DE60026514D1 - Neue prolinverbindungen als mikrobizide mittel - Google Patents
Neue prolinverbindungen als mikrobizide mittelInfo
- Publication number
- DE60026514D1 DE60026514D1 DE60026514T DE60026514T DE60026514D1 DE 60026514 D1 DE60026514 D1 DE 60026514D1 DE 60026514 T DE60026514 T DE 60026514T DE 60026514 T DE60026514 T DE 60026514T DE 60026514 D1 DE60026514 D1 DE 60026514D1
- Authority
- DE
- Germany
- Prior art keywords
- prolin
- microbicide
- compounds
- medium
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13254699P | 1999-05-05 | 1999-05-05 | |
US132546P | 1999-05-05 | ||
PCT/US2000/012172 WO2000066119A1 (en) | 1999-05-05 | 2000-05-05 | Novel prolines as antimicrobial agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60026514D1 true DE60026514D1 (de) | 2006-05-04 |
DE60026514T2 DE60026514T2 (de) | 2006-11-09 |
Family
ID=22454536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60026514T Expired - Fee Related DE60026514T2 (de) | 1999-05-05 | 2000-05-05 | Neue prolinverbindungen als mikrobizide mittel |
Country Status (9)
Country | Link |
---|---|
US (3) | US6333344B1 (de) |
EP (1) | EP1176959B1 (de) |
JP (1) | JP2002543129A (de) |
AT (1) | ATE319446T1 (de) |
AU (1) | AU769652B2 (de) |
CA (1) | CA2372176A1 (de) |
DE (1) | DE60026514T2 (de) |
ES (1) | ES2257296T3 (de) |
WO (1) | WO2000066119A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EE200200555A (et) * | 2000-03-27 | 2004-06-15 | Applied Research Systems Ars Holding N.V. | Farmatseutiliselt aktiivsed pürrolidiini derivaadid |
EP1268418B1 (de) * | 2000-03-27 | 2006-06-14 | Applied Research Systems ARS Holding N.V. | Pharmazeutisch wirksame pyrrolidin-derivate als bax-inhibitoren |
AU2002219555B2 (en) | 2000-12-28 | 2006-11-30 | Daiichi Pharmaceutical Co., Ltd. | VLA-4 Inhibitors |
EE200400022A (et) * | 2001-06-18 | 2004-04-15 | Applied Research Systems Ars Holding N.V. | Pürrolidiinoksadiasooli ja -tiadiasooli derivaadid, nende valmistamise meetod ja neid sisaldavad ravimkoostised |
RU2301800C2 (ru) * | 2002-04-19 | 2007-06-27 | Аризона Боард Оф Ридженс Он Бихав Оф Зе Юниверсити Оф Аризона | Способ модулирования фототоксичности |
JP2007502861A (ja) * | 2003-05-01 | 2007-02-15 | レプリダイン・インコーポレーテッド | 抗菌方法及び組成物 |
TWI340134B (en) | 2003-07-24 | 2011-04-11 | Daiichi Seiyaku Co | Cyclohexanecarboxylic acids |
JP2006143667A (ja) * | 2004-11-22 | 2006-06-08 | Ube Ind Ltd | ピペコリン酸アミド誘導体及び抗菌剤 |
US8076370B2 (en) * | 2005-05-03 | 2011-12-13 | Ranbaxy Laboratories Limited | Antimicrobial agents |
JP2009533315A (ja) * | 2006-04-10 | 2009-09-17 | ランバクシー ラボラトリーズ リミテッド | 抗菌剤 |
WO2012014109A1 (en) | 2010-07-30 | 2012-02-02 | Ranbaxy Laboratories Limited | Heterocyclic sulfonamides as inhibitors of transfer rna synthetase for use as antibacterial agents |
CN104736569A (zh) * | 2012-01-12 | 2015-06-24 | 耶鲁大学 | 通过e3泛素连接酶增强靶蛋白质及其他多肽降解的化合物和方法 |
GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
US10071164B2 (en) | 2014-08-11 | 2018-09-11 | Yale University | Estrogen-related receptor alpha based protac compounds and associated methods of use |
WO2016029146A1 (en) * | 2014-08-22 | 2016-02-25 | University Of Washington | Specific inhibitors of methionyl-trna synthetase |
KR102110566B1 (ko) | 2015-01-20 | 2020-05-13 | 아비나스 오퍼레이션스, 인코포레이티드 | 안드로겐 수용체의 표적화된 분해를 위한 화합물 및 방법 |
US20170327469A1 (en) | 2015-01-20 | 2017-11-16 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
JP7269731B2 (ja) | 2015-03-18 | 2023-05-09 | アルビナス・オペレーションズ・インコーポレイテッド | 標的タンパク質の分解向上のための化合物および方法 |
US20180147202A1 (en) | 2015-06-05 | 2018-05-31 | Arvinas, Inc. | TANK-BINDING KINASE-1 PROTACs AND ASSOCIATED METHODS OF USE |
US10772962B2 (en) | 2015-08-19 | 2020-09-15 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
US9938264B2 (en) | 2015-11-02 | 2018-04-10 | Yale University | Proteolysis targeting chimera compounds and methods of preparing and using same |
WO2018053354A1 (en) | 2016-09-15 | 2018-03-22 | Arvinas, Inc. | Indole derivatives as estrogen receptor degraders |
EP3526202A4 (de) | 2016-10-11 | 2020-04-29 | Arvinas, Inc. | Verbindungen und verfahren für gezielten abbau des androgenrezeptors |
MX2019005007A (es) | 2016-11-01 | 2019-07-18 | Arvinas Inc | Protac dirigidos a la proteína tau y métodos asociados de uso. |
LT3689868T (lt) | 2016-12-01 | 2023-12-27 | Arvinas Operations, Inc. | Tetrahidronaftaleno ir tetrahidroizochinolino dariniai kaip estrogenų receptorių destruktoriai |
