DE3682958D1 - Enzymatische herstellung optischer isomere von 2-halopropionsaeuren. - Google Patents

Enzymatische herstellung optischer isomere von 2-halopropionsaeuren.

Info

Publication number
DE3682958D1
DE3682958D1 DE8686201209T DE3682958T DE3682958D1 DE 3682958 D1 DE3682958 D1 DE 3682958D1 DE 8686201209 T DE8686201209 T DE 8686201209T DE 3682958 T DE3682958 T DE 3682958T DE 3682958 D1 DE3682958 D1 DE 3682958D1
Authority
DE
Germany
Prior art keywords
optical isomers
enzymatic production
halopropionic acids
halopropionic
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686201209T
Other languages
English (en)
Inventor
Alexander M Klibanov
Gerold Kirchner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of DE3682958D1 publication Critical patent/DE3682958D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE8686201209T 1985-02-27 1986-02-26 Enzymatische herstellung optischer isomere von 2-halopropionsaeuren. Expired - Fee Related DE3682958D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/706,039 US4601987A (en) 1985-02-27 1985-02-27 Enzymatic production of optical isomers of 2-halopropionic acids

Publications (1)

Publication Number Publication Date
DE3682958D1 true DE3682958D1 (de) 1992-01-30

Family

ID=24835974

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686201209T Expired - Fee Related DE3682958D1 (de) 1985-02-27 1986-02-26 Enzymatische herstellung optischer isomere von 2-halopropionsaeuren.

Country Status (13)

Country Link
US (1) US4601987A (de)
EP (1) EP0206436B1 (de)
AT (1) ATE70563T1 (de)
CZ (3) CZ132286A3 (de)
DD (3) DD258625A1 (de)
DE (1) DE3682958D1 (de)
ES (1) ES8705351A1 (de)
NZ (1) NZ215099A (de)
PL (1) PL148128B1 (de)
SK (2) SK329792A3 (de)
TR (1) TR23363A (de)
YU (3) YU28686A (de)
ZA (1) ZA861473B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61227797A (ja) * 1985-04-01 1986-10-09 Kanegafuchi Chem Ind Co Ltd 光学活性グリコ−ル類の製造方法
US5322791A (en) * 1985-12-20 1994-06-21 Wisconsin Alumni Research Foundation Process for preparing (S)-α-methylarylacetic acids
US4897357A (en) * 1985-12-31 1990-01-30 Ethyl Corporation (S) α-cyano-3-phenoxy-benzyl acetate
GB8600245D0 (en) * 1986-01-07 1986-02-12 Shell Int Research Preparation of 2-arylpropionic acids
US5032523A (en) * 1987-01-14 1991-07-16 Lion Corporation Preparation of optically active esters
JP2707076B2 (ja) * 1987-05-01 1998-01-28 チッソ株式会社 光学活性化合物の製造法
DE3727243A1 (de) * 1987-08-15 1989-02-23 Hoechst Ag Verfahren zur enzymatischen herstellung optisch aktiver phosphorhaltiger funktioneller essigsaeurederivate
JP2655893B2 (ja) * 1988-10-20 1997-09-24 ユニチカ株式会社 光学活性なβ−ハロ乳酸又はグリシジル酸の合成法
NL8802849A (nl) * 1988-11-18 1990-06-18 Stamicarbon Werkwijze voor de enantioselectieve bereiding van d-(-)-3-hal-methylpropionzuur of derivaten daarvan en de bereiding van captopril daaruit.
JPH02273196A (ja) * 1989-03-08 1990-11-07 Wisconsin Alumni Res Found ラセミ化合物の生体触媒分割のエナンチオ選択性の改良法
FR2646669B1 (fr) * 1989-05-02 1991-07-05 Rhone Poulenc Chimie Procede de separation enantiomeriquement selective des esters des acides halogeno-2 propioniques
US5108916A (en) * 1989-06-05 1992-04-28 Rhone-Poulenc Rorer, S.A. Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa
US5420037A (en) * 1989-09-26 1995-05-30 E. R. Squibb & Sons, Inc. Process for separation of enantiomeric 3-mercapto-2-substituted alkanoic acid using lipase P30 and synthesis of captopril type compounds
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5338730A (en) * 1990-06-19 1994-08-16 Sandoz Ltd. Use of the (R) isomer of 2-[(2-octa-decyloxymethyl-tetrahydro-2-furanylmethoxy)-hydroxyphosphinyloxy]-N,N,N-trimethylethanaminium hydroxide inner salt-4-oxide in treating multiple sclerosis
HU210548B (en) * 1990-06-19 1995-05-29 Sandoz Ag Process for preparing 2-tetrahydrofurane derivatives
US5106736A (en) * 1991-04-23 1992-04-21 E.R. Squibb & Sons, Inc. Enzymatic process for enantiomer-specific perparation of mercapto alkanoic acid compounds
AT398081B (de) * 1991-04-29 1994-09-26 Chemie Linz Gmbh Verfahren zur enzymatischen hydrolyse eines carbonsäurederivates
DE4117255A1 (de) * 1991-05-27 1992-12-03 Chemie Linz Deutschland Verfahren zur enzymatischen hydrolyse eines carbonsaeurederivates
JP2687789B2 (ja) * 1991-08-13 1997-12-08 田辺製薬株式会社 光学活性３−フェニルグリシッド酸エステル類化合物の製法
EP0538693A3 (en) * 1991-10-23 1994-08-17 Squibb & Sons Inc Stereoselective preparation of halophenyl alcohols
US5324662A (en) * 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
US5420337A (en) * 1992-11-12 1995-05-30 E. R. Squibb & Sons, Inc. Enzymatic reduction method for the preparation of compounds useful for preparing taxanes
US6277879B1 (en) 1994-08-03 2001-08-21 Sarawak Medichem Pharmaceuticals, Inc. Calanolide analogues and methods of their use
WO2000064903A2 (en) 1999-04-26 2000-11-02 Sarawak Medichem Pharmaceuticals, Inc. Methods for preparing antiviral calanolide compounds
KR100613691B1 (ko) * 2004-09-07 2006-08-21 한국화학연구원 토양 메타게놈 유래 신규 리파제 및 이를 이용하여 라세믹에틸 2-브로모프로피오네이트를 선택적으로 분할하는 방법
CN100436399C (zh) * 2006-06-27 2008-11-26 浙江工业大学 一种制备(s)-(-)-2-氯丙酸酯和(r)-(+)-2-氯丙酸的方法
CN104262091A (zh) * 2014-10-09 2015-01-07 王同俊 R-1-(2,5-二甲基苯基)乙醇及其酯的合成
CN104262092A (zh) * 2014-10-09 2015-01-07 王同俊 R-1-(2-甲基苯基)乙醇及其酯的合成
CN104262093A (zh) * 2014-10-09 2015-01-07 王同俊 R-1-(3-甲基苯基)乙醇及其酯的合成
CN104262094A (zh) * 2014-10-12 2015-01-07 王同俊 一种r-1-(4-氯苯基)乙醇及其酯的合成方法
CN104262096A (zh) * 2014-10-12 2015-01-07 王同俊 一种r-1-(4-溴苯基)乙醇及其酯的合成方法
CN104262095A (zh) * 2014-10-12 2015-01-07 王同俊 R-1-(4-氟苯基)乙醇及其酯的合成

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2055802A (en) * 1979-08-07 1981-03-11 Ici Ltd Process for the preparation of the optical isomers of alpha -chloro (or bromo) propionic acid esters
JPS5794295A (en) * 1980-12-04 1982-06-11 Sagami Chem Res Center Preparation of optically active ester and/or acid

Also Published As

Publication number Publication date
ES8705351A1 (es) 1987-05-01
NZ215099A (en) 1988-04-29
DD258625A1 (de) 1988-07-27
US4601987A (en) 1986-07-22
SK329792A3 (en) 1995-02-08
CZ329792A3 (en) 1993-06-16
EP0206436B1 (de) 1991-12-18
YU194687A (en) 1988-06-30
ZA861473B (en) 1987-01-28
CZ132286A3 (en) 1994-11-16
ES552498A0 (es) 1987-05-01
PL148128B1 (en) 1989-09-30
YU28686A (en) 1988-04-30
ATE70563T1 (de) 1992-01-15
EP0206436A2 (de) 1986-12-30
YU194587A (en) 1988-10-31
DD260085A1 (de) 1988-09-14
PL258141A1 (en) 1987-06-15
EP0206436A3 (en) 1988-09-21
DD260086A1 (de) 1988-09-14
SK329692A3 (en) 1995-02-08
TR23363A (tr) 1989-12-28
CZ329692A3 (en) 1993-06-16

Similar Documents

Publication Publication Date Title
DE3682958D1 (de) Enzymatische herstellung optischer isomere von 2-halopropionsaeuren.
DE3687946D1 (de) Verfahren zur herstellung der 2-keto-l-gulonsaeure.
DK33889D0 (da) Fremgangsmaade til fremstilling af optisk aktive 2-aryl-propionsyrer
DK0535939T3 (da) Fremgangsmåde til fremstilling af omega 9-type polyumættet fedtsyre
DE68906904D1 (de) Verfahren zur herstellung von optisch aktiven 2-arylalkansaeuren.
ATE86304T1 (de) Verfahren zur herstellung von 2-keto-lgulons|ure.
DE3765157D1 (de) Verfahren zur herstellung von macrolid-derivaten.
SE8105155L (sv) Forfarande for esterifiering av alfa-l-aspartyl-l-fenylalanin
DK0409521T3 (da) Forbedret enzymatisk oxidation af Ceph C til glutaryl-7-aminocephalosporansyre
DE3785697D1 (de) Herstellung von cyclopentenonen.
DE3667462D1 (de) Herstellung von dicarbonsaeuren oder dicarbonsaeureestern.
ATE84064T1 (de) Herstellung von mikroorganismen mit eiskristallbildungsaktivitaet.
DE68912236D1 (de) Verfahren zur Herstellung von hochgradig ungesättigten Fettsäuren.
ATE63337T1 (de) Verfahren zur enzymatischen trennung von optisch aktiven isomeren des 2-aminobutanols.
ATE129015T1 (de) Verfahren zur herstellung von mehrfach ungesättigten fettsäuren mit ungerader zahl von kohlenstoffatomen.
DE3877510D1 (de) Verfahren zur herstelllung von brenztraubensaeure.
ES2055122T3 (es) Procedimiento de preparacion de acidos 2-ariloxi- o 2-ariltio-alcanoicos.
DK0567830T3 (da) Fremgangsmåde til modifikation af lipaser
DE3764545D1 (de) Herstellungsverfahren von alpha-halogenierten organischen carbonatestern.
ATE128981T1 (de) Verfahren zur herstellung von phosphatidylcholin derivaten.
IT1136580B (it) Processo per la produzione di l-aminoacidi usando microorganismi immobilizzati

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee