DE3841397A1 - Poroeser resorbierbarer arzneistofftraeger - Google Patents
Poroeser resorbierbarer arzneistofftraegerInfo
- Publication number
- DE3841397A1 DE3841397A1 DE19883841397 DE3841397A DE3841397A1 DE 3841397 A1 DE3841397 A1 DE 3841397A1 DE 19883841397 DE19883841397 DE 19883841397 DE 3841397 A DE3841397 A DE 3841397A DE 3841397 A1 DE3841397 A1 DE 3841397A1
- Authority
- DE
- Germany
- Prior art keywords
- drug carrier
- drug
- acid
- porous
- varnish
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012907 medicinal substance Substances 0.000 title abstract 4
- 102000008186 Collagen Human genes 0.000 claims abstract description 11
- 108010035532 Collagen Proteins 0.000 claims abstract description 11
- 229920001436 collagen Polymers 0.000 claims abstract description 11
- 239000011248 coating agent Substances 0.000 claims abstract description 6
- 229920003232 aliphatic polyester Polymers 0.000 claims abstract description 5
- 239000003937 drug carrier Substances 0.000 claims description 23
- 239000002966 varnish Substances 0.000 claims description 15
- 229920000728 polyester Polymers 0.000 claims description 10
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 8
- 229920000954 Polyglycolide Polymers 0.000 claims description 6
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 6
- 229920002101 Chitin Polymers 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 239000011888 foil Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 3
- 239000004633 polyglycolic acid Substances 0.000 claims description 3
- 239000004626 polylactic acid Substances 0.000 claims description 3
- 235000019260 propionic acid Nutrition 0.000 claims description 3
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 3
- 102000009123 Fibrin Human genes 0.000 claims description 2
- 108010073385 Fibrin Proteins 0.000 claims description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 2
- 229950003499 fibrin Drugs 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 abstract description 7
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 18
- 229940079593 drug Drugs 0.000 description 17
- 239000004480 active ingredient Substances 0.000 description 9
- 238000002513 implantation Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 229960000907 methylthioninium chloride Drugs 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 3
- 229930182566 Gentamicin Natural products 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 239000000824 cytostatic agent Substances 0.000 description 3
- 230000001085 cytostatic effect Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 230000003111 delayed effect Effects 0.000 description 3
- 229960002518 gentamicin Drugs 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- RDEIXVOBVLKYNT-VQBXQJRRSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2-yl]o Chemical compound OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)C(C)N)N)[C@@H](N)C[C@H]1N.O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N RDEIXVOBVLKYNT-VQBXQJRRSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 229920001634 Copolyester Polymers 0.000 description 1
- 239000008156 Ringer's lactate solution Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229940126575 aminoglycoside Drugs 0.000 description 1
- 239000002639 bone cement Substances 0.000 description 1
- ZEWYCNBZMPELPF-UHFFFAOYSA-J calcium;potassium;sodium;2-hydroxypropanoic acid;sodium;tetrachloride Chemical compound [Na].[Na+].[Cl-].[Cl-].[Cl-].[Cl-].[K+].[Ca+2].CC(O)C(O)=O ZEWYCNBZMPELPF-UHFFFAOYSA-J 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011846 endoscopic investigation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19883841397 DE3841397A1 (de) | 1988-12-08 | 1988-12-08 | Poroeser resorbierbarer arzneistofftraeger |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19883841397 DE3841397A1 (de) | 1988-12-08 | 1988-12-08 | Poroeser resorbierbarer arzneistofftraeger |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3841397A1 true DE3841397A1 (de) | 1990-06-21 |
| DE3841397C2 DE3841397C2 (enrdf_load_stackoverflow) | 1992-11-12 |
Family
