DE3853825D1 - Ionophore als reagenz zur bestimmung von ionen. - Google Patents

Ionophore als reagenz zur bestimmung von ionen.

Info

Publication number
DE3853825D1
DE3853825D1 DE3853825T DE3853825T DE3853825D1 DE 3853825 D1 DE3853825 D1 DE 3853825D1 DE 3853825 T DE3853825 T DE 3853825T DE 3853825 T DE3853825 T DE 3853825T DE 3853825 D1 DE3853825 D1 DE 3853825D1
Authority
DE
Germany
Prior art keywords
ionophores
fused
ions
ion
dimensional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3853825T
Other languages
English (en)
Other versions
DE3853825T2 (de
Inventor
Divakaran Masilamani
Mariann Lucas
George Hammond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Honeywell International Inc
Original Assignee
AlliedSignal Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AlliedSignal Inc filed Critical AlliedSignal Inc
Application granted granted Critical
Publication of DE3853825D1 publication Critical patent/DE3853825D1/de
Publication of DE3853825T2 publication Critical patent/DE3853825T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18Bridged systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE3853825T 1987-07-31 1988-06-14 Ionophore als reagenz zur bestimmung von ionen. Expired - Fee Related DE3853825T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/080,721 US5162525A (en) 1987-07-31 1987-07-31 Fluorogenic and chromogenic three-dimensional ionophores as selective reagents for detecting ions in biological fluids
PCT/US1988/002043 WO1989000997A1 (en) 1987-07-31 1988-06-14 Ionophores as reagents for detecting ions

Publications (2)

Publication Number Publication Date
DE3853825D1 true DE3853825D1 (de) 1995-06-22
DE3853825T2 DE3853825T2 (de) 1995-11-09

Family

ID=22159183

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3853825T Expired - Fee Related DE3853825T2 (de) 1987-07-31 1988-06-14 Ionophore als reagenz zur bestimmung von ionen.

Country Status (7)

