DE3673161D1 - Renininhibitoren und verfahren zur anwendung derselben. - Google Patents
Renininhibitoren und verfahren zur anwendung derselben.Info
- Publication number
- DE3673161D1 DE3673161D1 DE8686308492T DE3673161T DE3673161D1 DE 3673161 D1 DE3673161 D1 DE 3673161D1 DE 8686308492 T DE8686308492 T DE 8686308492T DE 3673161 T DE3673161 T DE 3673161T DE 3673161 D1 DE3673161 D1 DE 3673161D1
- Authority
- DE
- Germany
- Prior art keywords
- renine
- inhibitors
- renine inhibitors
- rise
- controlled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/553—Renin inhibitors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/795,282 US4906613A (en) | 1985-11-05 | 1985-11-05 | Antiglaucoma compositions and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3673161D1 true DE3673161D1 (de) | 1990-09-06 |
Family
ID=25165170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686308492T Expired - Fee Related DE3673161D1 (de) | 1985-11-05 | 1986-10-31 | Renininhibitoren und verfahren zur anwendung derselben. |
Country Status (8)
Country | Link |
---|---|
US (2) | US4906613A (de) |
EP (2) | EP0243477A1 (de) |
JP (1) | JPS63501287A (de) |
AT (1) | ATE55054T1 (de) |
DE (1) | DE3673161D1 (de) |
ES (1) | ES2031822T3 (de) |
GR (1) | GR3000993T3 (de) |
WO (1) | WO1987002581A1 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5346887A (en) * | 1987-10-06 | 1994-09-13 | Abbott Laboratories | Glaucoma treatment |
US5036051A (en) * | 1987-10-06 | 1991-07-30 | Abbott Laboratories | Glaucoma treatment |
US4927807A (en) * | 1987-10-06 | 1990-05-22 | Abbott Laboratories | Glaucoma treatment |
GB8728560D0 (en) * | 1987-12-07 | 1988-01-13 | Glaxo Group Ltd | Chemical compounds |
GB8728561D0 (en) * | 1987-12-07 | 1988-01-13 | Glaxo Group Ltd | Chemical compounds |
ES2058489T3 (es) * | 1988-01-26 | 1994-11-01 | Sankyo Co | Oligopeptidos con actividades inhibidoras de la renina, su preparacion y su uso. |
US5059589A (en) * | 1988-09-08 | 1991-10-22 | Abbott Laboratories | Glaucoma treatment |
US5268374A (en) * | 1988-10-04 | 1993-12-07 | Abbott Laboratories | Non-peptide renin inhibitors |
IL92011A0 (en) * | 1988-10-19 | 1990-07-12 | Abbott Lab | Heterocyclic peptide renin inhibitors |
US5164388A (en) * | 1988-10-19 | 1992-11-17 | Abbott Laboratories | Heterocyclic peptide renin inhibitors |
AU4664089A (en) * | 1988-12-22 | 1990-07-10 | Upjohn Company, The | Transdermal and intranasal administration of renin inhibitory peptides |
FR2647675B1 (fr) * | 1989-06-05 | 1994-05-20 | Sanofi | Utilisation d'un derive de la statine dans le traitement des affections oculaires |
US5063208A (en) * | 1989-07-26 | 1991-11-05 | Abbott Laboratories | Peptidyl aminodiol renin inhibitors |
US5688770A (en) * | 1989-12-14 | 1997-11-18 | Schering Corporation | Antiglaucoma compositions and methods |
US5182266A (en) * | 1990-01-31 | 1993-01-26 | Abbott Laboratories | Method for treating renal disease |
WO1991016031A1 (en) * | 1990-04-23 | 1991-10-31 | Abbott Laboratories | Psoriasis treatment |
US5332742A (en) * | 1990-05-11 | 1994-07-26 | Abbott Laboratories | Renin inhibitors |
IE68045B1 (en) * | 1990-05-11 | 1996-05-15 | Abbott Lab | Renin inhibitors |
JPH04243835A (ja) * | 1990-08-29 | 1992-08-31 | Pfizer Inc | 高眼圧症又は緑内障治療用薬剤組成物及び治療方法 |
GB9127041D0 (en) * | 1991-12-20 | 1992-02-19 | Fujisawa Pharmaceutical Co | New use |
US6165490A (en) * | 1996-04-05 | 2000-12-26 | Staar Surgical Ag | Biological material, method of preparing such materials, uses thereof and products made therefrom |
US6420407B1 (en) | 1999-09-16 | 2002-07-16 | Gerald Horn | Ophthalmic formulation which modulates dilation |
