DE3851910D1 - Abtastsystem zur Bestimmung der Fluoreszenz. - Google Patents
Abtastsystem zur Bestimmung der Fluoreszenz.Info
- Publication number
- DE3851910D1 DE3851910D1 DE3851910T DE3851910T DE3851910D1 DE 3851910 D1 DE3851910 D1 DE 3851910D1 DE 3851910 T DE3851910 T DE 3851910T DE 3851910 T DE3851910 T DE 3851910T DE 3851910 D1 DE3851910 D1 DE 3851910D1
- Authority
- DE
- Germany
- Prior art keywords
- scanning system
- determining fluorescence
- fluorescence
- determining
- scanning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J1/00—Photometry, e.g. photographic exposure meter
- G01J1/02—Details
- G01J1/04—Optical or mechanical part supplementary adjustable parts
- G01J1/06—Restricting the angle of incident light
- G01J2001/062—Restricting the angle of incident light by fibre-optic packed bundle
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/12—Generating the spectrum; Monochromators
- G01J2003/1226—Interference filters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Photometry And Measurement Of Optical Pulse Characteristics (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/060,874 US4833332A (en) | 1987-06-12 | 1987-06-12 | Scanning fluorescent detection system |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3851910D1 true DE3851910D1 (de) | 1994-12-01 |
DE3851910T2 DE3851910T2 (de) | 1995-05-24 |
Family
ID=22032284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3851910T Expired - Lifetime DE3851910T2 (de) | 1987-06-12 | 1988-06-01 | Abtastsystem zur Bestimmung der Fluoreszenz. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4833332A (de) |
EP (1) | EP0294996B1 (de) |
JP (1) | JPS63317770A (de) |
AU (1) | AU601048B2 (de) |
CA (1) | CA1299772C (de) |
DE (1) | DE3851910T2 (de) |
IL (1) | IL86695A (de) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5863403A (en) * | 1984-03-29 | 1999-01-26 | The Board Of Regents Of The University Of Nebraska | Digital DNA typing |
US5360523A (en) * | 1984-03-29 | 1994-11-01 | Li-Cor, Inc. | DNA sequencing |
US4729947A (en) * | 1984-03-29 | 1988-03-08 | The Board Of Regents Of The University Of Nebraska | DNA sequencing |
US6207421B1 (en) | 1984-03-29 | 2001-03-27 | Li-Cor, Inc. | DNA sequencing and DNA terminators |
US6086737A (en) * | 1984-03-29 | 2000-07-11 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor |
US6004446A (en) * | 1984-03-29 | 1999-12-21 | Li-Cor, Inc. | DNA Sequencing |
US5571388A (en) * | 1984-03-29 | 1996-11-05 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof |
US5207880A (en) * | 1984-03-29 | 1993-05-04 | The Board Of Regents Of The University Of Nebraska | DNA sequencing |
US5346670A (en) * | 1986-12-24 | 1994-09-13 | British Technology Group U.S.A. Inc. | Phthalocyanine and tetrabenztriazaporphyrin reagents |
US5135717A (en) * | 1986-12-24 | 1992-08-04 | British Technology Group Usa Inc. | Tetrabenztriazaporphyrin reagents and kits containing the same |
US4919512A (en) * | 1988-10-17 | 1990-04-24 | Mcdonnell Douglas Corporation | Wavelength shift switch and sensing system |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
JPH083481B2 (ja) * | 1989-06-07 | 1996-01-17 | 日立ソフトウェアエンジニアリング株式会社 | 蛍光式電気泳動パターン読み取り装置 |
FR2649487B1 (fr) * | 1989-06-21 | 1991-09-20 | Europhor Sa | Capillaire d'electrophorese a dispositif optique incorpore |
US5108179A (en) * | 1989-08-09 | 1992-04-28 | Myers Stephen A | System and method for determining changes in fluorescence of stained nucleic acid in electrophoretically separated bands |
IT1234466B (it) * | 1989-09-20 | 1992-05-18 | Consiglio Nazionale Ricerche | Lidar a fluorescenza differenziale e relativo metodo di rilevamento |
US5274240A (en) * | 1990-01-12 | 1993-12-28 | The Regents Of The University Of California | Capillary array confocal fluorescence scanner and method |
US5091652A (en) * | 1990-01-12 | 1992-02-25 | The Regents Of The University Of California | Laser excited confocal microscope fluorescence scanner and method |
JP2524243B2 (ja) * | 1990-04-12 | 1996-08-14 | 日立ソフトウェアエンジニアリング株式会社 | 蛍光式電気泳動パタ―ン読み取り装置 |
JP2814408B2 (ja) * | 1990-05-22 | 1998-10-22 | 日立ソフトウェアエンジニアリング 株式会社 | 蛍光パターン読み取り装置および蛍光パターン読み取り方法 |
US5119316A (en) * | 1990-06-29 | 1992-06-02 | E. I. Du Pont De Nemours And Company | Method for determining dna sequences |
JP2814409B2 (ja) * | 1990-11-30 | 1998-10-22 | 日立ソフトウェアエンジニアリング 株式会社 | 多色泳動パターン読み取り装置 |
US5162654A (en) * | 1991-02-01 | 1992-11-10 | Wisconsin Alumni Research Foundation | Detection apparatus for electrophoretic gels |
WO1993019205A1 (en) * | 1992-03-19 | 1993-09-30 | The Regents Of The University Of California | Multiple tag labeling method for dna sequencing |
US5294799A (en) * | 1993-02-01 | 1994-03-15 | Aslund Nils R D | Apparatus for quantitative imaging of multiple fluorophores |
US5424841A (en) * | 1993-05-28 | 1995-06-13 | Molecular Dynamics | Apparatus for measuring spatial distribution of fluorescence on a substrate |
US6035914A (en) * | 1993-10-22 | 2000-03-14 | Martin Marietta Energy Systems Inc. | Counterfeit-resistant materials and a method and apparatus for authenticating materials |
WO1995019359A1 (en) * | 1994-01-12 | 1995-07-20 | Massachusetts Institute Of Technology | Process for making xanthene or cubane based compounds, and protease inhibitors |
JP3060001B2 (ja) * | 1995-05-12 | 2000-07-04 | 日立ソフトウエアエンジニアリング株式会社 | 蛍光式電気泳動パターン読み取り装置 |
US5582705A (en) * | 1995-05-19 | 1996-12-10 | Iowa State University Research Foundation, Inc. | Multiplexed capillary electrophoresis system |
JP3012794B2 (ja) * | 1995-10-02 | 2000-02-28 | 日立ソフトウエアエンジニアリング株式会社 | スキャナ装置 |
US5699157A (en) * | 1996-07-16 | 1997-12-16 | Caliper Technologies Corp. | Fourier detection of species migrating in a microchannel |
US5871628A (en) * | 1996-08-22 | 1999-02-16 | The University Of Texas System | Automatic sequencer/genotyper having extended spectral response |
US5880473A (en) * | 1997-07-28 | 1999-03-09 | Applied Imaging, Inc. | Multifluor-fluorescence in-situ hybridization (M-FISH) imaging techniques using multiple multiband filters with image registration |
AU4920297A (en) | 1996-10-25 | 1998-05-15 | Applied Imaging, Inc. | Multifluor-fluorescence in situ hybridization (m-fish) imaging techniques using multiple multiband filters with image registration |
US20030135122A1 (en) * | 1997-12-12 | 2003-07-17 | Spectrx, Inc. | Multi-modal optical tissue diagnostic system |
US6055451A (en) * | 1997-12-12 | 2000-04-25 | Spectrx, Inc. | Apparatus and method for determining tissue characteristics |
JP2949220B2 (ja) * | 1998-02-12 | 1999-09-13 | 工業技術院長 | 極微小顕微鏡分光装置 |
US6027628A (en) * | 1998-02-23 | 2000-02-22 | Yamamura; Hidetaka | Gel cassette for electrophoresis |
DE19816487A1 (de) * | 1998-04-14 | 1999-10-21 | Bodenseewerk Perkin Elmer Co | Vorrichtung zum Nachweis eines Fluoreszenzfarbstoffs |
US6078390A (en) * | 1998-05-04 | 2000-06-20 | General Scanning, Inc. | Scanning system and method of operation for automatically setting detection sensitivity |
JP4474050B2 (ja) * | 1998-09-11 | 2010-06-02 | スペクトルックス・インコーポレイテッド | マルチモード光学組織診断システム |
US6036021A (en) * | 1999-02-17 | 2000-03-14 | C.C. Imex | Package for electrophoresis gel |
WO2000055882A1 (en) | 1999-03-18 | 2000-09-21 | Cambridge Research & Instrumentation Inc. | High-efficiency multiple probe imaging system |
US20040147843A1 (en) * | 1999-11-05 | 2004-07-29 | Shabbir Bambot | System and method for determining tissue characteristics |
US6696022B1 (en) * | 1999-08-13 | 2004-02-24 | U.S. Genomics, Inc. | Methods and apparatuses for stretching polymers |
US6462816B1 (en) * | 2000-07-21 | 2002-10-08 | Symyx Technologies, Inc. | Parallel capillary electrophoresis system having signal averaging and noise cancellation |
JP3690271B2 (ja) * | 2000-11-29 | 2005-08-31 | 株式会社島津製作所 | 核酸の塩基配列決定のためのマトリックス値を得る方法 |
JP2002277326A (ja) * | 2001-03-19 | 2002-09-25 | Nireco Corp | 分光測光装置 |
US6844563B2 (en) * | 2001-05-22 | 2005-01-18 | Matsushita Electric Industrial Co., Ltd. | Fluorescence detecting device with integrated circuit and photodiode, and detection method |
EP1412724B1 (de) * | 2001-07-25 | 2016-03-23 | Life Technologies Corporation | Zeitverzögerungintegration in elektrophoretischen nachweissystemen |
US7262017B2 (en) | 2001-09-14 | 2007-08-28 | Torrey Pines Institute For Molecular Studies | Diagnostic markers for ischemia |
US7383134B2 (en) | 2002-01-15 | 2008-06-03 | Piper James R | Method and/or system for analyzing biological samples using a computer system |
EP2497564B1 (de) * | 2002-03-05 | 2014-05-14 | Caliper Life Sciences, Inc. | Elektrophoretische Trennung in einem mikrofluidischen Kanalnetzwerk |
US20050143933A1 (en) * | 2002-04-23 | 2005-06-30 | James Minor | Analyzing and correcting biological assay data using a signal allocation model |
US6999173B2 (en) * | 2003-09-25 | 2006-02-14 | Ffa Sciences Llc | Method and apparatus for ratio fluorometry |
EP1728080B1 (de) * | 2004-03-22 | 2014-11-26 | FFA Sciences, LLP | Entwicklung und verwendung von fluoreszenzsonden ungebundener analyten |
EP1786932A4 (de) * | 2004-08-23 | 2010-10-27 | Us Genomics Inc | Systeme und verfahren zur detektion und analyse von polymeren |
US20060257938A1 (en) * | 2005-05-10 | 2006-11-16 | Kleinfeld Alan M | Method of screening for drugs that block ligand binding to a lipid binding protein |
CA2616958A1 (en) * | 2005-05-20 | 2006-11-23 | Tir Technology Lp | Multicolour chromaticity sensor |
KR20090040343A (ko) * | 2006-07-18 | 2009-04-23 | 티아이알 테크놀로지 엘피 | 광의 세기 및 피크 파장을 결정하는 방법 및 장치 |
US7381972B1 (en) * | 2006-07-24 | 2008-06-03 | Science Applications International Corporation | System and method for light fluorescence detection |
WO2008060841A2 (en) | 2006-10-27 | 2008-05-22 | Ffa Sciences, Llc | Use of probes for unbound metabolites |
US8999636B2 (en) * | 2007-01-08 | 2015-04-07 | Toxic Report Llc | Reaction chamber |
US20100294665A1 (en) * | 2007-07-12 | 2010-11-25 | Richard Allen | Method and system for transferring and/or concentrating a sample |
DE102008011013B4 (de) * | 2008-02-25 | 2014-11-13 | Mevitec Gmbh | Verfahren und Einrichtung zur komplexen Stoffwechselanalyse |
US8361716B2 (en) * | 2008-10-03 | 2013-01-29 | Pathogenetix, Inc. | Focusing chamber |
JP5715068B2 (ja) | 2009-01-30 | 2015-05-07 | マイクロニクス, インコーポレイテッド | 携帯型高利得蛍光検出システム |
US9132423B2 (en) | 2010-01-29 | 2015-09-15 | Micronics, Inc. | Sample-to-answer microfluidic cartridge |
DE102012002086A1 (de) * | 2012-02-06 | 2013-08-08 | Carl Zeiss Meditec Ag | Verfahren zum Untersuchen von biologischem Gewebe und Vorrichtungen zum Untersuchen und Behandeln des Gewebes |
US9028776B2 (en) | 2012-04-18 | 2015-05-12 | Toxic Report Llc | Device for stretching a polymer in a fluid sample |
US8685708B2 (en) | 2012-04-18 | 2014-04-01 | Pathogenetix, Inc. | Device for preparing a sample |
KR20150096788A (ko) | 2012-12-21 | 2015-08-25 | 마이크로닉스 인코포레이티드. | 마이크로 유체공학 용도를 위한 저탄성 막 |
WO2014100725A1 (en) | 2012-12-21 | 2014-06-26 | Micronics, Inc. | Portable fluorescence detection system and microassay cartridge |
EP2935908B1 (de) | 2012-12-21 | 2019-08-14 | PerkinElmer Health Sciences, Inc. | Fluidkreisläufe und zugehörige herstellungsverfahren |
CA2911303C (en) | 2013-05-07 | 2021-02-16 | Micronics, Inc. | Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions |
EP2994750B1 (de) | 2013-05-07 | 2020-08-12 | PerkinElmer Health Sciences, Inc. | Mikrofluidische vorrichtungen und verfahren zur durchführung von serumtrennung und blutkreuzproben |
WO2014182847A1 (en) | 2013-05-07 | 2014-11-13 | Micronics, Inc. | Device for preparation and analysis of nucleic acids |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3588257A (en) * | 1968-10-14 | 1971-06-28 | Us Navy | Flame photometric method and apparatus for quantitatively analyzing material specimens |
US3764512A (en) * | 1972-05-02 | 1973-10-09 | Singer Co | Laser scanning electrophoresis instrument and system |
US4152723A (en) * | 1977-12-19 | 1979-05-01 | Sperry Rand Corporation | Method of inspecting circuit boards and apparatus therefor |
US4162405A (en) * | 1978-05-23 | 1979-07-24 | Britton Chance | Flying spot fluoro-meter for oxidized flavoprotein and reduced pyridine nucleotide |
US4451149A (en) * | 1980-07-28 | 1984-05-29 | Noeller Hans Guenter | Polarization fluoroimmunoassay apparatus |
US4421860A (en) * | 1980-10-07 | 1983-12-20 | The Regents Of The University Of California | Homogeneous fluoroimmunoassay involving autocorrelation processing of optically sensed signals |
AT390840B (de) * | 1983-06-08 | 1990-07-10 | Avl Verbrennungskraft Messtech | Verfahren zur fluorimetrischen bestimmung der konzentration von in einer substanz enthaltenen stoffen und anordnung zur durchfuehrung dieses verfahrens |
CA1244786A (en) * | 1983-12-20 | 1988-11-15 | Lloyd M. Smith | Synthesis of amino-derivitized oligonucleotides |
CA1258611A (en) * | 1984-01-16 | 1989-08-22 | Lloyd M. Smith | Method of dna sequencing |
US4729947A (en) * | 1984-03-29 | 1988-03-08 | The Board Of Regents Of The University Of Nebraska | DNA sequencing |
US4651011A (en) * | 1985-06-03 | 1987-03-17 | At&T Technologies, Inc. | Non-destructive method for determining the extent of cure of a polymer |
CA1340806C (en) * | 1986-07-02 | 1999-11-02 | James Merrill Prober | Method, system and reagents for dna sequencing |
-
1987
- 1987-06-12 US US07/060,874 patent/US4833332A/en not_active Expired - Lifetime
-
1988
- 1988-04-19 CA CA000564536A patent/CA1299772C/en not_active Expired - Lifetime
- 1988-06-01 EP EP88304979A patent/EP0294996B1/de not_active Expired - Lifetime
- 1988-06-01 DE DE3851910T patent/DE3851910T2/de not_active Expired - Lifetime
- 1988-06-10 JP JP63141860A patent/JPS63317770A/ja active Pending
- 1988-06-10 IL IL86695A patent/IL86695A/xx not_active IP Right Cessation
- 1988-06-10 AU AU17620/88A patent/AU601048B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0294996A2 (de) | 1988-12-14 |
US4833332A (en) | 1989-05-23 |
AU601048B2 (en) | 1990-08-30 |
EP0294996A3 (de) | 1991-04-10 |
EP0294996B1 (de) | 1994-10-26 |
JPS63317770A (ja) | 1988-12-26 |
IL86695A0 (en) | 1988-11-30 |
DE3851910T2 (de) | 1995-05-24 |
AU1762088A (en) | 1988-12-15 |
IL86695A (en) | 1992-01-15 |
CA1299772C (en) | 1992-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: NEN LIFE SCIENCE PRODUCTS, INC.(N.D.GES.DES STAATE |