DE3886852T2 - 17-Aryl-Steroide, ihre Herstellung und Zwischenprodukte zu ihrer Herstellung, ihre Anwendung als Arzneimittel und pharmazeutische Zusammensetzungen, die sie enthalten. - Google Patents

17-Aryl-Steroide, ihre Herstellung und Zwischenprodukte zu ihrer Herstellung, ihre Anwendung als Arzneimittel und pharmazeutische Zusammensetzungen, die sie enthalten.

Info

Publication number
DE3886852T2
DE3886852T2 DE3886852T DE3886852T DE3886852T2 DE 3886852 T2 DE3886852 T2 DE 3886852T2 DE 3886852 T DE3886852 T DE 3886852T DE 3886852 T DE3886852 T DE 3886852T DE 3886852 T2 DE3886852 T2 DE 3886852T2
Authority
DE
Germany
Prior art keywords
manufacture
intermediates
pharmaceutical compositions
compositions containing
pharmaceuticals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3886852T
Other languages
English (en)
Other versions
DE3886852D1 (de
Inventor
Lucien Nedelec
Francois Nique
Daniel Philibert
Martine Moguilewsky
Marie-Madeleine Bouton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of DE3886852D1 publication Critical patent/DE3886852D1/de
Publication of DE3886852T2 publication Critical patent/DE3886852T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE3886852T 1987-07-30 1988-07-28 17-Aryl-Steroide, ihre Herstellung und Zwischenprodukte zu ihrer Herstellung, ihre Anwendung als Arzneimittel und pharmazeutische Zusammensetzungen, die sie enthalten. Expired - Fee Related DE3886852T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8710794A FR2618783B1 (fr) 1987-07-30 1987-07-30 Nouveaux 17-aryle steroides, leurs procedes et des intermediaires de preparation comme medicaments et les compositions pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
DE3886852D1 DE3886852D1 (de) 1994-02-17
DE3886852T2 true DE3886852T2 (de) 1994-05-19

Family

ID=9353710

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3886852T Expired - Fee Related DE3886852T2 (de) 1987-07-30 1988-07-28 17-Aryl-Steroide, ihre Herstellung und Zwischenprodukte zu ihrer Herstellung, ihre Anwendung als Arzneimittel und pharmazeutische Zusammensetzungen, die sie enthalten.

Country Status (8)

Country Link
US (1) US4943566A (de)
EP (1) EP0305242B1 (de)
JP (1) JP2785017B2 (de)
AT (1) ATE99696T1 (de)
CA (1) CA1340342C (de)
DE (1) DE3886852T2 (de)
ES (1) ES2061706T3 (de)
FR (1) FR2618783B1 (de)

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HU208150B (en) * 1988-10-31 1993-08-30 Endorecherche Inc Process for producing new estrogen derivatives having steroid hormone inhibitor activity and pharmaceutical compositions comprising such derivatives
US5686465A (en) * 1988-10-31 1997-11-11 Endorecherche Inc. Sex steroid activity inhibitors
US5204337A (en) * 1988-10-31 1993-04-20 Endorecherche Inc. Estrogen nucleus derivatives for use in inhibition of sex steroid activity
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
US5364847A (en) * 1989-03-10 1994-11-15 Endorecherche Inhibitors of sex steroid biosynthesis and methods for their production and use
DK0411733T3 (da) * 1989-08-04 1999-06-28 Schering Ag 11-beta-aryl-gona-4,9-dien-3-oner
DE4008584A1 (de) * 1990-03-15 1991-09-26 Schering Ag Verfahren zur herstellung von zwischenprodukten fuer die antigestagensynthese (onapristonsynthese)
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
ZA924811B (en) * 1991-06-28 1993-12-29 Endorecherche Inc Controlled release systems and low dose androgens
DE4132182A1 (de) * 1991-09-24 1993-03-25 Schering Ag 11(beta)-substituierte 14, 17-ethanoestratriene, verfahren zur herstellung dieser verbindungen, sowie ihre verwendung zur herstellung von arzneimitteln
US6060503A (en) * 1991-12-02 2000-05-09 Endorecherche, Inc. Benzopyran-containing compounds and method for their use
US5679788A (en) * 1993-06-17 1997-10-21 Roussel Uclaf 11 beta-substituted-19 nor-steroids
FR2706454B1 (fr) * 1993-06-17 1995-09-15 Roussel Uclaf Nouveaux 19-Nor stéroïdes, procédé et intermédiaires de préparation, application comme médicaments et compositions pharmaceutiques les contenant.
US5639598A (en) * 1994-05-19 1997-06-17 The Trustees Of The University Of Pennsylvania Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
US5780220A (en) * 1994-05-19 1998-07-14 Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting HIV replication
US6900193B1 (en) 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
HU230492B1 (hu) * 1996-05-01 2016-08-29 The Government Of The United States Of America Új progesztációt gátló szerként használható 21-helyzetben szubsztituált progeszteron-származékok, ezeket tartalmazó gyógyszerkészítmények, alkalmazásuk
FR2757399B1 (fr) * 1996-12-23 1999-12-17 Hoechst Marion Roussel Inc Application de composes steroides substitues en 11 pour la fabrication de medicaments ayant une activite estrogene dissociee
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
CA2516319C (en) * 2003-02-28 2012-09-18 The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services Method for preparing 17.alpha.-acetoxy-11.beta.-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates
JP4274379B2 (ja) * 2006-05-12 2009-06-03 東京ニュークリア・サービス株式会社 ホウ素中性子捕獲療法用ターゲットの製造方法
JP4739358B2 (ja) * 2008-02-18 2011-08-03 住友重機械工業株式会社 ターゲット装置
WO2011150209A1 (en) 2010-05-26 2011-12-01 Corcept Therapeutics, Inc. Treatment of muscular dystrophy
CN107530435A (zh) 2015-03-02 2018-01-02 科赛普特治疗学股份有限公司 使用糖皮质激素受体拮抗剂和生长抑素治疗acth分泌型肿瘤
KR102495223B1 (ko) 2015-03-30 2023-02-01 코어셉트 쎄라퓨틱스 인코포레이티드 부신기능부전을 치료하기 위한 글루코코르티코이드와 조합된 글루코코르티코이드 수용체 길항제의 용도
CA2994422A1 (en) 2015-08-13 2017-02-16 Corcept Therapeutics, Inc. Method for differentially diagnosing acth-dependent cushing's syndrome
SG11201806101SA (en) 2016-01-19 2018-08-30 Corcept Therapeutics Inc Differential diagnosis of ectopic cushing's syndrome
EP3641780A4 (de) 2017-06-20 2021-02-24 Corcept Therapeutics, Inc. Verfahren zur behandlung von neuroepitheltumoren unter verwendung selektiver glucocorticoidrezeptormodulatoren
AU2021400069A1 (en) 2020-12-18 2023-07-06 Instil Bio (Uk) Limited Processing of tumor infiltrating lymphocytes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3502699A (en) * 1962-05-15 1970-03-24 Herchel Smith Novel delta4,9-3-ketosteroids and method for preparing same
US3346602A (en) * 1966-10-12 1967-10-10 Searle & Co 13beta-alkyl-11-alkylgona-1, 3, 5 (10)-trien-17-ones, ethers and esters thereof
US3629304A (en) * 1969-06-16 1971-12-21 Searle & Co 17alpha-alkynyl - 11beta 13beta - dialkylgona-1 3 5 (10)-triene - 3 17beta-diol 3-cycloalkyl ethers compositions and method
NL7405626A (nl) * 1974-04-26 1975-10-28 Akzo Nv Nieuwe 11-gesubstitueerde steroiden van de oestraanreeks.
US3962291A (en) * 1974-09-05 1976-06-08 G. D. Searle & Co. Total synthesis of 11-alkyl steroids
FR2377418A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
NL7701384A (nl) * 1977-02-10 1978-08-14 Akzo Nv Werkwijze voor het bereiden van nieuwe steroiden van de oestraanreeks.
FR2407940A1 (fr) * 1977-11-08 1979-06-01 Roussel Uclaf Nouveaux derives steroides 17 a-aryle, ou 17 a-heteroaryle, leur procede de preparation et leur application comme medicament
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
EP0305242A1 (de) 1989-03-01
FR2618783A1 (fr) 1989-02-03
EP0305242B1 (de) 1994-01-05
FR2618783B1 (fr) 1991-02-01
ES2061706T3 (es) 1994-12-16
CA1340342C (fr) 1999-01-26
US4943566A (en) 1990-07-24
ATE99696T1 (de) 1994-01-15
DE3886852D1 (de) 1994-02-17
JP2785017B2 (ja) 1998-08-13
JPS6442500A (en) 1989-02-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: HOECHST MARION ROUSSEL, PUTEAUX, FR

8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY CEDEX, FR

8339 Ceased/non-payment of the annual fee