DE60040860D1 - Mechanisch verlängerte neuronale zellen und methoden zur herstellung und verwendung dieser zellen - Google Patents

Mechanisch verlängerte neuronale zellen und methoden zur herstellung und verwendung dieser zellen

Info

Publication number
DE60040860D1
DE60040860D1 DE60040860T DE60040860T DE60040860D1 DE 60040860 D1 DE60040860 D1 DE 60040860D1 DE 60040860 T DE60040860 T DE 60040860T DE 60040860 T DE60040860 T DE 60040860T DE 60040860 D1 DE60040860 D1 DE 60040860D1
Authority
DE
Germany
Prior art keywords
cells
methods
manufacture
neuronal cells
mechanically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60040860T
Other languages
English (en)
Inventor
Douglas H Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Application granted granted Critical
Publication of DE60040860D1 publication Critical patent/DE60040860D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Mechanical Engineering (AREA)
  • Sustainable Development (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE60040860T 1999-08-17 2000-08-02 Mechanisch verlängerte neuronale zellen und methoden zur herstellung und verwendung dieser zellen Expired - Lifetime DE60040860D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14940899P 1999-08-17 1999-08-17
PCT/US2000/021078 WO2001012207A1 (en) 1999-08-17 2000-08-02 Mechanically elongated neuronal cells and methods for producing and using these cells

Publications (1)

Publication Number Publication Date
DE60040860D1 true DE60040860D1 (de) 2009-01-02

Family

ID=22530139

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60040860T Expired - Lifetime DE60040860D1 (de) 1999-08-17 2000-08-02 Mechanisch verlängerte neuronale zellen und methoden zur herstellung und verwendung dieser zellen

Country Status (9)

Country Link
US (2) US6264944B1 (de)
EP (1) EP1225906B1 (de)
JP (1) JP4679780B2 (de)
AT (1) ATE414523T1 (de)
AU (1) AU766096B2 (de)
CA (1) CA2380943C (de)
DE (1) DE60040860D1 (de)
DK (1) DK1225906T3 (de)
WO (1) WO2001012207A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7831305B2 (en) 2001-10-15 2010-11-09 Advanced Neuromodulation Systems, Inc. Neural stimulation system and method responsive to collateral neural activity
WO2003047422A2 (en) 2001-12-04 2003-06-12 The Trustees Of The University Of Pennsylvania Device and method using integrated neuronal cells and an electronic device
US20090169596A1 (en) * 2006-03-29 2009-07-02 Mikael Svensson Device for spinal cord nerve regeneration
US20160250385A1 (en) * 2013-11-04 2016-09-01 The Trustees Of The University Of Pennsylvania Neuronal replacement and reestablishment of axonal connections
US20170368180A1 (en) * 2014-12-12 2017-12-28 The Trustees Of The University Of Pennsylvania Methods of promoting nervous system regeneration
US11156595B2 (en) 2015-05-28 2021-10-26 Axogen Corporation Organotypic DRG-peripheral nerve culture system
US11513039B2 (en) 2015-05-28 2022-11-29 Axogen Corporation Nerve culture system
JP7235509B2 (ja) 2016-04-14 2023-03-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 植え込み可能な生きた電極およびその製造方法
CN109628305A (zh) * 2018-12-12 2019-04-16 北京理工大学 用于体外轴突应力学响应机制研究的多通道差速牵拉装置
WO2021102021A1 (en) * 2019-11-18 2021-05-27 The Trustees Of The University Of Pennsylvania Preservation of neuron health and regenerative capacity following nervous system injury

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084007A (en) * 1989-08-11 1992-01-28 Malin David H Method for chemical promotion of the effects of low current transcranial electrostimulation
US5968921A (en) * 1997-10-24 1999-10-19 Orgegon Health Sciences University Compositions and methods for promoting nerve regeneration

Also Published As

Publication number Publication date
CA2380943A1 (en) 2001-02-22
US6365153B2 (en) 2002-04-02
ATE414523T1 (de) 2008-12-15
EP1225906B1 (de) 2008-11-19
EP1225906A4 (de) 2002-09-18
CA2380943C (en) 2010-04-20
JP4679780B2 (ja) 2011-04-27
US6264944B1 (en) 2001-07-24
AU766096B2 (en) 2003-10-09
US20010038835A1 (en) 2001-11-08
WO2001012207A1 (en) 2001-02-22
EP1225906A1 (de) 2002-07-31
JP2003507089A (ja) 2003-02-25
AU6892600A (en) 2001-03-13
DK1225906T3 (da) 2009-03-16

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