US6291498B1 (en) | 1999-09-16 | 2001-09-18 | Gerald Horn | Method for optimizing pupil size using alpha antagonist |
US8889112B2 (en) * | 1999-09-16 | 2014-11-18 | Ocularis Pharma, Llc | Ophthalmic formulations including selective alpha 1 antagonists |
US20020082288A1 (en) * | 1999-09-16 | 2002-06-27 | Gerald Horn | Ophthalmic formulations comprising an imidazoline |
US6730065B1 (en) | 2000-09-15 | 2004-05-04 | Ocularis Pharma, Inc. | Night vision composition |
US20060211753A1 (en) * | 2000-11-03 | 2006-09-21 | Ocularis Pharma, Inc. | Method and composition which reduces stimulation of muscles which dilate the eye |
EP1896050A4 (de) | 2005-06-17 | 2010-01-27 | Regenerx Biopharmaceuticals | Lkktet- und / oder lkktnt-peptidzusammensetzungen und verfahren |
CA2899339C (en) | 2013-02-01 | 2021-07-06 | Ocularis Pharma, Llc | Aqueous ophthalmic solutions of phentolamine and medical uses thereof |
JP6436354B2 (ja) | 2013-02-01 | 2018-12-12 | オキュフィア・ファーマ・インコーポレイテッドOcuphire Pharma, Inc. | 視機能を改善するためのフェントラミンの連日眼科投与のための方法および組成物 |
SG11202104094YA (en) | 2018-10-26 | 2021-05-28 | Ocuphire Pharma Inc | Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders |
WO2021165369A1 (en) | 2020-02-19 | 2021-08-26 | Vestlandets Innovasjonsselskap As | Treatment of corneal vascularisation |
CN115368310A (zh) | 2021-05-18 | 2022-11-22 | 奥库菲尔医药公司 | 合成甲磺酸酚妥拉明的方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2461798A1 (de) * | 1974-01-12 | 1975-07-17 | Dainippon Pharmaceutical Co | Neue alkylphosphorylamine, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
FR2399409A1 (fr) * | 1977-08-04 | 1979-03-02 | Anvar | Nouveaux derives de la pepstatine, leur preparation et les compositions pharmaceutiques qui les contiennent |
US4269827A (en) * | 1980-06-23 | 1981-05-26 | The Massachusetts General Hospital | Process and composition for reducing blood pressure |
NO812612L (no) * | 1980-08-06 | 1982-02-08 | Ferring Pharma Ltd | Enzym-inhibitorer. |
US4478826A (en) * | 1981-10-08 | 1984-10-23 | Merck & Co., Inc. | Renin inhibitory peptides |
US4384994A (en) * | 1981-10-08 | 1983-05-24 | Merck & Co., Inc. | Renin inhibitory peptides |
US4470971A (en) * | 1981-10-19 | 1984-09-11 | Merck & Co., Inc. | Renin inhibitory peptides having His13 |
US4479941A (en) * | 1981-12-10 | 1984-10-30 | Merck & Co., Inc. | Renin inhibitory peptides having PHE13 delection |
FR2531951A1 (fr) * | 1982-08-17 | 1984-02-24 | Sanofi Sa | Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent |
US4478827A (en) * | 1983-05-09 | 1984-10-23 | The General Hospital Corporation | Renin inhibitors |
US4455303A (en) * | 1983-05-24 | 1984-06-19 | The General Hospital Corporation | Renin inhibitors |
US4485099A (en) * | 1983-06-15 | 1984-11-27 | Merck & Co., Inc. | Renin inhibitors containing a C-terminal amide cycle |
US4477441A (en) * | 1983-09-14 | 1984-10-16 | Merck & Co., Inc. | Renin inhibitors containing a C-terminal disulfide cycle |
US4477440A (en) * | 1983-09-14 | 1984-10-16 | Merck & Co., Inc. | Renin inhibitors containing an n-terminal disulfide cycle |
US4602093A (en) * | 1984-02-08 | 1986-07-22 | Merck & Co., Inc. | Novel substituted imidazoles, their preparation and use |
US4510085A (en) * | 1984-04-12 | 1985-04-09 | G.D. Searle & Co. | Antihypertensive tetrapeptide amides |
US4514332A (en) * | 1984-04-16 | 1985-04-30 | G. D. Searle & Co. | Tetrapeptide adamantyl amides |
US4574127A (en) * | 1984-05-07 | 1986-03-04 | Merck & Co., Inc. | Oxazoles and thiazoles containing an aminohydroxypropoxyphenyl moiety |
US4749698A (en) * | 1985-07-08 | 1988-06-07 | Rorer Pharmaceutical Corporation | Antihypertensive derivatives |
-
1985
- 1985-11-05 US US06/795,282 patent/US4906613A/en not_active Expired - Fee Related
-
1986
- 1986-10-31 EP EP86906688A patent/EP0243477A1/de active Pending
- 1986-10-31 DE DE8686308492T patent/DE3673161D1/de not_active Expired - Fee Related
- 1986-10-31 JP JP61503365A patent/JPS63501287A/ja active Pending
- 1986-10-31 EP EP86308492A patent/EP0246381B1/de not_active Expired - Lifetime
- 1986-10-31 AT AT86308492T patent/ATE55054T1/de not_active IP Right Cessation
- 1986-10-31 ES ES198686308492T patent/ES2031822T3/es not_active Expired - Lifetime
- 1986-10-31 WO PCT/US1986/002291 patent/WO1987002581A1/en not_active Application Discontinuation
-
1989
- 1989-12-14 US US07/450,766 patent/US5352666A/en not_active Expired - Fee Related
-
1990
- 1990-10-29 GR GR90400832T patent/GR3000993T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3000993T3 (en) | 1991-12-10 |
US4906613A (en) | 1990-03-06 |
ES2031822T3 (es) | 1993-01-01 |
US5352666A (en) | 1994-10-04 |
EP0243477A1 (de) | 1987-11-04 |
EP0246381A1 (de) | 1987-11-25 |
ATE55054T1 (de) | 1990-08-15 |
JPS63501287A (ja) | 1988-05-19 |
EP0246381B1 (de) | 1990-08-01 |
WO1987002581A1 (en) | 1987-05-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3673161D1 (de) | Renininhibitoren und verfahren zur anwendung derselben. | |
ATE89738T1 (de) | Antientzuendungsmittel. | |
DE3852697D1 (de) | Verfahren und System zur Stromversorgungssteuerung eines Rechnersystems. | |
ATA361585A (de) | Verfahren und vorrichtung zur oberflaechenbehandlung von flaechigen werkstuecken | |
ES2097972T3 (es) | Dispositivo para impedir la restenosis arterial. | |
DE3670341D1 (de) | Verfahren und einrichtung zum kontrollieren des aufladedruckes eines turboladers. | |
AT354952B (de) | Injektor zur fluessigkeitsbegasung und dessen verwendung | |
DE69532279D1 (de) | Methoden und zusammensetzung zur inhibition der angiogenese | |
DE69208412D1 (de) | Verfahren und Einrichtung zur Luftdestillation und die Verwendung bei der Zuführung von Gas in Stahlwerken | |
DE69419100T2 (de) | Verfahren und Vorrichtung zur Rückkopplungsregelung eines asymmetrischen Differenzdruckwandlers | |
DE68919007T2 (de) | Verfahren und Vorrichtung zur präzisen Lötzinnzuführung. | |
AT389117B (de) | Verfahren zur herstellung einer neuen, wasserfreien und stabilen deltakristallform von prazosinhydrochlorid | |
DE4395128T1 (de) | Verfahren und Vorrichtung zur Erleichterung der Brennstoffzufuhr in einem Druckraum | |
DE68917614D1 (de) | Verfahren zum Ausrichten und zur Herstellung eines Verbindungszapfens. | |
DE69224470D1 (de) | Verfahren und Gerät zur Erzeugung von Servomarken | |
DE3852357D1 (de) | Dünnfilmkohlewerkstoff und Verfahren zum Aufbringen. | |
DE3884585T2 (de) | Verfahren und Vorrichtung zum Ändern der Einstellung von Überdruck-Tellerventilen. | |
SE8803085L (sv) | Dosform foer avgivande av diltiazem | |
ATE96320T1 (de) | Castanospermin-ester zur hemmung der tumormetastasierung. | |
DE3668562D1 (de) | Verfahren und vorrichtung zur beschichtung mit wirbelbett und vortexeffekt. | |
DE3669733D1 (de) | Verfahren und vorrichtung fuer anwendung mit ueberdruckreaktoren. | |
ATA29686A (de) | Verfahren und spannvorrichtung zum kontinuierlichen richten von insbesondere duennen metallbaendern | |
DE69310695D1 (de) | Verfahren zur Steuerungshilfe eines tieffliegenden Flugkörpers | |
ATA32078A (de) | Verfahren zur herstellung von neuen amino-spiro (oxa(oder thia)-cycloalkanpenam) carbonsaeuren sowie von deren salzen und estern | |
DE3867728D1 (de) | Silanisierungsmittel und verfahren zur silanisierung. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |