DE433105C - Process for the preparation of water-soluble derivatives by salt-forming atomic groups of substituted aryl arsenic acids, aryl stibic acids and the corresponding oxides - Google Patents

Description

Process for the preparation of water-soluble derivatives by salt-forming Atomic groups of substituted arylarsinic acids, arylstibinic acids and the corresponding Oxides. The main patent 413147 describes a process for the preparation of water-soluble Derivatives protected by salt-forming atomic groups of substituted aryl arsines, therein consisting of allowing aldoses or ketoses to act on these compounds.

It has now also been found that by the action of aldoses or ketoses on amino or aminooxyarylarsinic or stibinic acids or the corresponding Oxides can also be obtained from the resulting water-soluble derivatives aqueous solutions deposited in solid form by precipitants of an organic nature can be.

Examples. r. 11.5 g hydrochloric acid 3 arnino-.f-oxybenzolar oxide are introduced into 70 cc of 5% glucose solution, 4 can no longer be diazotized. The cooled solution is neutralized with hydrochloric acid, filtered and stirred into 1.75 liters of alcohol. After a further 875 ccm of ether have been added, the precipitated white compound is separated off and dried in vacuo. It is clearly soluble in water.

2. m-aminophenylstibic acid, obtained from 6 g of hydrochloric acid m-aminophenylstibin chloride, well sucked off and washed, are mixed in 2o ccm of water, using 1.66 ccm Sodium hydroxide solution (d.o ° Be) brought into solution and after adding ro g galactose in a water bath stirred at 5o ° for 5 hours. After being weakly acidified with acetic acid, becomes filtered and the preparation precipitated by stirring into 25 parts of alcohol. It is 1; lar soluble in water.

3. 20 g of m-nitrophenylstibic acid become m-aminophenylstibine chloride reduced and this by rubbing with ice and adding ammonia to the m-aminophenylstibinoxide convicted. This is sucked off, washed out and the well sucked off product Stirred in 48 cc of water, 36 g of lactose added and in a water bath at 50 ° 5112 Stirred for hours. It is then filtered and the solution is stirred into 25 parts of alcohol. The precipitation is suctioned off, with Alcohol and ether washed and dried in vacuum. The preparation is soluble in water.

11.5 g of 3-amino-4-oxybenzene-l-arsic acid are dissolved in 55 cc of water and 4.2 cc of sodium hydroxide solution (40 ° Be), 27 g of glucose are added and the mixture is stirred in a water bath at 55 ° for 6 1/2 hours. The solution is worked up as indicated in Example 2. The preparation is clearly soluble in water.

5. 10.5 g of arsanilic acid are dissolved in 45 cc of water and 4.2 cc of NaOH (40 ° Be) and after adding 22.5 g of arabinose in a water bath at 55 ° 6'1_ Stirred for hours. The solution is worked up as indicated in example e. That The preparation obtained in this way is soluble in water.

Claims (1)

PATENT CLAIM: Further training of those protected by patent 413147 Invention, characterized in that for the purpose of representing water-soluble Derivatives of aryl arsenic acids substituted by salt-forming atomic groups, aryl istibic acids and the corresponding oxides of amino or atninooxyarylarsinic or stibinic acids or the corresponding oxides aldoses or ketoses can act and from the so resulting solutions, if necessary, the solid reaction products by means of suitable Separates precipitant of an organic nature.