DE3776611D1 - Derivate von phenyl-, pyrrolidin-2-yl-substituierten 5-ring heterocyclen mit antipsychotischer wirkung. - Google Patents
Derivate von phenyl-, pyrrolidin-2-yl-substituierten 5-ring heterocyclen mit antipsychotischer wirkung.Info
- Publication number
- DE3776611D1 DE3776611D1 DE8787201706T DE3776611T DE3776611D1 DE 3776611 D1 DE3776611 D1 DE 3776611D1 DE 8787201706 T DE8787201706 T DE 8787201706T DE 3776611 T DE3776611 T DE 3776611T DE 3776611 D1 DE3776611 D1 DE 3776611D1
- Authority
- DE
- Germany
- Prior art keywords
- ring
- phenyl
- pyrrolidin
- substituted
- heterocyclen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000000561 anti-psychotic effect Effects 0.000 title abstract 2
- -1 PHENYL- Chemical class 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8602305 | 1986-09-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3776611D1 true DE3776611D1 (de) | 1992-03-19 |
Family
ID=19848538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8787201706T Expired - Fee Related DE3776611D1 (de) | 1986-09-12 | 1987-09-09 | Derivate von phenyl-, pyrrolidin-2-yl-substituierten 5-ring heterocyclen mit antipsychotischer wirkung. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4791132A (enExample) |
| EP (1) | EP0259930B1 (enExample) |
| JP (1) | JPH0794432B2 (enExample) |
| AT (1) | ATE72435T1 (enExample) |
| AU (1) | AU609415B2 (enExample) |
| DE (1) | DE3776611D1 (enExample) |
| DK (1) | DK166275C (enExample) |
| ES (1) | ES2033297T3 (enExample) |
| GR (1) | GR3004436T3 (enExample) |
| IE (1) | IE60294B1 (enExample) |
| IL (1) | IL83841A (enExample) |
| NZ (1) | NZ221731A (enExample) |
| PH (1) | PH23898A (enExample) |
| ZA (1) | ZA876749B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4992441A (en) * | 1987-10-14 | 1991-02-12 | Mcneilab, Inc. | 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia |
| AU4704593A (en) * | 1992-08-06 | 1994-03-03 | Smithkline Beecham Plc | 5-(2-oxyphenyl)-pyrrole derivatives as dopamine d3 receptor antagonists |
| GB9307400D0 (en) * | 1993-04-08 | 1993-06-02 | Smithkline Beecham Plc | Compounds |
| GB9309573D0 (en) * | 1993-05-10 | 1993-06-23 | Merck Sharp & Dohme | Therapeutic agents |
| WO1995000508A1 (en) * | 1993-06-25 | 1995-01-05 | Smithkline Beecham Plc | Phenyrrole derivatives and their use as dopamine d3 antagonists |
| GB9315800D0 (en) * | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
| GB9315801D0 (en) * | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
| GB9320855D0 (en) * | 1993-10-09 | 1993-12-01 | Smithkline Beecham Plc | Compounds |
| GB9402197D0 (en) * | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Compounds |
| GB9403199D0 (en) * | 1994-02-19 | 1994-04-13 | Smithkline Beecham Plc | Compounds |
| GB9512129D0 (en) * | 1995-06-15 | 1995-08-16 | Smithkline Beecham Plc | Compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4219560A (en) * | 1978-04-17 | 1980-08-26 | Sandoz, Inc. | Piperidine and pyrrolidine alcohols |
| DE2835439A1 (de) * | 1978-08-12 | 1980-02-28 | Basf Ag | 2-(o-hydroxyphenyl)-pyrrol |
| US4321385A (en) * | 1980-02-04 | 1982-03-23 | Hoechst Roussel Pharmaceuticals Inc. | [(Aryl-1-pyrryl) methyl]-piperidinols and pyrrolidinols |
| US4539332A (en) * | 1983-11-14 | 1985-09-03 | Merck & Co., Inc. | 2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists |
-
1987
- 1987-09-08 PH PH35780A patent/PH23898A/en unknown
- 1987-09-09 AT AT87201706T patent/ATE72435T1/de not_active IP Right Cessation
- 1987-09-09 AU AU78191/87A patent/AU609415B2/en not_active Ceased
- 1987-09-09 DK DK470687A patent/DK166275C/da active
- 1987-09-09 IE IE240987A patent/IE60294B1/en not_active IP Right Cessation
- 1987-09-09 ES ES198787201706T patent/ES2033297T3/es not_active Expired - Lifetime
- 1987-09-09 EP EP87201706A patent/EP0259930B1/en not_active Expired - Lifetime
- 1987-09-09 IL IL83841A patent/IL83841A/xx not_active IP Right Cessation
- 1987-09-09 ZA ZA876749A patent/ZA876749B/xx unknown
- 1987-09-09 NZ NZ221731A patent/NZ221731A/xx unknown
- 1987-09-09 DE DE8787201706T patent/DE3776611D1/de not_active Expired - Fee Related
- 1987-09-09 US US07/094,746 patent/US4791132A/en not_active Expired - Fee Related
- 1987-09-10 JP JP62225427A patent/JPH0794432B2/ja not_active Expired - Lifetime
-
1992
- 1992-04-22 GR GR920400808T patent/GR3004436T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE60294B1 (en) | 1994-06-29 |
| JPS6377856A (ja) | 1988-04-08 |
| ZA876749B (en) | 1988-03-14 |
| JPH0794432B2 (ja) | 1995-10-11 |
| ATE72435T1 (de) | 1992-02-15 |
| DK166275C (da) | 1993-08-23 |
| IE872409L (en) | 1988-03-12 |
| IL83841A0 (en) | 1988-02-29 |
| GR3004436T3 (enExample) | 1993-03-31 |
| DK470687A (da) | 1988-03-13 |
| NZ221731A (en) | 1990-07-26 |
| AU609415B2 (en) | 1991-05-02 |
| AU7819187A (en) | 1988-03-17 |
| DK470687D0 (da) | 1987-09-09 |
| EP0259930A1 (en) | 1988-03-16 |
| IL83841A (en) | 1991-11-21 |
| EP0259930B1 (en) | 1992-02-05 |
| DK166275B (da) | 1993-03-29 |
| PH23898A (en) | 1989-12-18 |
| US4791132A (en) | 1988-12-13 |
| ES2033297T3 (es) | 1993-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |