DE4408498C2 - Transfer device for medicine and pharmacy - Google Patents

Description

The invention relates to a transfer device for medicine and pharmacy according to the preamble of An saying 1.

Such a decanting device is known from US 3,935,883, in which an active substance concentrate container 14 , a syringe 12 and a metering pump 40 are connected to a T-shaped housing 21 . Even if this known device has the function of automatically filling the syringe 12 with a constant amount of an active substance from the active substance container 14 , this device could also be used for transferring an active substance concentrate from the active substance container 14 into a solution in the metering pump 38 and with the Solution can be used in the syringe 12 . The T-shaped housing 120 has a multi-way distributor 122 to 138 , which can produce a conveying path between the active substance container 14 of the metering pump 40 and between the metering pump 40 and the syringe 12 . The conveying path between the active substance container 14 and the syringe is closed by a membrane 136 and the conveying path between the metering pump 38 and the active substance container 40 is closed by a membrane 138 . Due to the T-shaped design of the housing 120 , it can, however, in the event of a malfunction of one of the membranes 136 , 138 lead to an undesirable passage of an albeit only a small amount of the active substance from the active substance container 14 to the syringe 12 or else to a return flow from the metering pump 38 come into the active substance container 14 or into a connecting element 15 .

From FR 1 187 268 a device for control or Preparation of various mixtures known. In this The publication describes two multi-way distributors that are manually adjustable via lever elements. One of Multi-way distributor has a bore with a 90 ° Angle and the other a T-shaped hole. With the more distributors with the right-angled hole can only two connection paths are established. With the multi-way  distributors with the T-shaped bore can simultaneously three connection paths are established.

EP 0 416 454 A2 describes a method and a device known to administer a drug. For this A housing is known in the prior art, on which an action fabric container and a removal container with a solution are closed. Via one of the housing ge separate connection to the tapping container, the solution with the active ingredient concentrate for administration to a patient ten can be removed.

From DE-PS 6 34 916 is a metering device for the one known components of dental amalgams, in which dosing via a cylindrical cock plug and a be limits rotatable tap housing.

CH 291 843 is a dosing device for liquids ten, especially for mercury, known to have a housing has, in which a piston depending on the Piston position open the inlet from an active substance container net or closes.

The one from EP 416 454 A2, from DE-PS 6 34 916 and from CH 291 843 known prior art only discloses one order Filling possibility in one direction, that is, on one Path. In addition, the from DE-PS 6 34 916 and CH 291 843 be did not know constructions for exact dosing nes drug concentrate formed in a solution. she sometimes have complicated, long conveying routes and dead crowds mina, which make precise dosing impossible. The Device from EP 416 454 A2 and the device from FR 11 87 268 are also designed to be very complex and therefore not quick and easy in practical use manageable.

The device known from US 3 935 883 has the disadvantage that in the case in which at least one of the membranes 136 , 138 is malfunctioning, a direct connection between the agent container and the syringe can be unintentionally present, so that an undefined amount of agent substance can get into the syringe in an uncontrolled manner and the dosage of the active ingredient concentrate in the solution increases. Such a malfunction of the membranes can also result in a return flow from the metering pump into the active substance container or into a corresponding connecting element.

This disadvantage can also be adjusted manually Multi-way distributor, as known from FR 11 87 268, cannot be fixed. With one corresponding to the multi-way distributor from US 3 935 883 T-shaped multi-way distributor with manually adjustable tap plug, in which one T-shaped bore is formed when turned upside down Rotate between a compound drug container ter / dosing pump and dosing pump / syringe always briefly also a connection between the drug container and the syringe produced. To prevent this, the direction of rotation would have to be be specified for technical reasons. A solution to beseiti This deficiency could be that disclosed in FR 11 87 268 deliver right angle cock chicks. With this are always only two different connection paths can be established. The manufacturer The connection of three connection paths is with such a tap chick not possible.

The object of the present invention is therefore an order filling device of the type mentioned to create the is structurally simple, with a subset and / or total amount of an active ingredient concentrate is refillable, safe to use and with the under Compliance with these properties between three connections three connection paths can be established in a controlled manner.

The object is achieved by the features of characterizing part of claim 1 solved.  

The arrangement of the connecting device according to the invention it is possible to use three different connection paths manufacture in a controlled manner and thereby ensure that always only two, but never three, connections with each other are connected. The security standard is thus for a Three-way transfer system increased or the high safety standard A two-way system is therefore also required for a three path system reached.  

The transfer device proposed according to the invention serves as a safety device during the transfer of aggressive-toxic active ingredient concentrates and he allows the preparation of mixed solutions, in particular with cytostatic therapies (chemotherapy) in the me medicine and pharmacy. It guarantees a herme table-closed system in which a dosed, si Safe and antiseptic transfer of drug con centers can take place. This will help you with the "multi-step handling" previously associated Pro bleme solved.

The fact that according to the invention in the outside sealed housing not only the filling device tion 'ent for the introduction of the dosing pump taken active ingredient in the carrier solution, son which also integrates a multi-way distributor the release of aerosols, dusts and residues  prevented. This multi-way distributor provides in its Housing up to three different, necessary for the respective workflow end conveyor or flow paths according to the given rhythm of work.

The housing is therefore according to the invention and with the Features of claim 2 preferably as a stationary Part of a switching device used, for example wise, d. H. in this embodiment rotatable is arranged. This gives you a rotati asymmetrical arrangement of a cock plug in the Ge house. The angled hole provided in it forms the vertex of each other tied funding channels. This creates a simple one Execution of the transfer device. It can u. a. their Affect disposal favorably. The one with this and Ad used in other embodiments of the invention apter let different embodiments of Filling devices, dosing pumps and dispensing devices directions to. In particular, the so far as Filling device serving vials against containers larger content to be exchanged, so far because of this size and / or dimension not manageable were cash.

It is to make work easier and to avoid The cockerel chick regardless of its automatic or manual Actuation with a display of the cock plug position Mistake. The features of claim 3 serve this purpose. This can be used to transfer the kinetic energy on the moving part of the multi-way distributor ning switching device simultaneously as a pointer that on the respective adapter is aligned, who uses the. In addition, it will be appropriate to ensure that the respective position of the distributor recorded until it is released and after rotation of the distribution a new connection is established. It will  with the features of claim 4 in a simple manner by sharing the housing for this purpose enough. Such embodiments can also be Manufacture plastic and as a disposable decanter for Hospitals at the bedside or in the hospital provide pharmacy.

It is also appropriate to be considerate of the use of puncture needles that you usually take in the adapters for the solution and active ingredient concentrations step container used. Depending on the situation the circumstances pressure increases or negative pressures in the Mixer or in the container occur in the Her disturb the position of the mixture. That avoids the out management form, which with its main characteristics paint the subject of claim 5 is by a loading ventilation of the multi-way distributor, e.g. B. ventilation of the single adapter. This can be described in detail Measure implemented with the features of claim 6 lichen. Here, the ventilation flows regardless of their direction of flow in the reverse not affect the atmosphere because they have air filters have to happen. These air filters can ins special hydrophobic to make the stick prevent toxic liquids.

The system of the mixer according to the invention loads also seal to the outside. With the characteristics of the An saying 7 is automatically prevented that parts of the Mixture or its components even if the adapters are free, become free. The one for this Check valves placed open the connector paths inside the mixer also automatically the given work rhythm. Such a mixer can be operated safely and without hesitation submit its disposal.  

The claim 10 describes a comparatively fold embodiment of the invention, which we only the rotationally symmetrical described Housing with the rotating distributor and the Includes adapters, the number and arrangement depending on the The requirements of the individual case can also be expanded can. Such an embodiment of the invention he leaves a shape that is as in claim 11 described positively in a holder under bring, d. H. in particular lets hang under unfavorable external conditions, such as on the sick bed, an ergonomically favorable handling of the Mi to reach schers. On the other hand, there are such forms not a prerequisite for realizing the invention tongue. So claim 12 describes an execution type of transfer device according to the invention, the instead of the rotary mobility of the multi-way distributor a translational movement for that part sees.

The details, other features and other advantages parts result from the following description of embodiments of the invention based on the Figures in the drawing; show it

Fig. 1 shows a first embodiment of the invention in top view,

Fig. 2 shows the object of Fig. 1 in side view,

Fig. 3 shows the object of Figs. 1 and 2 in section along the line AA 'of Fig. 2,

Fig. 4 shows the subject of FIG. 1 to 3 in größertem ver scale partly in section and in a side view;

Fig. 5 the tap, which is used in the embodiment according to FIGS. 1 to 4,

Fig. 6 is a plan view of the subject of FIG. 5,

Fig. 7 is a section along the line AA 'of FIG. 5,

Fig. 8 is a modified embodiment of the dung OF INVENTION substantially in the Fig. 4 corresponding representation,

Fig. 9 shows the subject of FIG. 8 in a section along the line AA ',

Fig. 10 shows the subject of FIG. 8 in a section along the line BB 'of Fig. 8,

Fig. 11 is substantially the subject of FIG. 5 in side view and partly in section,

Fig. 12 the tap for the embodiment of Fig. 11,

Fig. 13 is a section along the line AA 'of Fig. 12,

Fig. 14 is a plan view of the subject of FIG. 12,

Fig. 15 shows a section along the line BB 'of Fig. 12,

Fig. 16 is a schematic representation of the mixer in plan view, wherein the adapters are partially shown in section,

FIG. 16a is a metering pump in the form of a disposable syringe,

Fig. 16b detachable adapter for the active substance concentrate container in different sizes,

Fig. 16c detachable adapter for different carrier solution container

Fig. 17 corresponding schematically and substantially in the Fig. 16 top view of the assembly of the mixer and its assembly,

Fig. 18-sectional enlargement the subject of FIG. 17 in an off,

Fig. 19 shows the front view of a mounting of the transferring device,

Fig. 20 is a side view of the object of Fig. 19.

In Fig. 1, a decanting device is Darge, which has a multi-way distributor 1 in a closed housing 13 , which produces flow paths and connections in predetermined rotary positions. The interconnected flow paths are externally visible by hatching in Fig. 1 he. On the one hand, they open into a pipe socket 2 , which, due to its shape at 3, forms an adapter for the tight connection of a metering pump, for example in the form of a disposable syringe 12 . With the multi-way distributor 1 communicates another pipe nozzle 4 , the shape at 5 an adapter for the liquid-tight aseptic connection of a removal container 32 , which can be designed, for example, as shown in FIG. 17 as a liquid bag. In the position shown Darge a disposable syringe 12 shown in FIG. 17 can be used to transfer a quantity of active substance determined by the piston position into the removal container 32 .

The housing 13 carries a third pipe socket 8 which , due to its shape at 10, forms a liquid-tight adapter for a medicine bottle 31 ( FIG. 17) which contains an active ingredient.

The adapters 3 and 5 and 10 are designed so that they can accommodate certain and possibly also commercially available forms of removal containers 32 , active substance concentrate containers 31 and metering pumps.

The multi-way distributor 1 consists of a cock plug 1 ', which is cylindrical and is arranged so that its axis of rotation in the illustration of FIG. 3 extends perpendicular to the plane of the drawing and to the horizontal plane of the housing 13 , in which the flow paths 14 lead to the adapters described. The cock plug 1 'has for this purpose an angled bore 14 ' ( Fig. 7) which forms the apex of the 14 interconnected paths 14 in the valve housing in the respective rotational position of the cock plug 1 '. It is it clear that by rotation of the rotationally symmetrical accommodated in the housing 13 cock plug the Verbin extension of the active substance concentrate container 31 to the metering pump 12 for drawing a metered amount of active ingredient and then a compound of the dosing pump 12 can be produced by the removal device 32 into the bag which forms the removal container 32 to transfer the measured portion of the active ingredient. The cylindrical body of the cock chick 1 'is, as shown for example in Figs. 2 and 5 rotatably with a switch 20 a related party. This switch has two externally arranged levers 20 ', which serve as handles for rotating the cock plug and also form pointers, each of which is connected to two interconnected flow paths 14 and thus adapters 2 , 3 ; 4 , 5 ; 8 , 10 are directed. The switch 20 carries latches 19 , z. B. in the form of ball catches or plastic warts which, as shown for example from the top view in FIG. 6, cooperate with grids 19 'which are formed as recesses in the housing cover. In each of the predetermined positions of the cock plug 1 'cause these parts to release the rotation of the cock plug when the lever changed its position and a determination of the cock plug as soon as the bore 14 ' is aligned with the flow paths 14 out.

. In the illustration of Figure 3 shows the adapter 2, 3; 4 , 5 ; 8.10 shown in more detail. The adapter 2 , 3 is connected by the position of the valve housing 1 'with the angled bore 14 ' via the flow paths 14 in the housing Ge with a puncture cannula 15 which protrudes into a cylindrical sleeve which has clamping webs 18 . The fact that the outer end face of the sleeve projects beyond the tip of the puncture cannula provides protection against contact with the puncture cannula. The clamping webs 18 hold the neck of the bag 32 , which is connected to the adapter 4, 5 , in a form-fitting and / or force-fitting manner. The pipe socket 8 carries a sleeve 10 which has a further insertion needle 16 in its axis for the stopper of the active substance concentrate container 31 and whose neck holds with the help of a wall thickening 17 which is designed as a press fit. In FIG. 16b, the adapter shown there for effective are is playing in substance concentrate containers of different size, eluting with 9 the small size, 1 0 the mitt sized size and 1 1, the adapter for the active substance is concentrate container designated with the maximum volume. These adapters are compared in Fig. 16c, the adapter 5 ', 6 and 7 for the different sizes of Ent removal devices, which are provided in their embodiment as bags or bottles containing a carrier solution.

In a further embodiment of the invention, which is shown particularly in FIGS. 8 to 15, a ventilation is provided for there designated 24 in the tap cock plug housing 13. This Be ventilation has to Fig. 10 in the Hahnkükenpassung 39 in the housing 13, a circumferential ventilation groove 28 in the cylinder mantle of the plug and in accordance with the exporting approximately example several inwardly from leading connecting channels 26. Other channels 27 com communicate with the groove 26 and open into air inlet openings 22 of the housing 13th To the outside, these air inlet openings 22 are closed with air filters 23 . One of the air channels 27 opens into the annular groove 26 and into the cannula 25 , which is introduced into the stopper of the active substance concentrate container 31 . This creates an air pressure equalization to the outside and inside.

In the embodiment of FIG. 16, the pipe socket 2 , 4 and 8 are in one piece with adapters, which bear in the inner thread 30 , which are used as a screw connection ver.

As can be seen from the described embodiments, the various embodiments of the mixer have a lenticular housing 13 , which adapters 2 , 3 ; 4 , 5 ; 8 , 10 carries, which are offset by 120 ° on the circumference of the housing. The disposable syringe 12 is designed as a piston syringe with connecting thread and volume division and serves as a metering pump, while the remaining adapters for the active substance concentrate container 31 and the active substance receiving container 32 are provided. The switch 24 is arranged on one of the curved housing cover, while the housing body is also cylindrical in accordance with the cylindrical shape of the tap plug 1 '.

This results in a simplified mount 35 , which is shown in FIGS. 19 and 20. According to its basic structure, it consists of a base plate 34 and a stand, which is provided with pairs of pins 36 , each of which form a device in which the pipe socket can be inserted and then held firmly and / or positively.

Claims (9)

1. decanting device with a closed housing ( 13 ), which is designed to seal with three pipe sockets ( 2 ; 4 ; 8 ) and adapters ( 3 ; 5 ; 10 ), each of which has a flow path ( 14 ),
with a metering pump ( 12 ), an active substance concentrate container ( 31 ) and a removal container ( 32 ), each of which is connected to one of the pipe sockets ( 2 ; 4 ; 8 ) via one of the adapters ( 3 ; 5 ; 10 ), and
with a multi-way distributor ( 1 ), which is arranged in the closed housing ( 13 ) in relation to the pipe socket ( 2 ; 4 ; 8 ) and has an angled bore ( 14 ') which can be connected to two flow paths ( 14 ) , wherein the pipe socket ( 2 ; 4 ; 8 ) with the adapters ( 3 ; 5 ; 10 ) are arranged offset on the housing circumference,
characterized,
that the housing ( 13 ) is lenticular, the multi-way distributor ( 1 ) has a cock plug ( 1 '), in which chem the angled bore ( 14 ') is formed, and the arc angle between the adapters ( 3 ; 5 ; 10 ) 120 ° be. 2. Transfer device according to claim 1, characterized in that with the multi-way distributor ( 1 ) a switch ( 24 ) is rotatably connected, which forms at least one pointer directed to an adapter ( 20 ). 3. Transfer device according to one of claims 1 or 2, characterized in that the switch ( 24 ) grid ( 19 ) and the housing ( 13 ) Ra ster ( 19 '), which in predetermined positions of the multi-way distributor ( 1 ') with each other the setting and release of the rotation of the multi-way distributor ( 1 ') work together. 4. Transfer device according to one of claims 1 to 3, characterized in that the inside of the housing ( 13 ) has ventilation from the outside. 5. Transfer device according to one of claims 1 to 4, characterized in that the fit ( 39 ) of the housing ( 13 ) for the Mehrwegever divider ( 1 ') has a circumferential ventilation groove ( 26 ) and least one of these leading to the outside ventilation channel ( 27 ) with at least one air filter ( 23 ). 6. Transfer device according to one of claims 1 to 5, characterized in that the housing ( 13 ) and / or the adapter ( 2 , 3 ; 4 , 5 ; 8 , 10 ) in the flow paths ( 14 ) have check valves for controlling the flow direction . 7. Transfer device according to one of claims 1 to 6, characterized in that at least the removal container ( 32 ) in the adapter has egg ne puncture cannula ( 15 , 16 ). 8. Transfer device according to claim 7, characterized in that the piercing needles ( 15 , 16 ) are touch-proof by an extension of the adapter in question. 9. Transfer device according to one of claims 1 to 8, characterized in that for the housing ( 13 ) a mount ( 35 ) is provided which with one or more adapters ( 2 , 3 ; 4 , 5 ; 8 , 10 ) force and is form-fitting.