - Google Patents

Funktionalisierte eingekapselte fluoreszierende nanokristalle

Info

Publication number
DE60132311D1
DE60132311D1 DE60132311T DE60132311T DE60132311D1 DE 60132311 D1 DE60132311 D1 DE 60132311D1 DE 60132311 T DE60132311 T DE 60132311T DE 60132311 T DE60132311 T DE 60132311T DE 60132311 D1 DE60132311 D1 DE 60132311D1
Authority
DE
Germany
Prior art keywords
functionalized
fluorescent nanocrystals
encapsulated fluorescent
encapsulated
complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60132311T
Other languages
English (en)
Other versions
DE60132311T2 (de
Inventor
Emilio Barbera-Guillem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Technologies Corp
Original Assignee
Biocrystal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocrystal Ltd filed Critical Biocrystal Ltd
Application granted granted Critical
Publication of DE60132311D1 publication Critical patent/DE60132311D1/de
Publication of DE60132311T2 publication Critical patent/DE60132311T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/586Liposomes, microcapsules or cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989Microcapsule with solid core [includes liposome]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991Coated
    • Y10T428/2993Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Nanotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Materials Engineering (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE60132311T 2000-02-18 2001-02-16 Funktionalisierte eingekapselte fluoreszierende nanokristalle Expired - Lifetime DE60132311T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US18360800P 2000-02-18 2000-02-18
US18360700P 2000-02-18 2000-02-18
US183607P 2000-02-18
US183608P 2000-02-18
US783469 2001-02-14
US09/783,469 US6761877B2 (en) 2000-02-18 2001-02-14 Functionalized encapsulated fluorescent nanocrystals
PCT/US2001/005108 WO2001061045A1 (en) 2000-02-18 2001-02-16 Functionalized encapsulated fluorescent nanocrystals

Publications (2)

Publication Number Publication Date
DE60132311D1 true DE60132311D1 (de) 2008-02-21
DE60132311T2 DE60132311T2 (de) 2009-01-02

Family

ID=27391706

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60132311T Expired - Lifetime DE60132311T2 (de) 2000-02-18 2001-02-16 Funktionalisierte eingekapselte fluoreszierende nanokristalle

Country Status (6)

