DE3782736T2 - Zuchtverfahren fuer leukocyten. - Google Patents

Zuchtverfahren fuer leukocyten.

Info

Publication number
DE3782736T2
DE3782736T2 DE8787903509T DE3782736T DE3782736T2 DE 3782736 T2 DE3782736 T2 DE 3782736T2 DE 8787903509 T DE8787903509 T DE 8787903509T DE 3782736 T DE3782736 T DE 3782736T DE 3782736 T2 DE3782736 T2 DE 3782736T2
Authority
DE
Germany
Prior art keywords
leukocytes
culturing
leukocyten
breeding process
days
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787903509T
Other languages
English (en)
Other versions
DE3782736D1 (de
Inventor
B Melink
A Shankar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Endotronics Inc
Original Assignee
Endotronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endotronics Inc filed Critical Endotronics Inc
Application granted granted Critical
Publication of DE3782736D1 publication Critical patent/DE3782736D1/de
Publication of DE3782736T2 publication Critical patent/DE3782736T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE8787903509T 1986-04-28 1987-04-27 Zuchtverfahren fuer leukocyten. Expired - Fee Related DE3782736T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85682786A 1986-04-28 1986-04-28
PCT/US1987/000924 WO1987006610A1 (en) 1986-04-28 1987-04-27 Method of culturing leukocytes

Publications (2)

Publication Number Publication Date
DE3782736D1 DE3782736D1 (de) 1992-12-24
DE3782736T2 true DE3782736T2 (de) 1993-06-09

Family

ID=25324599

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787903509T Expired - Fee Related DE3782736T2 (de) 1986-04-28 1987-04-27 Zuchtverfahren fuer leukocyten.

Country Status (6)

Country Link
US (2) US5541105A (de)
EP (1) EP0302894B1 (de)
JP (1) JP2529321B2 (de)
AT (1) ATE82588T1 (de)
DE (1) DE3782736T2 (de)
WO (1) WO1987006610A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2543719A1 (de) 2011-07-08 2013-01-09 Zellwerk GmbH Mäander-Bioreaktor und Verfahren zur dynamischen Expansion, Differenzierung und Ernte von hämatopoetischen Zellen

Families Citing this family (34)

