DE60039868D1 - ZUSAMMENSETZUNGEN VON POLYSÄUREN, NICHTIONISCHEN POLYMEREN VON ALKYLENOXID-MONOMEREN UND MEHRWERTIGEN KATIONEN, UND DEREN vERWENDUNG ZUR REDUZIERUNG DER GEWEBEADHÄSION - Google Patents

ZUSAMMENSETZUNGEN VON POLYSÄUREN, NICHTIONISCHEN POLYMEREN VON ALKYLENOXID-MONOMEREN UND MEHRWERTIGEN KATIONEN, UND DEREN vERWENDUNG ZUR REDUZIERUNG DER GEWEBEADHÄSION

Info

Publication number
DE60039868D1
DE60039868D1 DE60039868T DE60039868T DE60039868D1 DE 60039868 D1 DE60039868 D1 DE 60039868D1 DE 60039868 T DE60039868 T DE 60039868T DE 60039868 T DE60039868 T DE 60039868T DE 60039868 D1 DE60039868 D1 DE 60039868D1
Authority
DE
Germany
Prior art keywords
membranes
compositions
bioadhesive
adhesion
bioresorbable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60039868T
Other languages
English (en)
Inventor
Herbert E Schwartz
John M Blackmore
Stephanie M Cortese
William G Oppelt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FzioMed Inc
Original Assignee
FzioMed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/472,110 external-priority patent/US6869938B1/en
Application filed by FzioMed Inc filed Critical FzioMed Inc
Application granted granted Critical
Publication of DE60039868D1 publication Critical patent/DE60039868D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/062—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE60039868T 1999-04-02 2000-03-23 ZUSAMMENSETZUNGEN VON POLYSÄUREN, NICHTIONISCHEN POLYMEREN VON ALKYLENOXID-MONOMEREN UND MEHRWERTIGEN KATIONEN, UND DEREN vERWENDUNG ZUR REDUZIERUNG DER GEWEBEADHÄSION Expired - Lifetime DE60039868D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12757199P 1999-04-02 1999-04-02
US09/472,110 US6869938B1 (en) 1997-06-17 1999-12-27 Compositions of polyacids and polyethers and methods for their use in reducing adhesions
PCT/US2000/007963 WO2000059516A1 (en) 1999-04-02 2000-03-23 Compositions of polyacids and polyethers and methods for their use in reducing adhesions

Publications (1)

Publication Number Publication Date
DE60039868D1 true DE60039868D1 (de) 2008-09-25

Family

ID=26825748

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60039868T Expired - Lifetime DE60039868D1 (de) 1999-04-02 2000-03-23 ZUSAMMENSETZUNGEN VON POLYSÄUREN, NICHTIONISCHEN POLYMEREN VON ALKYLENOXID-MONOMEREN UND MEHRWERTIGEN KATIONEN, UND DEREN vERWENDUNG ZUR REDUZIERUNG DER GEWEBEADHÄSION

Country Status (8)

Country Link
EP (1) EP1181023B1 (de)
JP (1) JP2003530136A (de)
AT (1) ATE404210T1 (de)
AU (1) AU778853B2 (de)
CA (1) CA2366880C (de)
DE (1) DE60039868D1 (de)
ES (1) ES2311455T3 (de)
WO (1) WO2000059516A1 (de)