KR20190101406A (ko) | 2016-12-23 | 2019-08-30 | 아비나스 오퍼레이션스, 인코포레이티드 | Egfr 단백질분해 표적화 키메라 분자 및 관련 사용 방법 |
US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
JP2020504741A (ja) | 2016-12-23 | 2020-02-13 | アルビナス・オペレーションズ・インコーポレイテッドArvinas Operations, Inc. | Raf(急速進行性線維肉腫)ポリペプチドの標的分解のための化合物および方法 |
WO2018118598A1 (en) | 2016-12-23 | 2018-06-28 | Arvinas, Inc. | Compounds and methods for the targeted degradation of fetal liver kinase polypeptides |
US11191741B2 (en) | 2016-12-24 | 2021-12-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide |
EP3573977A4 (de) | 2017-01-26 | 2020-12-23 | Arvinas Operations, Inc. | Modulatoren der östrogenrezeptorproteolyse und zugehörige verfahren zur verwendung |
US11065231B2 (en) | 2017-11-17 | 2021-07-20 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides |
US11161841B2 (en) | 2018-04-04 | 2021-11-02 | Arvinas Operations, Inc. | Modulators of proteolysis and associated methods of use |
EP3841100A1 (de) | 2018-08-20 | 2021-06-30 | Arvinas Operations, Inc. | Gegen alpha-synnukleinprotein gerichtete proteolyse-targeting chimeräre (protac) verbindung mit e3-ubiquitin-ligase-bindender aktivität zur behandlung neurodegenerativer erkrankungen |
WO2021011913A1 (en) | 2019-07-17 | 2021-01-21 | Arvinas Operations, Inc. | Tau-protein targeting compounds and associated methods of use |
IL293961A (en) | 2019-12-19 | 2022-08-01 | Arvinas Operations Inc | Compounds and methods for targeted degradation of androgen receptor |
US11957759B1 (en) | 2022-09-07 | 2024-04-16 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
ES520132A0 (es) | 1982-02-27 | 1984-04-01 | Beecham Group Plc | Un procedimiento para la preparacion de derivados de 1-normon-2-ilo. |
US4452775A (en) | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
JPH03236389A (ja) * | 1990-02-13 | 1991-10-22 | Banyu Pharmaceut Co Ltd | 2―(2―カルバモイルピロリジニルチオ)カルバペネム誘導体 |
JPH04167172A (ja) | 1990-10-31 | 1992-06-15 | Nec Corp | ベクトルプロセッサ |
WO1995005384A1 (en) | 1993-08-13 | 1995-02-23 | Smithkline Beecham Plc | Derivatives of monic acids a and c having antibacterial, antimycoplasmatical, antifungal and herbicidal activity |
US5705487A (en) | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
EP0772611A1 (de) * | 1994-07-20 | 1997-05-14 | Byk Gulden Lomberg Chemische Fabrik GmbH | Piperazinothiopyridine zur bekämpfung von helicobacter-bakterien |
AU6500696A (en) | 1995-07-28 | 1997-02-26 | Cubist Pharmaceuticals, Inc. | Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents |
US5726195A (en) | 1995-07-28 | 1998-03-10 | Cubist Pharmaceuticals, Inc. | Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents |
CA2230122A1 (en) * | 1995-09-15 | 1997-03-20 | John Hargreaves Bateson | Pyrrolidine and thiazole derivatives with antibacterial and metallo-beta-lactamase inhibitory properties |
-
2000
- 2000-05-05 US US09/566,112 patent/US6333344B1/en not_active Expired - Fee Related
- 2000-05-05 AT AT00932063T patent/ATE319446T1/de not_active IP Right Cessation
- 2000-05-05 DE DE60026514T patent/DE60026514T2/de not_active Expired - Fee Related
- 2000-05-05 EP EP00932063A patent/EP1176959B1/de not_active Expired - Lifetime
- 2000-05-05 WO PCT/US2000/012172 patent/WO2000066119A1/en active IP Right Grant
- 2000-05-05 CA CA002372176A patent/CA2372176A1/en not_active Abandoned
- 2000-05-05 AU AU49845/00A patent/AU769652B2/en not_active Ceased
- 2000-05-05 JP JP2000615004A patent/JP2002543129A/ja not_active Withdrawn
- 2000-05-05 ES ES00932063T patent/ES2257296T3/es not_active Expired - Lifetime
-
2001
- 2001-08-22 US US09/935,033 patent/US6417217B1/en not_active Expired - Fee Related
-
2002
- 2002-06-17 US US10/173,054 patent/US6579894B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2002543129A (ja) | 2002-12-17 |
ES2257296T3 (es) | 2006-08-01 |
CA2372176A1 (en) | 2000-11-09 |
AU4984500A (en) | 2000-11-17 |
US6333344B1 (en) | 2001-12-25 |
EP1176959A4 (de) | 2002-10-09 |
US20030013724A1 (en) | 2003-01-16 |
DE60026514T2 (de) | 2006-11-09 |
US6579894B2 (en) | 2003-06-17 |
WO2000066119A1 (en) | 2000-11-09 |
US6417217B1 (en) | 2002-07-09 |
AU769652B2 (en) | 2004-01-29 |
EP1176959A1 (de) | 2002-02-06 |
ATE319446T1 (de) | 2006-03-15 |
EP1176959B1 (de) | 2006-03-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: MERCK & CO, INC., RAHWAY, N.J., US Owner name: CUBIST PHARMACEUTICALS, INC., LEXINGTON, MASS., US |
|
8339 | Ceased/non-payment of the annual fee |