DE60044937D1 - Analoge des 5(e)bromovinyluracils und verwandte pyrimidinnucleoside als antivirale mittel und verwendungsmethoden - Google Patents

Analoge des 5(e)bromovinyluracils und verwandte pyrimidinnucleoside als antivirale mittel und verwendungsmethoden

Info

Publication number
DE60044937D1
DE60044937D1 DE60044937T DE60044937T DE60044937D1 DE 60044937 D1 DE60044937 D1 DE 60044937D1 DE 60044937 T DE60044937 T DE 60044937T DE 60044937 T DE60044937 T DE 60044937T DE 60044937 D1 DE60044937 D1 DE 60044937D1
Authority
DE
Germany
Prior art keywords
bromovinyluracil
analogue
methods
antiviral agents
nucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60044937T
Other languages
English (en)
Inventor
Yung-Chi Cheng
Chung K Chu
Ling Li
Yongseok Choi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Georgia
Yale University
University of Georgia Research Foundation Inc UGARF
Original Assignee
University of Georgia
Yale University
University of Georgia Research Foundation Inc UGARF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Georgia, Yale University, University of Georgia Research Foundation Inc UGARF filed Critical University of Georgia
Application granted granted Critical
Publication of DE60044937D1 publication Critical patent/DE60044937D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE60044937T 1999-07-21 2000-07-20 Analoge des 5(e)bromovinyluracils und verwandte pyrimidinnucleoside als antivirale mittel und verwendungsmethoden Expired - Lifetime DE60044937D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/358,028 US6653318B1 (en) 1999-07-21 1999-07-21 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
PCT/US2000/019881 WO2001006986A2 (en) 1999-07-21 2000-07-20 5-(e)-bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use

Publications (1)

Publication Number Publication Date
DE60044937D1 true DE60044937D1 (de) 2010-10-21

Family

ID=23408010

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60044937T Expired - Lifetime DE60044937D1 (de) 1999-07-21 2000-07-20 Analoge des 5(e)bromovinyluracils und verwandte pyrimidinnucleoside als antivirale mittel und verwendungsmethoden

Country Status (8)

Country Link
US (2) US6653318B1 (de)
EP (1) EP1204415B1 (de)
CN (1) CN1420773A (de)
AT (1) ATE480238T1 (de)
AU (1) AU767676B2 (de)
CA (1) CA2378370C (de)
DE (1) DE60044937D1 (de)
WO (1) WO2001006986A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU777869B2 (en) 1999-09-24 2004-11-04 Shire Canada Inc. Method for the treatment or prevention of viral infection using nucleoside analogues
CA2389745C (en) 1999-11-04 2010-03-23 Shire Biochem Inc. Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
AU2002360697B2 (en) * 2001-12-20 2009-04-23 Beth Israel Deaconess Medical Center Treatment of EBV and KHSV infection and associated abnormal cellular proliferation
CN101066987B (zh) * 2007-06-14 2010-05-19 上海交通大学 溴呋啶的制备方法
WO2012051492A2 (en) * 2010-10-14 2012-04-19 University Of Georgia Research Foundation, Inc. Compounds and methods for inhibiting hiv latency
CN102649788B (zh) * 2011-02-28 2015-03-25 四川大学 β-L-2’-脱氧-胸腺嘧啶核苷衍生物及其制备方法和用途

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287188A (en) 1977-02-24 1981-09-01 Burroughs Wellcome Co. Purine derivatives
US4210638A (en) 1978-03-17 1980-07-01 Pcr, Inc. Antiviral composition and method of treating virus diseases
KR830005852A (ko) 1980-07-18 1983-09-14 미첼 페터 잭슨 피부와 점막의 비루스 감염치료에 적합한 국소치료제의 제조방법
JPS5843993A (ja) 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
US4777166A (en) 1982-03-30 1988-10-11 The United States Of America As Represented By The Secretary Of The Army 2-acetylpyridine thiosemicarbazone compositions as anitviral agents
US4596798A (en) 1982-03-30 1986-06-24 The United States Of America As Represented By The Secretary Of The Army 2-acetylpyridine thiosemicarbazones as antiviral agents
SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US5683990A (en) 1985-03-16 1997-11-04 Glaxo Wellcome Inc. Treatment of human viral infections
US4724232A (en) 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
DE3511411A1 (de) 1985-03-29 1986-10-02 Basf Ag, 6700 Ludwigshafen Verwendung von azolylmethyloxiranen zur bekaempfung von viralen erkrankungen
IL78643A0 (en) 1985-05-02 1986-08-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
GB8517402D0 (en) 1985-07-10 1985-08-14 Wellcome Found Treatment of viral infections
US5086044A (en) 1986-06-23 1992-02-04 Burroughs Wellcome Co. Treatment of human viral infections
GB8629892D0 (en) 1986-12-15 1987-01-28 Wellcome Found Antiviral compounds
US5602130A (en) 1987-03-20 1997-02-11 Allergan Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
GB8712745D0 (en) 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
US5597824A (en) 1987-11-03 1997-01-28 Abbott Laboratories Analogs of oxetanyl purines and pyrimidines
US5028596A (en) 1987-12-14 1991-07-02 Burroughs Wellcome Co. 1-(β-D-arabinofuranosyl)-5-propynyluracil for treatment of VZV infections
US5270315A (en) 1988-04-11 1993-12-14 Biochem Pharma Inc. 4-(purinyl bases)-substituted-1,3-dioxlanes
US5041449A (en) 1988-04-11 1991-08-20 Iaf Biochem International, Inc. 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
US5466806A (en) 1989-02-08 1995-11-14 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
NZ228645A (en) 1988-04-11 1991-09-25 Iaf Biochem Int 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections
US5047407A (en) 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
EP0353955A3 (de) 1988-08-02 1991-08-14 Beecham Group Plc Chemische Verbindungen
JPH02237922A (ja) 1989-01-24 1990-09-20 Green Cross Corp:The 抗ウィルス剤
UA45942A (uk) 1989-02-08 2002-05-15 Біокем Фарма, Інк. 1,3-оксатіолан, його похідні, спосіб (варіанти) його одержання та фармацевтична композиція
US5216142A (en) 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
IE902574A1 (en) 1989-07-17 1991-02-27 Univ Birmingham Antiviral pyrimidine nucleosides
US5700937A (en) 1990-02-01 1997-12-23 Emory University Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds
US5276151A (en) 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5204466A (en) 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5521163A (en) 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
US5248776A (en) 1990-12-05 1993-09-28 University Of Georgia Research Foundation, Inc. Process for enantiomerically pure β-L-1,3-oxathiolane nucleosides
US5444063A (en) 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US5925643A (en) 1990-12-05 1999-07-20 Emory University Enantiomerically pure β-D-dioxolane-nucleosides
US5179104A (en) 1990-12-05 1993-01-12 University Of Georgia Research Foundation, Inc. Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides
CA2085994A1 (en) 1991-04-24 1992-10-25 Shinji Sakata 1-beta-d-arabinofuranosyl-(e)-5- (2-halogenovinyl) uracil derivatives
GB9212276D0 (en) 1992-06-10 1992-07-22 Harper David R Anti-viral agents
US5587362A (en) 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
IL115156A (en) 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
MX9604483A (es) 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
US5840728A (en) 1996-08-07 1998-11-24 United States Of America As Represented By The Department Of Health And Human Services Conformationally locked nucleoside analogs as antiherpetic agents
US5792773A (en) 1996-11-15 1998-08-11 Yale University L-β-dioxolane uridine analog administration for treating Epstein-Barr virus infection
US6022876A (en) 1996-11-15 2000-02-08 Yale University L-β-dioxolane uridine analogs and methods for treating and preventing Epstein-Barr virus infections

Also Published As

Publication number Publication date
CA2378370A1 (en) 2001-02-01
EP1204415A2 (de) 2002-05-15
AU767676B2 (en) 2003-11-20
EP1204415A4 (de) 2002-09-04
WO2001006986A2 (en) 2001-02-01
CA2378370C (en) 2010-01-26
EP1204415B1 (de) 2010-09-08
AU6228800A (en) 2001-02-13
US6653318B1 (en) 2003-11-25
ATE480238T1 (de) 2010-09-15
CN1420773A (zh) 2003-05-28
WO2001006986A3 (en) 2001-10-25
US20040053891A1 (en) 2004-03-18

Similar Documents

Publication Publication Date Title
DE60101223D1 (de) Antivirale pyrimidin nucleoside derivate
MY136229A (en) Antiviral nucleoside derivatives
ATE245641T1 (de) Antivirale pyrimidinderivate
DK169991A (da) Antivirale forbindelser
IL173888A0 (en) Novel tricyclic nucleosides or nucleotides as therapeutic agents
ATE389656T1 (de) Pyrazolo(1,5-a)pyrimidin-verbindungen als antivirale agentien
TR200003513T2 (tr) Pirolo[2,3d]Pirimidin kompozisyonları ve kullanımları
DZ3487A1 (fr) Derives de nucleoside comme inhibiteurs de l'arn polymerase virale d'arn-dependant
ATE249219T1 (de) Antivirale verbindungen
ATE124412T1 (de) Antivirusderivate von (phosphonmethoxy)methoxy purin/pyrimidin.
DE69624813D1 (de) Robustaflavon und dessen derivate als antivirales mittel
ES2105684T3 (es) Derivados insaturados de fosfonato de purinas y pirimidinas.
DE60044937D1 (de) Analoge des 5(e)bromovinyluracils und verwandte pyrimidinnucleoside als antivirale mittel und verwendungsmethoden
DK1068209T3 (da) Fremgangsmåde til fremstilling af purinderivater og deres mellemprodukter
EP0453247A3 (de) Antivirale Verbindungen
AU2136200A (en) Modification of interferon alpha production
WO2007059330A3 (en) Cubane nucleoside analogs