DE3888197T2 - Gamma-interferon-formulierung. - Google Patents

Gamma-interferon-formulierung.

Info

Publication number
DE3888197T2
DE3888197T2 DE3888197T DE3888197T DE3888197T2 DE 3888197 T2 DE3888197 T2 DE 3888197T2 DE 3888197 T DE3888197 T DE 3888197T DE 3888197 T DE3888197 T DE 3888197T DE 3888197 T2 DE3888197 T2 DE 3888197T2
Authority
DE
Germany
Prior art keywords
gamma interferon
interferon formulation
formulation
gamma
interferon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3888197T
Other languages
English (en)
Other versions
DE3888197D1 (de
Inventor
Jiin-Yu Hwang-Felgner
Richard Jones
James Maher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DE3888197D1 publication Critical patent/DE3888197D1/de
Application granted granted Critical
Publication of DE3888197T2 publication Critical patent/DE3888197T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
DE3888197T 1987-11-03 1988-11-01 Gamma-interferon-formulierung. Expired - Lifetime DE3888197T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11643487A 1987-11-03 1987-11-03
PCT/US1988/003883 WO1989004177A1 (en) 1987-11-03 1988-11-01 Gamma interferon formulation

Publications (2)

Publication Number Publication Date
DE3888197D1 DE3888197D1 (de) 1994-04-07
DE3888197T2 true DE3888197T2 (de) 1994-08-18

Family

ID=22367187

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3888197T Expired - Lifetime DE3888197T2 (de) 1987-11-03 1988-11-01 Gamma-interferon-formulierung.

Country Status (15)

Country Link
EP (1) EP0386106B1 (de)
JP (1) JP2732877B2 (de)
KR (1) KR890701135A (de)
AU (1) AU621327B2 (de)
CA (1) CA1335176C (de)
DD (1) DD289470A5 (de)
DE (1) DE3888197T2 (de)
HK (1) HK29496A (de)
HU (1) HU210530A9 (de)
IE (1) IE60875B1 (de)
IL (1) IL88233A (de)
NZ (1) NZ226791A (de)
PT (1) PT88918B (de)
WO (1) WO1989004177A1 (de)
ZA (1) ZA888249B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007050165A1 (de) * 2007-10-19 2009-04-23 Stiftung Tierärztliche Hochschule Hannover Stabilisierung von hydrophoben Proteintherapeutika

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981485A (en) 1997-07-14 1999-11-09 Genentech, Inc. Human growth hormone aqueous formulation
IT1246296B (it) * 1990-07-25 1994-11-17 Sclavo Spa Procedimento di estrzione e purificazione del gamma interferone umano ricombinante
IL109350A (en) * 1993-05-12 2001-01-28 Genentech Inc Stable liquid preparations of gamma interferon
TW249202B (de) * 1993-08-13 1995-06-11 Ciba Gerigy Corp
IT1272252B (it) 1994-05-16 1997-06-16 Applied Research Systems Formulazioni liquide di interferone beta
US5453425A (en) * 1994-07-11 1995-09-26 Janssen Pharmaceutica N.V. Risperidone oral formulation
US5766582A (en) * 1994-10-11 1998-06-16 Schering Corporation Stable, aqueous alfa interferon solution formulations
UA61053C2 (en) 1995-03-21 2003-11-17 Applied Research Systems Stable liquid pharmaceutical compositions, method for its production and delivery form
JP2758154B2 (ja) * 1995-04-06 1998-05-28 エフ・ホフマン−ラ ロシユ アーゲー インターフェロンを含む液体製剤
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
JPH1149698A (ja) * 1997-07-31 1999-02-23 Santen Pharmaceut Co Ltd 安定性を向上させたラクトフェリンの水性製剤
ES2267258T3 (es) * 1998-04-02 2007-03-01 Genentech, Inc. Tratamiento de hipertrofia cardiaca.
LT4947B (lt) 2001-09-26 2002-08-26 Biotechnologijos Institutas Interferono alfa farmacinė kompozicija
US20030147850A1 (en) * 2001-09-27 2003-08-07 Pomytkin Igor Anatolievich Composition and methods for potentiating therapeutic effects of interferons
CU23432B6 (es) * 2005-11-02 2009-10-16 Ct Ingenieria Genetica Biotech Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras
JP5137055B2 (ja) * 2006-03-10 2013-02-06 塩野義製薬株式会社 安定化されたインターフェロン−γ組成物
JP2009091363A (ja) * 2008-11-21 2009-04-30 Asahi Kasei Pharma Kk Ｐｔｈの安定化水溶液注射剤
RU2564951C1 (ru) * 2014-08-28 2015-10-10 Закрытое акционерное общество "Вектор-Медика" (ЗАО "Вектор-Медика") Композиция водного раствора рекомбинантного интерферона альфа-2 человека для ректального применения

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2834605A1 (de) * 1978-08-07 1980-02-28 Henkel Kgaa Neue bis-aminopyridine, deren herstellung und verwendung als komponenten in oxidationshaarfarben sowie diese enthaltende haarfaerbemittel
EP0080879B1 (de) * 1981-11-28 1986-10-01 Sunstar Kabushiki Kaisha Stabilisiertes Interferon enthaltende pharmazeutische Zusammensetzung
JPS59175416A (ja) * 1983-03-25 1984-10-04 Sunstar Inc 皮膚および粘膜の角化異常治療用外用剤
JPS61277633A (ja) * 1985-05-31 1986-12-08 Toray Ind Inc インタ−フエロン組成物
DE3628468A1 (de) * 1986-08-21 1988-03-03 Thomae Gmbh Dr K Neue applikationsformen fuer (alpha)-interferone

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007050165A1 (de) * 2007-10-19 2009-04-23 Stiftung Tierärztliche Hochschule Hannover Stabilisierung von hydrophoben Proteintherapeutika
DE102007050165B4 (de) * 2007-10-19 2010-06-17 Stiftung Tierärztliche Hochschule Hannover Stabilisierte Lösung, Verfahren zu deren Herstellung sowie deren Verwendung und Arzneimittel in Form einer stabilisierten Lösung

Also Published As

Publication number Publication date
DD289470A5 (de) 1991-05-02
CA1335176C (en) 1995-04-11
DE3888197D1 (de) 1994-04-07
KR890701135A (ko) 1989-12-19
IL88233A0 (en) 1989-06-30
AU2724588A (en) 1989-06-01
IL88233A (en) 1993-08-18
AU621327B2 (en) 1992-03-12
IE883295L (en) 1989-05-03
HU210530A9 (en) 1995-04-28
NZ226791A (en) 1990-04-26
IE60875B1 (en) 1994-08-24
PT88918B (pt) 1993-01-29
JPH03500882A (ja) 1991-02-28
WO1989004177A1 (en) 1989-05-18
PT88918A (pt) 1988-12-01
EP0386106A1 (de) 1990-09-12
HK29496A (en) 1996-02-23
EP0386106B1 (de) 1994-03-02
ZA888249B (en) 1990-07-25
JP2732877B2 (ja) 1998-03-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition