DE3884536D1 - Hydrierverfahren zur bildung von di- oder tetrahydro-hmg-coa-reduktase-inhibitoren. - Google Patents

Hydrierverfahren zur bildung von di- oder tetrahydro-hmg-coa-reduktase-inhibitoren.

Info

Publication number
DE3884536D1
DE3884536D1 DE88307858T DE3884536T DE3884536D1 DE 3884536 D1 DE3884536 D1 DE 3884536D1 DE 88307858 T DE88307858 T DE 88307858T DE 3884536 T DE3884536 T DE 3884536T DE 3884536 D1 DE3884536 D1 DE 3884536D1
Authority
DE
Germany
Prior art keywords
hmg
coa
tetrahydro
forming
reductase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88307858T
Other languages
English (en)
Other versions
DE3884536T2 (de
Inventor
Ann Elizabeth Decamp
Thomas R Verhoeven
Ichiro Shinkai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/092,803 external-priority patent/US4826999A/en
Priority claimed from US07/092,804 external-priority patent/US4831165A/en
Priority claimed from US07/092,802 external-priority patent/US4876364A/en
Priority claimed from US07/092,801 external-priority patent/US4864035A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3884536D1 publication Critical patent/DE3884536D1/de
Publication of DE3884536T2 publication Critical patent/DE3884536T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE88307858T 1987-09-03 1988-08-24 Hydrierverfahren zur Bildung von Di- oder Tetrahydro-HMG-CoA-Reduktase-Inhibitoren. Expired - Fee Related DE3884536T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/092,803 US4826999A (en) 1987-09-03 1987-09-03 Hydrogenation process for the formation of 3,5-dihydro HMG-CoA reductase inhibitors
US07/092,804 US4831165A (en) 1987-09-03 1987-09-03 Hydrogenation process for the formation of 3,4-dihydro HMG-CoA reductase inhibitors
US07/092,802 US4876364A (en) 1987-09-03 1987-09-03 Hydrogenation process for the formation of 4A,5-dihydro HMG-CoA reductase inhibitors
US07/092,801 US4864035A (en) 1987-09-03 1987-09-03 Hydrogenation process for the formation of tetrahydro HMG-CoA reductase inhibitors

Publications (2)

Publication Number Publication Date
DE3884536D1 true DE3884536D1 (de) 1993-11-04
DE3884536T2 DE3884536T2 (de) 1994-04-28

Family

ID=27492599

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88307858T Expired - Fee Related DE3884536T2 (de) 1987-09-03 1988-08-24 Hydrierverfahren zur Bildung von Di- oder Tetrahydro-HMG-CoA-Reduktase-Inhibitoren.

Country Status (4)

Country Link
EP (1) EP0306210B1 (de)
JP (1) JP2688501B2 (de)
CA (1) CA1338016C (de)
DE (1) DE3884536T2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177104A (en) * 1990-04-03 1993-01-05 E. R. Squibb & Sons, Inc. 6-α-hydroxy derivatives of mevinic acids
US5089523A (en) * 1990-05-11 1992-02-18 E. R. Squibb & Sons, Inc. Fluorinated derivatives of mevinic acids
US5264455A (en) * 1990-07-06 1993-11-23 E. R. Squibb & Sons, Inc. Sulfur-substituted mevinic acid derivatives
US5286746A (en) * 1991-12-20 1994-02-15 E. R. Squibb & Sons, Inc. Sulfur-substituted mevinic acid derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
DD219956A1 (de) * 1983-09-01 1985-03-20 Akad Wissenschaften Ddr Verfahren zur herstellung heterogenisierter chiraler uebergangsmetall-phosphin-komplexkatalysatoren
DE3481190D1 (de) * 1983-10-11 1990-03-08 Merck & Co Inc Verfahren zur herstellung von 6(r)-(2-(8(s)(2,2-dimethylbutyryloxy)-2(s),6(s)-dimethyl-1,2,3,4,4a(s),5,6,7,8,8a(s)-decahydronaphthyl-1(s))ethyl)-4(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-on.

Also Published As

Publication number Publication date
DE3884536T2 (de) 1994-04-28
CA1338016C (en) 1996-01-30
EP0306210B1 (de) 1993-09-29
EP0306210A1 (de) 1989-03-08
JPH0196179A (ja) 1989-04-14
JP2688501B2 (ja) 1997-12-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee