DE3883453D1 - Hybride Plasminogenaktivatoren. - Google Patents

Hybride Plasminogenaktivatoren.

Info

Publication number
DE3883453D1
DE3883453D1 DE88305973T DE3883453T DE3883453D1 DE 3883453 D1 DE3883453 D1 DE 3883453D1 DE 88305973 T DE88305973 T DE 88305973T DE 3883453 T DE3883453 T DE 3883453T DE 3883453 D1 DE3883453 D1 DE 3883453D1
Authority
DE
Germany
Prior art keywords
plasminogen activators
hybrid plasminogen
hybrid
activators
plasminogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88305973T
Other languages
English (en)
Other versions
DE3883453T2 (de
Inventor
Michael Joseph Beecham Browne
Jeffery Hugh Beecham Robinson
Richard Anthony Godwin B Smith
Sarkis Barret Kalindjian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878715392A external-priority patent/GB8715392D0/en
Priority claimed from GB878715391A external-priority patent/GB8715391D0/en
Priority claimed from GB878719279A external-priority patent/GB8719279D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE3883453D1 publication Critical patent/DE3883453D1/de
Publication of DE3883453T2 publication Critical patent/DE3883453T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE88305973T 1987-07-01 1988-06-29 Hybride Plasminogenaktivatoren. Expired - Fee Related DE3883453T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878715392A GB8715392D0 (en) 1987-07-01 1987-07-01 Compounds
GB878715391A GB8715391D0 (en) 1987-07-01 1987-07-01 Compounds
GB878719279A GB8719279D0 (en) 1987-08-14 1987-08-14 Compounds

Publications (2)

Publication Number Publication Date
DE3883453D1 true DE3883453D1 (de) 1993-09-30
DE3883453T2 DE3883453T2 (de) 1994-03-17

Family

ID=27263478

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88305973T Expired - Fee Related DE3883453T2 (de) 1987-07-01 1988-06-29 Hybride Plasminogenaktivatoren.

Country Status (11)

Country Link
EP (1) EP0297882B1 (de)
JP (1) JPS6480287A (de)
AU (1) AU615919B2 (de)
DE (1) DE3883453T2 (de)
DK (1) DK359888A (de)
FI (1) FI883146A (de)
HU (1) HUT47151A (de)
IL (1) IL86909A0 (de)
NO (1) NO882886L (de)
NZ (1) NZ225215A (de)
PT (1) PT87869B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8826975D0 (en) * 1988-11-18 1988-12-21 Beecham Group Plc Novel compounds
AU6470590A (en) 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
GB9011861D0 (en) * 1990-05-26 1990-07-18 Beecham Group Plc Novel compounds
GB9013345D0 (en) * 1990-06-14 1990-08-08 Beecham Group Plc Novel compounds
GB9019120D0 (en) * 1990-09-01 1990-10-17 Beecham Group Plc Novel compounds
WO1999016889A1 (en) * 1997-10-01 1999-04-08 G.D. Searle & Co. Fusion proteins comprising an angiostatin moiety and their use in anti-tumor treatment
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
CN1443227A (zh) * 2001-05-21 2003-09-17 日本油漆株式会社 高浓度金属胶体溶液的制造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions
DE3361610D1 (en) * 1982-04-07 1986-02-06 Beecham Group Plc Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
GB8609948D0 (en) * 1986-04-23 1986-05-29 Beecham Group Plc Compounds
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation

Also Published As

Publication number Publication date
PT87869A (pt) 1989-06-30
NZ225215A (en) 1991-05-28
DK359888A (da) 1989-01-02
DE3883453T2 (de) 1994-03-17
DK359888D0 (da) 1988-06-29
FI883146A (fi) 1989-01-02
PT87869B (pt) 1995-03-01
EP0297882B1 (de) 1993-08-25
HUT47151A (en) 1989-01-30
AU615919B2 (en) 1991-10-17
FI883146A0 (fi) 1988-06-30
JPS6480287A (en) 1989-03-27
EP0297882A2 (de) 1989-01-04
AU1853388A (en) 1989-01-19
NO882886D0 (no) 1988-06-29
NO882886L (no) 1989-01-02
IL86909A0 (en) 1988-11-30
EP0297882A3 (en) 1989-08-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee