DE3683332D1 - Cyanatabspaltung von pergolidzwischenverbindung. - Google Patents

Cyanatabspaltung von pergolidzwischenverbindung.

Info

Publication number
DE3683332D1
DE3683332D1 DE8686306281T DE3683332T DE3683332D1 DE 3683332 D1 DE3683332 D1 DE 3683332D1 DE 8686306281 T DE8686306281 T DE 8686306281T DE 3683332 T DE3683332 T DE 3683332T DE 3683332 D1 DE3683332 D1 DE 3683332D1
Authority
DE
Germany
Prior art keywords
pergolide
cyanate
release
decyanating
alkali metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686306281T
Other languages
English (en)
Inventor
Jerry Wayne Misner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE3683332D1 publication Critical patent/DE3683332D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE8686306281T 1985-08-16 1986-08-14 Cyanatabspaltung von pergolidzwischenverbindung. Expired - Lifetime DE3683332D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/766,362 US4782152A (en) 1985-08-16 1985-08-16 Decyanation of pergolide intermediate

Publications (1)

Publication Number Publication Date
DE3683332D1 true DE3683332D1 (de) 1992-02-20

Family

ID=25076204

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686306281T Expired - Lifetime DE3683332D1 (de) 1985-08-16 1986-08-14 Cyanatabspaltung von pergolidzwischenverbindung.

Country Status (9)

Country Link
US (1) US4782152A (de)
EP (1) EP0213850B1 (de)
JP (1) JPH0670048B2 (de)
KR (1) KR870001540B1 (de)
AT (1) ATE71377T1 (de)
CA (1) CA1296324C (de)
DE (1) DE3683332D1 (de)
HU (1) HU196395B (de)
IL (1) IL79711A0 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
JP2534880B2 (ja) * 1987-11-17 1996-09-18 東洋運搬機株式会社 ホイルロ―ダの作業分析方法
US5463060A (en) 1992-05-21 1995-10-31 Eli Lilly And Company One-pot process
US6572879B1 (en) * 1995-06-07 2003-06-03 Alza Corporation Formulations for transdermal delivery of pergolide
IT1307934B1 (it) * 1999-01-27 2001-11-29 Poli Ind Chimica Spa Processo per la preparazione di derivati alchimercaptometilergolinici.
GB0409785D0 (en) * 2004-04-30 2004-06-09 Resolution Chemicals Ltd Preparation of cabergoline
US7339060B2 (en) 2005-03-23 2008-03-04 Resolution Chemicals, Ltd. Preparation of cabergoline
GB0505965D0 (en) * 2005-03-23 2005-04-27 Resolution Chemicals Ltd Preparation of cabergoline
US20070197576A1 (en) * 2006-02-08 2007-08-23 Resolution Chemicals Limited Production of Cabergoline and Novel Polymorphic Form Thereof
NZ728804A (en) 2014-09-25 2022-10-28 Boehringer Ingelheim Vetmedica Gmbh Combination treatment of sglt2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals
WO2019234069A1 (en) 2018-06-08 2019-12-12 Boehringer Ingelheim Vetmedica Gmbh Liquid pharmaceutical compositions comprising pergolide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4284775A (en) * 1978-10-30 1981-08-18 The Upjohn Company 1,4-Diazabicyclooctane di-N,N'-quaternized compounds
US4246265A (en) * 1979-10-01 1981-01-20 Eli Lilly And Company 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds

Also Published As

Publication number Publication date
EP0213850A3 (en) 1988-01-20
HUT41777A (en) 1987-05-28
US4782152A (en) 1988-11-01
HU196395B (en) 1988-11-28
JPS6245587A (ja) 1987-02-27
IL79711A0 (en) 1986-11-30
KR870001540B1 (ko) 1987-09-02
ATE71377T1 (de) 1992-01-15
CA1296324C (en) 1992-02-25
EP0213850B1 (de) 1992-01-08
EP0213850A2 (de) 1987-03-11
KR870002136A (ko) 1987-03-30
JPH0670048B2 (ja) 1994-09-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee