DE550585C - Process for obtaining vaccines from bacterial toxins - Google Patents

Process for obtaining vaccines from bacterial toxins

Info

Publication number
DE550585C
DE550585C DEK95794D DEK0095794D DE550585C DE 550585 C DE550585 C DE 550585C DE K95794 D DEK95794 D DE K95794D DE K0095794 D DEK0095794 D DE K0095794D DE 550585 C DE550585 C DE 550585C
Authority
DE
Germany
Prior art keywords
bacterial toxins
vaccines
bacterial
toxins
obtaining vaccines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEK95794D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kalle GmbH and Co KG
Original Assignee
Kalle GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalle GmbH and Co KG filed Critical Kalle GmbH and Co KG
Priority to DEK95794D priority Critical patent/DE550585C/en
Application granted granted Critical
Publication of DE550585C publication Critical patent/DE550585C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Description

Verfahren zur Gewinnung von Impfstoffen aus Bakterientoxinen In der Patentschrift 525 484 ist dargestellt worden, daß man die bakteriophagen Eigenschaften von Bakterien dazu benutzen kann, neuartige Heilmittel und Impfstoffe zu gewinnen, indem man sie systematisch auf, andere Bakterienkulturen umzüchtet.Process for obtaining vaccines from bacterial toxins In the Patent 525,484 has been shown to have bacteriophage properties of bacteria can be used to produce novel medicines and vaccines, by systematically cultivating other bacterial cultures.

Es ist nun gefunden worden, daß man die dort beschriebenen Bakterien auch zur Gewinnung von Impfstoffen aus Bakterientoxinen benutzen kann. Durch das Wachsen derselben auf Bakterientoxin wird dieses unter Schonung seiner immunisierenden Wirkung entgiftet. Man verfährt in der im Hauptpatent beschriebenen Weise, indem man auf den Bakterientoxinen diese Bakterienkulturen züchtet.It has now been found that the bacteria described there can also be used to obtain vaccines from bacterial toxins. By the If the same grows on bacterial toxin, this is done while sparing its immunizing Effect detoxifies. One proceeds in the manner described in the main patent by these bacterial cultures are grown on the bacterial toxins.

Derartig hergestellte Impfstoffe haben den Vorteil, daß sie einerseits reizlos injizierbar sind, andererseits ihre Giftwirkung verloren haben.Vaccines produced in this way have the advantage that they on the one hand are injectable without irritation, on the other hand have lost their poisonous effect.

Die Entgiftung von Bakterientoxinen wurde bisher dadurch erzielt, daß man den Bakterientoxinen ein Antitoxin beimischte und die dann entstehende mehr oder minder neutralisierte Mischung als Impfstoff verwendete, oder aber, daß man dem Bakteriengift einen chemischen Stoff, beispielsweise Formaldehyd, zusetzte, welcher, in entsprechender Weise angewandt, die Giftwirkung völlig vernichtete, ohne die immunisierende Wirkung zu zerstören. Das im ersten Falle entstehende Neutralgemisch kann unter Umständen wieder zerlegt werden, so daß die Giftkomponente wider frei wird. Die mit Formaldehyd dargestellten "Impfstoffe dagegen haben den Nachteil, daß sie bei der Injektion Schmerzen verursachen. Beispiel Diphtheriebazillen oder TetanusbaziIIen usw. werden in der üblichen Weise auf Bouillon gezüchtet und der Toxingrad festgelegt. Diese so gewonnenen und geprüften Toxine werden dann mit den in der Patentschrift 525484 beschriebenen Bazillenarten, z. B. Bac. subt., mesentericus, mycoides usw., beimpft und wachsen gelassen, um von Fall zu Fall nach etwa 14 bis 21 Tagen an Meerschweinchen oder Ratten auf ihre volle Entgiftung geprüft zu werden. Die jeweils gewünschte Immunisierung an Stelle der seither üblichen mit unentgifteten Toxinen kann nun auf ebensolche Weise mit dem Vorteil größerer Schnelligkeit und keizlosigkeit erfolgen.The detoxification of bacterial toxins has so far been achieved by that an antitoxin was added to the bacterial toxins and the resulting more or less neutralized mixture used as a vaccine, or that one added a chemical substance such as formaldehyde to the bacterial toxin, which, when applied appropriately, completely destroyed the poisonous effect, without destroying the immunizing effect. The neutral mixture produced in the first case can under certain circumstances be dismantled again, so that the poison component is released again will. The "vaccines made with formaldehyde, on the other hand, have the disadvantage cause pain when injected. Example diphtheria bacilli or Tetanus bacteria etc. are grown on broth in the usual way and the Degree of toxicity set. These toxins obtained and tested in this way are then combined with the Species of bacilli described in patent 525484, e.g. B. Bac. subt., mesenteric, mycoides, etc., inoculated and allowed to grow on a case by case basis after about 14 to 21 days to be tested on guinea pigs or rats for their full detoxification. The desired immunization instead of the non-detoxified one that has been customary since then Toxins can now be used in the same way with the advantage of greater speed and sterility take place.

Claims (1)

PATENTANSPRUCH: Abänderung des-Verfahrens des Hauptpatents 525 484 zur Herstellung von Impfstoffen aus Bakterientoxinen, dadurch gekennzeichnet, daß man Bakterien o. dgl. mit bakteriophagen und ähnlichen Eigenschaften, z. B. Bacillus subtilis, mesentericus, mycoides usw., auf Bakterientoxinen sich entwickeln lä$t. PATENT CLAIM: Modification of the process of the main patent 525 484 for the production of vaccines from bacterial toxins, characterized in that bacteria or the like with bacteriophage and similar properties, e.g. B. Bacillus subtilis, mesentericus, mycoides etc, can develop on bacterial toxins.
DEK95794D 1925-09-13 1925-09-13 Process for obtaining vaccines from bacterial toxins Expired DE550585C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEK95794D DE550585C (en) 1925-09-13 1925-09-13 Process for obtaining vaccines from bacterial toxins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEK95794D DE550585C (en) 1925-09-13 1925-09-13 Process for obtaining vaccines from bacterial toxins

Publications (1)

Publication Number Publication Date
DE550585C true DE550585C (en) 1932-05-12

Family

ID=7238212

Family Applications (1)

Application Number Title Priority Date Filing Date
DEK95794D Expired DE550585C (en) 1925-09-13 1925-09-13 Process for obtaining vaccines from bacterial toxins

Country Status (1)

Country Link
DE (1) DE550585C (en)

Similar Documents

Publication Publication Date Title
DE550585C (en) Process for obtaining vaccines from bacterial toxins
DE2823750C3 (en) Process for obtaining at least one hydrolysis product of an endotoxin from Bordetella pertussis
DE833673C (en) Method for producing a pig cholera lymph
SANO Studien über die Arginase
DE499580C (en) Process for the preparation of antitoxic pneumococcal serum
DE590908C (en) Process for making a scarlet fever serum
DE384689C (en) Process for the preparation of an effective swine fever serum
AT115408B (en) Process for the preparation of a protective agent against diphtheria in the form of a mass which can be rubbed into the skin.
DE338166C (en) Process for the production of harmless vaccines from toxic pathogenic microorganisms
DE814315C (en) Process for the production of serums, vaccines and the like like
DE216310C (en)
DE261518C (en)
Bosshard-Heer et al. Überlebensfähigkeit von Pseudomonas tomato (Okabe) Alstatt in verschiedenen Böden.
DE940315C (en) Process for the production of lymph against swine fever
DE672415C (en) Process for the preparation of vaccines against bogus burn in animals
DE1467817A1 (en) Process for the manufacture of vaccines
DE2727236A1 (en) PROCESS FOR PRODUCING SOLUTIONS OF FILTRATED LYSATES STARTING FROM MICRO-ORGANISM CULTURES AND THEREFORE PRODUCED MEDICINAL PRODUCTS
DE864439C (en) Process for the production of a detoxified toxin from the Siphonospora polymorpha by Brehmer
DE943312C (en) Process for the production of vaccines which can be used to obtain sera
DE575927C (en) Process for the production of synthetic masses from casein with the addition of substances that release formaldehyde
DE531780C (en) Process for the preparation of an agent for preventing or curing tuberculosis diseases
MORI Morphologische Studien über die Verdauung der Milchkügelchen
DE517204C (en) Process for the manufacture of vaccines
KIMURA Beiträge zur Kenntnis der Serumprotease Über die Kaolin-adsorbierbarkeit der Serumprotease und Antiprotease
Goto et al. Ein neues Pteridin aus Bombyx mori lem