DE3689369D1 - Terpen-amino-Alkohole und deren medizinische Verwendung. - Google Patents
Terpen-amino-Alkohole und deren medizinische Verwendung.Info
- Publication number
- DE3689369D1 DE3689369D1 DE86109915T DE3689369T DE3689369D1 DE 3689369 D1 DE3689369 D1 DE 3689369D1 DE 86109915 T DE86109915 T DE 86109915T DE 3689369 T DE3689369 T DE 3689369T DE 3689369 D1 DE3689369 D1 DE 3689369D1
- Authority
- DE
- Germany
- Prior art keywords
- amino alcohols
- medicinal use
- terpene amino
- terpene
- medicinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP60160782A JPH06726B2 (ja) | 1985-07-19 | 1985-07-19 | 含窒素テルペンアルコ−ル類及びこれを有効成分とする抗アレルギ−剤 |
JP61050784A JPH064566B2 (ja) | 1986-03-07 | 1986-03-07 | 含窒素テルペンアルコ−ル類及びこれを有効成分とする抗アレルギ−剤 |
JP8482286 | 1986-04-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3689369D1 true DE3689369D1 (de) | 1994-01-20 |
DE3689369T2 DE3689369T2 (de) | 1994-05-19 |
Family
ID=27294074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3689369T Expired - Fee Related DE3689369T2 (de) | 1985-07-19 | 1986-07-18 | Terpen-amino-Alkohole und deren medizinische Verwendung. |
Country Status (4)
Country | Link |
---|---|
US (4) | US4946857A (de) |
EP (1) | EP0209158B1 (de) |
CA (1) | CA1320724C (de) |
DE (1) | DE3689369T2 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6458847B1 (en) | 1995-08-08 | 2002-10-01 | University Of Alabama At Birmingham Research Foundation | Method for screening for drugs useful in inhibition of polymerization of aβ and tau peptides |
US6177472B1 (en) * | 1995-08-08 | 2001-01-23 | University Of Alabama At Birmingham Research Foundation | Regulation of alzheimer's disease proteins and uses thereof |
EP2305825B1 (de) | 1998-07-06 | 2015-01-14 | DCV Inc. doing business as Bio-Technical Resourses | Verfahren zur Vitaminherstellung |
US6410755B1 (en) | 1998-07-06 | 2002-06-25 | Dcv, Inc. | Method of vitamin production |
EP1095034A1 (de) * | 1998-07-06 | 2001-05-02 | Eastman Chemical Company | Darstellung von tocoferolen |
CN100390134C (zh) * | 2001-10-31 | 2008-05-28 | 高丽雅娜化妆品股份有限公司 | 含有植烷二元醇胺的治疗痤疮的组合物 |
WO2003072540A1 (en) * | 2002-02-26 | 2003-09-04 | Coreana Cosmetics Co., Ltd. | Novel pseudoceramides and cosmetic compositions comprising the same |
KR100539965B1 (ko) * | 2002-08-29 | 2006-01-10 | 주식회사 코리아나화장품 | 신규한 유사 세라마이드를 포함하는 아토피 피부염 예방및 완화용 화장료 조성물 |
ZA200704864B (en) * | 2004-12-20 | 2008-08-27 | Celanese Int Corp | Modified support materials for catalysts |
AU2006259415B2 (en) * | 2005-06-15 | 2012-08-30 | Massachusetts Institute Of Technology | Amine-containing lipids and uses thereof |
KR101734955B1 (ko) | 2008-11-07 | 2017-05-12 | 메사추세츠 인스티튜트 오브 테크놀로지 | 아미노알콜 리피도이드 및 그의 용도 |
PT2506857T (pt) | 2009-12-01 | 2018-05-14 | Translate Bio Inc | Entrega de arnm para o acréscimo de proteínas e enzimas em doenças genéticas humanas |
WO2012027675A2 (en) | 2010-08-26 | 2012-03-01 | Massachusetts Institute Of Technology | Poly(beta-amino alcohols), their preparation, and uses thereof |
WO2012135025A2 (en) | 2011-03-28 | 2012-10-04 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
WO2012170930A1 (en) | 2011-06-08 | 2012-12-13 | Shire Human Genetic Therapies, Inc | Lipid nanoparticle compositions and methods for mrna delivery |
JP6151707B2 (ja) | 2011-10-27 | 2017-06-21 | マサチューセッツ インスティテュート オブ テクノロジー | 薬物内包微小球の形成が可能なn−末端で官能基化されたアミノ酸誘導体 |
EP2859102A4 (de) | 2012-06-08 | 2016-05-11 | Shire Human Genetic Therapies | Nukleaseresistente polynukleotide und verwendungen davon |
EP2882706A1 (de) | 2012-08-13 | 2015-06-17 | Massachusetts Institute of Technology | Aminhaltige lipoide und ihre verwendungen |
NZ751462A (en) | 2013-03-14 | 2021-07-30 | Shire Human Genetic Therapies | Cftr mrna compositions and related methods and uses |
BR112015022660A2 (pt) | 2013-03-14 | 2017-10-31 | Shire Human Genetic Therapies | métodos para a purificação de rna mensageiro |
US9315472B2 (en) | 2013-05-01 | 2016-04-19 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
EP3060257B1 (de) | 2013-10-22 | 2021-02-24 | Translate Bio, Inc. | Lipidzusammensetzungen zur verabreichung von mrna |
EP4276176A3 (de) | 2013-10-22 | 2024-01-10 | Translate Bio, Inc. | Mrna-therapie für argininosuccinat-synthase-mangel |
EP3574923A1 (de) | 2013-10-22 | 2019-12-04 | Translate Bio, Inc. | Mrna-therapie für phenylketonurie |
SG11201608725YA (en) | 2014-04-25 | 2016-11-29 | Shire Human Genetic Therapies | Methods for purification of messenger rna |
MA48050A (fr) | 2014-05-30 | 2020-02-12 | Translate Bio Inc | Lipides biodégradables pour l'administration d'acides nucléiques |
KR102387898B1 (ko) | 2014-06-24 | 2022-04-15 | 샤이어 휴먼 지네틱 테라피즈 인크. | 핵산의 전달용 입체화학적으로 풍부한 조성물 |
WO2016004202A1 (en) | 2014-07-02 | 2016-01-07 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
AU2016278970B2 (en) | 2015-06-19 | 2020-10-29 | Massachusetts Institute Of Technology | Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell |
US11253605B2 (en) | 2017-02-27 | 2022-02-22 | Translate Bio, Inc. | Codon-optimized CFTR MRNA |
MX2019013752A (es) | 2017-05-16 | 2020-07-20 | Translate Bio Inc | Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr optimizado en codones. |
EP3841208A1 (de) | 2018-08-24 | 2021-06-30 | Translate Bio, Inc. | Verfahren zur reinigung von messenger-rna |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR33432E (fr) * | 1927-05-05 | 1928-09-28 | Fabrications Metalliques Atel | Douille-support |
US3755411A (en) * | 1971-02-01 | 1973-08-28 | Zoecon Corp | Halo or oxy substituted aliphatic di olefinic nitriles |
GB1403851A (en) * | 1973-01-03 | 1975-08-28 | Pierrel Spa | Isoprenoid amines |
US3873566A (en) * | 1973-02-28 | 1975-03-25 | Du Pont | 3-Pyrazolidinones and pyrazolidines |
JPS52131507A (en) * | 1976-04-24 | 1977-11-04 | Sankyo Co Ltd | Polyprenyl derivatives |
US4199519A (en) * | 1976-04-24 | 1980-04-22 | Sankyo Company Limited | Higher polyalkenyl fatty acids and esters |
IT1143583B (it) * | 1976-06-03 | 1986-10-22 | Wellcome Found | Derivati della idantoina e relativo procedimento di produzione |
FR2474863A1 (fr) * | 1980-01-31 | 1981-08-07 | Lab Chauvin Blache | Composition therapeutique contenant un derive d'imidazole et notamment destinee au traitement des thromboses |
GB2088355B (en) * | 1980-11-28 | 1984-08-30 | Takasago Perfumery Co Ltd | Process for preparing hydroxycitronellal |
DE3271901D1 (en) * | 1982-02-03 | 1986-08-07 | Ici Plc | Heterocyclic compounds useful as pesticides and processes for making them |
DE3224129A1 (de) * | 1982-06-29 | 1983-12-29 | Bayer Ag, 5090 Leverkusen | Substituierte azolyl-ketone und -alkohole |
JPS59181263A (ja) * | 1983-03-29 | 1984-10-15 | Nippon Nohyaku Co Ltd | ベンズイミダゾ−ル誘導体 |
US4754043A (en) * | 1985-10-03 | 1988-06-28 | American Home Products Corporation | Oxazole and thiazole naphthalenes as antiallergic agents |
DE3803860A1 (de) * | 1988-02-09 | 1989-08-17 | Basf Ag | N,n'-disubstituierte piperazine |
-
1986
- 1986-07-17 CA CA000514072A patent/CA1320724C/en not_active Expired - Fee Related
- 1986-07-18 EP EP86109915A patent/EP0209158B1/de not_active Expired - Lifetime
- 1986-07-18 DE DE3689369T patent/DE3689369T2/de not_active Expired - Fee Related
- 1986-07-21 US US06/887,431 patent/US4946857A/en not_active Expired - Lifetime
-
1990
- 1990-06-04 US US07/533,395 patent/US5143921A/en not_active Expired - Lifetime
-
1992
- 1992-06-05 US US07/894,567 patent/US5284850A/en not_active Expired - Fee Related
-
1993
- 1993-11-12 US US08/151,039 patent/US5428056A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0209158A2 (de) | 1987-01-21 |
EP0209158A3 (en) | 1989-01-11 |
US5143921A (en) | 1992-09-01 |
US5428056A (en) | 1995-06-27 |
CA1320724C (en) | 1993-07-27 |
US5284850A (en) | 1994-02-08 |
EP0209158B1 (de) | 1993-12-08 |
US4946857A (en) | 1990-08-07 |
DE3689369T2 (de) | 1994-05-19 |
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