DE375181C - Process for the production of water-soluble, durable preparations containing acetylsalicylic acid - Google Patents

Process for the production of water-soluble, durable preparations containing acetylsalicylic acid

Info

Publication number
DE375181C
DE375181C DEW59693D DEW0059693D DE375181C DE 375181 C DE375181 C DE 375181C DE W59693 D DEW59693 D DE W59693D DE W0059693 D DEW0059693 D DE W0059693D DE 375181 C DE375181 C DE 375181C
Authority
DE
Germany
Prior art keywords
durable
acetylsalicylic acid
soluble
water
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEW59693D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHEM FAB
Original Assignee
CHEM FAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHEM FAB filed Critical CHEM FAB
Priority to DEW59693D priority Critical patent/DE375181C/en
Application granted granted Critical
Publication of DE375181C publication Critical patent/DE375181C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Description

Verfahren zur Herstellung wasserlöslicher, haltbarer, Azetylsalizylsäure enthaltender Präparate. Die freie Azetylsalizylsäure ist als Pulver und in Tablettenform auch unter ungünstigen Verhältnissen haltbar, hat aber den Nachteil, wegen ihrer Azidität beim Einnehmen besonders größerer Mengen den Magen zu belästigen. Sie wird auch nicht so schnell resorbiert wie ihre Salze. Diese nun haben wieder den N achteil, hygroskopisch zu sein, und, wenn sie einmal Wasser angezogen haben, sich unter Abspaltung von Essigsäure durch den verseifenden Einfluß des Alkalis oder Erdalkalis zu zersetzen.Process for making water-soluble, durable, acetylsalicylic acid containing preparations. The free acetylsalicylic acid is available as a powder and in tablet form Durable even under unfavorable conditions, but has the disadvantage because of it Acidity when ingesting particularly large quantities, causing a nuisance to the stomach. she will also not absorbed as quickly as their salts. These now have the disadvantage again, to be hygroscopic and, once attracted to water, to split off to decompose of acetic acid by the saponifying influence of the alkali or alkaline earth.

Dies gilt besonders von dem Natrium- und Lithiumsalz; aber auch die haltbareren Kalzium- und Magnesiumsalze zersetzen sich, wenn sie in feuchtem und besonders auch in feuchtwarmem Klima in den üblichen Schachtel- oder Glasröhrchenverpackungen als Arzneimittel aufbewahrt werden. Es war deshalb bisher nicht möglich, nach den Tropen in handlicher billiger Verpackung lösliche, den Magen nicht belästigende Präparate aus Azetylsalizylsäure zu liefern.This is especially true of the sodium and lithium salts; but also the More durable calcium and magnesium salts decompose when in moist and especially in a warm and humid climate in the usual box or glass tube packaging be kept as medicinal products. It was therefore not possible to date after the The tropics are soluble in cheap, handy packaging and do not bother the stomach To deliver preparations made from acetylsalicylic acid.

Es wurde nun gefunden, daß Mischungen der Azetylsalizylsäure mit den Karbonaten der nicht giftigen Erdalkalien diesen Anforderungen entsprechen. Wird z. B. ein Gemisch aus Azetylsalizylsäure mit der äquivalenten Menge von Magnesiumkarbonat in Tablettenform gebracht, so zeigen diese Tabletten, auch in feuchtwarmerii Klima aufbewahrt, keine Zersetzung. Werden diese Tabletten in Wasser geworfen, so lösen sie sich in kurzer Zeit klar auf.It has now been found that mixtures of acetylsalicylic acid with the Carbonates of the non-toxic alkaline earths meet these requirements. Will z. B. a mixture of acetylsalicylic acid with the equivalent amount of magnesium carbonate Brought into tablet form, these tablets show, even in humid and warm climates stored, no decomposition. If these tablets are thrown into water, they will dissolve they clear up in a short time.

Die entsprechenden Mischungen mit kohlensaurem Kalk oder Magnesiumoxyd lösen sich etwas langsamer, schneller bei Körpertemperatur. Die Mischungen mit Kalziumhydroxyd erreichen nicht ganz die Haltbarkeit der übrigen.The corresponding mixtures with carbonate of lime or magnesium oxide dissolve a little slower, faster at body temperature. Mixtures with calcium hydroxide do not quite reach the shelf life of the rest.

Es ist bereits vorgeschlagen, das Kalziumsalz der Azetylsalizylsäure in der Weise herzustellen, daß die Azetylsalizylsäure mit Kalziumhydroxyd trocken gemischt und diese Mischung dann mit organischen Lösungsmitteln behandelt wird, bis die Umsetzung der beidenKomponenten erfolgt und dasKalziumsalz entstanden ist. Es findet sich in jener Literaturstelle aber kein Hinweis darauf, daß dieMischung derKomponenten als solcheVerwendung finden sollte und die bisher wohl erstrebte, aber noch nie erreichte Haltbarkeit und Beständigkeit fei tropischer Temperatur besitzt. ' Es ist ferner schon einmal angeregt worden, Azetysalizylsäure mit Natriumbikarbonat in Tablettenform überzuführen, aber diese Präparate waren nicht haltbar, obgleich doch beide Komponenten nicht hygroskopisch sind. Es- war deshalb nicht zu erwarten, daß die Mischungen nach vorliegender Erfindung technisch so vorteilhafte Eigenschaften haben würden.It has already been suggested to use the calcium salt of acetylsalicylic acid to be prepared in such a way that the acetylsalicylic acid is dry with calcium hydroxide mixed and this mixture is then treated with organic solvents, until the two components have reacted and the calcium salt has formed. However, there is no indication in that reference that the mixture the components should be used as such and the but never before achieved durability and resistance at tropical temperatures owns. 'It has also been suggested before, acetysalicylic acid with sodium bicarbonate in tablet form, but these preparations were not stable, although but both components are not hygroscopic. It was therefore not to be expected that the Mixtures according to the present invention are so technically advantageous Would have properties.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung wasserlöslicher, haltbarer, Azetvlsalizylsäure enthaltender Präparate, dadurch gekennzeichnet, daß Azetvlsalizylsäure mit Karbonaten, Hydroxyden oder Oxyden der nicht giftigen Erdalkalien in etwa äquivalentem Verhältnisse gemischt und nötigenfalls zu Tabletten gepreßt wird. PATENT CLAIM: Process for the production of water-soluble, durable preparations containing acetyl salicylic acid, characterized in that acetyl salicylic acid is mixed with carbonates, hydroxides or oxides of non-toxic alkaline earths in approximately equivalent proportions and, if necessary, pressed into tablets.
DEW59693D 1921-10-21 1921-10-21 Process for the production of water-soluble, durable preparations containing acetylsalicylic acid Expired DE375181C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEW59693D DE375181C (en) 1921-10-21 1921-10-21 Process for the production of water-soluble, durable preparations containing acetylsalicylic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEW59693D DE375181C (en) 1921-10-21 1921-10-21 Process for the production of water-soluble, durable preparations containing acetylsalicylic acid

Publications (1)

Publication Number Publication Date
DE375181C true DE375181C (en) 1923-05-08

Family

ID=7605818

Family Applications (1)

Application Number Title Priority Date Filing Date
DEW59693D Expired DE375181C (en) 1921-10-21 1921-10-21 Process for the production of water-soluble, durable preparations containing acetylsalicylic acid

Country Status (1)

Country Link
DE (1) DE375181C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1100034B (en) * 1958-05-31 1961-02-23 Dr Peter Schloesser Process for the production of sodium acetyl salicylate or of double salts of sodium acetyl salicylate with sodium bicarbonate

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1100034B (en) * 1958-05-31 1961-02-23 Dr Peter Schloesser Process for the production of sodium acetyl salicylate or of double salts of sodium acetyl salicylate with sodium bicarbonate

Similar Documents

Publication Publication Date Title
DE375181C (en) Process for the production of water-soluble, durable preparations containing acetylsalicylic acid
US1486002A (en) Process for the production of water-soluble durable preparations containing acetyl-salicylic acid
US2447396A (en) Preparation of stable medicinal salts of acetylsalicylic acid
DE423030C (en) Process for the preparation of easily soluble heavy metal compounds of iminodi- and nitrilotriacetic acid
DE1243597B (en) Method for producing a shower connection
DE660868C (en) Process for the preparation of N-methyl-C, C-allylisopropylbarbiturate sodium in a durable, dry, very easily soluble form in water
DE859348C (en) Process for the extraction of antibiotic substances from lichens
DE744655C (en) Process for the production of confectionery
DE854502C (en) Process for the production of durable formaldehyde solutions
AT120431B (en) Process for the production of double compounds of urea with sodium iodine.
DE525651C (en) Process for the production of stable complex compounds of pentavalent antimony which are soluble in water
AT219591B (en) Process for the production of sodium acetyl salicylate or of double salts of sodium acetyl salicylate with sodium bicarbonate
DE338735C (en) Process for the preparation of complex iron compounds of phosphoric acid esters of higher aliphatic polyhydroxyl compounds
AT92398B (en) Process for the preparation of the alkali and alkaline earth salts of benzylphthalamic acid.
DE430684C (en) Process for the preparation of a basic triiodophenol bismuth compound
AT92889B (en) Process for the production of long-lasting, rapidly soluble silver protein preparations.
DE852276C (en) Process for the preparation of salts of sulfourethanes
DE806993C (en) Process for the production of stable salts of acetylsalicylic acid
DE708912C (en) Oral and dental care products
DE445648C (en) Process for the preparation of derivatives of nuclear mercured phenols
AT148804B (en) Process for the preparation of N-methyl-C, C-allylisopropylbarbiturate sodium in a durable, dry form that is very easily soluble in water.
AT115388B (en) Process for the manufacture of preparations which develop hydrogen sulfide on contact with water.
DE578941C (en) Process for the preparation of santonin derivatives
DE670583C (en) Method for purifying gonad hormones
DE937927C (en) Process for the production of powdery preparations intended for souring dishes