Country Link
US (2) US5162525A (de)
EP (1) EP0371992B1 (de)
JP (1) JPH0613523B2 (de)
AT (1) ATE122677T1 (de)
CA (1) CA1305133C (de)
DE (1) DE3853825T2 (de)
WO (1) WO1989000997A1 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988008137A1 (en) * 1987-04-10 1988-10-20 The Flinders University Of South Australia Determination of ions in fluids
US5162508A (en) * 1987-12-18 1992-11-10 Compagnie Oris Industrie Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers
US5154890A (en) * 1990-11-07 1992-10-13 Hewlett-Packard Company Fiber optic potassium ion sensor
US5187103A (en) * 1991-01-31 1993-02-16 Miles Inc. Colorimetric method and reagent for the assay of lithium in a test sample
KR970001146B1 (ko) * 1993-07-16 1997-01-29 엘지전자 주식회사 가스측정용 바이오센서 및 그 제조방법
US5417959A (en) * 1993-10-04 1995-05-23 Mallinckrodt Medical, Inc. Functionalized aza-crytand ligands for diagnostic imaging applications
US5474743A (en) * 1993-10-21 1995-12-12 Minnesota Mining And Manufacturing Company Cation-sensing composite structure and compounds for use therein
US5958782A (en) * 1993-10-21 1999-09-28 Minnesota Mining And Manufacturing Company Cation-sensing composite structure and compounds for use therein
JPH09224724A (ja) * 1996-02-25 1997-09-02 Masamitsu Suzuki 指 輪
EP0894261B1 (de) 1996-04-16 2005-06-15 Novartis AG Kovalent immobilisierte fluorionophore als optische ionensensoren
AU2384797A (en) 1996-04-18 1997-11-12 Novartis Ag Fluoroionophores and their use in optical ion sensors
EP0915865B1 (de) 1996-07-22 2002-02-20 Novartis AG Kovalent immobilisierte fluoroionophoren für optische ionen-sensoren
US5710372A (en) * 1996-12-17 1998-01-20 Cincinnati Milacron Inc. Method of analysis for aqueous fluids
ATE306844T1 (de) * 1997-02-27 2005-11-15 Terumo Cardiovascular Sys Kassette zur messung von blut-parametern
US5997818A (en) * 1997-02-27 1999-12-07 Minnesota Mining And Manufacturing Company Cassette for tonometric calibration
US5822137A (en) * 1997-02-27 1998-10-13 Minnesota Mining & Manufacturing Co. Assembly for retaining optical components
US6009339A (en) 1997-02-27 1999-12-28 Terumo Cardiovascular Systems Corporation Blood parameter measurement device
AT405462B (de) * 1997-05-30 1999-08-25 Avl List Gmbh Verfahren zur bestimmung eines alkaliions
AT405461B (de) * 1997-05-30 1999-08-25 Avl List Gmbh Lumineszenzindikator
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6211359B1 (en) 1999-08-17 2001-04-03 Avl Medical Instruments Triaza-cryptand and method of determining an alkali ion
KR100372559B1 (ko) * 2000-08-14 2003-02-17 한국전력공사 칼륨이온을 선택적으로 흡착하는 새로운 발색성 칼릭스[4]아렌 아자크라운 에테르 유도체
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US7579463B2 (en) * 2000-12-20 2009-08-25 Life Technologies Corporation Crown ether derivatives
US6962992B2 (en) 2000-12-20 2005-11-08 Molecullar Probes, Inc. Crown ether derivatives
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7316700B2 (en) 2001-06-12 2008-01-08 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
WO2002100460A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Electric lancet actuator
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US6660526B2 (en) * 2001-12-21 2003-12-09 Bayer Corporation Potassium fluoroionophore
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7198606B2 (en) 2002-04-19 2007-04-03 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with analyte sensing
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
DE602004028463D1 (de) 2003-05-30 2010-09-16 Pelikan Technologies Inc Verfahren und vorrichtung zur injektion von flüssigkeit
DK1633235T3 (da) 2003-06-06 2014-08-18 Sanofi Aventis Deutschland Apparat til udtagelse af legemsvæskeprøver og detektering af analyt
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
EP1671096A4 (de) 2003-09-29 2009-09-16 Pelikan Technologies Inc Verfahren und apparatur für eine verbesserte probeneinfangvorrichtung
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1706026B1 (de) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Verfahren und vorrichtung zur verbesserung der fluidströmung und der probennahme
EP1751546A2 (de) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Bedruckbares wassergel für biosensoren
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US20060240560A1 (en) * 2005-01-31 2006-10-26 Eric Bakker Microsphere optical ion sensors based on doped silica gel templates
US8129365B2 (en) * 2005-10-11 2012-03-06 The Regents Of The University Of California Water-soluble, fluorescent compounds for detection of potassium ions
US8242203B2 (en) * 2005-11-10 2012-08-14 Eric Bakker Covalently attached nile blue derivatives for optical sensors
US7858383B2 (en) * 2006-05-03 2010-12-28 Opti Medical Systems Chromoionophore and method of determining sodium ions
US9279817B2 (en) 2007-04-13 2016-03-08 Aat Bioquest, Inc. Carbofluorescein lactone ion indicators and their applications
US20080254498A1 (en) * 2007-04-13 2008-10-16 Abd Bioquest, Inc. Fluorescent ion indicators and their applications
US9097730B2 (en) 2007-04-13 2015-08-04 Aat Bioquest, Inc. Fluorescein lactone ion indicators and their applications
EP2265324B1 (de) 2008-04-11 2015-01-28 Sanofi-Aventis Deutschland GmbH Integriertes System zur Messung von Analyten
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
CN102749312B (zh) * 2012-03-09 2014-06-25 华东师范大学 应用*啶鎓阴离子受体高选择性识别醋酸根离子的方法
CN106483111B (zh) * 2016-09-26 2018-11-30 华南师范大学 芘苯并噻唑席夫碱在检测银离子上的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2842862A1 (de) * 1978-10-02 1980-04-10 Boehringer Mannheim Gmbh Verfahren zur bestimmung von ionen, polaren und/oder lipophilen substanzen in fluessigkeiten
DE3202779A1 (de) * 1982-01-28 1983-08-04 Merck Patent Gmbh, 6100 Darmstadt Kaliumreagens und verfahren zur bestimmung von kaliumionen
CA1222438A (en) * 1983-05-12 1987-06-02 Steven C. Charlton Unified test means for ion determination
US4808539A (en) * 1987-04-15 1989-02-28 Technicon Instruments Corporation Compounds, reagents and procedures for determining cations
US5177221A (en) * 1987-04-15 1993-01-05 Miles Inc. Chromogenic hemispherands and their preparation

Also Published As

Publication number Publication date
JPH0613523B2 (ja) 1994-02-23
EP0371992A1 (de) 1990-06-13
EP0371992B1 (de) 1995-05-17
US5439828A (en) 1995-08-08
WO1989000997A1 (en) 1989-02-09
US5162525A (en) 1992-11-10
ATE122677T1 (de) 1995-06-15
CA1305133C (en) 1992-07-14
DE3853825T2 (de) 1995-11-09
JPH02501481A (ja) 1990-05-24

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Legal Events

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8339 Ceased/non-payment of the annual fee