ID=6368740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19883841397 Granted DE3841397A1 (de) | 1988-12-08 | 1988-12-08 | Poroeser resorbierbarer arzneistofftraeger |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE3841397A1 (enrdf_load_stackoverflow) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0788340A4 (en) * | 1994-10-25 | 1998-11-04 | Daratech Pty Ltd | CONTROLLED RELEASE CONTAINER WITH CORE AND OUTER SHELL |
| US5935594A (en) * | 1993-10-28 | 1999-08-10 | Thm Biomedical, Inc. | Process and device for treating and healing a tissue deficiency |
| US5981825A (en) * | 1994-05-13 | 1999-11-09 | Thm Biomedical, Inc. | Device and methods for in vivo culturing of diverse tissue cells |
| JP2986551B2 (ja) | 1994-09-30 | 1999-12-06 | 山之内製薬株式会社 | 骨形成用移植体 |
| WO2001070293A1 (en) * | 2000-03-18 | 2001-09-27 | The University Of Nottingham | Polymeric composite materials and their manufacture |
| US6461325B1 (en) | 1996-01-16 | 2002-10-08 | Baxter International Inc. | Fibrin delivery device and method for forming fibrin on a surface |
| WO2002038183A3 (en) * | 2000-11-10 | 2003-01-23 | Univ Cambridge Tech | Delivery devices |
| US6761908B1 (en) | 1994-04-27 | 2004-07-13 | Lohmann & Rauscher Gmbh & Co., Kg | Collagen preparation for the controlled release of active substances |
| WO2005041936A3 (en) * | 2003-10-21 | 2005-08-04 | Psimedica Ltd | Methods of treatment of cancer using a composition comprising a cytotoxic drug and a porous carrier material |
| WO2006019844A1 (en) * | 2004-07-15 | 2006-02-23 | Nanobac Life Sciences | Methods and compositions for the treatment of diseases characterized by pathological calcification |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996022115A1 (en) * | 1995-01-16 | 1996-07-25 | Baxter International Inc. | Self-supporting sheet-like material of cross-linked fibrin for preventing post operative adhesions |
| BE1012536A3 (fr) | 1998-11-04 | 2000-12-05 | Baxter Int | Element muni d'une couche de fibrine sa preparation et son utilisation. |
| US7135027B2 (en) | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2843963A1 (de) * | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
| US4563489A (en) * | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
-
1988
- 1988-12-08 DE DE19883841397 patent/DE3841397A1/de active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2843963A1 (de) * | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
| US4563489A (en) * | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
Non-Patent Citations (1)
| Title |
|---|
| WOOD, D.A.: Materials Used in Pharmacentical Formulation, Ed. A.T. Florence, Blackwell Scientific Publications, Oxford 1984, S. 71-123 * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5935594A (en) * | 1993-10-28 | 1999-08-10 | Thm Biomedical, Inc. | Process and device for treating and healing a tissue deficiency |
| US6761908B1 (en) | 1994-04-27 | 2004-07-13 | Lohmann & Rauscher Gmbh & Co., Kg | Collagen preparation for the controlled release of active substances |
| US5981825A (en) * | 1994-05-13 | 1999-11-09 | Thm Biomedical, Inc. | Device and methods for in vivo culturing of diverse tissue cells |
| US6264701B1 (en) | 1994-05-13 | 2001-07-24 | Kensey Nash Corporation | Device and methods for in vivo culturing of diverse tissue cells |
| JP2986551B2 (ja) | 1994-09-30 | 1999-12-06 | 山之内製薬株式会社 | 骨形成用移植体 |
| EP0788340A4 (en) * | 1994-10-25 | 1998-11-04 | Daratech Pty Ltd | CONTROLLED RELEASE CONTAINER WITH CORE AND OUTER SHELL |
| US6461325B1 (en) | 1996-01-16 | 2002-10-08 | Baxter International Inc. | Fibrin delivery device and method for forming fibrin on a surface |
| WO2001070293A1 (en) * | 2000-03-18 | 2001-09-27 | The University Of Nottingham | Polymeric composite materials and their manufacture |
| WO2002038183A3 (en) * | 2000-11-10 | 2003-01-23 | Univ Cambridge Tech | Delivery devices |
| WO2005041936A3 (en) * | 2003-10-21 | 2005-08-04 | Psimedica Ltd | Methods of treatment of cancer using a composition comprising a cytotoxic drug and a porous carrier material |
| WO2006019844A1 (en) * | 2004-07-15 | 2006-02-23 | Nanobac Life Sciences | Methods and compositions for the treatment of diseases characterized by pathological calcification |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3841397C2 (enrdf_load_stackoverflow) | 1992-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |