DE59205565D1 - Carbonsäureester-Schutzgruppen, ein Verfahren zu ihrer Herstellung, ihre Kopplung an eine funktionelle Gruppe sowie ihre Verwendung - Google Patents

Carbonsäureester-Schutzgruppen, ein Verfahren zu ihrer Herstellung, ihre Kopplung an eine funktionelle Gruppe sowie ihre Verwendung

Info

Publication number
DE59205565D1
DE59205565D1 DE59205565T DE59205565T DE59205565D1 DE 59205565 D1 DE59205565 D1 DE 59205565D1 DE 59205565 T DE59205565 T DE 59205565T DE 59205565 T DE59205565 T DE 59205565T DE 59205565 D1 DE59205565 D1 DE 59205565D1
Authority
DE
Germany
Prior art keywords
coupling
preparation
functional group
protecting groups
carboxylic ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE59205565T
Other languages
German (de)
English (en)
Inventor
Horst Prof Dr Kunz
Guenther Braum
Peter Braun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Research and Technologies GmbH and Co KG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE59205565T priority Critical patent/DE59205565D1/de
Application granted granted Critical
Publication of DE59205565D1 publication Critical patent/DE59205565D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE59205565T 1991-10-07 1992-10-05 Carbonsäureester-Schutzgruppen, ein Verfahren zu ihrer Herstellung, ihre Kopplung an eine funktionelle Gruppe sowie ihre Verwendung Expired - Fee Related DE59205565D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE59205565T DE59205565D1 (de) 1991-10-07 1992-10-05 Carbonsäureester-Schutzgruppen, ein Verfahren zu ihrer Herstellung, ihre Kopplung an eine funktionelle Gruppe sowie ihre Verwendung

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4133139 1991-10-07
DE4213706 1992-04-25
DE59205565T DE59205565D1 (de) 1991-10-07 1992-10-05 Carbonsäureester-Schutzgruppen, ein Verfahren zu ihrer Herstellung, ihre Kopplung an eine funktionelle Gruppe sowie ihre Verwendung

Publications (1)

Publication Number Publication Date
DE59205565D1 true DE59205565D1 (de) 1996-04-11

Family

ID=25907995

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59205565T Expired - Fee Related DE59205565D1 (de) 1991-10-07 1992-10-05 Carbonsäureester-Schutzgruppen, ein Verfahren zu ihrer Herstellung, ihre Kopplung an eine funktionelle Gruppe sowie ihre Verwendung

Country Status (6)

Country Link
US (2) US5439806A (enExample)
EP (1) EP0536671B1 (enExample)
JP (1) JP3339888B2 (enExample)
CA (1) CA2079921A1 (enExample)
DE (1) DE59205565D1 (enExample)
DK (1) DK0536671T3 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1008355A1 (en) * 1998-12-08 2000-06-14 Debio Recherche Pharmaceutique S.A. Method for identifying or analyzing polymer linkage sites on macromolecules using amino acid report binding
JPWO2004035817A1 (ja) * 2002-10-16 2006-02-16 協和メデックス株式会社 高密度リポ蛋白中のコレステロールの測定方法および試薬
US20110230479A1 (en) * 2005-04-15 2011-09-22 Longo Frank M Neurotrophin mimetics and uses thereof
JP2008536844A (ja) * 2005-04-15 2008-09-11 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル ニューロトロフィン類似体を用いた細胞生存促進法
US7612209B2 (en) * 2006-06-28 2009-11-03 Hoffmann-La Roche Inc. Pseudo proline dipeptides
CN104761515B (zh) 2009-11-12 2018-03-09 特罗菲克斯制药股份有限公司 神经营养蛋白模拟化合物及其盐的晶型
US10273219B2 (en) 2009-11-12 2019-04-30 Pharmatrophix, Inc. Crystalline forms of neurotrophin mimetic compounds and their salts

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE352831C (de) * 1920-08-14 1922-05-05 Aeg Drehzahlregler fuer elektrisch angetriebene Ringspinnmaschinen
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE2360794C2 (de) * 1973-12-06 1984-12-06 Hoechst Ag, 6230 Frankfurt Verfahren zur Herstellung von Peptiden
DE2857828C2 (enExample) * 1977-01-27 1990-06-07 Toyo Soda Mfg. Co., Ltd., Shinnanyo, Yamaguchi, Jp
JPS54119260A (en) * 1978-03-08 1979-09-17 Canon Inc Luminous flux diverging apparatus using prisms
AU545416B2 (en) * 1979-04-06 1985-07-11 Carlsberg Biotechnology Ltd. A/S A process for enzymatic production of peptides
JPS5645196A (en) * 1979-09-19 1981-04-24 Shionogi & Co Ltd Enzymatic synthesis of beta-lactam antibacterial agent
DE3371199D1 (en) * 1982-08-24 1987-06-04 Teijin Ltd Novel 6-nitroprostaglandin derivatives, process for production thereof, and use thereof
EP0145956A1 (de) * 1983-11-16 1985-06-26 Ciba-Geigy Ag Neue Amid-Verbindungen
US5159102A (en) * 1984-03-05 1992-10-27 Teijin Limited 7-thiaprostaglandins E, and process for producing same
US4841091A (en) * 1985-01-29 1989-06-20 Teijin Limited Process for producing 16-substituted prostaglandin es.
US4668628A (en) * 1985-04-01 1987-05-26 Stauffer Chemical Company Resolution of racemic mixtures of aliphatic acid esters
DE3528631A1 (de) * 1985-08-09 1987-02-12 Basf Ag Substituierte n-acyl-(alpha)-aminosaeureester, ihre verwendung als bioregulatoren insbesondere zur senkung des endogenen ethylenspiegels in pflanzen
GB8600245D0 (en) * 1986-01-07 1986-02-12 Shell Int Research Preparation of 2-arylpropionic acids
DE3743824C2 (de) * 1987-12-23 1997-03-06 Hoechst Ag Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung
US5108916A (en) * 1989-06-05 1992-04-28 Rhone-Poulenc Rorer, S.A. Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa
US5169780A (en) * 1989-06-22 1992-12-08 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US5089392A (en) * 1990-03-30 1992-02-18 The United States Of America As Represented By Of The Department Of Health And Human Services Fluorogenic substrates for measurement of lysosomal enzyme activities within intact cells
CA2074688A1 (en) * 1991-08-08 1993-02-09 Matthew T. Scholz Catalysts and casting article, method, and composition

Also Published As

Publication number Publication date
EP0536671A2 (de) 1993-04-14
DK0536671T3 (da) 1996-08-12
EP0536671A3 (enExample) 1994-04-27
JPH05221941A (ja) 1993-08-31
EP0536671B1 (de) 1996-03-06
US5639859A (en) 1997-06-17
CA2079921A1 (en) 1993-04-08
JP3339888B2 (ja) 2002-10-28
US5439806A (en) 1995-08-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS RESEARCH & TECHNOLOGIES GMBH & CO KG, 6592

8339 Ceased/non-payment of the annual fee