Country Link
US (3) US6761877B2 (de)
EP (1) EP1266032B1 (de)
AT (1) ATE383440T1 (de)
AU (1) AU2001237057A1 (de)
DE (1) DE60132311T2 (de)
WO (1) WO2001061045A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6761877B2 (en) * 2000-02-18 2004-07-13 Biocrystal, Ltd. Functionalized encapsulated fluorescent nanocrystals
ATE536550T1 (de) * 2000-10-06 2011-12-15 Life Technologies Corp Halbleiter nanokristalle enthaltende transfektibare mizellen
US20050059031A1 (en) * 2000-10-06 2005-03-17 Quantum Dot Corporation Method for enhancing transport of semiconductor nanocrystals across biological membranes
JP2003028797A (ja) * 2001-07-11 2003-01-29 Hitachi Software Eng Co Ltd 蛍光読み取り装置
JP4072994B2 (ja) * 2001-10-11 2008-04-09 学校法人日本大学 磁性粒子
JP3701622B2 (ja) 2002-03-27 2005-10-05 日立ソフトウエアエンジニアリング株式会社 半導体ナノ粒子蛍光試薬及び蛍光測定方法
JP3955225B2 (ja) * 2002-03-27 2007-08-08 日立ソフトウエアエンジニアリング株式会社 半導体ナノ粒子を用いる反応の反応測定方法及び該測定方法を用いる半導体ナノ粒子の品質評価方法
JP3847677B2 (ja) 2002-07-23 2006-11-22 日立ソフトウエアエンジニアリング株式会社 半導体ナノ粒子、その製造方法、及び半導体ナノ粒子蛍光試薬
JP2004077389A (ja) * 2002-08-21 2004-03-11 Hitachi Software Eng Co Ltd 半導体ナノ粒子を含む機能性蛍光試薬
US20050032246A1 (en) * 2002-11-14 2005-02-10 Mcmaster University Method of immobilizing membrane-associated molecules
US8367324B2 (en) * 2003-11-17 2013-02-05 Canon Kabushiki Kaisha Method for judging change in probe-bearing substrate, probe-bearing substrate and detecting apparatus
JP4528990B2 (ja) * 2003-12-09 2010-08-25 学校法人慶應義塾 脂質二重膜とナノサイズ蛍光体複合体
GB0400235D0 (en) * 2004-01-07 2004-02-11 Univ Sunderland Nanoparticles as agents for imaging finger prints
US20060014175A1 (en) * 2004-05-17 2006-01-19 Imad Naasani Functionalized fluorescent nanocrystal detection system
US7794600B1 (en) * 2004-08-27 2010-09-14 Nanosys, Inc. Purification of nanocrystal solutions by chromatography
US8486371B2 (en) * 2004-09-17 2013-07-16 The Regents Of The University Of Michigan Quantitative two-photon flow cytometry
US20060240227A1 (en) * 2004-09-23 2006-10-26 Zhijun Zhang Nanocrystal coated surfaces
US7368086B2 (en) 2004-10-29 2008-05-06 Invitrogen Corporation Functionalized fluorescent nanocrystals, and methods for their preparation and use
WO2006084248A2 (en) * 2005-02-04 2006-08-10 Antigenics, Inc. Compositions comprising a platinum complex, lipid, and surfactant
GB2441666B (en) * 2005-04-25 2010-12-29 Univ Arkansas Doped semiconductor nanocrystals and methods of making same
BRPI0614746A2 (pt) 2005-08-09 2011-04-12 Univ Sunderland partìculas de sìlica hidrofóbicas, métodos de fabricação e uso das mesmas, assim como métodos de detecção e/ou identificação de uma impressão digital ou outra massa ou depósito hidrofóbico
WO2007021757A2 (en) * 2005-08-15 2007-02-22 Massachusetts Institute Of Technology Fluorescent sensor and methods
US7514267B1 (en) * 2005-08-19 2009-04-07 Stcunm Detection systems utilizing supported lipid bilayers
US20070134685A1 (en) * 2005-09-06 2007-06-14 Invitrogen Corporation Control of chemical modification
JP4415972B2 (ja) * 2005-09-22 2010-02-17 ソニー株式会社 金属酸化物ナノ粒子の製造方法
US8337721B2 (en) 2005-12-02 2012-12-25 Vanderbilt University Broad-emission nanocrystals and methods of making and using same
PL1962805T3 (pl) 2005-12-08 2017-01-31 Insmed Incorporated Kompozycje środków przeciwzapalnych oparte na lipidach do leczenia infekcji płucnych
US20080191604A1 (en) * 2006-09-27 2008-08-14 Evident Technologies Retro-emission systems comprising microlens arrays and luminescent emitters
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
FR2918755B1 (fr) * 2007-07-09 2009-10-30 Commissariat Energie Atomique Procede de detection et de quantification d'analytes sur support solide avec des molecules fluorescentes encapsulees dans des immunoliposomes.
US20090171330A1 (en) * 2007-12-28 2009-07-02 Spectranetics Tunable nanoparticle tags to enhance tissue recognition
US20090270269A1 (en) * 2008-04-28 2009-10-29 Ashok Kumar Nano-scale fluoro-biosensors exhibiting a low false alarm rate for rapid detection of biological contaminants
US20110291049A1 (en) * 2008-06-10 2011-12-01 Board Of Trustees Of The University Of Arkansas Indium arsenide nanocrystals and methods of making the same
US20110070154A1 (en) * 2008-08-13 2011-03-24 Hyde Roderick A Artificial cells
US8895158B2 (en) 2011-08-10 2014-11-25 The Johns Hopkins University Nanoparticle taggants for explosive precursors
WO2013078252A1 (en) 2011-11-22 2013-05-30 Qd Vision, Inc. Quantum dot-containing compositions including an emission stabilizer, products including same, and method
EP2841108A4 (de) * 2012-04-25 2015-11-25 Tufts College Seidenmikrokügelchen sowie verfahren zur oberflächenschmierung
CA2891487A1 (en) 2012-11-29 2014-06-05 Insmed Incorporated Stabilized vancomycin formulations
WO2014134338A1 (en) * 2013-03-01 2014-09-04 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Oligonucleotide functionalized quantum dots
US9229611B2 (en) * 2013-03-05 2016-01-05 Oracle International Corporation Automatic management of client data consistency
CA2943049A1 (en) 2014-04-08 2015-10-15 Aradigm Corporation Liposomal ciprofloxacin formulations with activity against non-tuberculous mycobacteria
US9968555B2 (en) 2014-04-08 2018-05-15 Aradigm Corporation Liposomal formulations that form drug nanocrystals after freeze-thaw
PL3142643T3 (pl) 2014-05-15 2019-12-31 Insmed Incorporated Sposoby leczenia zakażeń płuc prątkami niegruźliczymi
WO2017147407A1 (en) * 2016-02-25 2017-08-31 Board Of Regents, The University Of Texas System Compositions comprising composite nanocarriers and methods of making and uses thereof
WO2019191627A1 (en) 2018-03-30 2019-10-03 Insmed Incorporated Methods for continuous manufacture of liposomal drug products

