DE60044846D1 - Linker zur synthese von oligosacchariden auf festträgern - Google Patents

Linker zur synthese von oligosacchariden auf festträgern

Info

Publication number
DE60044846D1
DE60044846D1 DE60044846T DE60044846T DE60044846D1 DE 60044846 D1 DE60044846 D1 DE 60044846D1 DE 60044846 T DE60044846 T DE 60044846T DE 60044846 T DE60044846 T DE 60044846T DE 60044846 D1 DE60044846 D1 DE 60044846D1
Authority
DE
Germany
Prior art keywords
present
solid support
molecule
linkers
protected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60044846T
Other languages
English (en)
Inventor
Peter H Seeberger
Rodrigo P Andrade
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of DE60044846D1 publication Critical patent/DE60044846D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/12—Libraries containing saccharides or polysaccharides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/18—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B80/00—Linkers or spacers specially adapted for combinatorial chemistry or libraries, e.g. traceless linkers or safety-catch linkers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Structural Engineering (AREA)
  • Saccharide Compounds (AREA)
DE60044846T 1999-03-05 2000-03-03 Linker zur synthese von oligosacchariden auf festträgern Expired - Lifetime DE60044846D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12293099P 1999-03-05 1999-03-05
PCT/US2000/005659 WO2000052018A2 (en) 1999-03-05 2000-03-03 Linkers for synthesis of oligosaccharides on solid supports

Publications (1)

Publication Number Publication Date
DE60044846D1 true DE60044846D1 (de) 2010-09-30

Family

ID=22405713

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60044846T Expired - Lifetime DE60044846D1 (de) 1999-03-05 2000-03-03 Linker zur synthese von oligosacchariden auf festträgern

Country Status (7)

Country Link
US (2) US6579725B1 (de)
EP (1) EP1175427B1 (de)
JP (1) JP2002538163A (de)
AT (1) ATE478083T1 (de)
CA (1) CA2363499C (de)
DE (1) DE60044846D1 (de)
WO (1) WO2000052018A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6824987B1 (en) * 1999-05-11 2004-11-30 President And Fellows Of Harvard College Small molecule printing
US7932213B2 (en) * 1999-05-11 2011-04-26 President And Fellows Of Harvard College Small molecule printing
US6753449B2 (en) 2001-10-09 2004-06-22 Arqule, Inc. Cleavable linker for solid phase synthesis
FR2866649A1 (fr) * 2004-02-25 2005-08-26 Commissariat Energie Atomique Bras espaceur moleculaire, procede de fabrication, et utilisations sur une puce d'analyse a molecules ou biomolecules
US20050261241A1 (en) * 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
AU2005258281A1 (en) * 2004-06-24 2006-01-05 The Scripps Research Institute Arrays with cleavable linkers
US8048940B2 (en) * 2004-07-09 2011-11-01 Vanderbilt University Reactive graphitic carbon nanofiber reinforced polymeric composites showing enhanced flexural strength
JP2008520965A (ja) * 2004-11-16 2008-06-19 コミサリア ア レネルジィ アトミーク 糖末端基を含むシラン化剤及び特に固体支持体の官能化のためのその使用
CN101384757A (zh) * 2006-01-03 2009-03-11 哈佛大学校长及研究员协会 小分子印渍
US8420607B2 (en) * 2006-06-30 2013-04-16 University Of Georgia Research Foundation, Inc. Anthrax carbohydrates, synthesis and uses thereof
AU2007349310B2 (en) 2006-06-30 2013-03-14 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS OF DISEASE CONTROL AND PREVENTION (WASHINGTON D.C.) Anthrax carbohydrates,synthesis and uses thereof
WO2013050554A1 (en) * 2011-10-05 2013-04-11 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Carbohydrate functionalised surfaces

Family Cites Families (26)

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Publication number Priority date Publication date Assignee Title
US4041061A (en) * 1975-11-18 1977-08-09 Johnson & Johnson Modified cyanoacrylate monomers and methods of preparation
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5550215A (en) 1991-11-22 1996-08-27 Holmes; Christopher P. Polymer reversal on solid surfaces
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5639866A (en) 1993-02-23 1997-06-17 Princeton University Single-step formation of multiple glycosidic linkages
CA2239298A1 (en) 1995-12-07 1997-06-12 Sabine Lahja Flitsch Solid phase organic synthesis
AU2341397A (en) 1996-03-21 1997-10-10 Princeton University Carbohydrate-based ligand library, assay and method
DE19621177A1 (de) 1996-05-24 1997-11-27 Basf Ag Kohlenhydratderivate und ihre Synthese an fester Phase
AUPO190596A0 (en) 1996-08-26 1996-09-19 Alchemia Pty Ltd Oligosaccharide synthesis
CA2256694A1 (en) 1996-11-15 1998-05-28 Ole Hindsgaul Combinatorial synthesis of carbohydrate libraries
AUPO440596A0 (en) 1996-12-30 1997-01-23 Fujisawa Pharmaceutical Co., Ltd. New compound
AUPO536797A0 (en) 1997-02-28 1997-03-20 Alchemia Pty Ltd Protected aminosugars
AU7114498A (en) 1997-04-09 1998-10-30 Cadus Pharmaceutical Corporation Supports for solid phase synthesis
JP2002502393A (ja) 1997-05-29 2002-01-22 インカラ・ファーマシューティカルズ・コーポレーション 炭水化物骨格化合物及びライブラリー
CA2304061A1 (en) 1997-09-24 1999-04-01 Alchemia Pty. Ltd. Protecting and linking groups for organic synthesis
CA2306076A1 (en) 1997-10-09 1999-04-22 Aventis Cropscience Gmbh Combinatorial preparation of phosphinic acid derivatives
WO1999039207A1 (en) 1998-01-29 1999-08-05 Pharmacopeia, Inc. Acid cleavable phenoxyalkyl linker for combinatorial synthesis
CA2260472A1 (en) 1998-02-11 1999-08-11 Xiao-Yi Xiao Safety-catch linkers
US6008321A (en) 1998-03-16 1999-12-28 Pharmacopeia, Inc. Universal linker for combinatorial synthesis
WO1999064032A1 (en) 1998-06-08 1999-12-16 Advanced Medicine, Inc. Combinatorial synthesis of multibinding libraries
US6310244B1 (en) 1998-07-23 2001-10-30 Pharmacopeia, Inc. Photocleavable and acid cleavable linkers for combinatorial chemistry
GB9816575D0 (en) 1998-07-31 1998-09-30 Zeneca Ltd Novel compounds
US6388022B1 (en) 1998-09-10 2002-05-14 Takeda Chemical Industires, Ltd. Linker binding carriers for organic synthesis, their production and use
GB9821669D0 (en) 1998-10-05 1998-12-02 Glaxo Group Ltd Chemical constructs and their uses
GB9822436D0 (en) 1998-10-14 1998-12-09 Cambridge Combinatorial Ltd Sintered/co-sintered materials

Also Published As

Publication number Publication date
CA2363499C (en) 2010-06-01
WO2000052018A3 (en) 2001-10-18
WO2000052018A9 (en) 2002-06-27
JP2002538163A (ja) 2002-11-12
US6579725B1 (en) 2003-06-17
EP1175427A2 (de) 2002-01-30
ATE478083T1 (de) 2010-09-15
US20030232452A1 (en) 2003-12-18
CA2363499A1 (en) 2000-09-08
WO2000052018A2 (en) 2000-09-08
EP1175427B1 (de) 2010-08-18

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