DE3910760A1 - Neue verwendung bekannter substanzen sowie verfahren zur herstellung von geeigneten praeparaten - Google Patents
Neue verwendung bekannter substanzen sowie verfahren zur herstellung von geeigneten praeparatenInfo
- Publication number
- DE3910760A1 DE3910760A1 DE3910760A DE3910760A DE3910760A1 DE 3910760 A1 DE3910760 A1 DE 3910760A1 DE 3910760 A DE3910760 A DE 3910760A DE 3910760 A DE3910760 A DE 3910760A DE 3910760 A1 DE3910760 A1 DE 3910760A1
- Authority
- DE
- Germany
- Prior art keywords
- gamma
- linolenic acid
- phospholipids
- amides
- glycolipids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims description 7
- 238000000034 method Methods 0.000 title claims description 5
- 238000004519 manufacturing process Methods 0.000 title 1
- 206010003645 Atopy Diseases 0.000 claims abstract description 11
- 229930186217 Glycolipid Natural products 0.000 claims abstract description 11
- 150000001408 amides Chemical class 0.000 claims abstract description 11
- 150000002148 esters Chemical class 0.000 claims abstract description 11
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 11
- 150000003839 salts Chemical class 0.000 claims abstract description 11
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 claims abstract description 9
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 claims abstract description 9
- 235000020664 gamma-linolenic acid Nutrition 0.000 claims abstract description 9
- 229960002733 gamolenic acid Drugs 0.000 claims abstract description 9
- 238000011282 treatment Methods 0.000 claims abstract description 9
- 230000001154 acute effect Effects 0.000 claims abstract description 8
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 claims abstract description 6
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 claims abstract description 6
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 claims abstract description 6
- 150000003165 prostaglandin E1 derivatives Chemical class 0.000 claims description 8
- 210000004400 mucous membrane Anatomy 0.000 claims description 6
- 229940098330 gamma linoleic acid Drugs 0.000 claims description 2
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 abstract description 6
- 230000000699 topical effect Effects 0.000 abstract description 2
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 abstract 1
- IUKXMNDGTWTNTP-RHDCIPCHSA-N 15-HETrE Chemical compound CCCCCC(O)\C=C\C=C/C\C=C/CCCCCCC(O)=O IUKXMNDGTWTNTP-RHDCIPCHSA-N 0.000 abstract 1
- 229960000711 alprostadil Drugs 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 abstract 1
- 235000004496 Oenothera biennis Nutrition 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 240000004355 Borago officinalis Species 0.000 description 1
- 235000007689 Borago officinalis Nutrition 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 241000235575 Mortierella Species 0.000 description 1
- 241000219925 Oenothera Species 0.000 description 1
- 240000008916 Oenothera biennis Species 0.000 description 1
- 102000013566 Plasminogen Human genes 0.000 description 1
- 108010051456 Plasminogen Proteins 0.000 description 1
- 235000001537 Ribes X gardonianum Nutrition 0.000 description 1
- 235000001535 Ribes X utile Nutrition 0.000 description 1
- 235000016919 Ribes petraeum Nutrition 0.000 description 1
- 244000281247 Ribes rubrum Species 0.000 description 1
- 235000002355 Ribes spicatum Nutrition 0.000 description 1
- 239000000150 Sympathomimetic Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 229940045761 evening primrose extract Drugs 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 230000001975 sympathomimetic effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960000103 thrombolytic agent Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pediatric Medicine (AREA)
- Nutrition Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3910760A DE3910760A1 (de) | 1989-04-04 | 1989-04-04 | Neue verwendung bekannter substanzen sowie verfahren zur herstellung von geeigneten praeparaten |
| EP90105854A EP0399175B1 (en) | 1989-04-04 | 1990-03-28 | PGE1 and derivatives for dermal or mucosal application |
| AT90105854T ATE157541T1 (de) | 1989-04-04 | 1990-03-28 | Pge1 und derivate für mukosale oder dermale anwendung |
| DE69031360T DE69031360T2 (de) | 1989-04-04 | 1990-03-28 | PGE1 und Derivate für mukosale oder dermale Anwendung |
| CA002013809A CA2013809C (en) | 1989-04-04 | 1990-04-04 | Agent for the prophylaxis of atopy and methods for preparing and using same |
| US08/420,334 US5591446A (en) | 1989-04-04 | 1995-04-11 | Methods and agents for the prophylaxis of atopy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3910760A DE3910760A1 (de) | 1989-04-04 | 1989-04-04 | Neue verwendung bekannter substanzen sowie verfahren zur herstellung von geeigneten praeparaten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3910760A1 true DE3910760A1 (de) | 1990-10-11 |
| DE3910760C2 DE3910760C2 (enExample) | 1992-01-02 |
Family
ID=6377750
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3910760A Granted DE3910760A1 (de) | 1989-04-04 | 1989-04-04 | Neue verwendung bekannter substanzen sowie verfahren zur herstellung von geeigneten praeparaten |
| DE69031360T Expired - Fee Related DE69031360T2 (de) | 1989-04-04 | 1990-03-28 | PGE1 und Derivate für mukosale oder dermale Anwendung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69031360T Expired - Fee Related DE69031360T2 (de) | 1989-04-04 | 1990-03-28 | PGE1 und Derivate für mukosale oder dermale Anwendung |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0399175B1 (enExample) |
| AT (1) | ATE157541T1 (enExample) |
| DE (2) | DE3910760A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5252602A (en) * | 1991-10-11 | 1993-10-12 | Rafeul Alam | Effects of misoprostol on allergic responses |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3403251A1 (de) * | 1983-02-01 | 1984-08-02 | Efamol Ltd., Guildford, Surrey | Pharmazeutische diaetetische zusammensetzung |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4009282A (en) * | 1973-12-17 | 1977-02-22 | The Regents Of The University Of Michigan | Treatment of proliferating skin diseases with prostaglandins |
| EP0391218B1 (en) * | 1989-04-04 | 1996-03-13 | Beiersdorf Aktiengesellschaft | Agent for the atopy prophylaxis |
-
1989
- 1989-04-04 DE DE3910760A patent/DE3910760A1/de active Granted
-
1990
- 1990-03-28 EP EP90105854A patent/EP0399175B1/en not_active Expired - Lifetime
- 1990-03-28 DE DE69031360T patent/DE69031360T2/de not_active Expired - Fee Related
- 1990-03-28 AT AT90105854T patent/ATE157541T1/de not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3403251A1 (de) * | 1983-02-01 | 1984-08-02 | Efamol Ltd., Guildford, Surrey | Pharmazeutische diaetetische zusammensetzung |
Non-Patent Citations (6)
| Title |
|---|
| Chemical Abstracts, Vol. 100: 80453w * |
| Chemical Abstracts, Vol. 109: 127829b * |
| Chemical Abstracts, Vol. 109: 209935x * |
| Chemical Abstracts, Vol. 78: 80127v * |
| Chemical Abstracts, Vol. 99: 47698t * |
| FORTH, W. et.al. (Hrsg.): Allgemeine und spezielle Pharmakologie und Toxikologie, 5. Aufl., Mannheim-Wien-Zürich, Wissenschaftsverlag, 1988, S. 197-9 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE157541T1 (de) | 1997-09-15 |
| EP0399175A2 (en) | 1990-11-28 |
| EP0399175B1 (en) | 1997-09-03 |
| DE69031360D1 (de) | 1997-10-09 |
| DE3910760C2 (enExample) | 1992-01-02 |
| DE69031360T2 (de) | 1998-04-02 |
| EP0399175A3 (en) | 1992-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| D2 | Grant after examination | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: DALTEX MEDICAL SCIENCES, INC., FAIRFIELD, N.J., US |
|
| 8328 | Change in the person/name/address of the agent |
Free format text: VON KREISLER, A., DIPL.-CHEM. SELTING, G., DIPL.-ING. WERNER, H., DIPL.-CHEM. DR.RER.NAT. FUES, J.,DIPL.-CHEM. DR.RER.NAT. BOECKMANN GEN. DALLMEYER, G., DIPL.-ING. HILLERINGMANN, J., DIPL.-ING. JOENSSON, H., DIPL.-CHEM. DR.RER.NAT. MEYERS, H., DIPL.-CHEM. DR.RER.NAT., PAT.-ANWAELTE, 5000 KOELN |
|
| 8381 | Inventor (new situation) |
Free format text: MELNIK, BODO, DR.MED., 4830 GUETERSLOH, DE PLEWIG, GERD, PROF. DR.MED., 8000 MUENCHEN, DE |
|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BEIERSDORF AG, 2000 HAMBURG, DE |
|
| 8339 | Ceased/non-payment of the annual fee |