DE60033180D1 - Auf dem rinderimmunschwächevirus (biv) basierte vektoren - Google Patents
Auf dem rinderimmunschwächevirus (biv) basierte vektorenInfo
- Publication number
- DE60033180D1 DE60033180D1 DE60033180T DE60033180T DE60033180D1 DE 60033180 D1 DE60033180 D1 DE 60033180D1 DE 60033180 T DE60033180 T DE 60033180T DE 60033180 T DE60033180 T DE 60033180T DE 60033180 D1 DE60033180 D1 DE 60033180D1
- Authority
- DE
- Germany
- Prior art keywords
- biv
- gene
- vectors
- operably linked
- packaging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15051—Methods of production or purification of viral material
- C12N2740/15052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US734836 | 1991-07-24 | ||
US46446099A | 1999-12-14 | 1999-12-14 | |
US464460 | 1999-12-14 | ||
US24949200P | 2000-11-17 | 2000-11-17 | |
US249492P | 2000-11-17 | ||
US09/734,836 US6864085B2 (en) | 1999-12-14 | 2000-12-12 | Bovine immunodeficiency virus (BIV) based vectors |
PCT/US2000/033725 WO2001044458A2 (en) | 1999-12-14 | 2000-12-13 | Bovine immunodeficiency virus (biv) based vectors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60033180D1 true DE60033180D1 (de) | 2007-03-15 |
DE60033180T2 DE60033180T2 (de) | 2007-10-25 |
Family
ID=27400217
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60033180T Expired - Lifetime DE60033180T2 (de) | 1999-12-14 | 2000-12-13 | Auf dem rinderimmunschwächevirus (biv) basierte vektoren |
DE60043870T Expired - Lifetime DE60043870D1 (de) | 1999-12-14 | 2000-12-13 | Auf bovinem Immundefizienvirus (BIV) basierende Vektoren |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60043870T Expired - Lifetime DE60043870D1 (de) | 1999-12-14 | 2000-12-13 | Auf bovinem Immundefizienvirus (BIV) basierende Vektoren |
Country Status (10)
Country | Link |
---|---|
EP (2) | EP1852511B1 (de) |
JP (3) | JP2003517312A (de) |
AT (2) | ATE352636T1 (de) |
AU (1) | AU778110B2 (de) |
CA (1) | CA2392221C (de) |
DE (2) | DE60033180T2 (de) |
ES (2) | ES2340073T3 (de) |
IL (2) | IL149704A0 (de) |
NZ (1) | NZ519034A (de) |
WO (1) | WO2001044458A2 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2170622B1 (es) | 1999-12-03 | 2004-05-16 | Consejo Superior De Investigaciones Cientificas | Clones y vectores infectivos derivados de coronavirus y sus aplicaciones. |
IL149704A0 (en) * | 1999-12-14 | 2002-11-10 | Novartis Ag | Bovine immunodeficiency virus (biv) based vectors |
US7575924B2 (en) | 2000-11-13 | 2009-08-18 | Research Development Foundation | Methods and compositions relating to improved lentiviral vectors and their applications |
IL157335A0 (en) | 2001-03-13 | 2004-02-19 | Novartis Ag | Lentiviral packaging constructs |
AU2002327412A1 (en) | 2001-08-02 | 2003-02-17 | Institut Clayton De La Recherche | Methods and compositions relating to improved lentiviral vector production systems |
NZ532060A (en) | 2001-10-02 | 2005-11-25 | Inst Clayton De La Rech | Methods and compositions relating to restricted expression lentiviral vectors and their applications |
ES2208051B1 (es) * | 2002-01-24 | 2005-08-16 | Consejo Sup. Investig. Cientificas | Secuencia de acido nucleico que comprende la señal de encapsidacion del rna de un coronavirus del grupo 1 y sus aplicaciones. |
CN1643164A (zh) * | 2002-02-04 | 2005-07-20 | 诺瓦提斯公司 | 以重组牛免疫缺陷病毒为基础的基因转移系统 |
GB2450688A (en) * | 2005-05-11 | 2009-01-07 | Viragen Inc | Ovalbumin promoter constructs for retroviral vectors |
