DE575913C - Process for the production of highly purified substances containing the male sex hormone - Google Patents

Process for the production of highly purified substances containing the male sex hormone

Info

Publication number
DE575913C
DE575913C DE1930575913D DE575913DD DE575913C DE 575913 C DE575913 C DE 575913C DE 1930575913 D DE1930575913 D DE 1930575913D DE 575913D D DE575913D D DE 575913DD DE 575913 C DE575913 C DE 575913C
Authority
DE
Germany
Prior art keywords
male sex
sex hormone
highly purified
production
substances containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1930575913D
Other languages
German (de)
Inventor
Dr Max Gehrke
Dr Walter Schoeller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schering Kahlbaum AG
Original Assignee
Schering Kahlbaum AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Kahlbaum AG filed Critical Schering Kahlbaum AG
Application granted granted Critical
Publication of DE575913C publication Critical patent/DE575913C/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Description

Verfahren zur Gewinnung hochgereinigter, das männliche Sexualhormon enthaltender Stoffe Es ist bekannt, daß man aus den Drüsen des männlichen Genitalapparates wie auch aus anderen Organen oder Ausscheidungen des männlichen Organismus, wie Blut, Harn, Fäces u. dgl., das männliche Sexualhormon extrahieren und die so gewonnenen Hormonöle auf verschiedene Weise reinigen kann.Process for obtaining highly purified, the male sex hormone containing substances It is known that from the glands of the male genital apparatus as well as from other organs or excretions of the male organism, such as Extract blood, urine, feces and the like, the male sex hormone and the thus obtained Hormonal oils can cleanse in a number of ways.

Obgleich man nun bereits das Follikelhormon durch Destillation im Hochvakuum gereinigt und dabei in kristallisierter Form erhalten hat, war - trotz mancher Ähnlichkeit, die das männliche Sexualhormon im chemischen Verhalten mit dem Follikelhormon aufweist - bei seinem sonstigen, andersartigen Verhalten, z. B. hinsichtlich seines übergehens in Äther beim Ausäthern einer alkalischen Lösung, nicht anzunehmen, daß die Hochvakuumdestillation auf das männliche Sexualhormon übertragen werden kann.Although the follicular hormone is now already obtained by distillation in the High vacuum cleaned and thereby obtained in crystallized form was - despite some resemblance that the male sex hormone has in chemical behavior the follicular hormone has - in its other, different behavior, z. B. with regard to its transition into ether when etherifying an alkaline solution, do not assume that the high vacuum distillation on the male sex hormone can be transferred.

Durch eine derartige Destillation kann man vorgereinigte, männliches Sexualhormon enthaltende Hormonöle unter sehr stark vermindertem Druck weiterreihigen, wobei der Wert der Wirksamkeit der Hormone um das Dreibis Sechsfache gesteigert wird.Such a distillation can produce pre-purified, male Hormone oils containing sex hormones under very much reduced pressure, whereby the value of the effectiveness of the hormones increased by three to six times will.

Man kann nicht nur die übliche Vakuumdestillation anwenden, sondern auch mit oder ohne Vakuum im inerten Gasstrom oder mit erhitztem Wasserdampf destillieren. Beispiel Man unterwirft ein vorgereinigtes Hormonöl, das eine Kapauneinheit des männlichen Sexualhormons in i bis 5 mg enthält, der fraktionierten Hochvakuumdestillation. Dabei geht ein gelbes, in Äther, Aceton, Benzol, Alkoholen und fetten ölen lösliches, in Wasser dagegen fast unlösliches öl über, das eine Kapauneinheit in o, i bis o, o i mg enthält. Im Destillat finden sich 75 bis 9o% der eingesetzten Hormonmenge wieder.You can not only use the usual vacuum distillation, but also distill with or without vacuum in an inert gas stream or with heated steam. Example One submits a pre-purified hormone oil, which is a capon unit of the male sex hormone in 1 to 5 mg, the fractional high vacuum distillation. This is a yellow, soluble in ether, acetone, benzene, alcohols and fatty oils, in water, on the other hand, almost insoluble oil, which is a capon unit in o, i to o, o contains i mg. The distillate contains 75 to 90% of the amount of hormones used again.

Die Abhängigkeit der Destillationstemperatur vom Druck kann folgender Tabelle entnommen werden 0,0i mm i20 bis iq.o°, 0,005 nun i o8 bis i i 2', 0,00i mm 92 bis 98°, 0,0003 mm 89 bis 98°. Die fraktionierte Hochvakuumdestillation kann: gegebenenfalls wiederholt werden.The following table shows the dependence of the distillation temperature on the pressure 0.0i mm i20 to iq.o °, 0.005 now i o8 to ii 2 ', 0.00i mm 92 to 98 °, 0.0003 mm 89 to 98 °. The fractional high vacuum distillation can: if necessary, be repeated.

Claims (1)

PATENTANSPRUCH: Verfahren zur Gewinnung hochgereinigter, das männliche Sexualhormon enthaltender Stoffe, dadurch gekennzeichnet, daß man vorgereinigte Hormonöle der fraktionierten Hochvakuumdestillation unterwirft.PATENT CLAIM: Process for obtaining highly purified, the male Substances containing sex hormones, characterized in that they are pre-cleaned Subjected hormone oils to fractional high vacuum distillation.
DE1930575913D 1930-09-28 1930-09-28 Process for the production of highly purified substances containing the male sex hormone Expired DE575913C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE575913T 1930-09-28

Publications (1)

Publication Number Publication Date
DE575913C true DE575913C (en) 1933-05-04

Family

ID=6569833

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1930575913D Expired DE575913C (en) 1930-09-28 1930-09-28 Process for the production of highly purified substances containing the male sex hormone

Country Status (1)

Country Link
DE (1) DE575913C (en)

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