DE60114772D1 - Aromatisches guanylhydrazon zur behandlung resistenter viraler infektionen - Google Patents

Aromatisches guanylhydrazon zur behandlung resistenter viraler infektionen

Info

Publication number
DE60114772D1
DE60114772D1 DE60114772T DE60114772T DE60114772D1 DE 60114772 D1 DE60114772 D1 DE 60114772D1 DE 60114772 T DE60114772 T DE 60114772T DE 60114772 T DE60114772 T DE 60114772T DE 60114772 D1 DE60114772 D1 DE 60114772D1
Authority
DE
Germany
Prior art keywords
treatment
aromatic
infections
guanylhydrazone
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60114772T
Other languages
English (en)
Other versions
DE60114772T2 (de
Inventor
Dorian Bevec
Joachim Hauber
Sabine Obert
Gyorgy Keri
Laszlo Orfi
Istvan Szekely
Axel Choidas
Gerald Bacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE60114772D1 publication Critical patent/DE60114772D1/de
Application granted granted Critical
Publication of DE60114772T2 publication Critical patent/DE60114772T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60114772T 2000-02-02 2001-02-02 Aromatisches guanylhydrazon zur behandlung resistenter viraler infektionen Expired - Fee Related DE60114772T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17979500P 2000-02-02 2000-02-02
EP00102050 2000-02-02
EP00102050 2000-02-02
US179795P 2000-02-02
PCT/EP2001/001126 WO2001056553A2 (en) 2000-02-02 2001-02-02 Pharmaceutically active aromatic guanylhydrazones

Publications (2)

Publication Number Publication Date
DE60114772D1 true DE60114772D1 (de) 2005-12-15
DE60114772T2 DE60114772T2 (de) 2006-07-20

Family

ID=26070491

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60114772T Expired - Fee Related DE60114772T2 (de) 2000-02-02 2001-02-02 Aromatisches guanylhydrazon zur behandlung resistenter viraler infektionen

Country Status (7)

Country Link
US (2) US20030203969A1 (de)
EP (1) EP1255541B1 (de)
AT (1) ATE308982T1 (de)
AU (1) AU2001240578A1 (de)
DE (1) DE60114772T2 (de)
ES (1) ES2250363T3 (de)
WO (1) WO2001056553A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001269092A1 (en) * 2000-06-27 2002-01-08 Axxima Pharmaceuticals Ag Inhibitors of hepatitis b virus infection
WO2003006426A1 (en) * 2001-07-13 2003-01-23 Axxima Pharmaceuticals Ag Aromatic guanylhydrazones as effective compounds against neurodiseases
WO2003024407A2 (en) 2001-09-21 2003-03-27 Message Pharmaceuticals, Inc. Inhibitors of rnase p proteins as antibacterial compounds
PL370480A1 (en) * 2001-11-07 2005-05-30 F.Hoffmann-La Roche Ag Aminopyrimidines and pyridines
EP1389480A1 (de) * 2002-08-14 2004-02-18 Mondobiotech Interferon SA Therapeutische Anwendung von Guanylhydrazone zur Hemmung von CD83 abhängige Verfahren und Reifung der dendritischen Zellen
EP1413300A1 (de) * 2002-10-26 2004-04-28 Mondobiotech SA Pyrimidinium-Guanidiniminoethylphenyl-Guanidinoalkyl-Amine und Guanidiniminoethylphenyl-Guanidinoalkylamine als pharmazeutische Wirkstoffe
PT1583542E (pt) 2003-01-14 2008-09-17 Gilead Sciences Inc Composições e métodos para terapia de combinação antiviral
EP1686949A2 (de) * 2003-11-24 2006-08-09 Viropharma Incorporated Verbindungen, zusammensetzungen und verfahren zur behandlung und prophylaxe von hepatitis-c-virusinfektionen und relevanten erkrankungen
US7244765B2 (en) 2004-06-25 2007-07-17 Cytokine Pharmasciences, Inc Guanylhydrazone salts, compositions, processes of making and methods of using
CN102936212A (zh) * 2004-08-17 2013-02-20 辉凌公司 脒腙化合物、组合物、制备方法及使用方法
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) * 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
DE102006028371A1 (de) * 2006-06-19 2007-12-20 Rheinische Friedrich-Wilhelms Universität Mittel gegen Malaria
US20100104536A1 (en) * 2007-03-20 2010-04-29 Indravadan Ambalal Modi P38 inhibitors
WO2008156573A1 (en) 2007-06-12 2008-12-24 Provid Pharmaceuticals, Inc. Kinase inhibitors, compositions thereof, and methods of use therewith
RU2477271C2 (ru) * 2011-01-12 2013-03-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кабардино-Балкарский государственный университет им. Х.М. Бербекова" (КБГУ) Моно- и дикетимины на основе 4,4'-диацетилдифенилоксида и гуанидина и способ их получения
US20150044178A1 (en) 2011-12-28 2015-02-12 Kyoto Prefectural Public University Corporation Normalization of culture of corneal endothelial cells
US10813920B2 (en) 2013-11-14 2020-10-27 The Doshisha Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage
CN110331110B (zh) * 2019-07-26 2021-07-13 中南民族大学 一种利用废糖蜜和细菌高效还原水中六价铬并回收铬的方法
WO2023230431A1 (en) * 2022-05-23 2023-11-30 Glaxo Wellcome Uk Limited Inhibitors of deoxyhypusine synthase for the treatment and prevention of respiratory virus infections
CN116102468B (zh) * 2023-02-22 2024-07-09 中国科学技术大学 靶向人脂质运载蛋白2的先导化合物或其药学上可接受的盐及其制备方法与应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US573684A (en) * 1896-12-22 Alexander hill motes
US6008255A (en) * 1994-01-21 1999-12-28 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
US5599984A (en) * 1994-01-21 1997-02-04 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
DE69739734D1 (de) * 1996-11-15 2010-02-25 Cytokine Pharmasciences Inc Guanylhydrazone die nützlich sind zur behandlung von mit t-zellen verbundenen krankheiten

Also Published As

Publication number Publication date
WO2001056553A3 (en) 2002-03-28
WO2001056553A2 (en) 2001-08-09
EP1255541B1 (de) 2005-11-09
AU2001240578A1 (en) 2001-08-14
US20030203969A1 (en) 2003-10-30
ATE308982T1 (de) 2005-11-15
DE60114772T2 (de) 2006-07-20
US20050171176A1 (en) 2005-08-04
EP1255541A2 (de) 2002-11-13
ES2250363T3 (es) 2006-04-16

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee