DE60009926D1 - Stabilisierung von gefriergetrocknetem kuchen - Google Patents

Stabilisierung von gefriergetrocknetem kuchen

Info

Publication number
DE60009926D1
DE60009926D1 DE60009926T DE60009926T DE60009926D1 DE 60009926 D1 DE60009926 D1 DE 60009926D1 DE 60009926 T DE60009926 T DE 60009926T DE 60009926 T DE60009926 T DE 60009926T DE 60009926 D1 DE60009926 D1 DE 60009926D1
Authority
DE
Germany
Prior art keywords
stabilizing
freeze dried
dried cake
freeze
sugar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60009926T
Other languages
English (en)
Other versions
DE60009926T2 (de
Inventor
Lindgaard Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk Health Care AG
Original Assignee
Novo Nordisk Health Care AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Health Care AG filed Critical Novo Nordisk Health Care AG
Application granted granted Critical
Publication of DE60009926D1 publication Critical patent/DE60009926D1/de
Publication of DE60009926T2 publication Critical patent/DE60009926T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Peptides Or Proteins (AREA)
  • Freezing, Cooling And Drying Of Foods (AREA)
  • Preparation Of Fruits And Vegetables (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
DE60009926T 1999-08-17 2000-08-16 Stabilisierung von gefriergetrocknetem kuchen Expired - Lifetime DE60009926T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA199901130 1999-08-17
DK113099 1999-08-17
PCT/DK2000/000454 WO2001012653A1 (en) 1999-08-17 2000-08-16 Stabilisation of freeze-dried cake

Publications (2)

Publication Number Publication Date
DE60009926D1 true DE60009926D1 (de) 2004-05-19
DE60009926T2 DE60009926T2 (de) 2005-04-07

Family

ID=8101362

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60009926T Expired - Lifetime DE60009926T2 (de) 1999-08-17 2000-08-16 Stabilisierung von gefriergetrocknetem kuchen

Country Status (6)

Country Link
EP (1) EP1210361B1 (de)
JP (1) JP2003507388A (de)
AT (1) ATE264340T1 (de)
AU (1) AU6558400A (de)
DE (1) DE60009926T2 (de)
WO (1) WO2001012653A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0402315A3 (en) 2001-12-21 2009-03-30 Novo Nordisk Healthcare Ag Liquid composition of factor vii polypeptides
GB0207092D0 (en) * 2002-03-26 2002-05-08 Sod Conseils Rech Applic Stable pharmaceutical composition containing factor VIII
PL224001B1 (pl) * 2002-05-02 2016-11-30 Wyeth Corp Sposób wytwarzania stabilnej liofilizowanej kompozycji obejmującej monomeryczne koniugaty pochodna kalicheamycyny/przeciwciało anty-CD22, kompozycja otrzymana tym sposobem oraz jej zastosowanie
EP1503798B8 (de) * 2002-05-03 2012-03-14 Novo Nordisk Health Care AG Stabilisierte feste zusammensetzungen von modifizierter faktor vii
CN1671410B (zh) * 2002-06-21 2010-05-12 诺和诺德医疗保健公司 因子ⅶ多肽的稳定化固体组合物
EP3103869A1 (de) * 2003-03-18 2016-12-14 Novo Nordisk Health Care AG Verfahren zur herstellung von factor vii polypeptiden
US7897734B2 (en) 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
ES2382157T3 (es) 2003-06-25 2012-06-05 Novo Nordisk Health Care Ag Composición líquida de polipépttidos del factor VII
EP3378470A1 (de) * 2003-12-19 2018-09-26 Novo Nordisk Health Care AG Stabilisierte zusammensetzungen aus faktor-vii-polypeptiden
AU2011203354B2 (en) * 2003-12-19 2014-07-17 Novo Nordisk Health Care Ag Stabilised compositions of factor VII polypeptides
ATE551050T1 (de) * 2008-09-03 2012-04-15 Octapharma Ag Stabilisierte zusammensetzungen für rekombinant hergestellten faktor viii
FR2947181B1 (fr) * 2009-06-26 2012-05-04 Lfb Biotechnologies Composition de facteur vii
EP2726495B1 (de) 2011-06-28 2019-03-06 Leukocare Ag Verfahren zum verhindern der entfaltung eines (poly)peptids und/oder induzieren der (neu)-faltung eines (poly)peptids
MX2018005134A (es) * 2015-11-05 2018-06-06 Novo Nordisk As Formulacion de factor viii (fviii).

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT308050B (de) * 1970-08-28 1973-06-25 Boehringer Mannheim Gmbh Reagens zur Bestimmung der γ-Glutamyltranspeptidase
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
JPH0650999B2 (ja) * 1988-09-12 1994-07-06 日本商事株式会社 血液凝固因子安定化法
US5656730A (en) * 1995-04-07 1997-08-12 Enzon, Inc. Stabilized monomeric protein compositions

Also Published As

Publication number Publication date
ATE264340T1 (de) 2004-04-15
EP1210361A1 (de) 2002-06-05
DE60009926T2 (de) 2005-04-07
WO2001012653A1 (en) 2001-02-22
JP2003507388A (ja) 2003-02-25
AU6558400A (en) 2001-03-13
EP1210361B1 (de) 2004-04-14

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition