DE545755C - Process for the extraction of a natural substance from urine, which influences the cardiac activity and the blood circulation - Google Patents

Process for the extraction of a natural substance from urine, which influences the cardiac activity and the blood circulation

Info

Publication number
DE545755C
DE545755C DEF68002D DEF0068002D DE545755C DE 545755 C DE545755 C DE 545755C DE F68002 D DEF68002 D DE F68002D DE F0068002 D DEF0068002 D DE F0068002D DE 545755 C DE545755 C DE 545755C
Authority
DE
Germany
Prior art keywords
urine
blood circulation
extraction
influences
natural substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEF68002D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HEINRICH KRAUT DR
EMIL KARL FREY DR
Original Assignee
HEINRICH KRAUT DR
EMIL KARL FREY DR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HEINRICH KRAUT DR, EMIL KARL FREY DR filed Critical HEINRICH KRAUT DR
Priority to DEF68002D priority Critical patent/DE545755C/en
Application granted granted Critical
Publication of DE545755C publication Critical patent/DE545755C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Description

Verfahren zur Gewinnung eines natürlichen, die Herztätigkeit und den Blutkreislauf beeinflussenden Stoffes aus Harn Durch das Patent 518 292 ist ein Verfahren zur :,bscheidung eines Produktes aus Harn geschützt, das eine natürliche Regelung des Blutkreislaufs und der Herztätigkeit ausübt und als Kreislaufhormon bezeichnet werden soll.Process for obtaining a natural substance from urine, which influences the heart and blood circulation The patent 518 292 protects a process for:, separation of a product from urine, which exercises a natural regulation of the blood circulation and the heart activity and is to be referred to as a circulatory hormone.

Bei der weiteren Bearbeitung wurde nun gefunden, daß sich das Kreislaufhormon aus dem Harn bzw. aus den nach dem Verfahren des Hauptpatents 518 292 erhältlichen wäßrigen Lösungen durch Adsorption an Benzoesäure nach an sich üblichen Methoden abscheiden und aus dem dabei erhältlichen Adsorbat nach Entfernen der Benzoesäure durch Extrahieren mittels der dafür üblichen Lösungsmittel gewinnen läßt. Die dabei erhältlichen Ausbeuten an wirksamen Stoffen sind abhängig von der Beschaffenheit des Ausgangsmaterials. Es konnten bis zu etwa 8o v. H. des wirksamen Stoffes in der genannten Weise gewonnen werden. Da über den chemischen Aufbau des Kreislaufhormons nichts Näheres bekannt ist, war der durch das genannte Verfahren gezeigte neue Weg für die Gewinnung dieses Hormons, wenn er sich auch an sich bekannter Arbeitsmethoden bedient, in keiner Weise vorauszusehen. Das neue Verfahren stellt daher eine bemerkenstv erte Bereicherung der Technik dar. Beispiel i In i o 1 der nach dem erwähnten Verfahren durch Uranylacetatfällung des Harns gereinigten Lösungen gießt man ¢o ccm einer gesättigten alkoholischen Lösung von Benzoesäure. Der entstehende Niederschlag wird abfiltriert und die Benzoesäure mit Alkohol und Äther herausgewaschen Beispiel 2 In io 1 Harn läßt man goo ccm gesättigte alkoholische Benzoesäurelösung unter Rühren einfließen. Der Niederschlag wird filtriert, getrocknet, mit Alkohol aufgenommen und wiederum filtriert. Der Rückstand wird mit schwachem Alkali gelöst und durch eine Säurefällung abermals um ein Mehrfaches gereinigt.In further processing it has now been found that the circulatory hormone is separated from the urine or from the aqueous solutions obtainable by the process of main patent 518 292 by adsorption on benzoic acid according to conventional methods and from the adsorbate obtainable after removal of the benzoic acid Extraction can be obtained by means of the solvents customary for this purpose. The yields of active substances that can be obtained depend on the nature of the starting material. It could be up to about 8o BC. H. of the active substance can be obtained in the manner mentioned. Since nothing more is known about the chemical structure of the circulatory hormone, the new way shown by the above-mentioned method for the production of this hormone, even if it makes use of known working methods, could not be foreseen in any way. The new process therefore represents a remarkable enrichment of the technology. EXAMPLE 1 In 10 1 of the solutions purified by uranyl acetate precipitation of the urine according to the process mentioned, ¢ o ccm of a saturated alcoholic solution of benzoic acid is poured. The resulting precipitate is filtered off and the benzoic acid is washed out with alcohol and ether. EXAMPLE 2 Goo cc of saturated alcoholic benzoic acid solution is poured into 10 1 urine while stirring. The precipitate is filtered off, dried, taken up in alcohol and filtered again. The residue is dissolved with a weak alkali and cleaned again several times over by acid precipitation.

Claims (1)

PATENTANSPRUCH: Abänderung des durch Patent 518 292 geschützten Verfahrens zur Gewinnung eines natürlichen, die Herztätigkeit und den Blutkreislauf beeinflussenden Stoffes aus Harn, dadurch gekennzeichnet, daß man diesen Stoff aus Harn bzw. aus den nach dein Verfahren des Patents 5 i 8 29s erhältlichen -wäßrigen Lösungen -,durch Adsorption an Benzoesäure nach an sich üblichen Methoden abscheidet und aus dem dabei erhältlichen Adsorbat die Benzoesäure durch Extrahieren mittels der dafür üblichen organischen Lösungsmittel entfernt.PATENT CLAIM: Modification of the process protected by patent 518 292 for obtaining a natural substance from urine which influences heart activity and blood circulation, characterized in that this substance is obtained from urine or from the aqueous ones obtainable by the process of patent 5 i 8 29s Solutions -, separated by adsorption on benzoic acid according to conventional methods and the benzoic acid is removed from the adsorbate obtainable by extraction using the organic solvents customary for this purpose.
DEF68002D 1926-08-20 1926-08-20 Process for the extraction of a natural substance from urine, which influences the cardiac activity and the blood circulation Expired DE545755C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEF68002D DE545755C (en) 1926-08-20 1926-08-20 Process for the extraction of a natural substance from urine, which influences the cardiac activity and the blood circulation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF68002D DE545755C (en) 1926-08-20 1926-08-20 Process for the extraction of a natural substance from urine, which influences the cardiac activity and the blood circulation

Publications (1)

Publication Number Publication Date
DE545755C true DE545755C (en) 1932-03-05

Family

ID=7110813

Family Applications (1)

Application Number Title Priority Date Filing Date
DEF68002D Expired DE545755C (en) 1926-08-20 1926-08-20 Process for the extraction of a natural substance from urine, which influences the cardiac activity and the blood circulation

Country Status (1)

Country Link
DE (1) DE545755C (en)

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