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DE3786978T2 (de) * 1986-09-29 1994-03-03 Suzuki Shokan Co Verfahren für die Zuführung von Kulturmedium und Kultursystem.
AU2925789A (en) * 1987-12-17 1989-07-19 Browning's Clinical Pathology Services Limited Lymphokine activation of cells for adoptive immunotherapy, e.g. of hiv infection
US4999298A (en) * 1988-04-27 1991-03-12 W. R. Grace & Co.-Conn. Hollow fiber bioreactor culture system and method
CA2015294A1 (en) * 1989-04-28 1990-10-28 John J. Rinehart Generation and expansion of lak cells
GR1001034B (el) * 1989-07-21 1993-03-31 Ortho Pharma Corp Μεθοδος διεγερσης του πολλαπλασιασμου λεμφοκυτταρων περιφερειακου αιματος.
JPH05502369A (ja) * 1989-09-14 1993-04-28 セルコ、インコーポレイテッド 養子免疫療法に用いられる生体外増殖リンパ性細胞の製造方法
WO1991018972A1 (en) * 1990-05-30 1991-12-12 Cellco, Inc. Culturing bone marrow cells for adoptive immunotherapy
US5476780A (en) * 1991-07-04 1995-12-19 Japan Tobacco, Inc. Method for culturing T precursor cells under conditions of high oxygen concentration
EP1060247B2 (de) 1998-02-24 2011-10-26 Sisters of Providence in Oregon Ox-40-rezeptor-bindemittel zur verwendung in verfahren zur verbesserung der antigenspezifischen immunantwort gegen tumore
DE19945162A1 (de) * 1999-09-21 2001-04-26 Herbert Maerkl Verfahren zur Kultivierung von Zellen, Membranmodul, Verwendung eines Membranmoduls und Reaktionssystem zur Kultivierung von Zellen
EP2029722B1 (de) 2006-05-22 2019-10-16 Biovest International, Inc. Verfahren und system zur zellproduktion
JP2010519936A (ja) * 2007-03-05 2010-06-10 カリディアンビーシーティー、インコーポレーテッド 中空繊維バイオリアクター内における細胞の動きを制御する方法
CA2680130C (en) * 2007-03-05 2016-01-12 Caridianbct, Inc. Cell expansion system and methods of use
KR20100016187A (ko) * 2007-04-06 2010-02-12 카리디안비씨티, 인크. 개선된 생물반응기 표면
WO2008128165A2 (en) * 2007-04-13 2008-10-23 Caridianbct, Inc. Cell expansion system and methods of use
US8691565B2 (en) 2008-03-05 2014-04-08 Terumo Bct, Inc. Method of reseeding adherent cells grown in a hollow fiber bioreactor system
EP2625263B1 (de) 2010-10-08 2020-03-11 Terumo BCT, Inc. Konfigurierbare verfahren und systeme für züchtung und ernte von zellen in einem hohlfaser-bioreaktorsystem
WO2012171030A2 (en) 2011-06-10 2012-12-13 Biovest International, Inc. Method and apparatus for antibody production and purification
WO2012171026A2 (en) 2011-06-10 2012-12-13 Biovest International, Inc. Methods for high yield virus production
EP2771351B1 (de) 2011-10-28 2017-06-14 Patrys Limited Pat-lm1-epitope und verfahren zu ihrer verwendung
EP2885393A1 (de) 2012-08-20 2015-06-24 Terumo BCT, Inc. Verfahren zum laden und verteilen von zellen in einem bioreaktor eines zellexpansionssystems
EP2909302A4 (de) 2012-08-28 2016-07-27 Biovest Int Inc Bioherstellungssuite und verfahren zur herstellung grosser mengen von zellen, viren und biomolekülen
WO2014036488A1 (en) 2012-08-31 2014-03-06 Biovest International, Inc. Methods for producing high-fidelity autologous idiotype vaccines
JP6539585B2 (ja) 2013-02-01 2019-07-03 デンドロサイト バイオテック ピーティーワイ リミテッド 抗ｃｄ８３抗体及びその使用
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
US10077421B2 (en) 2014-04-24 2018-09-18 Terumo Bct, Inc. Measuring flow rate
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
EP3464565A4 (de) 2016-05-25 2020-01-01 Terumo BCT, Inc. Zellexpansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
CN117247899A (zh) 2017-03-31 2023-12-19 泰尔茂比司特公司 细胞扩增
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515894A (en) * 1979-03-20 1985-05-07 Ortho Pharmaceutical Corporation Hybrid cell line for producing monoclonal antibody to human T cells
US4515893A (en) * 1979-04-26 1985-05-07 Ortho Pharmaceutical Corporation Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells
US4515895A (en) * 1979-04-26 1985-05-07 Ortho Pharmaceutical Corporation Hybrid cell line for producing monoclonal antibody to human helper T cells
US4364932A (en) * 1979-09-18 1982-12-21 Ortho Pharmaceutical Corporation Monoclonal antibody to human cytotoxic and suppressor T cells and methods of preparing same
JPS5642584A (en) * 1979-09-18 1981-04-20 Asahi Chem Ind Co Ltd Cell cultivation method
US4444887A (en) * 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
US4464355A (en) * 1981-03-26 1984-08-07 Hooper Trading Co. Serum-free and mitogen-free T-cell growth factor and process for making same
US4401756A (en) * 1981-04-14 1983-08-30 Immunex Corporation Process for preparing human interleukin 2
US4407945A (en) * 1981-04-29 1983-10-04 Immunex Corporation Constitutive production of interleukin 2 by a T cell hybridoma
US4473642A (en) * 1981-04-29 1984-09-25 Immunex Corporation Constitutive production of interleukin 2 by a T cell hybridoma
US4544632A (en) * 1981-06-12 1985-10-01 Yuichi Yamamura Human T cell lines and method of producing same
US4404280A (en) * 1981-07-16 1983-09-13 Steven Gillis Process for preparing murine interleukin 2 in the presence of interleukin 1 from an interleukin 2 nonproducer malignant cell line and cell line therefor
US4490289A (en) * 1982-09-16 1984-12-25 Hoffmann-La Roche Inc. Homogeneous human interleukin 2
JPS60137284A (ja) * 1983-12-23 1985-07-20 Sumitomo Chem Co Ltd 抗体産生細胞の取得方法、及びそれを用いた抗体の製造方法
US4804628A (en) * 1984-10-09 1989-02-14 Endotronics, Inc. Hollow fiber cell culture device and method of operation
JPS61280270A (ja) * 1985-06-03 1986-12-10 Teijin Ltd 細胞培養装置
US4690915A (en) * 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2543719A1 (de) 2011-07-08 2013-01-09 Zellwerk GmbH Mäander-Bioreaktor und Verfahren zur dynamischen Expansion, Differenzierung und Ernte von hämatopoetischen Zellen
DE102011106914A1 (de) 2011-07-08 2013-01-10 Zellwerk Gmbh Mäander- Bioreaktor und Verfahren zu dynamischen Expansion, Differenzierung und Ernte von hämatopoetischen Zellen
DE102011106914B4 (de) * 2011-07-08 2015-08-27 Zellwerk Gmbh Mäander- Bioreaktor und Verfahren zu dynamischen Expansion, Differenzierung und Ernte von hämatopoetischen Zellen

Also Published As

Publication number Publication date
US5541105A (en) 1996-07-30
EP0302894B1 (de) 1992-11-19
US5631006A (en) 1997-05-20
ATE82588T1 (de) 1992-12-15
EP0302894A1 (de) 1989-02-15
JPH01502315A (ja) 1989-08-17
DE3782736D1 (de) 1992-12-24
JP2529321B2 (ja) 1996-08-28
WO1987006610A1 (en) 1987-11-05
EP0302894A4 (de) 1989-02-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee