ATE71377T1 - Cyanatabspaltung von pergolidzwischenverbindung. - Google Patents
Cyanatabspaltung von pergolidzwischenverbindung.Info
- Publication number
- ATE71377T1 ATE71377T1 AT86306281T AT86306281T ATE71377T1 AT E71377 T1 ATE71377 T1 AT E71377T1 AT 86306281 T AT86306281 T AT 86306281T AT 86306281 T AT86306281 T AT 86306281T AT E71377 T1 ATE71377 T1 AT E71377T1
- Authority
- AT
- Austria
- Prior art keywords
- pergolide
- cyanate
- elimination
- decyanating
- alkali metal
- Prior art date
Links
- YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 title abstract 2
- 229960004851 pergolide Drugs 0.000 title abstract 2
- XLJMAIOERFSOGZ-UHFFFAOYSA-M cyanate Chemical compound [O-]C#N XLJMAIOERFSOGZ-UHFFFAOYSA-M 0.000 title 1
- 230000008030 elimination Effects 0.000 title 1
- 238000003379 elimination reaction Methods 0.000 title 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/766,362 US4782152A (en) | 1985-08-16 | 1985-08-16 | Decyanation of pergolide intermediate |
| EP86306281A EP0213850B1 (de) | 1985-08-16 | 1986-08-14 | Cyanatabspaltung von Pergolidzwischenverbindung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE71377T1 true ATE71377T1 (de) | 1992-01-15 |
Family
ID=25076204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86306281T ATE71377T1 (de) | 1985-08-16 | 1986-08-14 | Cyanatabspaltung von pergolidzwischenverbindung. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4782152A (de) |
| EP (1) | EP0213850B1 (de) |
| JP (1) | JPH0670048B2 (de) |
| KR (1) | KR870001540B1 (de) |
| AT (1) | ATE71377T1 (de) |
| CA (1) | CA1296324C (de) |
| DE (1) | DE3683332D1 (de) |
| HU (1) | HU196395B (de) |
| IL (1) | IL79711A0 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU196598B (en) * | 1986-04-25 | 1988-12-28 | Richter Gedeon Vegyeszet | Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds |
| JP2534880B2 (ja) * | 1987-11-17 | 1996-09-18 | 東洋運搬機株式会社 | ホイルロ―ダの作業分析方法 |
| US5463060A (en) | 1992-05-21 | 1995-10-31 | Eli Lilly And Company | One-pot process |
| US6572879B1 (en) * | 1995-06-07 | 2003-06-03 | Alza Corporation | Formulations for transdermal delivery of pergolide |
| IT1307934B1 (it) * | 1999-01-27 | 2001-11-29 | Poli Ind Chimica Spa | Processo per la preparazione di derivati alchimercaptometilergolinici. |
| GB0409785D0 (en) * | 2004-04-30 | 2004-06-09 | Resolution Chemicals Ltd | Preparation of cabergoline |
| GB0505965D0 (en) * | 2005-03-23 | 2005-04-27 | Resolution Chemicals Ltd | Preparation of cabergoline |
| US7339060B2 (en) | 2005-03-23 | 2008-03-04 | Resolution Chemicals, Ltd. | Preparation of cabergoline |
| US20070197576A1 (en) * | 2006-02-08 | 2007-08-23 | Resolution Chemicals Limited | Production of Cabergoline and Novel Polymorphic Form Thereof |
| DK3197429T3 (da) | 2014-09-25 | 2024-08-26 | Boehringer Ingelheim Vetmedica Gmbh | Kombinationsbehandling med sglt2-hæmmere og dopaminagonister til forebyggelse af metaboliske lidelser af dyr i hestefamilien |
| US20190374534A1 (en) | 2018-06-08 | 2019-12-12 | Boehringer Ingelheim Vetmedica Gmbh | Liquid pharmaceutical compositions comprising pergolide |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166182A (en) * | 1978-02-08 | 1979-08-28 | Eli Lilly And Company | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
| US4284775A (en) * | 1978-10-30 | 1981-08-18 | The Upjohn Company | 1,4-Diazabicyclooctane di-N,N'-quaternized compounds |
| US4246265A (en) * | 1979-10-01 | 1981-01-20 | Eli Lilly And Company | 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds |
-
1985
- 1985-08-16 US US06/766,362 patent/US4782152A/en not_active Expired - Lifetime
-
1986
- 1986-08-13 IL IL79711A patent/IL79711A0/xx not_active IP Right Cessation
- 1986-08-13 CA CA000515847A patent/CA1296324C/en not_active Expired - Lifetime
- 1986-08-14 KR KR1019860006712A patent/KR870001540B1/ko not_active Expired
- 1986-08-14 EP EP86306281A patent/EP0213850B1/de not_active Expired - Lifetime
- 1986-08-14 AT AT86306281T patent/ATE71377T1/de active
- 1986-08-14 DE DE8686306281T patent/DE3683332D1/de not_active Expired - Lifetime
- 1986-08-15 JP JP61191954A patent/JPH0670048B2/ja not_active Expired - Lifetime
- 1986-08-15 HU HU863600A patent/HU196395B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0670048B2 (ja) | 1994-09-07 |
| KR870002136A (ko) | 1987-03-30 |
| IL79711A0 (en) | 1986-11-30 |
| CA1296324C (en) | 1992-02-25 |
| DE3683332D1 (de) | 1992-02-20 |
| HUT41777A (en) | 1987-05-28 |
| EP0213850B1 (de) | 1992-01-08 |
| US4782152A (en) | 1988-11-01 |
| KR870001540B1 (ko) | 1987-09-02 |
| HU196395B (en) | 1988-11-28 |
| EP0213850A2 (de) | 1987-03-11 |
| EP0213850A3 (en) | 1988-01-20 |
| JPS6245587A (ja) | 1987-02-27 |
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