DE3750140D1 - Inhibierung der interleukin-1-bildung durch monocyten und/oder makrophagen. - Google Patents
Inhibierung der interleukin-1-bildung durch monocyten und/oder makrophagen.Info
- Publication number
- DE3750140D1 DE3750140D1 DE3750140T DE3750140T DE3750140D1 DE 3750140 D1 DE3750140 D1 DE 3750140D1 DE 3750140 T DE3750140 T DE 3750140T DE 3750140 T DE3750140 T DE 3750140T DE 3750140 D1 DE3750140 D1 DE 3750140D1
- Authority
- DE
- Germany
- Prior art keywords
- monocyten
- macrophage
- interleukin
- inhibition
- formation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89790986A | 1986-08-19 | 1986-08-19 | |
US07/063,550 US4794114A (en) | 1986-08-19 | 1987-06-17 | Inhibition of interleukin-1 production by monocytes and/or macrophages |
PCT/US1987/002014 WO1988001169A1 (en) | 1986-08-19 | 1987-08-17 | Inhibition of interleukin-1 production by monocytes and/or macrophages |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3750140D1 true DE3750140D1 (de) | 1994-07-28 |
Family
ID=26743522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3750140T Expired - Lifetime DE3750140D1 (de) | 1986-08-19 | 1987-08-17 | Inhibierung der interleukin-1-bildung durch monocyten und/oder makrophagen. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4794114A (de) |
EP (1) | EP0321490B1 (de) |
JP (1) | JPH01503782A (de) |
AT (1) | ATE107507T1 (de) |
AU (1) | AU7880087A (de) |
CA (1) | CA1292694C (de) |
DE (1) | DE3750140D1 (de) |
DK (1) | DK199788A (de) |
GR (1) | GR871277B (de) |
WO (1) | WO1988001169A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05503919A (ja) * | 1989-06-13 | 1993-06-24 | スミスクライン・ビーチャム・コーポレイション | 単球および/またはマクロファージによるインターロイキン―1または腫瘍壊死因子生成の抑制 |
WO1990015534A1 (en) * | 1989-06-13 | 1990-12-27 | Smithkline Beecham Corporation | Monokine activity interference |
US5714140A (en) * | 1989-12-13 | 1998-02-03 | Otsuka Pharmaceutical Co., Ltd. | Method for inhibiting the production of bioactive IL-1 by administering M-CSF |
EP0489690A1 (de) * | 1990-12-05 | 1992-06-10 | Ciba-Geigy Ag | Substituierte N-Benzoyl-N'-(2-phenylethyl)-piperazine |
GB9026926D0 (en) * | 1990-12-12 | 1991-01-30 | Smith Kline French Lab | Novel process |
US6156304A (en) * | 1990-12-20 | 2000-12-05 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Gene transfer for studying and treating a connective tissue of a mammalian host |
US5858355A (en) * | 1990-12-20 | 1999-01-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | IRAP gene as treatment for arthritis |
US6413511B1 (en) | 1990-12-20 | 2002-07-02 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Cartilage alterations by administering to joints chondrocytes comprising a heterologous polynucleotide |
US6159464A (en) * | 1990-12-20 | 2000-12-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Viral vectors to inhibit leukocyte infiltration or cartilage degradation of joints |
US6228356B1 (en) | 1990-12-20 | 2001-05-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Viral vectors to inhibit leukocyte infiltration or cartilage degradation of joints |
JPH06502178A (ja) * | 1990-12-31 | 1994-03-10 | 藤沢薬品工業株式会社 | イミダゾトリアジン誘導体 |
US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
NZ274063A (en) * | 1993-09-17 | 1997-11-24 | Smithkline Beecham Corp | Cytokine suppressive anti-inflammatory drug binding protein (csbp) and its use |
US5783664A (en) * | 1993-09-17 | 1998-07-21 | Smithkline Beecham Corporation | Cytokine suppressive anit-inflammatory drug binding proteins |
US5552422A (en) * | 1995-01-11 | 1996-09-03 | Merck Frosst Canada, Inc. | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents |
KR20000057137A (ko) | 1996-11-19 | 2000-09-15 | 스티븐 엠. 오드레 | 아릴 및 헤테로아릴로 치환된 융합 피롤 항염증제 |
AR015425A1 (es) * | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion |
US6930101B1 (en) | 1999-05-17 | 2005-08-16 | The Regents Of The University Of California | Thiazolopyrimidines useful as TNFα inhibitors |
US7186714B2 (en) * | 2001-06-21 | 2007-03-06 | Smithkline Beecham Corporation | Imidazo[1,2-α]pyridine derivatives for the prophylaxis and treatment of herpes viral infections |
ES2262893T3 (es) | 2001-10-05 | 2006-12-01 | Smithkline Beecham Corporation | Derivados de imidazo-piridina para su uso en el tratamiento de infeccion virica por herpes. |
CA2526285A1 (en) | 2003-05-15 | 2004-12-23 | Arqule, Inc. | Inhibitors of p38 and methods of using the same |
WO2006010082A1 (en) * | 2004-07-08 | 2006-01-26 | Arqule, Inc. | 1,4-disubstituted naphtalenes as inhibitors of p38 map kinase |
EP2258704A1 (de) * | 2004-10-19 | 2010-12-08 | ArQule, Inc. | Synthese aus Imidazooxazol- und Imidazothiazol-hemmern der P38-map-kinase |
BRPI0921862A2 (pt) * | 2008-12-05 | 2015-12-29 | Arqule Inc | inibidores de raf e seus usos |
EP3791880A1 (de) | 2009-04-29 | 2021-03-17 | Amarin Pharmaceuticals Ireland Limited | Pharmazeutische zusammensetzungen enthaltend epa |
GB201321743D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1541321A (en) * | 1976-03-10 | 1979-02-28 | Metabio | 2,3-dihydroimidazo(2,1-b)thiazole derivatives and process for their preparation |
US4064260A (en) * | 1976-07-29 | 1977-12-20 | E. I. Du Pont De Nemours And Company | Anti-inflammatory diarylimidazothiazoles and their corresponding S-oxides |
US4263311A (en) * | 1976-09-27 | 1981-04-21 | Smithkline Corporation | 5,6-Phenyl-2,3-dihydroimidazo [2,1-b] thiazoles |
US4153706A (en) * | 1978-02-13 | 1979-05-08 | Smithkline Corporation | 6-Hydroxy-5,6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazoles |
US4175127A (en) * | 1978-09-27 | 1979-11-20 | Smithkline Corporation | Pyridyl substituted 2,3-dihydroimidazo[2,1-b]thiazoles |
GB2039882A (en) * | 1979-01-05 | 1980-08-20 | Ciba Geigy Ag | Bicyclic thiadiaza compounds and their use as medicaments |
US4186205A (en) * | 1979-01-08 | 1980-01-29 | Smithkline Corporation | 2,3-Di(4-substituted phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles |
US4507481A (en) * | 1983-07-29 | 1985-03-26 | Pennwalt Corporation | Pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines |
-
1987
- 1987-06-17 US US07/063,550 patent/US4794114A/en not_active Expired - Fee Related
- 1987-08-12 CA CA000544320A patent/CA1292694C/en not_active Expired - Lifetime
- 1987-08-13 GR GR871277A patent/GR871277B/el unknown
- 1987-08-17 EP EP87905839A patent/EP0321490B1/de not_active Expired - Lifetime
- 1987-08-17 DE DE3750140T patent/DE3750140D1/de not_active Expired - Lifetime
- 1987-08-17 AU AU78800/87A patent/AU7880087A/en not_active Abandoned
- 1987-08-17 WO PCT/US1987/002014 patent/WO1988001169A1/en active IP Right Grant
- 1987-08-17 JP JP62505257A patent/JPH01503782A/ja active Pending
- 1987-08-17 AT AT87905839T patent/ATE107507T1/de not_active IP Right Cessation
-
1988
- 1988-04-12 DK DK199788A patent/DK199788A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1988001169A1 (en) | 1988-02-25 |
ATE107507T1 (de) | 1994-07-15 |
AU7880087A (en) | 1988-03-08 |
EP0321490A1 (de) | 1989-06-28 |
US4794114A (en) | 1988-12-27 |
CA1292694C (en) | 1991-12-03 |
EP0321490A4 (de) | 1990-05-14 |
GR871277B (en) | 1987-12-18 |
EP0321490B1 (de) | 1994-06-22 |
JPH01503782A (ja) | 1989-12-21 |
DK199788D0 (da) | 1988-04-12 |
DK199788A (da) | 1988-04-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |