DE60016288D1 - Isolierung von vorläuferzellen und deren verwendung zum wiederaufbau von bindegewebe - Google Patents
Isolierung von vorläuferzellen und deren verwendung zum wiederaufbau von bindegewebeInfo
- Publication number
- DE60016288D1 DE60016288D1 DE60016288T DE60016288T DE60016288D1 DE 60016288 D1 DE60016288 D1 DE 60016288D1 DE 60016288 T DE60016288 T DE 60016288T DE 60016288 T DE60016288 T DE 60016288T DE 60016288 D1 DE60016288 D1 DE 60016288D1
- Authority
- DE
- Germany
- Prior art keywords
- marker
- expressed
- precursor cells
- detectable
- morphogenic protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1317—Chondrocytes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Botany (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE20023640U DE20023640U1 (de) | 1999-10-06 | 2000-10-06 | Isolierung von Vorläuferzellen und deren Verwendung zum Wiederaufbau von Bindegewebe |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99203274 | 1999-10-06 | ||
EP99203274 | 1999-10-06 | ||
EP99203290 | 1999-10-07 | ||
EP99203290 | 1999-10-07 | ||
PCT/BE2000/000120 WO2001025402A1 (en) | 1999-10-06 | 2000-10-06 | Isolation of precursor cells and their use for tissue repair |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60016288D1 true DE60016288D1 (de) | 2004-12-30 |
DE60016288T2 DE60016288T2 (de) | 2005-12-01 |
Family
ID=26153376
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE20023640U Expired - Lifetime DE20023640U1 (de) | 1999-10-06 | 2000-10-06 | Isolierung von Vorläuferzellen und deren Verwendung zum Wiederaufbau von Bindegewebe |
DE60016288T Expired - Lifetime DE60016288T2 (de) | 1999-10-06 | 2000-10-06 | Isolierung von vorläuferzellen und deren verwendung zum wiederaufbau von bindegewebe |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE20023640U Expired - Lifetime DE20023640U1 (de) | 1999-10-06 | 2000-10-06 | Isolierung von Vorläuferzellen und deren Verwendung zum Wiederaufbau von Bindegewebe |
Country Status (10)
Country | Link |
---|---|
US (2) | US7863045B2 (de) |
EP (1) | EP1282690B9 (de) |
AT (1) | ATE283349T1 (de) |
AU (1) | AU7634400A (de) |
CA (1) | CA2386506C (de) |
DE (2) | DE20023640U1 (de) |
DK (1) | DK1282690T3 (de) |
ES (1) | ES2230157T3 (de) |
PT (1) | PT1282690E (de) |
WO (1) | WO2001025402A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7482114B2 (en) | 1999-10-06 | 2009-01-27 | Tigenix N.V. | In vivo assay and molecular markers for testing the phenotypic stability of cell populations, and selected cell populations for autologous transplantation |
ES2234673T3 (es) | 1999-10-06 | 2005-07-01 | Tigenix N.V. | Prueba in vivo para verificar la estabilidad fenotipica. |
AU2002309330A1 (en) * | 2001-05-17 | 2002-11-25 | Isotis N.V. | Isolation method of mesenchymal cells |
US7375077B2 (en) | 2003-09-19 | 2008-05-20 | The Board Of Trustees Of The University Of Illinois | In vivo synthesis of connective tissues |
EP1576957A1 (de) | 2004-03-18 | 2005-09-21 | Universiteit Twente | Wiederherstellung zerstörten Gewebes mit Hilfe von pluripotenten Zellen |
RU2008141279A (ru) | 2006-03-20 | 2010-04-27 | Тижени Н. В. (Be) | Способы сохранения, улучшения и восстановления хрящевого фенотипа хондроцитов |
EP2094310B1 (de) | 2006-11-24 | 2013-12-25 | Tigenix N.V. | Markergene zur verwendung bei der identifizierung von chondrozyten-phänotypischer stabilität und beim screenen von faktoren zur beeinflussung der knorpelproduktion |
WO2010031876A1 (en) | 2008-09-22 | 2010-03-25 | Universiteit Gent | Carboxyethylated cyclodextrin polysulfates useful as medicaments |
ES2370794B1 (es) * | 2010-05-25 | 2012-10-31 | Servicio Andaluz De Salud | Biomarcador de células cartilaginosas humanas. |
WO2012048275A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
JP6612227B2 (ja) | 2013-11-16 | 2019-11-27 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
EP3122866B1 (de) | 2014-03-25 | 2019-11-20 | Terumo BCT, Inc. | Passives ersetzen von medien |
JP6830059B2 (ja) | 2014-09-26 | 2021-02-17 | テルモ ビーシーティー、インコーポレーテッド | スケジュール化された細胞フィーディング |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
JP7034949B2 (ja) | 2016-05-25 | 2022-03-14 | テルモ ビーシーティー、インコーポレーテッド | 細胞の増殖 |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11692174B2 (en) * | 2017-02-08 | 2023-07-04 | Sapphiros Ai Bio Llc | Systems, methods, and apparatus for induced pluripotent stem cell isolation and combinatorial production |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
CN110612344B (zh) | 2017-03-31 | 2023-09-12 | 泰尔茂比司特公司 | 细胞扩增 |
WO2019118768A1 (en) * | 2017-12-13 | 2019-06-20 | Rita Perlingeiro | Enhanced differentiation and maturation of pluripotent stem cell-derived myogenic cells |
GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5904717A (en) * | 1986-01-28 | 1999-05-18 | Thm Biomedical, Inc. | Method and device for reconstruction of articular cartilage |
US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
US5197985A (en) * | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
US5733542A (en) * | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
US6010696A (en) * | 1990-11-16 | 2000-01-04 | Osiris Therapeutics, Inc. | Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells |
US5811094A (en) * | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
US5837539A (en) * | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
EP0801675B1 (de) * | 1994-07-29 | 2003-04-16 | The United States of America, as Represented by the Secretary, Department of Agriculture | Saccharomyces-behandlung zur verringerung von campylobakter- und salmonella-populationen in geflügel |
US5972703A (en) * | 1994-08-12 | 1999-10-26 | The Regents Of The University Of Michigan | Bone precursor cells: compositions and methods |
US5648219A (en) * | 1995-06-07 | 1997-07-15 | Zymogenetics, Inc. | Immortalized dendritic cells |
US5683906A (en) * | 1994-09-09 | 1997-11-04 | Zymogenetics, Inc. | Preparation of immortalized cells |
EP0804554A1 (de) * | 1994-09-09 | 1997-11-05 | ZymoGenetics, Inc. | Herstellung von immortalisierten zellen |
US5830682A (en) * | 1994-09-09 | 1998-11-03 | Zymogenetics | Preparation of immortalized cells |
AU715996B2 (en) * | 1995-06-12 | 2000-02-17 | Ramot University Authority For Applied Research And Industrial Development Ltd. | FGFR3 as a marker for mesenchymal skeletal progenitor cells |
WO1997007200A1 (en) * | 1995-08-16 | 1997-02-27 | The Board Of Trustees Of The Leland Stanford Junior University | Adult oligodendrocyte precursor cell compositions and methods |
JP2000503542A (ja) * | 1996-01-16 | 2000-03-28 | デピュイ オーソピーディック,インコーポレイテッド | 造血及び非造血組織からの前駆細胞の分離及び in vivo 骨及び軟骨再生におけるそれらの使用 |
US6200606B1 (en) * | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
US5919702A (en) * | 1996-10-23 | 1999-07-06 | Advanced Tissue Science, Inc. | Production of cartilage tissue using cells isolated from Wharton's jelly |
WO1998035022A1 (en) * | 1997-02-06 | 1998-08-13 | Osiris Therapeutics, Inc. | p21?CIP1 OR p27KIP1¿ EFFECTS ON THE REGULATION OF DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS |
AU7984498A (en) | 1997-06-25 | 1999-01-04 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Serum-free cell growth medium |
US6235527B1 (en) * | 1997-11-29 | 2001-05-22 | University Of Utah Research Foundation | Lineage restricted glial precursors from the central nervous system |
-
2000
- 2000-10-06 DE DE20023640U patent/DE20023640U1/de not_active Expired - Lifetime
- 2000-10-06 CA CA2386506A patent/CA2386506C/en not_active Expired - Lifetime
