DE394735C - Process for the production of vaccines or immune sera, with the exception of those against cancer - Google Patents
Process for the production of vaccines or immune sera, with the exception of those against cancerInfo
- Publication number
- DE394735C DE394735C DEJ22366D DEJ0022366D DE394735C DE 394735 C DE394735 C DE 394735C DE J22366 D DEJ22366 D DE J22366D DE J0022366 D DEJ0022366 D DE J0022366D DE 394735 C DE394735 C DE 394735C
- Authority
- DE
- Germany
- Prior art keywords
- vaccines
- against cancer
- pus
- exception
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 5
- 229960005486 vaccine Drugs 0.000 title claims description 5
- 206010028980 Neoplasm Diseases 0.000 title claims description 3
- 201000011510 cancer Diseases 0.000 title claims description 3
- 210000004201 immune sera Anatomy 0.000 title description 3
- 229940042743 immune sera Drugs 0.000 title description 3
- 238000004519 manufacturing process Methods 0.000 title description 3
- 244000052769 pathogen Species 0.000 claims description 8
- 239000007795 chemical reaction product Substances 0.000 claims description 5
- 230000001717 pathogenic effect Effects 0.000 claims description 5
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000003053 immunization Effects 0.000 description 4
- 238000002649 immunization Methods 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 2
- 241000700647 Variola virus Species 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010891 electric arc Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Description
Verfahren zur Herstellung von Impfstoffen bzw. Immunseren mit Ausnahme eines solchen gegen Krebs. Zur Herstellung des in Betracht kommenden Impfstoffes bzw. der Immunseren soll nach dem vorliegenden Verfahren nicht, wie üblich, der Erreger oder dessen Giftstoff, sondern das das Wesen der Krankheit darstellende Reaktionsprodukt zwischen Erreger und Organismus verwendet werden, so daß die Immunisierung spezifisch gegen das Reaktionsprodukt gerichtet ist. Das wichtigste Beispiel für letzteres ist der bei den verschiedenen Krankheiten gebildete Eiter. Dieser enthält neben einer geringen Menge der Erreger hauptsächlich in ganz be- stimmter Weise veränderte Körperzellen und Sekrete.Process for the production of vaccines or immune sera, with the exception of those against cancer. To produce the vaccine or immune sera in question, according to the present process, not the pathogen or its toxin, as usual, but the reaction product between pathogen and organism representing the nature of the disease, so that the immunization is specifically against the reaction product is directed. The most important example of the latter is the pus formed in various diseases. This contains a small amount of pathogens mainly throughout of certain way altered body cells and secretions.
Die Verwendung des Eiters bei der Pockenlymphe ist bekannt. Doch handelt es sich auch hier um die Verwendung der wenig abgeschwächten Erreger, die eine örtliche Erkrankung der gleichen Ait hervorrufen. Es wurde nun gefunden, daß sich auch gegen Erkrankungen, bei denen eine Hautimpfung und Immunisierung nach Art der Pocken nicht möglich ist, eine kräftige Immunisierung erzielen läßt, wenn das Reaktionsprodukt parenteralzugeführtwird. DiebesteWirkungzeigte sich, wenn der Eiter bei der Abtötung der Erreger in seiner ursprünglichen Beschaffenheit möglichst wenig verändert wird. Dies ist bei Verwendung chemischer Zusätze wie Phenol oder von Lichtstrahlen oder durch Erhitzen unter Vermeidung höherer Temperaturen der Fall. Geeignet ist auch die Erwärinung nach vorherige#r Eintrocknung. Der Herstellungsgang wird durch die folgenden Ausführungsbeispiele erläutert.The use of pus in smallpox lymph is well known. But act Here, too, it is a question of the use of the little attenuated pathogen that has a local Cause disease of the same ait. It has now been found that against Diseases in which skin inoculation and smallpox-type immunization fail is possible to achieve a vigorous immunization if the reaction product delivered parenterally. The best effect was shown when the pus was killed the pathogen is changed as little as possible in its original condition. This is when using chemical additives such as phenol or light rays or the case by heating while avoiding higher temperatures. Is also suitable the heating after previous drying. The manufacturing process is controlled by the the following embodiments explained.
i. Der Eiter wird nach Möglichkeit steril aufgefangen.i. The pus is collected sterile if possible.
2. Der Eiter wird dann zwecks Abtötung der in ihm noch lebenden Krankheitserreger a) bei Temperaturen bis 65' ein- oder mehrmals je eine Stunde lang erwärmt, b) mit fünf Prozent Phenolzusatz vermischt und erwärmt wie unter a) oder c) in dünnen Schichten der Einwirkung von Lichtstrahlen, z. B. des Sonnenlichts oder der elektrischen Bogenlainpe oder der Quecksilberdampflampe (letztere beide in etwa i m Entfernung), ausgesetzt, im ganzen 12 Stunden lang.2. The pus is then heated for the purpose of killing the pathogens still living in it a) at temperatures up to 65 ' one or more times for one hour, b) mixed with five percent phenol and heated in thin layers as under a) or c) the action of light rays, e.g. B. to sunlight or the electric arc lamp or the mercury vapor lamp (the latter both approximately in the distance), exposed for a total of 12 hours.
3. Der so behandelte Eiter wird durch Kulturverfahren oder Tierversuch auf Sterilität geprüft und 4. dann durch Zusatz von Wasser oder physiologischer Kochsalzlösung auf die zur Immunisierung geeignete Konzentration gebracht, wobei ein vorhandener Phenolgehalt o,5 Prozent betragen soll. 3. The pus treated in this way is checked for sterility by culture methods or animal experiments and 4. then brought to the concentration suitable for immunization by adding water or physiological saline solution, the phenol content should be 0.5 percent.
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEJ22366D DE394735C (en) | 1922-01-26 | 1922-01-26 | Process for the production of vaccines or immune sera, with the exception of those against cancer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEJ22366D DE394735C (en) | 1922-01-26 | 1922-01-26 | Process for the production of vaccines or immune sera, with the exception of those against cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
DE394735C true DE394735C (en) | 1924-05-12 |
Family
ID=7200933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DEJ22366D Expired DE394735C (en) | 1922-01-26 | 1922-01-26 | Process for the production of vaccines or immune sera, with the exception of those against cancer |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE394735C (en) |
-
1922
- 1922-01-26 DE DEJ22366D patent/DE394735C/en not_active Expired
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