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4614796A (en) 1983-03-25 1986-09-30 Nippon Shinyaku Co., Ltd. Liposome and method of manufacture therefor
WO1987007150A1 (en) * 1986-05-30 1987-12-03 The Johns Hopkins University Receptor-targeted drug delivery systems
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US5151507A (en) * 1986-07-02 1992-09-29 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US5227489A (en) * 1988-08-01 1993-07-13 Ciba Corning Diagnostics Corp. Stable hydrophilic acridinium esters suitable for liposome encapsulation
US5578718A (en) * 1990-01-11 1996-11-26 Isis Pharmaceuticals, Inc. Thiol-derivatized nucleosides
US5187085A (en) * 1990-09-28 1993-02-16 Applied Biosystems, Inc. Nucleic acid sequence analysis with nucleoside-5'-o-(1-thiotriphosphates)
YU187991A (sh) * 1990-12-11 1994-09-09 Hoechst Aktiengesellschaft 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba
US5364759B2 (en) * 1991-01-31 1999-07-20 Baylor College Medicine Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats
US5650277A (en) * 1992-07-02 1997-07-22 Diagenetics Ltd. Method of determining the presence and quantifying the number of di- and trinucleotide repeats
US6048616A (en) 1993-04-21 2000-04-11 Philips Electronics N.A. Corp. Encapsulated quantum sized doped semiconductor particles and method of manufacturing same
US5637258A (en) * 1996-03-18 1997-06-10 Nanocrystals Technology L.P. Method for producing rare earth activited metal oxide nanocrystals
JP4245664B2 (ja) * 1996-07-29 2009-03-25 ナノスフェアー インコーポレイテッド オリゴヌクレオチドを備えた金ナノ粒子を使用して標的該酸を検出する方法
DE19724796A1 (de) * 1997-06-06 1998-12-10 Max Delbrueck Centrum Mittel zur Antitumortherapie
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6207392B1 (en) * 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6221602B1 (en) 1998-11-10 2001-04-24 Bio-Pixels Ltd. Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination
US6114038A (en) 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
WO2000028089A1 (en) 1998-11-10 2000-05-18 Biocrystal Limited Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination
US6194213B1 (en) * 1999-12-10 2001-02-27 Bio-Pixels Ltd. Lipophilic, functionalized nanocrystals and their use for fluorescence labeling of membranes
US6179912B1 (en) * 1999-12-20 2001-01-30 Biocrystal Ltd. Continuous flow process for production of semiconductor nanocrystals
US6761877B2 (en) * 2000-02-18 2004-07-13 Biocrystal, Ltd. Functionalized encapsulated fluorescent nanocrystals

Also Published As

Publication number Publication date
DE60132311T2 (de) 2009-01-02
US20020001716A1 (en) 2002-01-03
US7244413B2 (en) 2007-07-17
EP1266032B1 (de) 2008-01-09
US20050019486A1 (en) 2005-01-27
ATE383440T1 (de) 2008-01-15
US7060252B2 (en) 2006-06-13
EP1266032A1 (de) 2002-12-18
EP1266032A4 (de) 2005-01-19
US20060099147A1 (en) 2006-05-11
WO2001061045A1 (en) 2001-08-23
US6761877B2 (en) 2004-07-13
AU2001237057A1 (en) 2001-08-27

Similar Documents

Publication Publication Date Title
DE60132311D1 (de) Funktionalisierte eingekapselte fluoreszierende nanokristalle
DE60234382D1 (de) Nanokristalle
ATE342508T1 (de) Kapseln, enthaltend feststoffpartikeln von signalerzeugenden organischen substanzen
DE69833378D1 (de) Fluoreszierende polarisation
DE60136034D1 (de) Molekular-Modifikations-Assays
JP2005513471A5 (de)
ATE320819T1 (de) Bestimmung von antigenen mittels oligonukleotid- antikörper-konjugaten
DE60135912D1 (de) Nachweis der hybridisierung von nukleinsäuren durch fluoreszenzpolarisation
AU3659002A (en) Methods, circuits and compositions of matter for in vivo detection of biomolecule concentrations using fluorescent tags
DE60137203D1 (de) Poröse ferro- oder ferrimagnetische glasteilchen für molekültrennung
DE69635801D1 (de) Prostataspezifisches membranes antigen und seine anwendungen
MX9708698A (es) Plataforma de sensor y metodo para la deteccion paralela de una pluralidad de analitos utilizando luminescencia evanescentemente excitada.
DK1728066T3 (da) Fluorometer
DE50210457D1 (de) Vorrichtung zur referenzierung von fluoreszenzsignalen
ATE516501T1 (de) Verfahren für die fluoreszenz-detektion einer substanz
AU7532501A (en) Method for increasing luminescence assay sensitivity
SE9802558D0 (sv) Device for detection of fluorescent
NO20052553D0 (no) Cobalaminanalyse.
DE69604920D1 (de) Verwendung einer phycobiliprotein-peptidkomplexverbindung als fluoreszenzlabel
DE60114804D1 (de) Konstruierte fluoreszenzproteine mit langen wellenlängen
DE69924147D1 (de) Floureszenzintensitäts-test für eine protein- oder peptidbindung an nukleinsäuren
DE69732034D1 (de) Assay-verfahren
DE60222091D1 (de) Dendritische chemilumineszierende Substrate
DE60213986D1 (de) Neuen reagenzien in chemilumineszenz-nachweisverfahren
DE59910326D1 (de) Verwendung derivatisierter Reagenzien in Chemilumineszenz- und Elektrochemilumineszenz-Nachweisverfahren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LIFE TECHNOLOGIES CORP. (N.D.GES.D. STAATES DE, US

8380 Miscellaneous part iii

Free format text: PFANDRECHT

8380 Miscellaneous part iii

Free format text: PFANDRECHT AUFGEHOBEN