DE3807594A1 - Antikoerper, verfahren zu ihrer herstellung, oligosaccharid-haptene und klone zur erzeugung der antikoerper sowie verwendung der antikoerper zur diagnose und therapie von tumoren - Google Patents

Antikoerper, verfahren zu ihrer herstellung, oligosaccharid-haptene und klone zur erzeugung der antikoerper sowie verwendung der antikoerper zur diagnose und therapie von tumoren

Info

Publication number
DE3807594A1
DE3807594A1 DE3807594A DE3807594A DE3807594A1 DE 3807594 A1 DE3807594 A1 DE 3807594A1 DE 3807594 A DE3807594 A DE 3807594A DE 3807594 A DE3807594 A DE 3807594A DE 3807594 A1 DE3807594 A1 DE 3807594A1
Authority
DE
Germany
Prior art keywords
residue
oligosaccharide
antibodies
mannose
glycoproteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE3807594A
Other languages
German (de)
English (en)
Other versions
DE3807594C2 (https=
Inventor
Erfinder Wird Nachtraeglich Benannt Der
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE3844628A priority Critical patent/DE3844628C2/de
Application filed by Individual filed Critical Individual
Priority to DE3807594A priority patent/DE3807594A1/de
Priority to AT89903099T priority patent/ATE90793T1/de
Priority to JP1502832A priority patent/JP2693247B2/ja
Priority to PCT/DE1989/000146 priority patent/WO1989008845A1/de
Priority to DE8989903099T priority patent/DE58904746D1/de
Priority to EP89903099A priority patent/EP0406259B1/de
Publication of DE3807594A1 publication Critical patent/DE3807594A1/de
Application granted granted Critical
Publication of DE3807594C2 publication Critical patent/DE3807594C2/de
Priority to US08/128,264 priority patent/US5625037A/en
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57525—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE3807594A 1988-03-08 1988-03-08 Antikoerper, verfahren zu ihrer herstellung, oligosaccharid-haptene und klone zur erzeugung der antikoerper sowie verwendung der antikoerper zur diagnose und therapie von tumoren Granted DE3807594A1 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE3807594A DE3807594A1 (de) 1988-03-08 1988-03-08 Antikoerper, verfahren zu ihrer herstellung, oligosaccharid-haptene und klone zur erzeugung der antikoerper sowie verwendung der antikoerper zur diagnose und therapie von tumoren
DE3844628A DE3844628C2 (en) 1988-03-08 1988-03-08 New antibodies reactive with N-glycan structures of cell membrane surf
JP1502832A JP2693247B2 (ja) 1988-03-08 1989-03-08 抗体の製造方法
PCT/DE1989/000146 WO1989008845A1 (fr) 1988-03-08 1989-03-08 Anticorps, leur procede de production, haptenes d'oligosaccharides et clones pour la production de ces anticorps, et utilisation des anticorps pour le diagnostic et la therapie de tumeurs
AT89903099T ATE90793T1 (de) 1988-03-08 1989-03-08 Antikoerper, verfahren zu ihrer herstellung, klone zur erzeugung der antikoerper sowie verwendung der antikoerper zur diagnose und therapie von tumoren.
DE8989903099T DE58904746D1 (de) 1988-03-08 1989-03-08 Antikoerper, verfahren zu ihrer herstellung, klone zur erzeugung der antikoerper sowie verwendung der antikoerper zur diagnose und therapie von tumoren.
EP89903099A EP0406259B1 (de) 1988-03-08 1989-03-08 Antikörper, verfahren zu ihrer herstellung, klone zur erzeugung der antikörper sowie verwendung der antikörper zur diagnose und therapie von tumoren
US08/128,264 US5625037A (en) 1988-03-08 1993-09-28 Antibodies, method of preparing same, oligosaccharides and clones for providing said antibodies, and the use of said antibodies for tumor diagnosis and therapy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3807594A DE3807594A1 (de) 1988-03-08 1988-03-08 Antikoerper, verfahren zu ihrer herstellung, oligosaccharid-haptene und klone zur erzeugung der antikoerper sowie verwendung der antikoerper zur diagnose und therapie von tumoren

Publications (2)

Publication Number Publication Date
DE3807594A1 true DE3807594A1 (de) 1989-09-21
DE3807594C2 DE3807594C2 (https=) 1993-04-22

Family

ID=6349168

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3807594A Granted DE3807594A1 (de) 1988-03-08 1988-03-08 Antikoerper, verfahren zu ihrer herstellung, oligosaccharid-haptene und klone zur erzeugung der antikoerper sowie verwendung der antikoerper zur diagnose und therapie von tumoren
DE8989903099T Expired - Fee Related DE58904746D1 (de) 1988-03-08 1989-03-08 Antikoerper, verfahren zu ihrer herstellung, klone zur erzeugung der antikoerper sowie verwendung der antikoerper zur diagnose und therapie von tumoren.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8989903099T Expired - Fee Related DE58904746D1 (de) 1988-03-08 1989-03-08 Antikoerper, verfahren zu ihrer herstellung, klone zur erzeugung der antikoerper sowie verwendung der antikoerper zur diagnose und therapie von tumoren.

Country Status (4)

Country Link
EP (1) EP0406259B1 (https=)
JP (1) JP2693247B2 (https=)
DE (2) DE3807594A1 (https=)
WO (1) WO1989008845A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003016915A1 (en) * 2001-08-20 2003-02-27 Biotie Therapies Corp. Tumor specific oligosaccharide sequences and use thereof
WO2004017810A3 (en) * 2002-08-20 2004-06-10 Biotie Therapies Corp Tumor specific oligosaccharide epitopes and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894442A (en) * 1985-04-12 1990-01-16 Kuraray Co., Ltd. Monoclonal antibodies that bind to alpha-acid glycoprotein

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Biochemistry, 1985, 24, S. 4665-4671 *
CA 105: 189 019p, 1986 *
CA 86: 104 294r, 1977 *
Diagnose + Labor 36, S. 41-54, 1986 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003016915A1 (en) * 2001-08-20 2003-02-27 Biotie Therapies Corp. Tumor specific oligosaccharide sequences and use thereof
US8236487B2 (en) 2001-08-20 2012-08-07 Glykos Finland Oy Tumor specific oligosaccharide sequences and use thereof
US8697061B2 (en) 2001-08-20 2014-04-15 Glykos Finland Oy Tumor specific oligosaccharide epitopes and use thereof
WO2004017810A3 (en) * 2002-08-20 2004-06-10 Biotie Therapies Corp Tumor specific oligosaccharide epitopes and use thereof
EP2322209A2 (en) 2002-08-20 2011-05-18 Glykos Finland Oy Tumor specific oligosaccharide epitopes and use thereof

Also Published As

Publication number Publication date
JPH03503281A (ja) 1991-07-25
JP2693247B2 (ja) 1997-12-24
EP0406259A1 (de) 1991-01-09
DE58904746D1 (de) 1993-07-22
WO1989008845A1 (fr) 1989-09-21
EP0406259B1 (de) 1993-06-16
DE3807594C2 (https=) 1993-04-22

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