DE60120712T2 - Kallikrein gen - Google Patents

Kallikrein gen Download PDF

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Publication number
DE60120712T2
DE60120712T2 DE60120712T DE60120712T DE60120712T2 DE 60120712 T2 DE60120712 T2 DE 60120712T2 DE 60120712 T DE60120712 T DE 60120712T DE 60120712 T DE60120712 T DE 60120712T DE 60120712 T2 DE60120712 T2 DE 60120712T2
Authority
DE
Germany
Prior art keywords
protein
klk15
nucleic acid
substance
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60120712T
Other languages
German (de)
English (en)
Other versions
DE60120712D1 (en
Inventor
George M. Toronto YOUSEF
Eleftherios P. Toronto DIAMANDIS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mount Sinai Hospital
Original Assignee
Mount Sinai Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mount Sinai Hospital filed Critical Mount Sinai Hospital
Publication of DE60120712D1 publication Critical patent/DE60120712D1/de
Application granted granted Critical
Publication of DE60120712T2 publication Critical patent/DE60120712T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21034—Plasma kallikrein (3.4.21.34)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE60120712T 2000-08-11 2001-08-10 Kallikrein gen Expired - Lifetime DE60120712T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22485300P 2000-08-11 2000-08-11
US224853P 2000-08-11
PCT/CA2001/001141 WO2002014485A2 (en) 2000-08-11 2001-08-10 Kallikrein gene

Publications (2)

Publication Number Publication Date
DE60120712D1 DE60120712D1 (en) 2006-07-27
DE60120712T2 true DE60120712T2 (de) 2007-07-19

Family

ID=22842508

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60120712T Expired - Lifetime DE60120712T2 (de) 2000-08-11 2001-08-10 Kallikrein gen

Country Status (9)

Country Link
US (2) US7199229B2 (enExample)
EP (1) EP1309703B1 (enExample)
JP (1) JP2004505649A (enExample)
AT (1) ATE330017T1 (enExample)
AU (2) AU2001287384B2 (enExample)
CA (1) CA2418422C (enExample)
DE (1) DE60120712T2 (enExample)
ES (1) ES2266245T3 (enExample)
WO (1) WO2002014485A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7022497B1 (en) * 1999-03-11 2006-04-04 Mt. Sinai Hospital Human kallikrein-like genes
US9012141B2 (en) * 2000-03-27 2015-04-21 Advaxis, Inc. Compositions and methods comprising KLK3 of FOLH1 antigen
US7199229B2 (en) * 2000-08-11 2007-04-03 Mount Sinai Hospital Kallikrein gene
EP1330652B1 (en) * 2000-10-27 2007-06-27 Mount Sinai Hospital Method for detecting ovarian cancer based on human kallikrein 6 (hk6)
WO2002037112A2 (en) * 2000-11-01 2002-05-10 Mount Sinai Hospital Detection of ovarian cancer
WO2002097438A1 (en) * 2001-05-25 2002-12-05 Mount Sinai Hospital Method of detecting and monitoring prostate and ovarian cancers
KR20040081420A (ko) * 2001-10-16 2004-09-21 마운트 시나이 하스피틀 코포레이션 난소암의 검출 방법
AU2003266038A1 (en) * 2002-08-28 2004-03-19 Mount Sinai Hospital Methods for detecting endocrine cancer using kallikrein 13 (klk13) as a biomarker
CA2497058A1 (en) * 2002-08-28 2004-03-11 Mount Sinai Hospital Methods for detecting breast and ovarian cancer
EP1546728A2 (en) * 2002-09-26 2005-06-29 Mount Sinai Hospital Methods for detecting endocrine cancer
CA2516591A1 (en) * 2003-02-26 2004-09-10 Mount Sinai Hospital Multiple marker assay for detection of ovarian cancer
CA2516588A1 (en) * 2003-02-27 2004-09-10 Mount Sinai Hospital Assay for detection of renal cell carcinoma
CA2468651A1 (en) * 2003-06-13 2004-12-13 Eleftherios P. Diamandis Detection of neurodegenerative diseases
US20060269971A1 (en) * 2003-09-26 2006-11-30 Mount Sinai Hospital Methods for detecting prostate cancer
EP1711616A1 (en) * 2004-01-28 2006-10-18 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with kallikrein 15 (klk15)
JP5757863B2 (ja) 2008-05-19 2015-08-05 アドバクシス インコーポレイテッド 異種抗原のための二重送達システム
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
CN107412756A (zh) 2010-10-01 2017-12-01 宾夕法尼亚大学理事会 李斯特菌疫苗载体用于在寄生虫感染的个体中扭转免疫无应答的用途
CA2829960A1 (en) 2011-03-11 2012-09-20 John Rothman Listeria-based adjuvants
BR112014022662A2 (pt) 2012-03-12 2017-10-03 Advaxis Inc Inibição da função de célula supressora seguindo tratamento de vacina de listeria
GB201513921D0 (en) * 2015-08-05 2015-09-23 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7022497B1 (en) 1999-03-11 2006-04-04 Mt. Sinai Hospital Human kallikrein-like genes
AU2001271427A1 (en) * 2000-06-26 2002-01-08 Sugen, Inc. Novel proteases
CA2416691A1 (en) 2000-07-21 2002-01-31 Incyte Genomics, Inc. Proteases
US7199229B2 (en) 2000-08-11 2007-04-03 Mount Sinai Hospital Kallikrein gene
EP1330652B1 (en) * 2000-10-27 2007-06-27 Mount Sinai Hospital Method for detecting ovarian cancer based on human kallikrein 6 (hk6)
US6962793B2 (en) 2000-10-27 2005-11-08 Mount Sinai Hospital Methods for detecting Alzheimers disease
WO2002037112A2 (en) * 2000-11-01 2002-05-10 Mount Sinai Hospital Detection of ovarian cancer
WO2002097438A1 (en) * 2001-05-25 2002-12-05 Mount Sinai Hospital Method of detecting and monitoring prostate and ovarian cancers
KR20040081420A (ko) * 2001-10-16 2004-09-21 마운트 시나이 하스피틀 코포레이션 난소암의 검출 방법
EP1490687A1 (en) 2002-04-04 2004-12-29 Mount Sinai Hospital Corporation Methods for detecting ovarian cancer
CA2497058A1 (en) 2002-08-28 2004-03-11 Mount Sinai Hospital Methods for detecting breast and ovarian cancer
AU2003266038A1 (en) 2002-08-28 2004-03-19 Mount Sinai Hospital Methods for detecting endocrine cancer using kallikrein 13 (klk13) as a biomarker
EP1546728A2 (en) 2002-09-26 2005-06-29 Mount Sinai Hospital Methods for detecting endocrine cancer
CA2516591A1 (en) 2003-02-26 2004-09-10 Mount Sinai Hospital Multiple marker assay for detection of ovarian cancer
CA2516588A1 (en) 2003-02-27 2004-09-10 Mount Sinai Hospital Assay for detection of renal cell carcinoma
CA2468651A1 (en) 2003-06-13 2004-12-13 Eleftherios P. Diamandis Detection of neurodegenerative diseases
US20060269971A1 (en) 2003-09-26 2006-11-30 Mount Sinai Hospital Methods for detecting prostate cancer

Also Published As

Publication number Publication date
ES2266245T3 (es) 2007-03-01
US20040058342A1 (en) 2004-03-25
EP1309703A2 (en) 2003-05-14
WO2002014485A3 (en) 2003-01-09
CA2418422A1 (en) 2002-02-21
CA2418422C (en) 2011-06-07
WO2002014485A2 (en) 2002-02-21
JP2004505649A (ja) 2004-02-26
US7507403B2 (en) 2009-03-24
US20070178114A1 (en) 2007-08-02
AU8738401A (en) 2002-02-25
US7199229B2 (en) 2007-04-03
DE60120712D1 (en) 2006-07-27
EP1309703B1 (en) 2006-06-14
ATE330017T1 (de) 2006-07-15
AU2001287384B2 (en) 2007-03-29

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