DE60038544D1 - Metastasemodelle mit grünfluoreszierendem protein (gfp) als marker - Google Patents

Metastasemodelle mit grünfluoreszierendem protein (gfp) als marker

Info

Publication number
DE60038544D1
DE60038544D1 DE60038544T DE60038544T DE60038544D1 DE 60038544 D1 DE60038544 D1 DE 60038544D1 DE 60038544 T DE60038544 T DE 60038544T DE 60038544 T DE60038544 T DE 60038544T DE 60038544 D1 DE60038544 D1 DE 60038544D1
Authority
DE
Germany
Prior art keywords
gfp
tumor
contain
tumors
tissues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60038544T
Other languages
English (en)
Other versions
DE60038544T2 (de
Inventor
Yuying Tan
Takashi Chishima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anticancer Inc
Original Assignee
Anticancer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22850696&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60038544(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Anticancer Inc filed Critical Anticancer Inc
Application granted granted Critical
Publication of DE60038544D1 publication Critical patent/DE60038544D1/de
Publication of DE60038544T2 publication Critical patent/DE60038544T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0271Chimeric vertebrates, e.g. comprising exogenous cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0045Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
    • A61K49/0047Green fluorescent protein [GFP]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0063Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0097Cells, viruses, ghosts, red blood cells, viral vectors, used for imaging or diagnosis in vivo
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE60038544T 1999-01-07 2000-01-07 Metastasemodelle mit grünfluoreszierendem protein (gfp) als marker Expired - Lifetime DE60038544T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US226856 1999-01-07
US09/226,856 US6251384B1 (en) 1997-04-28 1999-01-07 Metastasis models using green fluorescent protein (GFP) as a marker
PCT/US2000/000243 WO2000040274A1 (en) 1999-01-07 2000-01-07 Metastasis models using green fluorescent protein (gfp) as a marker

Publications (2)

Publication Number Publication Date
DE60038544D1 true DE60038544D1 (de) 2008-05-21
DE60038544T2 DE60038544T2 (de) 2009-07-09

Family

ID=22850696

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60038544T Expired - Lifetime DE60038544T2 (de) 1999-01-07 2000-01-07 Metastasemodelle mit grünfluoreszierendem protein (gfp) als marker

Country Status (8)

Country Link
US (3) US6251384B1 (de)
EP (1) EP1156833B1 (de)
JP (1) JP3709343B2 (de)
AT (1) ATE391515T1 (de)
AU (1) AU783517B2 (de)
CA (1) CA2358439C (de)
DE (1) DE60038544T2 (de)
WO (1) WO2000040274A1 (de)

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US20050005310A1 (en) * 1999-07-12 2005-01-06 Genentech, Inc. Expression vectors and methods
DE60137501D1 (de) * 2000-03-17 2009-03-12 Anticancer Inc Optisches abbildungssystem zur darstellung der genexpression des gesamten körpers und anwendungen
US7244232B2 (en) * 2001-03-07 2007-07-17 Biomed Solutions, Llc Process for identifying cancerous and/or metastatic cells of a living organism
CN1738649A (zh) * 2001-07-09 2006-02-22 抗癌公司 用荧光蛋白作为标记物使感染成像
EP1281767A3 (de) * 2001-07-31 2003-05-28 Aladar A. Szalay Lichtausstrahlende Mikroorganismen und Zellen für die Diagnose und Therapie von Tumoren
ATE478556T1 (de) * 2001-09-10 2010-09-15 Anticancer Inc Verbesserte beobachtungsgenauigkeit bei der absiedelung von tumoren
CN1623001A (zh) * 2001-12-31 2005-06-01 抗癌公司 监视细菌肿瘤治疗的系统
US7280680B2 (en) 2002-03-04 2007-10-09 Riken Method and apparatus for observing three-dimensional localizations of in vivo expressed genes as well as method and apparatus for observing minute three-dimensional localizations of in vivo expressed genes
US20030228261A1 (en) * 2002-06-05 2003-12-11 Aladar Szalay Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue
EP1369491A1 (de) * 2002-06-05 2003-12-10 Aladar A. Szalay Lichtemittierende Mikroorganismen und Zellen für die Diagnose und Therapie von Krankheiten assoziiert mit Wunden oder entzündetem Gewebe
CA2496761C (en) 2002-08-21 2015-06-02 Revivicor, Inc. Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
US20050019925A1 (en) * 2002-11-14 2005-01-27 Genentech, Inc. Intron fusion construct and method of using for selecting high-expressing production cell lines
CN1947006B (zh) * 2003-02-07 2014-11-05 抗癌公司 免疫低下的啮齿类动物作为双色肿瘤模型
JP2006521116A (ja) 2003-03-27 2006-09-21 ピーティーシー セラピューティクス,インコーポレーテッド 抗真菌性および/または抗増殖性分子を同定するためのtRNAスプライシング経路の酵素の標的化
EP2319318A3 (de) 2003-03-27 2011-08-17 PTC Therapeutics, Inc. Verfahren zur Identifizierung von Verbindungen mit tRNA-Splicing Endonuklease als Aufhänger, und Verwendungen für diese Verbindungen als anti-Proliferationsmittel
US20050039220A1 (en) * 2003-05-27 2005-02-17 Meng Yang Imageable animal model of SARS infection
AU2004246547B2 (en) * 2003-06-09 2008-10-30 Toku Pte Ltd System and method for providing a service
ATE420160T1 (de) 2003-06-18 2009-01-15 Genelux Corp Modifizierte rekombinante vacciniaviren, verwendungen davon
US8634607B2 (en) 2003-09-23 2014-01-21 Cambridge Research & Instrumentation, Inc. Spectral imaging of biological samples
US7321791B2 (en) * 2003-09-23 2008-01-22 Cambridge Research And Instrumentation, Inc. Spectral imaging of deep tissue
US7155274B1 (en) 2003-11-21 2006-12-26 Imaging Diagnostic Systems, Inc. Optical computed tomography scanner for small laboratory animals
WO2005099363A2 (en) 2004-03-26 2005-10-27 Whitehead Institute For Biomedical Research Methods of diagnosing, preventing and treating cancer metastasis
WO2006014899A2 (en) 2004-07-26 2006-02-09 Dow Global Technologies Inc. Process for improved protein expression by strain engineering
CN101916359B (zh) 2005-01-27 2012-06-20 剑桥研究和仪器设备股份有限公司 把样本的不同区域分类到相应类别的方法和设备
EP3138403A1 (de) 2005-08-09 2017-03-08 Revivicor, Inc. Ctla4-ig exprimierende transgene huftiere und verwendungen davon
WO2007070784A2 (en) * 2005-12-12 2007-06-21 The Uab Research Foundation Fluorescent detection of cancer and fluorescent guided surgical removal
EP1840570A1 (de) * 2006-03-31 2007-10-03 F. Hoffmann-La Roche Ag Tumormodell unter Verwendung von grünem Fluoreszenzprotein
TW200819540A (en) 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
EP2426142A3 (de) * 2006-10-16 2012-06-13 Genelux Corporation Modifizierte Impfstoffvirusstämme zur Verwendung in einem Diagnose- und Therapieverfahren
EP2121916A1 (de) * 2006-12-20 2009-11-25 Danisco US, INC., Genencor Division Tests für verbesserte pilzstämme
AU2008245696B2 (en) 2007-04-27 2013-11-07 Pelican Technology Holdings, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
WO2008156655A2 (en) * 2007-06-15 2008-12-24 Genelux Corporation Vaccinia virus vectors encoding a sodium-dependent transporter protein for imaging and/or treatment of tumors
CA2700543A1 (en) * 2007-10-01 2009-04-09 Anticancer, Inc. Imageable rodent model of asthma
WO2009139921A2 (en) * 2008-05-16 2009-11-19 Genelux Corporation Microorganisms for preventing and treating neoplasms accompanying cellular therapy
WO2010006168A2 (en) * 2008-07-09 2010-01-14 University Of Rochester Methods of treating cancer using and agent that modulates activity of the calcitonin-gene related peptide ("cgrp") receptor
CN114262690A (zh) 2011-04-15 2022-04-01 吉恩勒克斯公司 减毒的痘苗病毒的克隆毒株及其使用方法
WO2013052915A2 (en) 2011-10-05 2013-04-11 Genelux Corporation Method for detecting replication or colonization of a biological therapeutic
JP6436669B2 (ja) * 2014-07-22 2018-12-12 国立大学法人福井大学 子宮肉腫転移モデル動物
USD809116S1 (en) 2015-11-02 2018-01-30 Pura Scents Dispenser
US9827343B2 (en) 2015-11-02 2017-11-28 Pura Scents, Inc. Scent dispensation and fluid level sensing
USD816506S1 (en) 2015-11-02 2018-05-01 Pura Scents, Inc. Vial for a scent dispenser
US20200270557A1 (en) * 2017-09-18 2020-08-27 President And Fellows Of Harvard College Human in vitro orthotopic and metastatic models of cancer
CN116539862B (zh) * 2022-07-20 2024-03-12 成都诺医德医学检验实验室有限公司 一种基于类器官共生长平台测试肿瘤转移能力的方法

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US5491084A (en) * 1993-09-10 1996-02-13 The Trustees Of Columbia University In The City Of New York Uses of green-fluorescent protein
US5650135A (en) * 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US5874304A (en) * 1996-01-18 1999-02-23 University Of Florida Research Foundation, Inc. Humanized green fluorescent protein genes and methods
EP0954591A2 (de) 1996-05-31 1999-11-10 Baxter International Inc. Mini-adenoviraler vektor
CA2289283C (en) 1997-04-28 2009-08-11 Anticancer, Inc. Metastasis models using green fluorescent protein (gfp) as a marker

Also Published As

Publication number Publication date
CA2358439C (en) 2010-06-29
US6251384B1 (en) 2001-06-26
US20040191173A1 (en) 2004-09-30
CA2358439A1 (en) 2000-07-13
EP1156833A1 (de) 2001-11-28
AU783517B2 (en) 2005-11-03
DE60038544T2 (de) 2009-07-09
JP2002534398A (ja) 2002-10-15
WO2000040274A1 (en) 2000-07-13
AU2406900A (en) 2000-07-24
ATE391515T1 (de) 2008-04-15
US6759038B2 (en) 2004-07-06
US20020026649A1 (en) 2002-02-28
EP1156833B1 (de) 2008-04-09
JP3709343B2 (ja) 2005-10-26

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