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US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
ATE425776T1 (de) * 2000-04-28 2009-04-15 Fziomed Inc Haemostatische zusammenstellung von polysauren und polyalkylenoxyden und deren verwendungsmethoden
JP4794057B2 (ja) * 2001-02-28 2011-10-12 京セラ株式会社 骨修復材の製造方法および骨修復材
FR2823119B1 (fr) * 2001-04-05 2004-02-20 Seppic Sa Adjuvant d'immunite contenant un cation metallique complexe et vaccin le contenant
WO2005000374A1 (ja) * 2003-06-30 2005-01-06 Denki Kagaku Kogyo Kabushiki Kaisha 脊椎・脊髄手術用癒着防止材
US7914805B2 (en) 2003-07-31 2011-03-29 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing radiation-treated polymer for improved delivery of therapeutic agent
CN1220528C (zh) * 2003-08-19 2005-09-28 大连永兴医用材料有限公司 羧甲基壳聚糖/羧甲基纤维素防手术粘连膜及其制备方法
DE10350481A1 (de) * 2003-10-29 2005-06-16 Henkel Kgaa Festigkeitsoptimierte Polymere mit gemischten Oxyalkyleneinheiten
SE0401182D0 (sv) * 2004-05-05 2004-05-05 Q Med Ab Novel use of a viscoelastic composition
CA2565944C (en) * 2004-05-07 2011-07-19 S.K. Pharmaceuticals, Inc. Stabilized hyaluronan preparations and related methods
US8288362B2 (en) 2004-05-07 2012-10-16 S.K. Pharmaceuticals, Inc. Stabilized glycosaminoglycan preparations and related methods
KR101125934B1 (ko) 2008-11-19 2012-03-21 한남대학교 산학협력단 열감응성 조직 유착 방지 조성물 및 이의 제조 방법
US9445795B2 (en) 2009-10-16 2016-09-20 Confluent Surgical, Inc. Prevention of premature gelling of delivery devices for pH dependent forming materials
KR101142234B1 (ko) * 2009-12-28 2012-07-09 한남대학교 산학협력단 주사 주입이 용이한 다공성 미세입자 필러 시스템
CA2731187A1 (en) * 2010-03-16 2011-09-16 Confluent Surgical, Inc. Mitigating thrombus formation on medical devices by influencing ph microenvironment near the surface
CA2730598C (en) * 2010-03-16 2018-03-13 Confluent Surgical, Inc. Modulating drug release rate by controlling the kinetics of the ph transition in hydrogels
WO2013033168A1 (en) * 2011-08-30 2013-03-07 Mast Biosurgery Ag Polyactic acid/alginate containing surgical barrier
DE102012222365A1 (de) * 2012-12-05 2014-06-05 Aesculap Ag Zusammensetzung zur Anwendung bei der Prophylaxe von post-chirurgischen Adhäsionen
EP2774953B1 (de) * 2013-03-08 2018-06-27 Fluoron Gmbh Gelierbare Zusammensetzungen
JP6437087B2 (ja) * 2014-07-24 2018-12-12 メディートックス インコーポレイテッド 熱感応性癒着防止用組成物及びその用途
US20180169295A1 (en) * 2016-12-21 2018-06-21 Industrial Technology Research Institute Film, manufacturing method thereof, and use thereof
CN113069598B (zh) * 2020-01-06 2022-05-17 中国科学院宁波材料技术与工程研究所 血液透析器的抗凝改性方法
CN113842358B (zh) * 2021-10-29 2023-05-09 佛山市南海东方澳龙制药有限公司 一种兽用子宫注入剂及其制备方法和应用

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US4024073A (en) * 1972-01-08 1977-05-17 Toray Industries, Inc. Hydrogel and production thereof
US4618491A (en) * 1984-06-05 1986-10-21 Daicel Chemical Industries Ltd. Stable gel composition containing a carboxymethyl cellulose salt and a process for the preparation of them
JPS61133221A (ja) * 1984-11-30 1986-06-20 Du Pont Mitsui Polychem Co Ltd 剛性および耐熱性にすぐれた熱可塑性重合体の製造法
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Also Published As

Publication number Publication date
AU778853B2 (en) 2004-12-23
CA2366880A1 (en) 2000-10-12
EP1181023A1 (de) 2002-02-27
ES2311455T3 (es) 2009-02-16
EP1181023B1 (de) 2008-08-13
ATE404210T1 (de) 2008-08-15
CA2366880C (en) 2013-02-12
EP1181023A4 (de) 2004-03-31
WO2000059516A1 (en) 2000-10-12
AU4177000A (en) 2000-10-23
JP2003530136A (ja) 2003-10-14

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