- 2000-10-06 AT AT00965662T patent/ATE283349T1/de active
- 2000-10-06 DE DE60016288T patent/DE60016288T2/de not_active Expired - Lifetime
- 2000-10-06 DK DK00965662T patent/DK1282690T3/da active
- 2000-10-06 AU AU76344/00A patent/AU7634400A/en not_active Abandoned
- 2000-10-06 PT PT00965662T patent/PT1282690E/pt unknown
- 2000-10-06 EP EP00965662A patent/EP1282690B9/de not_active Expired - Lifetime
- 2000-10-06 ES ES00965662T patent/ES2230157T3/es not_active Expired - Lifetime
- 2000-10-06 WO PCT/BE2000/000120 patent/WO2001025402A1/en active IP Right Grant
-
2008
- 2008-07-18 US US12/176,256 patent/US7863045B2/en not_active Expired - Fee Related
-
2011
- 2011-01-03 US US12/983,658 patent/US20110158960A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2386506C (en) | 2012-02-21 |
ATE283349T1 (de) | 2004-12-15 |
EP1282690B9 (de) | 2005-03-02 |
PT1282690E (pt) | 2005-02-28 |
EP1282690A1 (de) | 2003-02-12 |
DE20023640U1 (de) | 2005-06-23 |
ES2230157T3 (es) | 2005-05-01 |
DE60016288T2 (de) | 2005-12-01 |
US20090123927A1 (en) | 2009-05-14 |
US7863045B2 (en) | 2011-01-04 |
DK1282690T3 (da) | 2005-02-28 |
US20110158960A1 (en) | 2011-06-30 |
WO2001025402A1 (en) | 2001-04-12 |
CA2386506A1 (en) | 2001-04-12 |
EP1282690B1 (de) | 2004-11-24 |
AU7634400A (en) | 2001-05-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60016288D1 (de) | Isolierung von vorläuferzellen und deren verwendung zum wiederaufbau von bindegewebe | |
Ambrosi et al. | A revised perspective of skeletal stem cell biology | |
Gelain et al. | Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures | |
Crigler et al. | Isolation of a mesenchymal cell population from murine dermis that contains progenitors of multiple cell lineages | |
Phillips et al. | Directed differentiation of human induced pluripotent stem cells toward bone and cartilage: in vitro versus in vivo assays | |
Kleinman et al. | Matrigel: basement membrane matrix with biological activity | |
Wang et al. | Mechanomics: an emerging field between biology and biomechanics | |
Julien et al. | Dual functional activity of semaphorin 3B is required for positioning the anterior commissure | |
Watt | Epidermal stem cells: markers, patterning and the control of stem cell fate | |
WO2005103716A3 (en) | Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts | |
Delannet et al. | Transforming growth factor-β control of cell-substratum adhesion during avian neural crest cell emigration in vitro | |
Tsuchiya et al. | Osteogenic differentiation capacity of porcine dental follicle progenitor cells | |
Fleming et al. | Bioengineered human skeletal muscle capable of functional regeneration | |
Vinante et al. | Heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor in normal and neoplastic hematopoiesis | |
Jones | Isolation and characterization of human epidermal stem cells | |
CN107567494A (zh) | 间充质干细胞的细胞培养方法 | |
KR102263824B1 (ko) | 심장 세포 배양 재료 | |
Viil et al. | Laminin-rich blood vessels display activated growth factor signaling and act as the proliferation centers in Dupuytren’s contracture | |
Lund et al. | sdf1 Expression reveals a source of perivascular-derived mesenchymal stem cells in zebrafish | |
CN102482645A (zh) | 与干细胞活性相关的凝血栓蛋白1、凝血栓蛋白2、白细胞介素17b受体和肝素结合表皮生长因子样生长因子和其应用 | |
Williams et al. | Engineering the CNS stem cell microenvironment | |
Arnesen et al. | The effects of collagen type I topography on myoblasts in vitro | |
CN102212460A (zh) | 干细胞筛选系统、其制备方法及干细胞的筛选方法 | |
Stanke et al. | The early expression of VAChT and VIP in mouse sympathetic ganglia is not induced by cytokines acting through LIFRβ or CNTFRα | |
Theodorescu et al. | TGF-β gene expression depends on tissue architecture |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |