DE102009040016B4 - Device for the application of fluid medicaments - Google Patents

Abstract

Device (1) for administering fluid medicaments comprising an at least two-part mutually rotatable housing (6, 7) with a plurality of ports (11, 12, 13) and at least one fluid intake element, wherein a medicament via the fluid intake element at least from a first reservoir (2) removable and a second container via a hose connection (4) can be filled and wherein alternately connects a first passage with a second passage, a third passage parallel blocking and thereby an exposure of liquid in the environment is prevented, characterized in that a housing part (7 ) has a through bore (35) as an inner housing wall (33) and an integrally molded handle (10) and a housing part (6) has a cylindrical housing wall (30), wherein both are rotatably supported each other and the cylindrical housing wall (30) at least one first at right angles in the radial direction extending flow channel (50) and a second approximately 45 ° degrees to the radial direction extending flow channel (60), wherein the flow channels (50, 60) each open into a connection channel.

Description

The invention relates to a device for administering fluid medicaments, in particular cytostatics, comprising an at least two-part mutually rotatable housing having a plurality of terminals and at least one liquid receiving element, wherein a drug via the liquid receiving element at least from a first reservoir can be removed and a second container via a hose connection can be filled and wherein alternately a first passageway connects to a second passageway, a third passageway can be blocked in parallel, thereby preventing exposure of liquid to the environment.

Many medicinal products must be prepared in appropriate amounts before use, before they can be injected or perfused. Typically, these are liquid applications of drugs that are injected or infused directly via the intravenous route. In general, the commercially available drugs are available as solutions or emulsions. Drug solutions may be applied by adding suitable diluents, such as an isotonic saline, or may be administered by adding emulsifiers to an isotonic saline solution. The application and the dilution of medicaments are carried out in a conventional manner by means of syringes which are provided with a needle.

When a drug is to be dissolved in a liquid, a dilution solution is withdrawn from a corresponding container with a syringe and introduced into the container containing the drug. For this purpose, a septum is usually present on a medication container, which is pierced with a needle of the syringe. After adding a dilution solution to the drug, an injection device is then connected to the drug container or the containing dilution solution with drugs, using a syringe, removed from the drug container and injected the drug in solution.

Furthermore, it is possible that a removal of a drug solution from a container via so-called "spikes" takes place, wherein a dilution solution using a spike, which usually has two tips, can get into the container. In this case, the container containing the medicament is usually below a container containing a dilution solution, so that an inflow of the dilution solution can take place via the mandrel into the container containing the medicament. After dissolution of the drug in the container, a removal of the prepared solution via the mandrel is possible, wherein a hose can establish a connection between the mandrel and an injection device, for example a needle. If the drug solution is withdrawn from the container via a syringe, then the syringe can then be used to inject it at a suitable injection site.

However, the aforesaid route for diluting injectable medicaments, by handling open, sharp objects such as the spike or needle, creates an inherent risk of contamination of the environment which may come in contact with the drug. This is of particular concern when the use of hazardous, such as toxic, drugs is provided, as is done, for example, in the context of the treatment of cancer with cytotoxic drugs. In such a case, the medical staff handling the medicines will be exposed to the danger that an exposure of the medicament will exert an effect on the organism whose treatment will result in an effect which will be effective in the therapeutic treatment of the medicament Patients should be counteracted. Thus exposure to cytotoxic agents may cause a carcinogenic effect on the medical staff, which should be avoided at all costs.

Furthermore, devices are known from the prior art, which have in the removal of a drug from a container a hydrophobic filter which is suitable to prevent both the passage of aerosols to the outside, as well as the ingress of microorganisms inwards. However, such devices are not completely isolated since conventional devices simultaneously connect both the diluent solution container and the medicament container and allow subsequent withdrawal of the drug solution. Thus, after dissolution of the drug, a removal of the dissolved drug by another device, such as a syringe, take place, which brings with it the risk of contamination of the drug with the environment.

Furthermore, devices are known from the prior art in which an application of medicaments is made possible, in which the medicament is located within an evacuated container, which is connected via a valve with a syringe containing a diluting solution. To prepare a drug solution, the dilution solution is introduced into the evacuated container and the drug located there dissolved in the dilution solution. After mixing the drug with the solution for injection is about an adjustment of the valve position between container and syringe delivery of the drug solution to a desired injection site possible without having to re-puncture another container. However, such a prior art has the disadvantage that for the drug filling a separate container must be present, which withstands a negative pressure, whereby conventionally existing application devices for infusions with such a closed system can not be operated. It is therefore necessary a high expenditure on equipment, which precludes the use of such a device.

From the WO 91/18632 is a multi-way valve, comprising a six-port housing, a valve body and a finger grip known. The valve body has a flow channel inclined against the direction of extension of the valve body and a flow channel which is angled away at an angle of 120 ° in a plane perpendicular to the direction of extension of the valve body. Three ports each are arranged in a lower level and the other three in an upper level. A lower level terminal may be connected to a top level terminal with the flow channel inclined to the extending direction of the valve body. A disadvantage of this multi-way valve is its geometric configuration, which causes the multi-way valve is applied in a horizontal position and is therefore used for medical structures that do not need to be changed frequently. Furthermore, the connection of a reservoir with a drug with one of the connections due to the horizontal preferred position only via a hose connection is possible, resulting in volume losses of sometimes very expensive drugs.

The object of the invention is therefore to provide a device for the application of fluid drugs, which meets a high safety standard, has a sufficient density to prevent contamination and is compatible with injection devices of the prior art.

According to the invention the object is achieved in that a housing part has a through hole as the inner housing wall and a integrally molded handle and a housing part has a cylindrical housing wall, both are rotatably supported each other and the cylindrical housing at least a first at right angles in the radial direction flow channel and a second Having approximately 45 ° degrees to the radial direction extending flow channel, the flow channels each open into a connection channel. Further advantageous embodiments will be apparent from the dependent claims.

The device according to the invention has two corresponding housing parts, which are rotatably mounted one inside the other. For this reason, a housing part has a through hole as the inner housing wall, while the second housing part has a cylindrical housing wall, which is insertable into the through hole, so that a positive connection between the first and second housing part is formed. The inner housing walls of the two housing parts are protected to the outside by an outer housing, which are also provided either for rotatably moving a housing part relative to the other housing part or for connecting storage containers and connecting hoses via corresponding connection elements. In this case, the flow direction of the liquid (medicament) is determined via the inner housing walls. For this purpose, the inner cylindrical housing wall of the first housing part has at least one first flow passage extending at right angles in the radial direction and a second flow passage extending approximately at 45 ° to the radial direction. The two flow channels open into a connection, which is preferably integrally formed on the outer housing wall of the second housing part. Due to the possibility of rotation about a common axis of rotation of the two housing parts, it is therefore possible to alternately connect a first terminal to a second terminal and to block a third terminal in parallel thereto. Thus, there is an influence on the direction of flow of the liquids to be picked up and forwarded, in particular of a fluid medicament. Depending on the position of the cylindrical inner housing wall opposite the through-bore of the inner housing wall of the second housing part, a liquid (fluid) can thus reach the connections alternately via the flow channels. At the same time, the other flow channel is closed in each case when both housing parts are rotated relative to one another by 90 ° and the previously blocked flow channel is opened and the open flow channel is closed. Thus, alternately a connection of two flow channels can be opened and closed, whereby a liquid with changing flow direction passes from one flow channel to another flow channel. Thus, a controllable filling and / or removal of liquids from storage containers is possible, which can be connected to the device (three-way valve), wherein the filling and removal of liquids via the existing connections and a liquid receiving element is possible. To the trained Connections and the liquid receiving element can be connected directly or through adapters or hose connections to reservoirs with liquids and / or containers for liquid absorption, so that the filling or removal of a liquid depending on the position of the device from two interconnected containers is possible, wherein for removal preferably a can be connected to a port syringe, with which the liquid from a container, for example via a spike, is sucked in and after rotation of the device in another container, such as an infusion container, can be dispensed. In order to ensure the removal of the liquid from the reservoir, in this case preferably by means of the syringe in the reservoir, an overpressure can be generated, which is created by the fact that first sucked air via a filter unit with the help of the syringe and then discharged directly into the reservoir. The removal of liquid from one or more storage containers is in this case several times possible, so that a mixing of drugs in liquid form can take place and thus, for example, by adding several liquids in a connected container this can be supplied a cocktail of medicines.

Due to the design of the two housing parts with a through hole as an inner housing wall or a cylindrical inner housing wall, there is the advantage that a simple assembly of the housing parts can take place and a large sliding surface is formed between the housing parts. By the sliding surfaces in this case tilting of the housing parts is avoided during assembly and at the same time a sealing surface formed by a sliding fit, which prevents leakage of liquid.

In an embodiment of the invention, it is provided that the outer housing wall of a housing part has at least one Luer connection for the removal of a medicament from at least one storage container and a further Luer connection for the filling of a second container. To remove a drug from a reservoir in this case a piercing spike is used, which is formed directly connectable to the Luer connector and is additionally protected by a protective cap to avoid injury. After removal of the cap, this piercing spike is introduced into the reservoir and remains in this reservoir until it is completely emptied. In contrast, a second Luer connector for a syringe and a third Luer connector for connection, for example, with an infusion bag, is provided, which is connected directly via a hose with end Luer fittings with the device. Thus, depending on the position of the two housing parts sucked air to each other and pressed after rotation of the two housing parts in the reservoir, then the drug is sucked from the reservoir and pressed after re-twisting of the two housing parts via the second flow channel into the connecting line. In order to facilitate this procedure, in a first position of the corresponding inner housing wall, an axial passage to a suction filter is released to suck air and to press in a second position in the reservoir and to allow the removal of a drug from a reservoir. In a third position, a radial passage channel for filling an infusion bag is released. The respective other passage channel is blocked in this case, so that inadvertent leakage of the liquids from an open connection piece or in an undesired flow direction is avoided.

In a particular embodiment of the invention, it is provided that the first housing part is constructed in two parts and protrudes at both ends of the housing part and merges into a hollow-walled turntable. Due to the two-part design of the housing part, it is possible to introduce a first housing part in the existing through hole of the second housing part and then set up the second part of the first housing part on the protruding housing part. Preferably, in this case, the first housing part end consists of a respective hollow-walled turntable, which allows a manual handle of the three-way valve, in which the turntable can be further rotated stepwise at least in a preferred direction relative to the second housing part. A first turntable is in this case integrally connected to the inner cylindrical housing wall, which has at its free end a rotary lock, for example a hexagon. A second turntable is equipped with a corresponding lock, which can be fixed to the free end of the cylindrical housing by means of a clamp or screw. Thus, the first housing part can be inserted into the second housing part and connected by the two outer slewing rings in such a way that a captive assembly is formed. The design of the two slewing rings also makes it possible, regardless of whether the operator is a right-handed person or a left-handed person to use the device or the three-way valve in its preferred handling, so that either the left or the right turntable for further rotation of the first housing part relative to the second housing part can be used.

In order to create a compact unit and to ensure sufficient tightness of the two housing parts, it is further provided that the two slewing rings take up the second housing part encompassing, wherein the inner and outer housing wall are at least partially enclosed. Thus, the second housing part is captively fixed by the housing part, at the same time a readily available rotary motion is made possible by the existing through hole and the cylindrical extension of the first housing part, without jamming or tilting of the two housing parts could occur against each other.

In a further particular embodiment of the invention it is provided that the two slewing rings have a plurality of circumferentially distributed and inner recesses, which correspond with locking lugs of the second housing part. By the locking recesses and locking lugs is thus ensured at a rotation of the two housing parts that exactly the next rotational position has been reached. Reaching the user of the three-way valve can be clearly felt by the engagement of the locking lug. In a preferred embodiment, the latching recesses and latching lugs are designed such that a rotation can take place only in a preferred direction. This ensures that successive individual operations can be performed, for example, aspiration of air and increase the pressure in the reservoir, removal of the liquid and delivery of the liquid to a connected container, such as an infusion bag. As a further aid to the user of the three-way valve is provided in an advantageous manner that the two turntables circumferentially distributed on the outside, preferably offset by 90 ° degrees, have different markings. With the aid of the markings, the user can thus always check in which position the three-way valve is currently in order to carry out the next work step. The respective offset by 90 ° degrees arranged marks correspond in this case directly with the respective latching steps of the two housing parts.

The two slewing rings of the first housing part can in this case be round or polygonal with rounded edges, so that a good grip is guaranteed and due to the existing size of the slewing rings a small amount of force sufficient. Inadvertent rotation of the two housing parts is hereby prevented on the one hand and on the other hand ensures a smooth running, so that with normal force application, a rotation can be done.

In a further embodiment of the invention, it is provided that the second housing part consists of an inner and outer cylindrical housing wall, wherein the two housing walls are connected to each other via radial braces, which simultaneously accommodate the flow channels. The present embodiment of the second housing part advantageously enables the production by an injection molding process and, moreover, a stable embodiment for the second housing part is achieved with the least possible expenditure of material. For better handling is further provided that on the second housing part, a handle, preferably in one piece, is formed. The handle serves to hold the device during the execution of the individual steps, in particular during rotation of the first housing part relative to the second housing part. Furthermore, the second housing part has a plurality of radially protruding connections, which are arranged in extension of the inner struts and extend the flow channels in the radial direction. The braces thus not only serve to connect the inner and outer casings of the second housing part, but in addition they also fulfill the purpose of liquid transport, since the flow channels are formed in these struts. This measure, in turn, ensures that a low-cost construction is achieved with low-cost material and simple production methods. The protruding connections consist of so-called Luer connections, which are either provided with a captive union nut or have a Luer thread, so that a nut can be screwed onto the Luer connection. For example, the protective cap for the piercing spike can be fixed by means of a union nut on the existing Luer connection. As far as the Luer connections have a thread, it is possible to screw a commercially available syringe or a connecting hose directly to the Luer connection, so that a liquid-tight connection to the device, that is, the three-way valve can be made.

In a further embodiment of the invention, it is provided that a bottle adapter is used to connect a storage bottle, which is cup-shaped. The connection adapter hereby has at least two support feet, which come to bear abutting directly on the device. This measure serves to be able to safely intercept even larger weights of a possible reservoir and also to avoid damage to the reservoir or the device when handling the device and in particular to prevent a discontinuation of the attached reservoir. Of the Bottle adapter is firmly connected in this case with the reservoir, wherein the bottle adapter on the pot-shaped side to the reservoir has circumferentially distributed a plurality of slots. In addition, the bottle adapter has an annular, interrupted by the slots collar which lays around the neck of the bottle. Thus, it is ensured that the bottle adapter is positively placed on the reservoir and together with this forms a captive unit. After connection to the device via a Luer connection is thus a screwed connection between the reservoir and the device, so that in this way it is also ensured that no liquid from the reservoir can inadvertently get into the environment.

In a further embodiment of the invention, it is provided that a connection is connected to a filter unit which consists of a filter material and a non-return spring acting in one direction. The filter unit is in this case preferably arranged in the hollow-walled handle and allows the suction of air through a connected syringe. The sucked air is in turn added to the reservoir before it comes to the removal of the liquid. To ensure that no liquid can enter the environment in a later process step or the sucked air, the filter unit has next to the filter material a check spring, which works only in one direction. In the present case, the return spring allows suction of air, but prevents the pressurized air with the help of the syringe, the air can escape through the filter back into the atmosphere.

The connection of an infusion bag is preferably via a hose connection which can be fixed at one end to the device by means of a Luer connection, while at the other end the hose connection has a connection adapter which has an elastic protective cap for a puncture spike used for the transfer of fluid for protection against injuries. The reservoir for the liquid may for example consist of an ampoule or a glass bottle, while the delivery is carried out in a second container, which is preferably designed as an infusion bag. Known infusion bags in this case have two connections, wherein at least one connection for receiving a piercing spike serves as a connection adapter, while another connection can be configured as a pressure relief valve. As far as different reservoir sizes are used, additional adapters may be provided to permit removal of fluids from these reservoirs to be delivered directly to the three-way valve.

In a particularly preferred embodiment of the invention, provision is made for one or more devices to be used in a serial arrangement, so that, for example, a medicament cocktail from different storage containers can be supplied to an infusion bag. For this purpose, two or more devices, if necessary, are connected in series with one another via the Luer connections and the respective medicaments are taken out of the storage containers one after the other and transported via the existing flow channels to the infusion bag.

The present invention is thus characterized by its simple design and manageability, it being ensured in any case that after receiving the drug from a reservoir no liquid is discharged to the environment and beyond no possibly contaminated with the drug air into the environment arrives. It is therefore assumed that the system is closed. This is ensured by first using the syringe air sucked through a filter with a check valve and then discharged into the reservoir. This creates an overpressure in the reservoir, which makes it possible, with the help of the syringe, after a rotation of the three-way valve is carried out to remove a desired amount from the reservoir. After further rotation of the three-way valve, a connection channel is opened to a further connection, to which, for example, a hose connection of an infusion bag is connected. Thus, the drug in the syringe can be delivered via the flow channel and the connecting tube into the infusion bag. Depending on the amount of the proposed drug, this process can be repeated several times with the same drug or it can be taken from different reservoirs medication and fed to the infusion bag, as far as an exchange of the reservoir takes place. Alternatively, multiple three-way valves arranged in series may be used to deliver various medicaments into the infusion bag.

The invention will be explained again with reference to the figures.

It shows

1 in a perspective view of the device according to the invention,

2 in a perspective exploded view of the device according to 1 .

3 in a sectional perspective view of the device in the assembled state in a first rotational position,

4 in a sectional perspective view of the essential elements of the device according to the invention,

5 in a perspective view, a first housing part,

6 in a sectional view that first housing part according to 5 .

7 in a further sectional view that first housing part according to 5 .

8th in a perspective view, the second part of the first housing part,

9 in a perspective view that second housing part,

10 in a perspective view that second housing part with attached Luer nuts,

11 in a sectional perspective view of the second housing part according to 9 .

12 in a further sectional perspective view of the second housing part according to 9 .

13 in a perspective view, a connection adapter for the reservoir,

14 in a perspective view of a filter unit for use with the device according to the invention,

15 in a perspective exploded view of the filter unit according to 14 .

16 a stinger and

17 a protective cap for the piercing spike.

1 shows in a perspective view of the essential components of a device 1 with other components for connecting a storage container 2 and an infusion bag 18 are provided. In the device according to the invention 1 it is a so-called three-way valve, which is the flow direction of a liquid from a reservoir 2 first in an injection 3 and from the syringe 3 via a hose connection 4 and a connection adapter 5 in an infusion bag 18 allowed.

The device 1 consists of two housing parts, namely a first housing part 6 and a second housing part 7 , which are rotatably mounted in each other and with the aid of a turntable 8th . 9 allow a rotation against each other. The first housing part 6 is here in a second housing part 7 with a handle 10 recorded, so a good handling of the device 1 is possible. Over several circumferentially formed Luer connectors 11 . 12 . 13 the second housing part is the connection with the other components. This is the syringe 3 pointing to the luer connector 11 screwed with thread. The luer connector 12 also has a thread to a protective cap for a lying in the cap piercing 42 with the help of a union nut 15 set. The piercing spike 42 Here is a snug fit in the Luer connector 12 stored. After removing the protective cap can be a bottle adapter 16 with the help of the union nut 15 at the device 1 be attached. The bottle adapter 16 was previously with the reservoir 2 connected so that the reservoir 2 captive with the device 1 can be screwed. About a luer connector 13 and a union nut 17 the connection of a connecting hose takes place 4 , which at the other end via the connection adapter 5 with an infusion bag 18 can be connected. The connection adapter 5 consists of a basic body 28 with diametrically opposed, pivotally arranged brackets 19 . 20 and one through a protective cap 21 Concealed piercing spike 42 , In extension of the piercing spike is a Luer connector 22 present, so a connection via a union nut 23 with the connection hose 4 can be done. By squeezing the two clamps 19 . 20 can the piercing spike 42 be pressed into the infusion bag and after releasing the two staples 19 . 20 becomes with the hackenförmigen ends a grasping of the connection 26 of the infusion bag 18 allows, so that slipping can be excluded. The infusion bag 18 serves to accommodate an infusion solution, which can be additionally mixed with the drug. For connection of the connecting hose 4 to the connection adapter 5 is the connection 26 provided, which offers the possibility not visible from this drawing figure piercing spike through a rubber membrane in the infusion bag 18 stab. About another connection 27 It is also possible to connect additional adapters, or this connection 27 is equipped with a check valve, so that an overpressure from the infusion bag 18 can escape.

Furthermore, to the device according to the invention 1 a filter unit 25 connected, which is the suction of air through the syringe 3 allows. The sucked air serves, with the help of the syringe 3 the air in the reservoir 2 to push it into the reservoir 2 an overpressure arises. Only with the pressure in the reservoir 2 there is a possibility of taking the drug from the reservoir 2 by means of the syringe 3 Remove by suction. For this it is imperative that the reservoir 2 next to the drug has an air cushion, which by means of the syringe 3 can be put under pressure. For manufacturing reasons, the storage bottles 2 never be completely filled, so that below the filling opening will always form an air cushion, which in connection with the device according to the invention 1 can be used to remove the drug after an overpressure has been achieved. The peculiarity of the present device according to the invention 1 is that, as in 1 shown, a closed system, which after connection of the reservoir 2 with the help of the bottle adapter 16 and after connection of the infusion bag 18 with the help of the connection hose 4 and the connection adapter, as well as the required syringe for liquid transport and the device according to the invention 1 is trained. As far as to generate the overpressure in the reservoir 2 Air must be sucked, this is done by the filter unit 25 which has a check valve, so that although air sucked into the system, but can not be discharged to the outside.

The essential details of the device according to the invention 1 will be explained again in detail with reference to the following figures, wherein substantially the first and second housing part 6 . 7 as well as the design of the bottle adapter 16 will be shown. The housing parts 6 . 7 are shown in different sectional views to explain the operation.

2 shows in a perspective exploded view of the main components of the device according to the invention 1 , This is the first housing part 6 , which consists of a cylindrical housing wall 30 with a turntable 8th exists, with the turntable 8th is preferably integrally connected to the cylindrical housing wall. Furthermore belongs to the first housing part another turntable 9 , which has a hexagon 31 on a hexagonal molding 32 can be placed, wherein by means of a clamping mechanism or optionally by means of a screw connection of the two parts of the first housing part 6 can be done. The first housing part is picked up 6 in the second housing part 7 , which consists of an inner housing wall 33 and an outer housing wall 34 consists. The inner housing wall 33 has a through hole 35 on, so that the cylindrical housing wall 30 of the first housing part 6 into the through hole 35 can be introduced. Circumferentially distributed are located on the second housing part 7 several luer connectors, one of which is a first luer connector 12 and a second luer connector 13 are each shown with a union nut. Another Luer connector is hidden behind the second housing part 7 , To the housing part 7 is a handle 10 , which is hollow-walled and has the shape of a circular ring segment, integrally formed. Inside the handle 10 is a connection piece 36 of the second housing part 7 on which a filter unit 25 can be put on. The filter unit 25 consists of a valve cap 37 , a valve disc 38 , a valve and filter housing 39 , a filter disc 40 and a filter cap 41 , With the help of the valve cap 37 becomes the filter unit 25 on the connection 36 undetachably and clamped attached. About the filter unit 25 there is the possibility of having a connected syringe on the luer connector 13 Add air from the environment and then into a reservoir, which preferably via the Luer port 12 is connected to deliver. Following this, the liquid can be sucked out of the reservoir with the help of the syringe and after twisting the two housing parts 6 . 7 the device 1 to the Luer connection 13 for delivery to an infusion bag. From the 2 is further seen that the luer connector 12 for receiving a piercing spike 42 is provided, which by a protective cap 14 with threaded neck 43 on the second housing part 7 the device 1 can be screwed on. After removal of the protective cover 14 can be a bottle adapter 16 with the help of the union nut 15 on the second housing part 7 the device 1 be determined. A closer description of the bottle adapter 16 is out 13 refer to. The filter unit 25 is in 14 and 15 shown while the two housing parts 6 . 7 will be explained in detail in the following figures.

3 shows in a sectional perspective view of the 1 known device 1 without connecting hose and connection adapter. From this view, the second housing part 7 recognizable in cut form, as well as a part of the first housing part 6 with turntable 8th and cylindrical housing wall 30 , The rotational position of the two housing parts 6 . 7 each other opens a flow channel 50 passing through a radially extending and rectangular angled flow channel section 50a the cylindrical housing wall 30 and a flow channel section 50b and 50c is formed, wherein the flow channel sections 50b and 50c in the radial struts 51 . 52 of the second housing part 7 are formed. The struts 51 . 52 connect the inner housing wall 33 With the outer housing wall 34 of the second housing part 7 , To the second housing part 7 is the handle 10 formed, which is seen only on one side due to the cut representation. Inside the handle 10 lies the filter unit 25 , which have a connection piece 36 with the second housing part 7 connected is. Typically, a press fit is chosen here. At the Luer port 11 of the second housing part 7 is an injection 3 connected with a piston while on the connector 12 a reservoir via a bottle adapter 2 connected. A stinging thorn 42 , which in the connection 12 held over a press fit, protrudes into the interior of the reservoir 2 , The bottle adapter 16 Here is a union nut 15 with the second housing part 7 screwed so that a secure attachment is guaranteed. The luer connector 13 with union nut 17 also serves to connect a connecting hose 4 which is not shown in this figure. The rotational position of the turntable 8th of the first housing part 6 opens the flow channel 50 so in a first step with the help of the syringe 3 and the piston 54 Air from the atmosphere through the filter unit 25 can be sucked. A subsequent rotation of the turntable 8th then allows a connection of the syringe 3 with the reservoir 2 so that the sucked air to generate an overpressure in the reservoir 2 can be pressed. Thereafter, the liquid from the reservoir 2 sucked and thus enters the syringe 3 , Another turn of the turntable 8th then make a connection of the syringe 3 with the luer connector 13 Her, so the drug on the Luer connector 13 and the connected connection hose can be dispensed into a further container, wherein the further container is usually an infusion bag. Depending on the amount of required drug, this process can be repeated several times, with multiple devices 1 can be arranged one behind the other and directly to the Luer connector 13 so that, if necessary, different drugs can be delivered as a cocktail of medications in the infusion bag. The entire arrangement of the device according to the invention 1 is intended for single use until the drug from the reservoir 2 is used up. For this reason, the connection between the reservoir needs 2 and the second housing part 7 after penetrating the piercing spike 42 through a rubber membrane 55 of the storage container 2 not to be removed. Likewise, the syringe 3 not from the luer connector 11 removed and the connecting tube from the luer connector 13 so that a closed system until emptying the reservoir 2 is present.

4 shows in a sectional perspective view of the device 1 with syringe 3 and piercing spike 42 , The syringe 3 is at the luer port 11 attached and screwed onto the existing Luer thread while the piercing spike 42 in a press fit of the Luer connector 12 is included and a union nut 15 is provided for attachment of the protective cap or the bottle adapter. The sectional view clearly shows how the first housing part 6 in the second housing part 7 is received and in particular, that the first housing part 6 from an inner housing wall 30 with integrally formed turntable 8th and a second turntable 9 consists. In contrast, there is the second housing part 7 from an outer cylindrical wall 34 and an inner cylindrical wall 33 , In the illustrated rotational position of the first housing part 6 opposite the second housing part 7 becomes a flow channel 60 formed, which consists of a running at an angle of 45 degrees flow channel section 60a in the cylindrical housing wall 30 of the first housing part 6 and a flow channel section 60b such as 60c consists, wherein the flow channel sections 60b and 60c in the struts 52 of the second housing part 7 are formed. The illustration of the syringe 3 corresponds in this illustration a position after the air has been discharged into the reservoir, not shown, generating an overpressure. In the next step, the liquid is sprayed using the syringe 3 sucked out of the reservoir and can then after a rotation of the first housing part 6 opposite the second housing part 7 be forwarded to another Luer connector to which a connection tube can be connected to the infusion bag.

5 shows in an enlarged perspective view a part of the first housing part 6 with the turntable 8th and the cylindrical housing wall 30 , The turntable 8th is square in the embodiment shown with rounded corners and has on its outer side circumferentially distributed by 90 degrees offset markings 61 on. On the inside at the height of the markings 61 are recesses 62 , which for receiving a latching lug of the second housing part 7 are provided. Due to the formation of this recess 62 and the corresponding latching lugs can thus the first housing part 6 only in one direction within the through bore of the second housing part 7 to be twisted. This ensures that the various steps are performed one after the other in the correct order. The cylindrical housing wall 30 has a flow passage section 45 degrees to the radial direction 60a on, as well as a radial direction at right angles angled flow channel section 50a , With the help of flow channel sections 50a . 60a connects to the various luer terminals of the second housing part 7 manufactured and thus allows depending on the selected rotational position, a transport of the liquid or the drug. For locking the two parts of the first housing part 6 has the cylindrical housing wall 30 a hexagon at the end 63 on, which in a corresponding recess of the second turntable 9 can be used, wherein by a jamming or possibly a screw securing the two parts of the first housing part 6 is guaranteed.

6 shows in a sectional perspective view of the housing part 6 according to 5 , from this sectional view it becomes clear that the turntable 8th is executed hollow-walled and the cylindrical housing wall 30 for receiving the flow channel sections 50a and 60a is provided.

7 shows in a perspective sectional view of the 5 known part of the first housing part 6 in a further sectional view and that in the radial direction through the cylindrical housing wall 30 at the level of the flow channel section 50a , from which it can be seen that this is formed at right angles in each case extending in the radial direction.

8th shows in a perspective view of the second turntable 9 with hexagonal recess 64 , which for receiving the hexagon of the second housing part with turntable 8th is provided. This turntable has circumferentially distributed around 90 degrees offset markings 65 on, however, are in this turntable 9 no recesses formed. The two turntables 8th . 9 are each about a leadership approach 66 respectively 67 in the cylindrical bore of the second housing part 7 guided and rotatably supported, wherein due to a corresponding fit accuracy inadvertent leakage of the liquid in the region of the contact points of the first and second housing part 6 . 7 can be excluded.

9 shows in a perspective view of the second housing part 7 with outer housing wall 34 and inner housing wall 33 and handle 10 , The inner housing wall 33 at the same time forms the through hole 35 so that the first housing part 6 in the second housing part 7 can be inserted accurately. Circumferentially distributed are located on the outer housing wall 34 the luer connectors 11 . 12 . 13 , which are partially provided with a Luer thread. From this detailed description it can be seen further that circumferentially distributed two locking lugs 70 integral with the second housing part 7 are connected. The locking lugs 70 are in a corresponding arrangement to the recesses of the first housing part 6 designed so that, as already stated, the two housing parts 6 . 7 only in one direction of rotation can be rotated against each other.

10 shows the off 9 known view of the second housing part 7 with union nuts 15 . 17 ,

11 shows the off 9 known shape of the second housing part 7 in a sectional view and that in the radial direction at the height of the Luer connections 11 . 12 and the connecting piece 36 , From this illustration it can be seen that the luer connectors 11 . 12 with a flow channel section 50b . 50c which correspond to the luer terminals 11 . 12 are arranged, in the cylindrical through hole 35 lead. Offset in the axial direction also opens the Luer connector 13 in this through hole 35 so that depending on the respective rotational positions in each case a connection between two Luer connections by means of the first housing part 6 can be produced. The connecting piece 36 has a flow channel section 71 , which also in the through hole 35 empties.

12 shows in a further sectional view of the second housing part 7 , at the level of the Luer connector 13 which is provided in the present case for connecting a connecting hose. Also, the flow passage formed here opens into the through hole 35 ,

13 shows the bottle adapter 16 which has a cylindrical connection 80 with luer thread 81 directly with the second housing part 7 can be screwed through the union nut. For supporting the bottle adapter 16 are two radial braces 82 provided, which with a rounded top 83 directly on the outer housing wall 34 of the second housing part 7 to come to rest. On the upper side, the bottle adapter 16 a cup-shaped formation, which by axialverlaufende slots 84 is interrupted, so that the individual segments are pressed resiliently outward when the bottle adapter 16 is placed on the reservoir. Furthermore, the individual elements point between the slots 84 an inwardly projecting collar 85 on, which lays directly around the bottleneck of the reservoir and thus prevents slipping.

14 shows the filter unit 25 in a perspective view, the items of the filter unit 25 from the following 15 can be seen.

15 shows in a perspective exploded view of the filter unit 25 with their individual parts and that a valve cap 37 with a connector 91 , which for pressing in the connection piece of the second housing part 7 is provided. The valve cap 37 serves to accommodate a valve disc 38 , a valve and filter housing 39 , a filter disc 40 and a filter cap 41 , where the valve cap 37 and the valve and filter housing 39 as well as the filter cap 41 be pressed together and overall the filter unit 25 result. The filter disc 40 allows cleaning of the aspirated air by means of the syringe, while the valve disc 38 is designed as a check valve and an air inlet only from below through an opening 92 allows. The valve disc 38 gets into a recess 94 of the valve and filter housing 39 used, with a centric elevation with a sealing edge 95 is trained. The valve disc 38 itself consists of an annular body 96 , with axial slots 97 that the annular body 96 subdivide into segments. In the center of the valve disc 38 there is a spherical membrane 98 , which at the sealing edge 95 comes to the plant. During aspiration of air, the membrane becomes 98 from the sealing edge 95 lifted and at an overpressure against the sealing edge 95 pressed so that the function of a check valve is met.

16 shows in a side view of the 2 . 3 and 4 known piercing spike 42 ,

17 shows the off 2 known protective cover 14 for the piercing spine 42 , which with the help of a Luer thread 99 and the union nut, not shown, can be attached to the second housing part. The plug-in spike 42 serves directly to remove the liquid from the reservoir, the protective cover needs to be removed only once from the piercing spike and after pressing the piercing spike into the reservoir by means of the bottle adapter 16 a firm connection between the reservoir and the second housing part is made via a Luer gland.

The present invention is characterized in that a closed system is formed, wherein by means of a syringe 3 via a filter unit 25 First air can be sucked in and at the same time be cleaned and it is ensured with the help of a check seal, that upon actuation of the syringe 3 depending on the different rotational positions of the two housing parts 6 . 7 no air can escape to each other. Depending on the rotational position of the two housing parts 6 . 7 Thus, air can first be sucked from the atmosphere and then released after rotation by 90 degrees to produce an overpressure in the reservoir. In the subsequent step can from the reservoir liquid using the syringe 3 are removed and then after rotation by 90 degrees, the liquid absorbed via a further flow channel to a Luer connection are given, that is, via a connecting line, such as an infusion bag, are supplied. The entire assembly is intended for single use, until the reservoir is used up. In the event that a cocktail of medicines is required, a double or optionally triple arrangement of this device can be used in a serial arrangement, so that the medication can be taken from different storage containers in succession and delivered via the connecting line to the infusion bag.

LIST OF REFERENCE NUMBERS

1

contraption

2

reservoir

3

syringe

4

hose connection

5

connection adapter

6

housing part

7

housing part

8th

slewing ring

9

slewing ring

10

handle

11

Luer connector

12

Luer connector

13

Luer connector

14

protective cap

15

Nut

16

bottle adapter

17

Nut

18

infusion bag

19

clinch

20

clinch

21

protective cap

22

Luer connector

23

Nut

24

The End

25

filter unit

26

connection

27

connection

28

body

30

housing

31

hexagon

32

Sechskantanformung

33

housing

34

housing

35

Through Hole

36

spigot

37

valve cap

38

valve disc

39

Valve and filter housing

40

filter disc

41

filter cap

42

Einsteckdorn

43

threaded extension

50

Flow channel

50a

Flow channel section

50b

Flow channel section

50c

Flow channel section

51

brace

52

brace

54

piston

55

rubber membrane

60

Flow channel

60a

Flow channel section

60b

Flow channel section

60c

Flow channel section

61

marks

62

recesses

63

hexagon

64

recess

65

mark

66

leadership approach

67

leadership approach

70

locking lugs

71

Flow channel section

80

connection

81

Luer thread

82

struts

83

essay

84

slots

85

collar

91

connector

92

opening

94

recess

95

sealing edge

96

annular body

97

slot

98

membrane

99

Luer thread

Claims (25)

