DE575913C - Process for the production of highly purified substances containing the male sex hormone - Google Patents
Process for the production of highly purified substances containing the male sex hormoneInfo
- Publication number
- DE575913C DE575913C DE1930575913D DE575913DD DE575913C DE 575913 C DE575913 C DE 575913C DE 1930575913 D DE1930575913 D DE 1930575913D DE 575913D D DE575913D D DE 575913DD DE 575913 C DE575913 C DE 575913C
- Authority
- DE
- Germany
- Prior art keywords
- male sex
- sex hormone
- highly purified
- production
- substances containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
Verfahren zur Gewinnung hochgereinigter, das männliche Sexualhormon enthaltender Stoffe Es ist bekannt, daß man aus den Drüsen des männlichen Genitalapparates wie auch aus anderen Organen oder Ausscheidungen des männlichen Organismus, wie Blut, Harn, Fäces u. dgl., das männliche Sexualhormon extrahieren und die so gewonnenen Hormonöle auf verschiedene Weise reinigen kann.Process for obtaining highly purified, the male sex hormone containing substances It is known that from the glands of the male genital apparatus as well as from other organs or excretions of the male organism, such as Extract blood, urine, feces and the like, the male sex hormone and the thus obtained Hormonal oils can cleanse in a number of ways.
Obgleich man nun bereits das Follikelhormon durch Destillation im Hochvakuum gereinigt und dabei in kristallisierter Form erhalten hat, war - trotz mancher Ähnlichkeit, die das männliche Sexualhormon im chemischen Verhalten mit dem Follikelhormon aufweist - bei seinem sonstigen, andersartigen Verhalten, z. B. hinsichtlich seines übergehens in Äther beim Ausäthern einer alkalischen Lösung, nicht anzunehmen, daß die Hochvakuumdestillation auf das männliche Sexualhormon übertragen werden kann.Although the follicular hormone is now already obtained by distillation in the High vacuum cleaned and thereby obtained in crystallized form was - despite some resemblance that the male sex hormone has in chemical behavior the follicular hormone has - in its other, different behavior, z. B. with regard to its transition into ether when etherifying an alkaline solution, do not assume that the high vacuum distillation on the male sex hormone can be transferred.
Durch eine derartige Destillation kann man vorgereinigte, männliches Sexualhormon enthaltende Hormonöle unter sehr stark vermindertem Druck weiterreihigen, wobei der Wert der Wirksamkeit der Hormone um das Dreibis Sechsfache gesteigert wird.Such a distillation can produce pre-purified, male Hormone oils containing sex hormones under very much reduced pressure, whereby the value of the effectiveness of the hormones increased by three to six times will.
Man kann nicht nur die übliche Vakuumdestillation anwenden, sondern auch mit oder ohne Vakuum im inerten Gasstrom oder mit erhitztem Wasserdampf destillieren. Beispiel Man unterwirft ein vorgereinigtes Hormonöl, das eine Kapauneinheit des männlichen Sexualhormons in i bis 5 mg enthält, der fraktionierten Hochvakuumdestillation. Dabei geht ein gelbes, in Äther, Aceton, Benzol, Alkoholen und fetten ölen lösliches, in Wasser dagegen fast unlösliches öl über, das eine Kapauneinheit in o, i bis o, o i mg enthält. Im Destillat finden sich 75 bis 9o% der eingesetzten Hormonmenge wieder.You can not only use the usual vacuum distillation, but also distill with or without vacuum in an inert gas stream or with heated steam. Example One submits a pre-purified hormone oil, which is a capon unit of the male sex hormone in 1 to 5 mg, the fractional high vacuum distillation. This is a yellow, soluble in ether, acetone, benzene, alcohols and fatty oils, in water, on the other hand, almost insoluble oil, which is a capon unit in o, i to o, o contains i mg. The distillate contains 75 to 90% of the amount of hormones used again.
Die Abhängigkeit der Destillationstemperatur vom Druck kann folgender
Tabelle entnommen werden
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE575913T | 1930-09-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE575913C true DE575913C (en) | 1933-05-04 |
Family
ID=6569833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1930575913D Expired DE575913C (en) | 1930-09-28 | 1930-09-28 | Process for the production of highly purified substances containing the male sex hormone |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE575913C (en) |
-
1930
- 1930-09-28 DE DE1930575913D patent/DE575913C/en not_active Expired
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