DE60107872D1 - Herstellung von wirkstoffpartikeln durch evaporation-präzipitation in wässrige lösungen - Google Patents

Herstellung von wirkstoffpartikeln durch evaporation-präzipitation in wässrige lösungen

Info

Publication number
DE60107872D1
DE60107872D1 DE60107872T DE60107872T DE60107872D1 DE 60107872 D1 DE60107872 D1 DE 60107872D1 DE 60107872 T DE60107872 T DE 60107872T DE 60107872 T DE60107872 T DE 60107872T DE 60107872 D1 DE60107872 D1 DE 60107872D1
Authority
DE
Germany
Prior art keywords
drug
preparation
aqueous solutions
active substances
evaporation precipitation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60107872T
Other languages
English (en)
Other versions
DE60107872T2 (de
Inventor
P Johnston
O Williams
J Young
Xiaoxia Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Application granted granted Critical
Publication of DE60107872D1 publication Critical patent/DE60107872D1/de
Publication of DE60107872T2 publication Critical patent/DE60107872T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE60107872T 2000-11-03 2001-10-22 Herstellung von wirkstoffpartikeln durch evaporation-präzipitation in wässrige lösungen Expired - Lifetime DE60107872T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24547900P 2000-11-03 2000-11-03
US245479P 2000-11-03
US09/808,332 US6756062B2 (en) 2000-11-03 2001-03-14 Preparation of drug particles using evaporation precipitation into aqueous solutions
US808332 2001-03-14
PCT/US2001/051337 WO2002047659A2 (en) 2000-11-03 2001-10-22 Preparation of drug particles using evaporation precipitation into aqueous solutions

Publications (2)

Publication Number Publication Date
DE60107872D1 true DE60107872D1 (de) 2005-01-20
DE60107872T2 DE60107872T2 (de) 2005-05-19

Family

ID=26937266

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60107872T Expired - Lifetime DE60107872T2 (de) 2000-11-03 2001-10-22 Herstellung von wirkstoffpartikeln durch evaporation-präzipitation in wässrige lösungen

Country Status (8)

Country Link
US (1) US6756062B2 (de)
EP (1) EP1335705B1 (de)
JP (1) JP2004515525A (de)
AT (1) ATE284676T1 (de)
AU (1) AU2002243441A1 (de)
CA (1) CA2427625A1 (de)
DE (1) DE60107872T2 (de)
WO (1) WO2002047659A2 (de)

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US8551526B2 (en) * 2000-11-03 2013-10-08 Board Of Regents, The University Of Texas System Preparation of drug particles using evaporation precipitation into aqueous solutions
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US7803404B2 (en) 2005-09-14 2010-09-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
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CN101292958B (zh) * 2007-04-27 2011-04-27 北京化工大学 一种超细达那唑粉体的制备方法
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EP2162120B1 (de) * 2007-06-04 2016-05-04 Bend Research, Inc Nanopartikel mit nicht ionisierbarem zellulosepolymer und amphipilem nicht ionisierbarem blockcopolymer
US9545384B2 (en) 2007-06-04 2017-01-17 Bend Research, Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate
US20100215747A1 (en) * 2007-07-13 2010-08-26 Corey Jay Bloom Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers
EP2231169B1 (de) * 2007-12-06 2016-05-04 Bend Research, Inc. Pharmazeutische zusammensetzungen mit nanopartikeln und resuspensionsmaterial
US9233078B2 (en) * 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
EP2570147B1 (de) 2008-06-13 2017-10-18 MannKind Corporation Trockenpulverinhalator und System zur Wirkstofffreisetzung
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
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SG10202010355PA (en) 2010-03-12 2020-11-27 Berg Llc Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof
RU2531455C2 (ru) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
WO2012027378A2 (en) * 2010-08-23 2012-03-01 President And Fellows Of Harvard College Particles for drug delivery and other applications
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
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Also Published As

Publication number Publication date
JP2004515525A (ja) 2004-05-27
ATE284676T1 (de) 2005-01-15
DE60107872T2 (de) 2005-05-19
WO2002047659A3 (en) 2002-09-06
CA2427625A1 (en) 2002-06-20
US20020081334A1 (en) 2002-06-27
EP1335705B1 (de) 2004-12-15
EP1335705A2 (de) 2003-08-20
US6756062B2 (en) 2004-06-29
WO2002047659A2 (en) 2002-06-20
AU2002243441A1 (en) 2002-06-24

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