DE60132239D1 - Verfahren zur vorbereitung von mikropartikeln zur verwendung in pharmazeutischen zusammensetzungen zur inhalation - Google Patents

Verfahren zur vorbereitung von mikropartikeln zur verwendung in pharmazeutischen zusammensetzungen zur inhalation

Info

Publication number
DE60132239D1
DE60132239D1 DE60132239T DE60132239T DE60132239D1 DE 60132239 D1 DE60132239 D1 DE 60132239D1 DE 60132239 T DE60132239 T DE 60132239T DE 60132239 T DE60132239 T DE 60132239T DE 60132239 D1 DE60132239 D1 DE 60132239D1
Authority
DE
Germany
Prior art keywords
inhalation
pharmaceutical compositions
preparing microparticles
microparticles
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60132239T
Other languages
English (en)
Other versions
DE60132239T2 (de
Inventor
John Nicholas Staniforth
Haggis Harris
David Alexander Vodden Morton
Robin Bannister
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vectura Ltd
Original Assignee
Vectura Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27447911&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60132239(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0029261A external-priority patent/GB0029261D0/en
Priority claimed from GB0030946A external-priority patent/GB0030946D0/en
Priority claimed from PCT/GB2001/001606 external-priority patent/WO2001076575A2/en
Priority claimed from GB0124010A external-priority patent/GB0124010D0/en
Application filed by Vectura Ltd filed Critical Vectura Ltd
Application granted granted Critical
Publication of DE60132239D1 publication Critical patent/DE60132239D1/de
Publication of DE60132239T2 publication Critical patent/DE60132239T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60132239T 2000-11-30 2001-11-30 Verfahren zur vorbereitung von mikropartikeln zur verwendung in pharmazeutischen zusammensetzungen zur inhalation Expired - Lifetime DE60132239T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB0029261A GB0029261D0 (en) 2000-11-30 2000-11-30 Method of making particles for use in a pharmaceutical composition
GB0029261 2000-11-30
GB0030946A GB0030946D0 (en) 2000-12-19 2000-12-19 Method of making particles for use in a pharmaceutical composition
GB0030946 2000-12-19
PCT/GB2001/001606 WO2001076575A2 (en) 2000-04-07 2001-04-09 The treatment of respiratory diseases
WOPCT/GB01/01606 2001-04-09
GB0124010A GB0124010D0 (en) 2001-10-05 2001-10-05 Pharmaceutical compositions for inhalation
GB0124010 2001-10-05
PCT/GB2001/005334 WO2002043702A2 (en) 2000-11-30 2001-11-30 Pharmaceutical compositions for inhalation

Publications (2)

Publication Number Publication Date
DE60132239D1 true DE60132239D1 (de) 2008-02-14
DE60132239T2 DE60132239T2 (de) 2008-05-08

Family

ID=27447911

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60132239T Expired - Lifetime DE60132239T2 (de) 2000-11-30 2001-11-30 Verfahren zur vorbereitung von mikropartikeln zur verwendung in pharmazeutischen zusammensetzungen zur inhalation

Country Status (10)

Country Link
EP (2) EP1337241B1 (de)
JP (1) JP4380988B2 (de)
AU (3) AU2211502A (de)
CA (1) CA2429665C (de)
CY (2) CY1117749T1 (de)
DE (1) DE60132239T2 (de)
DK (1) DK2283818T3 (de)
ES (1) ES2296831T3 (de)
NZ (1) NZ526059A (de)
WO (2) WO2002043702A2 (de)

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US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
ATE375142T1 (de) * 2001-03-30 2007-10-15 Jagotec Ag Medizinische aerosolformulierungen
GB0208742D0 (en) * 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
BR0212833A (pt) 2001-09-26 2004-10-13 Baxter Int Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
WO2003075977A2 (en) * 2002-03-05 2003-09-18 Cleveland State University Agglomerated particles for aerosol drug delivery
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
CN102688224A (zh) * 2003-04-14 2012-09-26 维克特拉有限公司 用于提高剂量效率的药物组合物和装置
AU2004231342A1 (en) 2003-04-14 2004-11-04 Vectura Ltd Dry power inhaler devices and dry power formulations for enhancing dosing efficiency
GB0321607D0 (en) 2003-09-15 2003-10-15 Vectura Ltd Manufacture of pharmaceutical compositions
EP1663180A1 (de) * 2003-09-15 2006-06-07 Vectura Limited Pharmazeutische zusammensetzungen zur behandlung von vorzeitiger ejakulation durch pulmonale inhalation
GB0327723D0 (en) 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
US20050287077A1 (en) * 2004-02-10 2005-12-29 James E. Shipley Process for preparing stable SOL of pharmaceutical ingredients and hydrofluorocarbon
GB0409703D0 (en) * 2004-04-30 2004-06-02 Vectura Ltd Pharmaceutical compositions
GB0410399D0 (en) * 2004-05-10 2004-06-16 Arakis Ltd The treatment of respiratory disease
GB0418791D0 (en) 2004-08-23 2004-09-22 Glaxo Group Ltd Novel process
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
GB0426301D0 (en) * 2004-11-30 2004-12-29 Vectura Ltd Pharmaceutical formulations
US20060153889A1 (en) * 2005-01-10 2006-07-13 Friel Francis M Discontinuous surface coating for particles
EP1917301B1 (de) * 2005-08-05 2014-04-23 3M Innovative Properties Company Zusammensetzungen mit verbesserter flussfähigkeit
GB0525254D0 (en) 2005-12-12 2006-01-18 Jagotec Ag Powder compositions for inhalation
GB0613161D0 (en) 2006-06-30 2006-08-09 Novartis Ag Organic Compounds
GB0801876D0 (en) * 2008-02-01 2008-03-12 Vectura Group Plc Suspension formulations
PL3111926T3 (pl) * 2009-05-29 2020-06-29 Pearl Therapeutics, Inc. Kompozycje, sposoby i układy do dostarczania dwóch lub większej liczby środków czynnych do układu oddechowego
DE102009049470A1 (de) * 2009-10-15 2011-04-28 Süd-Chemie AG Verfahren zur Herstellung von feinteiligen Lithiumtitan-Spinellen und deren Verwendung
GB0921481D0 (en) 2009-12-08 2010-01-20 Vectura Ltd Process and product
CA2784207C (en) * 2009-12-14 2018-06-05 Chiesi Farmaceutici S.P.A. Antibiotic microparticles for inhalation
TR201811349T4 (tr) * 2010-04-01 2018-09-21 Chiesi Farm Spa İnhalasyon i̇çi̇n kuru toz taşiyici parti̇külleri̇n hazirlanmasi i̇çi̇n proses.
ITUD20100112A1 (it) * 2010-06-09 2011-12-10 Farma Derma S R L Preparazione per uso vaginale e rettale e relativo procedimento di produzione
TW201304822A (zh) 2010-11-15 2013-02-01 Vectura Ltd 組成物及用途
WO2012073025A1 (en) 2010-11-30 2012-06-07 Vectura Limited Glucosaminoglucans such as heparin for use in the treatment of pulmonary inflammation such as copd
US9763965B2 (en) 2012-04-13 2017-09-19 Glaxosmithkline Intellectual Property Development Limited Aggregate particles
WO2014078435A1 (en) 2012-11-14 2014-05-22 W. R. Grace & Co.-Conn. Compositions containing a biologically active material and a non-ordered inorganic oxide
GB201305825D0 (en) 2013-03-28 2013-05-15 Vectura Ltd New use
EP2957552B1 (de) 2014-06-16 2020-01-22 Arven Ilac Sanayi Ve Ticaret A.S. Vilanterolformulierungen
TR201407010A2 (tr) 2014-06-16 2015-12-21 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Vilanterol formülasyonları.
JP6502501B2 (ja) 2014-09-09 2019-04-17 ベクトゥラ・リミテッド グリコピロレートを含む製剤、方法、及び装置
MX2017005692A (es) 2014-10-31 2017-08-07 Glaxosmithkline Ip Dev Ltd Formulacion en polvo.
EP3233195B1 (de) * 2014-12-17 2020-04-15 L'oreal Komposit partikel und seine herstellung
US20210353650A1 (en) * 2020-05-18 2021-11-18 Cai Gu Huang Pharmaceutical formulation containing remdesivir and its active metabolites for dry powder inhalation

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US5506203C1 (en) * 1993-06-24 2001-02-06 Astra Ab Systemic administration of a therapeutic preparation
DE4323636A1 (de) * 1993-07-15 1995-01-19 Hoechst Ag Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung
MX9704550A (es) * 1994-12-22 1997-10-31 Astra Ab Formulaciones de medicamentos en aerosol.
US6524557B1 (en) * 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
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US6086376A (en) * 1998-01-30 2000-07-11 Rtp Pharma Inc. Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant
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US7521068B2 (en) * 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
PT1283036E (pt) † 1998-11-13 2008-03-06 Jagotec Ag Inalador de pó seco de dose múltipla com um reservatório de pó
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PE20011227A1 (es) † 2000-04-17 2002-01-07 Chiesi Farma Spa Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros
EP1337239B2 (de) † 2000-11-30 2015-11-25 Vectura Limited Partikel zur verwendung in einer pharmazeutischen zusammensetzung

Also Published As

Publication number Publication date
EP1337241A2 (de) 2003-08-27
DE60132239T2 (de) 2008-05-08
WO2002043702A3 (en) 2002-10-17
NZ526059A (en) 2005-05-27
EP1337240B1 (de) 2011-07-27
EP1337241B1 (de) 2008-01-02
EP1337240A2 (de) 2003-08-27
EP1337240B2 (de) 2014-09-24
WO2002043701A3 (en) 2002-10-17
WO2002043702A2 (en) 2002-06-06
CY1117749T1 (el) 2017-05-17
ES2296831T3 (es) 2008-05-01
CA2429665C (en) 2013-10-22
AU2211502A (en) 2002-06-11
WO2002043701A2 (en) 2002-06-06
AU2002222115B2 (en) 2006-09-28
CY1119400T1 (el) 2018-02-14
DK2283818T3 (en) 2017-10-16
JP4380988B2 (ja) 2009-12-09
JP2004514504A (ja) 2004-05-20
CA2429665A1 (en) 2002-06-06
AU2002222118A1 (en) 2002-06-11

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Legal Events

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8364 No opposition during term of opposition