DE60114245D1 - Verfahren und vorrichtung zur identifizierung und quantifizierung chemischer komponenten einer mischung - Google Patents

Verfahren und vorrichtung zur identifizierung und quantifizierung chemischer komponenten einer mischung

Info

Publication number
DE60114245D1
DE60114245D1 DE60114245T DE60114245T DE60114245D1 DE 60114245 D1 DE60114245 D1 DE 60114245D1 DE 60114245 T DE60114245 T DE 60114245T DE 60114245 T DE60114245 T DE 60114245T DE 60114245 D1 DE60114245 D1 DE 60114245D1
Authority
DE
Germany
Prior art keywords
data
identifying
mixture
chemical components
chromatograms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60114245T
Other languages
English (en)
Other versions
DE60114245T2 (de
Inventor
Thomas Vogels
Florian Wulfert
Der Greef Jan Van
Albert Tas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Original Assignee
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NL1015875A external-priority patent/NL1015875C2/nl
Application filed by Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO filed Critical Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Application granted granted Critical
Publication of DE60114245D1 publication Critical patent/DE60114245D1/de
Publication of DE60114245T2 publication Critical patent/DE60114245T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8665—Signal analysis for calibrating the measuring apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8641—Baseline
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8658—Optimising operation parameters
    • G01N30/8662—Expert systems; optimising a large number of parameters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8675—Evaluation, i.e. decoding of the signal into analytical information
    • G01N30/8686—Fingerprinting, e.g. without prior knowledge of the sample components

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Electron Tubes For Measurement (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
DE60114245T 2000-08-03 2001-08-03 Verfahren und vorrichtung zur identifizierung und quantifizierung chemischer komponenten einer mischung Expired - Lifetime DE60114245T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NL1015875 2000-08-03
NL1015875A NL1015875C2 (nl) 2000-08-03 2000-08-03 Werkwijze en systeem voor het identificeren en kwantificeren van chemische componenten van een te onderzoeken mengsel van materialen.
NL1016034 2000-08-28
NL1016034A NL1016034C2 (nl) 2000-08-03 2000-08-28 Werkwijze en systeem voor het identificeren en kwantificeren van chemische componenten van een te onderzoeken mengsel van materialen.
PCT/NL2001/000590 WO2002013228A2 (en) 2000-08-03 2001-08-03 Method and system for identifying and quantifying chemical components of a mixture

Publications (2)

Publication Number Publication Date
DE60114245D1 true DE60114245D1 (de) 2005-11-24
DE60114245T2 DE60114245T2 (de) 2006-07-13

Family

ID=26643217

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60114245T Expired - Lifetime DE60114245T2 (de) 2000-08-03 2001-08-03 Verfahren und vorrichtung zur identifizierung und quantifizierung chemischer komponenten einer mischung

Country Status (10)

Country Link
US (2) US6743364B2 (de)
EP (1) EP1384248B1 (de)
JP (1) JP2004506216A (de)
AT (1) ATE307387T1 (de)
AU (1) AU2001294343A1 (de)
CA (1) CA2417621A1 (de)
DE (1) DE60114245T2 (de)
IL (1) IL154188A0 (de)
NL (1) NL1016034C2 (de)
WO (1) WO2002013228A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6687395B1 (en) * 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
NL1016034C2 (nl) * 2000-08-03 2002-02-08 Tno Werkwijze en systeem voor het identificeren en kwantificeren van chemische componenten van een te onderzoeken mengsel van materialen.
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
AU2002217904A1 (en) * 2000-11-28 2002-06-11 Surromed, Inc. Methods for efficiently minig broad data sets for biological markers
US20020115056A1 (en) * 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US20050170372A1 (en) * 2001-08-13 2005-08-04 Afeyan Noubar B. Methods and systems for profiling biological systems
IL160324A0 (en) * 2001-08-13 2004-07-25 Beyond Genomics Inc Method and system for profiling biological systems
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
US6835927B2 (en) * 2001-10-15 2004-12-28 Surromed, Inc. Mass spectrometric quantification of chemical mixture components
AU2003239409A1 (en) * 2002-05-09 2003-11-11 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
WO2003102543A2 (en) * 2002-05-31 2003-12-11 Waters Investments Limited A method of using data binning in the analysis of chromatograhpy/spectrometry data
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US7457708B2 (en) * 2003-03-13 2008-11-25 Agilent Technologies Inc Methods and devices for identifying related ions from chromatographic mass spectral datasets containing overlapping components
US7022980B2 (en) * 2004-02-02 2006-04-04 Agilent Technologies, Inc. Spectral axis transform
US7248360B2 (en) * 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
CA2501003C (en) 2004-04-23 2009-05-19 F. Hoffmann-La Roche Ag Sample analysis to provide characterization data
GB2413695B (en) * 2004-04-30 2009-01-21 Micromass Ltd Mass spectrometer
US7488935B2 (en) * 2005-06-24 2009-02-10 Agilent Technologies, Inc. Apparatus and method for processing of mass spectrometry data
US8511140B2 (en) * 2005-10-25 2013-08-20 Waters Technologies Corporation Baseline modeling in chromatography
GB2432712B (en) * 2005-11-23 2007-12-27 Micromass Ltd Mass spectrometer
GB0609253D0 (en) * 2006-05-10 2006-06-21 Micromass Ltd Mass spectrometer
WO2008085116A1 (en) * 2007-01-10 2008-07-17 Ge Healthcare Bio-Sciences Ab Mult i -modal ion exchange chromotography resins
JP5455649B2 (ja) * 2007-01-12 2014-03-26 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 接続型低フロー分離技術
US7783458B2 (en) * 2007-06-22 2010-08-24 Ricardo Claps Discrete principal component analysis (DPCA)
US8554518B1 (en) 2007-06-22 2013-10-08 Ricardo Claps Discrete principal component analysis (DPCA) for pattern recognition and diagnostics of tissue pathologies such as cancer
KR20110084182A (ko) * 2008-09-09 2011-07-21 드 슈타트 데르 네덜란덴, 베르테겐부어디그트 두어 드 미니스터 반 폭스겐트존하이트 벨지인 엔 스포츠 Ｌｃｍｓ 기술 및 이의 용도
US8158003B2 (en) 2009-08-26 2012-04-17 International Business Machines Corporation Precision peak matching in liquid chromatography-mass spectroscopy
US8935101B2 (en) 2010-12-16 2015-01-13 Thermo Finnigan Llc Method and apparatus for correlating precursor and product ions in all-ions fragmentation experiments
WO2013026026A2 (en) 2011-08-17 2013-02-21 Smiths Detection Inc. Shift correction for spectral analysis
US20150032383A1 (en) * 2012-03-29 2015-01-29 Koninklijke Philips N.V. Method and system for filtering gas chromatography-mass spectrometry data
JP6115288B2 (ja) * 2012-04-27 2017-04-19 株式会社島津製作所 質量分析におけるピーク検出方法及びそのシステム
US11215589B2 (en) * 2016-11-09 2022-01-04 Shimadzu Corporation Data analyzer for chromatograph mass spectrometry
EP3742391A1 (de) * 2018-03-29 2020-11-25 Leica Microsystems CMS GmbH Vorrichtung und computerimplementiertes verfahren unter verwendung von basislinienschätzung und halbquadratischer minimierung zur bildunschärfeentfernung

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01311218A (ja) * 1988-06-09 1989-12-15 Shimadzu Corp 分析データ処理装置
JP3391862B2 (ja) * 1993-10-05 2003-03-31 株式会社日立製作所 クロマトグラム解析方法
US5644503A (en) * 1994-03-28 1997-07-01 Hitachi, Ltd. Methods and apparatuses for analyzing multichannel chromatogram
GB2308917B (en) * 1996-01-05 2000-04-12 Maxent Solutions Ltd Reducing interferences in elemental mass spectrometers
US5672869A (en) * 1996-04-03 1997-09-30 Eastman Kodak Company Noise and background reduction method for component detection in chromatography/spectrometry
JP3550479B2 (ja) * 1997-06-10 2004-08-04 株式会社日立製作所 クロマトグラフィ分析方法及びクロマトグラフィ分析装置
DE69823206T2 (de) 1997-07-25 2004-08-19 Affymetrix, Inc. (a Delaware Corp.), Santa Clara Verfahren zur herstellung einer bio-informatik-datenbank
US6560542B1 (en) * 2000-01-24 2003-05-06 The Cielo Institute Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
NL1016034C2 (nl) * 2000-08-03 2002-02-08 Tno Werkwijze en systeem voor het identificeren en kwantificeren van chemische componenten van een te onderzoeken mengsel van materialen.

Also Published As

Publication number Publication date
CA2417621A1 (en) 2002-02-14
US6743364B2 (en) 2004-06-01
ATE307387T1 (de) 2005-11-15
IL154188A0 (en) 2003-07-31
WO2002013228A3 (en) 2003-10-16
EP1384248B1 (de) 2005-10-19
NL1016034C2 (nl) 2002-02-08
JP2004506216A (ja) 2004-02-26
WO2002013228A2 (en) 2002-02-14
EP1384248A2 (de) 2004-01-28
AU2001294343A1 (en) 2002-02-18
US20040267459A1 (en) 2004-12-30
DE60114245T2 (de) 2006-07-13
US20020053545A1 (en) 2002-05-09
US7056434B2 (en) 2006-06-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: GROSSE, SCHUMACHER, KNAUER, VON HIRSCHHAUSEN, 8033