US10072067B2 (en) * | 2014-01-30 | 2018-09-11 | Children's Hospital Medical Center | Fetal hemoglobin for genetic correction of sickle cell disease |
GB202114532D0 (en) * | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral Vectors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5380830A (en) * | 1989-09-18 | 1995-01-10 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Molecular clones of bovine immunodeficiency-like virus |
US6013516A (en) * | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
FR2768743B1 (fr) | 1997-09-23 | 2001-09-14 | Bio Merieux | Procede de lyse de micro-organisme |
ES2245042T3 (es) * | 1997-09-24 | 2005-12-16 | The Regents Of The University Of California | Vectores de lentivirus de no primates y sistemas de empaquetamiento. |
AU763007B2 (en) * | 1998-05-22 | 2003-07-10 | Oxford Biomedica (Uk) Limited | Retroviral delivery system |
IL149704A0 (en) * | 1999-12-14 | 2002-11-10 | Novartis Ag | Bovine immunodeficiency virus (biv) based vectors |
-
2000
- 2000-12-13 IL IL14970400A patent/IL149704A0/xx unknown
- 2000-12-13 AU AU22598/01A patent/AU778110B2/en not_active Ceased
- 2000-12-13 CA CA2392221A patent/CA2392221C/en not_active Expired - Fee Related
- 2000-12-13 JP JP2001545535A patent/JP2003517312A/ja active Pending
- 2000-12-13 ES ES07001113T patent/ES2340073T3/es not_active Expired - Lifetime
- 2000-12-13 ES ES00986343T patent/ES2281369T3/es not_active Expired - Lifetime
- 2000-12-13 DE DE60033180T patent/DE60033180T2/de not_active Expired - Lifetime
- 2000-12-13 EP EP07001113A patent/EP1852511B1/de not_active Expired - Lifetime
- 2000-12-13 WO PCT/US2000/033725 patent/WO2001044458A2/en active IP Right Grant
- 2000-12-13 AT AT00986343T patent/ATE352636T1/de active
- 2000-12-13 EP EP00986343A patent/EP1238092B1/de not_active Expired - Lifetime
- 2000-12-13 NZ NZ519034A patent/NZ519034A/en not_active IP Right Cessation
- 2000-12-13 AT AT07001113T patent/ATE458062T1/de not_active IP Right Cessation
- 2000-12-13 DE DE60043870T patent/DE60043870D1/de not_active Expired - Lifetime
-
2002
- 2002-05-16 IL IL149704A patent/IL149704A/en not_active IP Right Cessation
-
2010
- 2010-02-26 JP JP2010043354A patent/JP2010166919A/ja active Pending
-
2013
- 2013-12-24 JP JP2013265269A patent/JP2014110789A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2259801A (en) | 2001-06-25 |
JP2014110789A (ja) | 2014-06-19 |
IL149704A (en) | 2013-02-28 |
EP1238092B1 (de) | 2007-01-24 |
AU778110B2 (en) | 2004-11-18 |
WO2001044458A2 (en) | 2001-06-21 |
EP1852511A1 (de) | 2007-11-07 |
JP2010166919A (ja) | 2010-08-05 |
ES2281369T3 (es) | 2007-10-01 |
DE60043870D1 (de) | 2010-04-01 |
CA2392221A1 (en) | 2001-06-21 |
ES2340073T3 (es) | 2010-05-28 |
DE60033180T2 (de) | 2007-10-25 |
ATE458062T1 (de) | 2010-03-15 |
WO2001044458A3 (en) | 2001-11-29 |
ATE352636T1 (de) | 2007-02-15 |
CA2392221C (en) | 2012-01-31 |
IL149704A0 (en) | 2002-11-10 |
EP1852511B1 (de) | 2010-02-17 |
JP2003517312A (ja) | 2003-05-27 |
EP1238092A2 (de) | 2002-09-11 |
NZ519034A (en) | 2005-02-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2733832C1 (ru) | Искусственный ген Stbl_RBD_TrM_SC2, кодирующий бицистронную структуру, образованную последовательностями рецепторсвязывающего домена гликопротеина S коронавируса SARS-CoV-2, трансмембранного региона, P2A-пептида и гликопротеина G VSV, рекомбинантная плазмида pStem-rVSV-Stbl_RBD_TrM_SC2, обеспечивающая экспрессию искусственного гена, и рекомбинантный штамм вируса везикулярного стоматита rVSV-Stbl_RBD_TrM_SC2, используемый для создания вакцины против коронавируса SARS-CoV-2 | |
Hahn et al. | Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation. | |
Binley et al. | Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins | |
Jeffers et al. | Covalent modifications of the ebola virus glycoprotein | |
Chambers et al. | Nucleotide sequence of the gene encoding the fusion glycoprotein of Newcastle disease virus | |
Pinter et al. | Localization of the labile disulfide bond between SU and TM of the murine leukemia virus envelope protein complex to a highly conserved CWLC motif in SU that resembles the active-site sequence of thiol-disulfide exchange enzymes | |
Donson et al. | The nucleotide sequence of a geminivirus from Digitaria sanguinalis | |
DE60033180D1 (de) | Auf dem rinderimmunschwächevirus (biv) basierte vektoren | |
ATE291632T1 (de) | Auf lentivirus basierende gentransfer-vektoren | |
DK28191A (da) | Dna-planteekspressionskassette og dennes anvendelse | |
DK1224314T3 (da) | Lentiviralt triplex-DNA samt vektorer og rekombinante celler indeholder lentiviralt triplex-DNA | |
DK0490972T3 (da) | Ekspressionssystemer for rekombinante negativstreng-RNA-vira og vacciner | |
Dash et al. | Deletion of a single N-linked glycosylation site from the transmembrane envelope protein of human immunodeficiency virus type 1 stops cleavage and transport of gp160 preventing env-mediated fusion | |
Du et al. | Efficient replication and generation of recombinant bovine adenovirus‐3 in nonbovine cotton rat lung cells expressing I‐SceI endonuclease | |
RU2733831C1 (ru) | Искусственный ген, кодирующий бицистронную структуру, образованную последовательностями рецептор-связующего домена гликопротеина S коронавируса SARS-CoV-2, P2A-пептида и гликопротеина G VSV, рекомбинантная плазмида pStem-rVSV-Stbl_RBD_SC2, обеспечивающая экспрессию искусственного гена и рекомбинантный штамм вируса везикулярного стоматита rVSV-Stbl_RBD_SC2, используемого для создания вакцины против коронавируса SARS-CoV-2 | |
PT632129E (pt) | Vectores recombinantes de virus sincicial para utilizacoes medicinais e de diagnostico e processos para a preparacao de vectores recombinantes de virus sincicial | |
ATE258987T1 (de) | Helfersystem zur wirkungssteigerung der aav- vektorproduktion | |
Beyer et al. | Recombinant expression of lymphocytic choriomeningitis virus strain WE glycoproteins: a single amino acid makes the difference | |
Gaudin et al. | Soluble ectodomain of rabies virus glycoprotein expressed in eukaryotic cells folds in a monomeric conformation that is antigenically distinct from the native state of the complete, membrane-anchored glycoprotein | |
JP2004524805A5 (de) | ||
Davies et al. | Structure and replication of geminivirus genomes | |
Nakayama et al. | Leucine at position 278 of the AIK-C measles virus vaccine strain fusion protein is responsible for reduced syncytium formation | |
Alkhatib et al. | Characterization of a cleavage mutant of the measles virus fusion protein defective in syncytium formation | |
Morimoto et al. | Comparison of rabies virus G proteins produced by cDNA-transfected animal cells that display either inducible or constitutive expression of the gene | |
WO2002008436A3 (en) | Mini-adenoviral vector system for vaccination |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |