DE501503C - Process for the preparation of preparations with a tuberculin-like effect - Google Patents
Process for the preparation of preparations with a tuberculin-like effectInfo
- Publication number
- DE501503C DE501503C DEI31956D DEI0031956D DE501503C DE 501503 C DE501503 C DE 501503C DE I31956 D DEI31956 D DE I31956D DE I0031956 D DEI0031956 D DE I0031956D DE 501503 C DE501503 C DE 501503C
- Authority
- DE
- Germany
- Prior art keywords
- preparations
- tuberculin
- preparation
- effect
- coli
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title claims description 13
- 238000000034 method Methods 0.000 title claims description 6
- 229960001005 tuberculin Drugs 0.000 claims description 5
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229940046892 lead acetate Drugs 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Description
Verfahren zur Darstellung von Präparaten mit tuberkulinartiger Wirkung In dem Patent ¢87 199 ist ein Verfahren zur Darstellung von gereinigten Tuberkulinpräparaten beliebiger Herkunft beschrieben, welches darin besteht, daß die Ausgangspräparate einem Reinigungs- bzw. IsolierungsprozeG unterworfen werden.Process for the preparation of preparations with a tuberculin-like effect In the patent [87 199] there is a method for the preparation of purified tuberculin preparations of any origin, which consists in the fact that the starting preparations be subjected to a cleaning or isolation process.
Bei weiterer Bearbeitung dieses Gebietes wurde nun die Beobachtung gemacht, daß Präparate der Coli-Gruppe statt Tuberkulinpräparaten dem Verfahren des Hauptpatents unterworfen, zu Produkten führen, welche ebenso wie die Produkte des Hauptpatents eine ausgesprochene Tuberkulinwirh-ung zeige_Z und daher in der Diagnose und Therapie Verm endung finden können.With further processing of this area now the observation made that preparations of the Coli group instead of tuberculin preparations the procedure subject to the main patent, lead to products which, like the products of the main patent show a pronounced tuberculin virus and therefore in the Diagnosis and therapy can find common ground.
Beispiel 2o g eines Coli-Präparates verschiedener Herkunft, z. B. hergestellt aus einer Coli-Bouillon durch Alkoholfältung, werden in wäßriger Lösung mit Eisendialysat von Eiweiß befreit. Aus dem nötigenfalls eingeengten Filtrat werden die wirksamen Stoffe mit Pikrinsäure gefällt und die entstandenen Fällungen mit salzsäurehaltigem Wasser zerlegt. Aus den so gereinigten Lösungen können die wirksamen Stoffe, wie in dem Hauptpatent beschrieben ist, isoliert werden.Example 20 g of a coli preparation of various origins, e.g. B. produced from a coli broth by alcohol cold, are in aqueous solution freed from protein with iron dialysate. From the if necessary concentrated filtrate the active substances are precipitated with picric acid and the resulting precipitations with water containing hydrochloric acid. From the solutions purified in this way, the effective Substances, as described in the main patent, are isolated.
Zum gleichen Ziele kommt man, wenn man beispielsweise lnit Bleiacetat enteiweißt und das Blei mit Schwefelwasserstoff entfernt.One arrives at the same goal if, for example, one uses lead acetate deproteinized and the lead removed with hydrogen sulfide.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEI31956D DE501503C (en) | 1927-08-16 | 1927-08-16 | Process for the preparation of preparations with a tuberculin-like effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEI31956D DE501503C (en) | 1927-08-16 | 1927-08-16 | Process for the preparation of preparations with a tuberculin-like effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE501503C true DE501503C (en) | 1930-07-02 |
Family
ID=7188018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEI31956D Expired DE501503C (en) | 1927-08-16 | 1927-08-16 | Process for the preparation of preparations with a tuberculin-like effect |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE501503C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3826857A1 (en) * | 1988-08-08 | 1990-02-22 | Isg Kreutzer Import Und Servic | Drinking water filter unit |
-
1927
- 1927-08-16 DE DEI31956D patent/DE501503C/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3826857A1 (en) * | 1988-08-08 | 1990-02-22 | Isg Kreutzer Import Und Servic | Drinking water filter unit |
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