Contraption ( 1 ) for the application of fluid medicaments comprising an at least two-part mutually rotatable housing ( 6 . 7 ) with several connections ( 11 . 12 . 13 ) and at least one liquid receiving element, wherein a medicament via the liquid receiving element at least from a first reservoir ( 2 ) and a second container via a hose connection ( 4 ) and wherein alternately a first passageway connects to a second passageway, a third passageway can be blocked in parallel, thereby preventing an exposition of liquid into the environment, characterized in that a housing part ( 7 ) a through hole ( 35 ) as inner housing wall ( 33 ) and an integrally molded handle ( 10 ) and a housing part ( 6 ) a cylindrical housing wall ( 30 ), wherein both are rotatably mounted in each other and the cylindrical housing wall ( 30 ) at least a first right-angle radially extending flow channel ( 50 ) and a second approximately at 45 ° to the radial direction extending flow channel ( 60 ), wherein the flow channels ( 50 . 60 ) each lead into a connection channel. Contraption ( 1 ) according to claim 1, characterized in that at least one connection ( 11 . 12 . 13 ) for the removal of a medicament from at least one first reservoir ( 2 ) and another for the filling of a second container ( 18 ) is trained. Contraption ( 1 ) according to claim 1 or 2, characterized in that in a first position of the corresponding inner housing walls ( 30 . 33 ) an axial passage for the removal of a drug from a reservoir ( 2 ) is released and in a second position, a radial passage for filling an infusion bag ( 18 ) is releasable. Contraption ( 1 ) according to one of claims 1, 2 or 3, characterized in that at least one housing part ( 6 . 7 ) an inner ( 33 ) and an outer housing wall ( 34 ) having. Contraption ( 1 ) according to one of claims 1 to 4, characterized in that the first housing part ( 6 ) is constructed in two parts and at both ends of the second housing part ( 7 protrudes and into a hollow-walled turntable ( 8th . 9 ) passes over. Contraption ( 1 ) according to one of claims 1 to 5, characterized in that a turntable ( 8th ) integral with the inner cylindrical housing wall ( 30 ), which at its free end a rotational lock, such as a hexagon ( 32 ), and that a second turntable ( 9 ) equipped with a corresponding lock and on the free end of the cylindrical housing ( 30 ) can be fixed by means of a clamping or screwing. Contraption ( 1 ) according to one of claims 1 to 6, characterized in that the two slewing rings ( 8th . 9 ) the second housing part ( 7 ), whereby the inner ( 33 ) and outer housing wall ( 34 ) is at least partially enclosed. Contraption ( 1 ) according to one of claims 1 to 7, characterized in that at least one turntable ( 8th . 9 ) a plurality of circumferentially distributed and inner recesses ( 62 ), which with locking lugs ( 70 ) of the second housing part ( 7 ) correspond. Contraption ( 1 ) according to one of claims 1 to 8, characterized in that the two slewing rings ( 8th . 9 ) circumferentially distributes different markings on the outside ( 65 ) exhibit. Contraption ( 1 ) according to one of claims 1 to 9, characterized in that the two slewing rings ( 8th . 9 ) are round or polygonal with rounded edges. Contraption ( 1 ) according to one of claims 1 to 10, characterized in that the second housing part ( 7 ) from an inner ( 33 ) and outer hollow cylindrical housing wall ( 34 ), wherein the two housing walls ( 33 . 34 ) via radial struts ( 51 . 52 ), which simultaneously receive the connection channels. Contraption ( 1 ) according to one of claims 1 to 11, characterized in that the second housing part ( 8th ) a plurality of radially protruding connections ( 11 . 12 . 13 ), which in extension of the internal struts ( 51 . 52 ) are arranged and extend the connection channels in the radial direction. Contraption ( 1 ) according to one of claims 1 to 12, characterized in that the connections ( 11 . 12 . 13 ) consist of Luer connections, which either with a captive union nut ( 15 . 17 ) or have a Luer thread. Contraption ( 1 ) according to one of claims 1 to 13, characterized in that one of the connections ( 11 . 12 . 13 ) for receiving a piercing spike ( 42 ), wherein a removable protective cap ( 14 ) with the help of a union nut ( 15 ) is determinable. Contraption ( 1 ) according to one of claims 1 to 14, characterized in that a bottle adapter ( 16 ) for connecting a storage bottle ( 2 ) is arranged on a Luer connection, which is cup-shaped. Drug delivery system comprising at least one device according to one of claims 1 to 15, at least one storage container with a bottle adapter, a screw connection and a second container, characterized in that the bottle adapter ( 16 ) via at least two support feet ( 82 ), which directly on the device ( 1 ) come supporting to the plant. Drug delivery system according to claim 16, characterized in that the bottle adapter ( 16 ) on the cup-shaped side circumferentially distributed a plurality of slots ( 84 ) having. Drug delivery system according to claim 16 or 17, characterized in that the bottle adapter ( 16 ) arranged in a ring, through the slots ( 84 ) interrupted collar ( 85 ), which lays around the bottleneck. Drug delivery system according to claim 16, 17 or 18, characterized in that a connection with a filter unit ( 25 ), which consists of a filter material and a non-return spring acting in one direction. Drug delivery system according to one of claims 16 to 19, characterized in that a drug from the reservoir ( 2 ) by a piercing spike ( 42 ) is removable. Drug delivery system according to one of claims 16 to 20, characterized in that one of the luer terminals ( 11 . 12 . 13 ) existing hose connection ( 4 ) at the other end a connection adapter ( 5 ) which, for protection against injury, has an elastic protective cap ( 21 ) for a piercing spike used for the transfer of liquids ( 42 ) having. Drug delivery system according to one of claims 16 to 21, characterized in that at least one first reservoir ( 2 ) is designed as an ampoule for taking medicaments and at least one second container is designed as an infusion bag ( 18 ) is formed and can be filled with drugs. Drug delivery system according to one of claims 16 to 22, characterized in that the infusion bag ( 18 ) two connections ( 26 . 27 ), wherein at least one connection ( 26 . 27 ) for receiving a piercing spike ( 42 ) of the connection adapter ( 5 ) and at least one connection is designed as a pressure relief valve. Drug delivery system according to one of claims 16 to 23, characterized in that for the removal of liquids of different container sizes, an adapter is provided which the device with a liquid-containing storage container ( 2 ) connects. Drug delivery system according to one of claims 16 to 24, characterized in that a plurality of devices ( 1 ) are arranged serially.

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