DE3587605D1 - Interleukin-1 und dessen derivat. - Google Patents

Interleukin-1 und dessen derivat.

Info

Publication number
DE3587605D1
DE3587605D1 DE85309453T DE3587605T DE3587605D1 DE 3587605 D1 DE3587605 D1 DE 3587605D1 DE 85309453 T DE85309453 T DE 85309453T DE 3587605 T DE3587605 T DE 3587605T DE 3587605 D1 DE3587605 D1 DE 3587605D1
Authority
DE
Germany
Prior art keywords
interleukin
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE85309453T
Other languages
English (en)
Other versions
DE3587605T2 (de
Inventor
Masaaki Yamada
Yasuji Furutani
Michiko Yamayoshi
Mitsue Notake
Junichi Yamagishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27522040&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3587605(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP27866584A external-priority patent/JP2579747B2/ja
Priority claimed from JP60039762A external-priority patent/JPS61199786A/ja
Priority claimed from JP60112474A external-priority patent/JPS61271222A/ja
Priority claimed from JP60171493A external-priority patent/JPS6232887A/ja
Priority claimed from JP60200894A external-priority patent/JPS6261585A/ja
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Publication of DE3587605D1 publication Critical patent/DE3587605D1/de
Application granted granted Critical
Publication of DE3587605T2 publication Critical patent/DE3587605T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE85309453T 1984-12-25 1985-12-23 Interleukin-1 und dessen Derivat. Expired - Lifetime DE3587605T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP27866584A JP2579747B2 (ja) 1984-12-25 1984-12-25 ヒトインタ−ロイキン１をコ−ドする新規ｄｎａ
JP60039762A JPS61199786A (ja) 1985-02-28 1985-02-28 ウサギインタ−ロイキン１をコ−ドする新規ｄｎａ
JP60112474A JPS61271222A (ja) 1985-05-24 1985-05-24 ヒトインターロイキン１ポリペプチド及びその製造法
JP60171493A JPS6232887A (ja) 1985-08-02 1985-08-02 インタ−ロイキン１活性を示すポリペプチド及びそれをコ−ドするｄｎａ
JP60200894A JPS6261585A (ja) 1985-09-11 1985-09-11 インタ−ロイキン１活性を示すポリペプチド類及びそれをコ−ドするｄｎａ

Publications (2)

Publication Number Publication Date
DE3587605D1 true DE3587605D1 (de) 1993-11-04
DE3587605T2 DE3587605T2 (de) 1994-03-17

Family

ID=27522040

Family Applications (1)

Application Number Title Priority Date Filing Date
DE85309453T Expired - Lifetime DE3587605T2 (de) 1984-12-25 1985-12-23 Interleukin-1 und dessen Derivat.

Country Status (4)

Country Link
US (2) US5376639A (de)
EP (1) EP0188920B1 (de)
KR (1) KR950000712B1 (de)
DE (1) DE3587605T2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3588241T2 (de) * 1984-05-18 2002-12-05 New England Medical Center Inc Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
US5998578A (en) * 1984-05-18 1999-12-07 New England Medical Center Hospitals, Inc. Biologically active fragments of IL-1β
EP0569687B1 (de) * 1984-05-18 2002-08-21 New England Medical Center Hospitals, Inc. Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
US6107465A (en) * 1984-12-21 2000-08-22 Otsuka Pharmaceutical Co., Ltd. IL-1β and derivatives thereof and drugs
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
US5342614A (en) * 1984-12-21 1994-08-30 Otsuka Pharmaceutical Co., Ltd. Method of treating arthritus or inflammation with IL-1β or derivatives thereof
EP0188920B1 (de) * 1984-12-25 1993-09-29 Dainippon Pharmaceutical Co., Ltd. Interleukin-1 und dessen Derivat
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene
EP0200986B2 (de) 1985-04-25 1998-03-11 F. Hoffmann-La Roche Ag Rekombinantes Humaninterleukin-1
JPS6291197A (ja) * 1985-10-17 1987-04-25 Dainippon Pharmaceut Co Ltd 抗ヒトインタ−ロイキン１抗体，その製法及びその使用法
JPS62185098A (ja) * 1986-02-10 1987-08-13 Otsuka Pharmaceut Co Ltd インタ−ロイキン−２活性を有するポリペプチド
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
US5017692A (en) * 1986-09-04 1991-05-21 Schering Corporation Truncated human interleukin-a alpha
DK590387A (da) * 1986-11-13 1988-05-14 Otsuka Pharma Co Ltd Antistoffer mod interleukin-1
ZA89202B (en) * 1988-01-15 1989-09-27 Hoffmann La Roche Recombinant human interleukin-1 alpha polypeptides
JP2698976B2 (ja) * 1988-02-03 1998-01-19 大日本製薬株式会社 新規ポリペプチド及びそれをコードするｄｎａ
US5290917A (en) * 1988-02-03 1994-03-01 Dainippon Pharmaceutical Co., Ltd. Modified polypeptides of IL-1α
US5120534A (en) * 1988-07-29 1992-06-09 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and medicament for treating thrombocytopenia
US6107071A (en) * 1996-09-24 2000-08-22 Smithkline Beecham Corporation Histidinol dehydrogenase
US20050282198A1 (en) * 1997-05-29 2005-12-22 Interleukin Genetics, Inc. Diagnostics and therapeutics for diseases associated with an IL-1 inflammatory haplotype
GB9711040D0 (en) * 1997-05-29 1997-07-23 Duff Gordon W Prediction of inflammatory disease
US7176179B1 (en) 1997-05-30 2007-02-13 The Regents Of The University Of California Selective induction of cell death by delivery of amino-terminal interleukin-1-α pro-piece polypeptide
US6191269B1 (en) * 1997-05-30 2001-02-20 The Regents Of The University Of California Selective induction of cell death by delivery of amino-terminal interleukin-1-α pro-piece polypeptide
WO1999037321A1 (fr) * 1998-01-22 1999-07-29 Gosudarstvenny Nauchno-Issledovatelsky Institut Osobo Chistykh Biopreparatov (Gosnii Ochb) Preparation immuno-modulatrice a base d'interleukine 1 et procede de preparation
US20030154504A1 (en) 1998-06-24 2003-08-14 Farese Robert V. Methods and compositions for modulating carbohydrate metabolism
US20030026806A1 (en) * 2000-10-27 2003-02-06 Amgen Inc. Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof
US20080118920A1 (en) * 2004-05-03 2008-05-22 Duff Gordon W Diagnostics And Therapeutics For Diseases Associated With An Il-1 Inflammatory Haplotype

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4512974A (en) * 1982-12-08 1985-04-23 Moldawer Lyle L Treatment of protein malnourished surgical patients
US4542017A (en) * 1982-12-09 1985-09-17 Moldawer Lyle L Treatment of protein malnourished bacterially infected humans with LEM
US4745057A (en) * 1984-05-18 1988-05-17 Eli Lilly And Company Method, vectors and transformants for high expression of heterologous polypeptides in yeast
DE3588241T2 (de) * 1984-05-18 2002-12-05 New England Medical Center Inc Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
IE61353B1 (en) * 1984-06-19 1994-11-02 Immunex Corp Purified interleukin 1
EP0188920B1 (de) * 1984-12-25 1993-09-29 Dainippon Pharmaceutical Co., Ltd. Interleukin-1 und dessen Derivat
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene
EP0200986B2 (de) * 1985-04-25 1998-03-11 F. Hoffmann-La Roche Ag Rekombinantes Humaninterleukin-1
US4816436A (en) * 1986-10-29 1989-03-28 Immunex Corporation Anti-arthritic use of interleukin-1 proteins
US5047505A (en) * 1987-01-27 1991-09-10 Du Pont Merck Pharmaceutical Company High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
ZA89202B (en) * 1988-01-15 1989-09-27 Hoffmann La Roche Recombinant human interleukin-1 alpha polypeptides
US5039790A (en) * 1989-01-11 1991-08-13 Monsanto Company Bioactive fragment of interleukin-1-B that has antagonistic activity
US5075288A (en) * 1990-09-05 1991-12-24 The University Of Tennessee Research Corporation Somnogenic fragment of interleukin-1β

Also Published As

Publication number Publication date
KR860005024A (ko) 1986-07-16
KR950000712B1 (ko) 1995-01-27
EP0188920A2 (de) 1986-07-30
US5376639A (en) 1994-12-27
EP0188920B1 (de) 1993-09-29
EP0188920A3 (en) 1987-05-20
US5494663A (en) 1996-02-27
DE3587605T2 (de) 1994-03-17

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings