DE60009098D1 - Methode für die selektive protektion der proliferation der normalen zellen und der selektiven beseitigung der tumorzellen, die eine inaktivierte p53 pathway haben - Google Patents

Methode für die selektive protektion der proliferation der normalen zellen und der selektiven beseitigung der tumorzellen, die eine inaktivierte p53 pathway haben

Info

Publication number
DE60009098D1
DE60009098D1 DE60009098T DE60009098T DE60009098D1 DE 60009098 D1 DE60009098 D1 DE 60009098D1 DE 60009098 T DE60009098 T DE 60009098T DE 60009098 T DE60009098 T DE 60009098T DE 60009098 D1 DE60009098 D1 DE 60009098D1
Authority
DE
Germany
Prior art keywords
selective
pathway
cells
tumor cells
inactivated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60009098T
Other languages
English (en)
Other versions
DE60009098T2 (de
Inventor
Franco Tato'
Antonio Zanetti
Milena Grossi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Roma La Sapienza
Original Assignee
Universita degli Studi di Roma La Sapienza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita degli Studi di Roma La Sapienza filed Critical Universita degli Studi di Roma La Sapienza
Application granted granted Critical
Publication of DE60009098D1 publication Critical patent/DE60009098D1/de
Publication of DE60009098T2 publication Critical patent/DE60009098T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • C12N5/0093—Purging against cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE60009098T 1999-09-21 2000-09-21 Methode für die selektive protektion der proliferation der normalen zellen und der selektiven beseitigung der tumorzellen, die eine inaktivierte p53 pathway haben Expired - Lifetime DE60009098T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT1999RM000580A IT1306187B1 (it) 1999-09-21 1999-09-21 Metodo per l'eradicazione selettiva di cellule tumorali aventi lafunzione di p53 inattiva.
ITRM990580 1999-09-21
PCT/IT2000/000373 WO2001021765A2 (en) 1999-09-21 2000-09-21 Method for the selective protection of proliferating normal cells and the selective eradication of tumor cells having an inactive p53 pathway

Publications (2)

Publication Number Publication Date
DE60009098D1 true DE60009098D1 (de) 2004-04-22
DE60009098T2 DE60009098T2 (de) 2005-03-24

Family

ID=11406961

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60009098T Expired - Lifetime DE60009098T2 (de) 1999-09-21 2000-09-21 Methode für die selektive protektion der proliferation der normalen zellen und der selektiven beseitigung der tumorzellen, die eine inaktivierte p53 pathway haben

Country Status (8)

Country Link
EP (1) EP1214397B1 (de)
AT (1) ATE262033T1 (de)
AU (1) AU7555000A (de)
CA (1) CA2385424A1 (de)
DE (1) DE60009098T2 (de)
ES (1) ES2218224T3 (de)
IT (1) IT1306187B1 (de)
WO (1) WO2001021765A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2003006060A1 (ja) * 2001-07-09 2004-10-28 協和醗酵工業株式会社 Ｓｈ３ドメイン結合阻害剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988010259A1 (en) * 1987-06-19 1988-12-29 Syracuse University Cytochalasin purification methods and compositions
GB9518536D0 (en) * 1995-09-11 1995-11-08 Pharma Mar Sa Three new cytotoxic macrolides from a marine sponge

Also Published As

Publication number Publication date
ES2218224T3 (es) 2004-11-16
EP1214397A2 (de) 2002-06-19
DE60009098T2 (de) 2005-03-24
EP1214397B1 (de) 2004-03-17
ATE262033T1 (de) 2004-04-15
ITRM990580A0 (it) 1999-09-21
WO2001021765A2 (en) 2001-03-29
AU7555000A (en) 2001-04-24
WO2001021765A3 (en) 2001-10-11
ITRM990580A1 (it) 2001-03-21
IT1306187B1 (it) 2001-05-30
CA2385424A1 (en) 2001-03-29

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition